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The results of a randomized double-blind study with two comparable treatment groups are reported. In the course of treatment the frequency of angina pectoris during exercise as measured by a 4-point rating scale of symptom intensity decreased significantly for both groups. In comparison to the base line data the mean total workload increased significantly in both treatment groups (Molsidomin from 379 to 526 watt min; ISDN from 382 to 524 watt min-1). The product of systolic blood pressure and heart rate (BP X HR) under maximal workload increased significantly in both groups (Molsidomin from 17.5 to 20.9 mmHg min-1 1000(-1); ISDN from 17.7 to 20.2 mmHg min-1 1000(-1). The decrease in the ischaemic ST-segment depression on the level of maximal workload of the base line test was significant for both groups for all measures (Molsidomin from 0.27 to 0.08 mV; ISDN from 0.28 to 0.07 mV). The decrease of the ST-segment depression on the individual maximal workload level was significant for all measures in the Molsidomin group, but only on the first day of treatment in the ISDN group.