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Dear Sir, It has been suggested that patients with Crohn's Disease (CD) exhibit a higher prevalence of psychiatric disorders compared to the normal population.1 Psychiatric disturbances and stress could be psychological factors participating in the exacerbation of inflammatory bowel disease (IBD).2 Patients with IBD are thought to be at a rather increased risk for suicide.3 So far, psychosis appearing as a cardinal clinical manifestation preceding diagnosis of CD has not been described. We report a patient with extensive small bowel CD, who was admitted to the hospital because of psychiatric …

Dear Sir, It is well established that haematological malignancies could develop during the clinical course of Inflammatory Bowel Disease (IBD).1,2 Epidemiological data suggest that this risk might be increased3 and be related with the use of either immunosuppressants or biologic agents.4 So far, these malignancies have been observed after the establishment of diagnosis of IBD. We describe the case of a patient in whom the diagnosis of Crohn's disease (CD) was made 6 years after the diagnosis of chronic lymphoid leukaemia. To the best of our knowledge, the appearance of CD years after the establishment of chronic lymphoid leukaemia has not yet been described. A 71-year old man was admitted to …

Dear Sir, Psoriasis is a chronic, relapsing, autoimmune disease that represents a relatively rare extraintestinal manifestation especially in patients with inflammatory bowel disease.1,2 In Germany the relative risk of developing psoriasis in a patient with Crohn's disease (CD) has been estimated to be 2.1.3 The underlying relationship between these two disorders is largely unknown although it seems to comprise genetic data (involvement of shared predisposing loci or genes), immunological data (inflammation mechanisms such as activation pathway of Th17 lymphocytes), and environmental co-factors (smoking, possibly certain …