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Start Over Author "Izurieta, A" Publisher oxford university press (oup)
72 results on '"Izurieta, A"'

1. 2080. Reduced risk of SARS-CoV-2 infection among household contacts with hybrid immunity from recent COVID-19 vaccination and SARS-CoV-2 infection

Author

Rolfes, Melissa A, primary, Talbot, H Keipp, additional, Grace Morrissey, Kerry, additional, Stockwell, Melissa, additional, Maldonado, Yvonne A, additional, McLean, Huong, additional, Lutrick, Karen, additional, Bowman, Natalie M, additional, Rao, Suchitra, additional, Salvatore, Phillip P, additional, Izurieta, Hector, additional, Schmitz, Jonathan, additional, Zhu, Yuwei, additional, Hart, Kimberly W, additional, Battan-Wraith, Steph, additional, Merrill, Lori S, additional, McLaren, Son H, additional, Sano, Ellen, additional, Sarnquist, Clea, additional, Goodman, Sara H, additional, Petrie, Joshua, additional, Ledezma, Karla I, additional, Pryor, Kathleen, additional, Bullock, Ayla, additional, Yang, Amy, additional, Biddle, Jessica E, additional, Smith-Jeffcoat, Sarah E, additional, Johnson, Sheroi, additional, Asturias, Edwin J, additional, Lin, Jessica T, additional, Ellingson, Katherine, additional, Belongia, Edward, additional, Govindaranjan, Prasanthi, additional, Valdez de Romero, Ana, additional, Olivo, Vanessa, additional, Mellis, Alexandra, additional, and Grijalva, Carlos G, additional

Published
2023
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2. 2302. Transmissibility of SARS-CoV-2 by symptom: data from a case-ascertained household transmission study

Author

Mellis, Alexandra, primary, Smith-Jeffcoat, Sarah E, additional, Petrie, Joshua, additional, Keipp Talbot, H, additional, Morrissey, Kerry Grace, additional, Stockwell, Melissa, additional, Maldonado, Yvonne A, additional, Bowman, Natalie M, additional, Lutrick, Karen, additional, Rao, Suchitra, additional, Salvatore, Phillip P, additional, Biddle, Jessica E, additional, Olivo, Vanessa, additional, Battan-Wraith, Steph, additional, Merrill, Lori S, additional, McLaren, Son H, additional, Sano, Ellen, additional, Diaz, Anny, additional, Sarnquist, Clea, additional, Govindaranjan, Prasanthi, additional, Goodman, Sara H, additional, Ellingson, Katherine, additional, Ledezma, Karla I, additional, Pryor, Kathleen, additional, Lin, Jessica T, additional, Bullock, Ayla, additional, Yang, Amy, additional, Belongia, Edward, additional, McLean, Huong, additional, Asturias, Edwin J, additional, Izurieta, Hector, additional, Hart, Kimberly W, additional, Schmitz, Jonathan, additional, Zhu, Yuwei, additional, Rolfes, Melissa A, additional, and Grijalva, Carlos G, additional

Published
2023
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3. Knowledge and perception of asymptomatic malaria in the Volta region of Ghana

Author

Orish, Verner N, primary, Kyeremateng, Caleb, additional, Appiah, Baffoe P, additional, Addei, Isaac B, additional, Ayaba, Moses A, additional, Kwadzokpui, Precious K, additional, Marinkovic, Aleksandra, additional, Prakash, Stephanie, additional, Okorie, Chuku, additional, Izurieta, Ricardo, additional, and Sanyaolu, Adekunle, additional

Published
2023
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6. Regional divergence in the skull morphometry of adult male Galapagos sea lion

Author

Salomé Izurieta-Benitez, Marjorie Riofrío-Lazo, Jorge Torres, Gustavo Jimenez-Uzcategui, Diego O Urquía, and Diego Páez-Rosas

Subjects
Ecology, Genetics, Animal Science and Zoology, Ecology, Evolution, Behavior and Systematics, Nature and Landscape Conservation
Abstract

The skull often reveals adaptation to ecological and environmental influences. Food availability affects the somatic growth of otariids, and population abundance can influence male intrasexual competition. We hypothesized there would be regional differences between Galapagos sea lion (GSL, Zalophus wollebaeki) rookeries as a result of variance in ecosystem metrics and population abundance. We used skull measures related to individual size and aggressiveness. We analyzed 19 linear measures for size and 15 for aggressiveness taken on 49 adult male skulls of GSL collected in four bioregions of the archipelago. Nine skull measures had a significant effect on individual clustering into bioregions (P < 0.001). The most discriminating measures were snout length, supraorbital process width, nasal length, and canine width. We found a significant relationship between skull grouping patterns and chlorophyll-α levels (proxy marine productivity and body growth) and GSL population abundance (proxy of agonistic behavior) of each bioregion, as well as with the interaction between both variables (P < 0.001). Our results suggest significant regional differences in GSL skull morphometry, which could be associated with resource availability and level of male intrasexual competition in the archipelago. This information is important for understanding the life history of this species.

Published
2022

7. The doors remain open

Author

Ordás, Jara Gayán, primary, Izurieta, Carlos Eduardo, additional, Crespo, Eva María Pueo, additional, Landolfi, Stefania, additional, and Diz, Fernando Worner, additional

Published
2022
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8. Risk Factors for COVID-19 Deaths Among Elderly Nursing Home Medicare Beneficiaries in the Prevaccine Period

Author

Yixin Jiao, Yun Lu, Yue Wu, Hector S. Izurieta, Richard A. Forshee, Michael Wernecke, Yoganand Chillarige, David J. Graham, Jeffrey A. Kelman, Jing Wang, and Mikhail Menis

Subjects
Male, Population, Ethnic group, Disease, Medicare, Risk Factors, Pandemic, Humans, Immunology and Allergy, Medicine, education, Socioeconomic status, Aged, Proportional Hazards Models, Retrospective Studies, education.field_of_study, business.industry, Proportional hazards model, Hazard ratio, COVID-19, Retrospective cohort study, United States, Nursing Homes, Hospitalization, Editorial Commentary, AcademicSubjects/MED00290, Infectious Diseases, business, Demography
Abstract

BackgroundWe evaluated prevaccine pandemic period COVID-19 death risk factors among nursing home (NH) residents.MethodsIn a retrospective cohort study covering Medicare fee-for-service beneficiaries aged ≥65 years residing in US NHs, we estimated adjusted hazard ratios (HRs) using multivariate Cox proportional hazards regressions.ResultsAmong 608251 elderly NH residents, 57398 (9.4%) died of COVID-19–related illness 1 April to 22 December 2020; 46.9% (26893) of these deaths occurred without prior COVID-19 hospitalizations. We observed a consistently increasing age trend for COVID-19 deaths. Racial/ethnic minorities shared similarly high risk of NH COVID-19 deaths with whites. NH facility characteristics for-profit ownership and low health inspection ratings were associated with higher death risk. Resident characteristics (male [HR, 1.69], end-stage renal disease [HR, 1.42], cognitive impairment [HR, 1.34], and immunocompromised status [HR, 1.20]) were death risk factors. Other individual-level characteristics were less predictive of death than in community-dwelling population.ConclusionsLow NH health inspection ratings and private ownership contributed to COVID-19 death risks. Nearly half of NH COVID-19 deaths occurred without prior COVID-19 hospitalization and older residents were less likely to get hospitalized with COVID-19. No substantial differences were observed by race/ethnicity and socioeconomic status for NH COVID-19 deaths.

Published
2021

9. Recombinant Zoster Vaccine (Shingrix): Real-World Effectiveness in the First 2 Years Post-Licensure

Author

Heng-Ming Sung, Bradley Lufkin, Hector S. Izurieta, Jeffrey A. Kelman, Michael Wernecke, Kathleen Dooling, Yoganand Chillarige, Paula Ehrlich Agger, Yun Lu, Ruth Link-Gelles, Richard A. Forshee, Thomas MaCurdy, and Xiyuan Wu

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Herpes Zoster Vaccine, 030106 microbiology, Neuralgia, Postherpetic, Medicare, Herpes Zoster, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, Postherpetic neuralgia, business.industry, Hazard ratio, Middle Aged, medicine.disease, United States, Clinical trial, Regimen, Infectious Diseases, Cohort, Zoster vaccine, business, medicine.drug, Cohort study
Abstract

BackgroundShingrix (recombinant zoster vaccine) was licensed to prevent herpes zoster, dispensed as 2 doses given 2–6 months apart among adults aged ≥50 years. Clinical trials yielded efficacy of >90% for confirmed herpes zoster, but post-market performance has not been evaluated. Efficacy of a single dose and a delayed second dose and efficacy among persons with autoimmune or immunosuppressive conditions have not been studied. We aimed to assess post-market vaccine effectiveness of Shingrix.MethodsWe conducted a cohort study among Medicare Part D community-dwelling beneficiaries aged >65 years. Herpes zoster was identified using a medical office visit diagnosis with treatment, and postherpetic neuralgia was identified using a validated algorithm. We used inverse probability of treatment weighting to improve cohort balance and marginal structural models to estimate hazard ratios.ResultsWe found a vaccine effectiveness of 70.1% (95% confidence interval [CI], 68.6–71.5) and 56.9% (95% CI, 55.0–58.8) for 2 and 1 doses, respectively. The 2-dose vaccine effectiveness was not significantly lower for beneficiaries aged >80 years, for second doses received at ≥180 days, or for individuals with autoimmune conditions. The vaccine was also effective among individuals with immunosuppressive conditions. Two-dose vaccine effectiveness against postherpetic neuralgia was 76.0% (95% CI, 68.4–81.8).ConclusionsThis large real-world observational study of the effectiveness of Shingrix demonstrates the benefit of completing the 2-dose regimen. Second doses administered beyond the recommended 6 months did not impair effectiveness. Our effectiveness estimates were lower than the clinical trials estimates, likely due to differences in outcome specificity.

Published
2021

10. Natural History of Coronavirus Disease 2019: Risk Factors for Hospitalizations and Deaths Among >26 Million US Medicare Beneficiaries

Author

David J. Graham, Michael Wernecke, Douglas Pratt, Mao Hu, Jeffrey A. Kelman, Richard A. Forshee, Mikhail Menis, Yue Wu, Hector S. Izurieta, Yun Lu, Yoganand Chillarige, and Yixin Jiao

Subjects
education.field_of_study, business.industry, Mortality rate, 010102 general mathematics, Population, Retrospective cohort study, Odds ratio, medicine.disease, 01 natural sciences, Comorbidity, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Severity of illness, Immunology and Allergy, Population study, Medicine, 030212 general & internal medicine, 0101 mathematics, education, business, Medicaid, Demography
Abstract

BackgroundThe current study was performed to evaluate risk factors for severe coronavirus disease 2019 (COVID-19) outcomes among Medicare beneficiaries during the pandemic’s early phase.MethodsIn a retrospective cohort study covering Medicare fee-for-service beneficiaries, we separated out elderly residents in nursing homes (NHs) and those with end-stage renal disease (ESRD) from the primary study population of individuals age ≥65 years. Outcomes included COVID-19 hospital encounters and COVID-19-associated deaths. We estimated adjusted odds ratios (ORs) using logistic regression.ResultsWe analyzed 25 333 329 elderly non-NH beneficiaries without ESRD, 653 966 elderly NH residents, and 292 302 patients with ESRD. COVID-related death rates (per 10 000) were much higher among elderly NH residents (275.7) and patients with ESRD (60.8) than in the primary study population (5.0). Regression-adjusted clinical predictors of death among the primary population included immunocompromised status (OR, 1.43), frailty index conditions such as cognitive impairment (3.16), and other comorbid conditions, including congestive heart failure (1.30). Demographic-related risk factors included male sex (OR, 1.77), older age (3.09 for 80- vs 65-year-olds), Medicaid dual-eligibility status (2.17), and racial/ethnic minority. Compared with whites, ORs were higher for blacks (2.47), Hispanics (3.11), and Native Americans (5.82). Results for COVID-19 hospital encounters were consistent.ConclusionsFrailty, comorbid conditions, and race/ethnicity were strong risk factors for COVID-19 hospitalization and death among the US elderly.

Published
2020

13. Comparative Effectiveness of Influenza Vaccines Among US Medicare Beneficiaries Ages 65 Years and Older During the 2019–2020 Season

Author

Douglas Pratt, Jeffrey A. Kelman, Michael Lu, Julie Loc, Michael Wernecke, Thomas E. MaCurdy, Yun Lu, Arnstein Lindaas, Yuqin Wei, Yoganand Chillarige, Hector S. Izurieta, and Richard A. Forshee

Subjects
Microbiology (medical), Influenza vaccine, medicine.medical_treatment, Medicare, Inverse probability of treatment weighting, symbols.namesake, Influenza A Virus, H1N1 Subtype, Primary prevention, Influenza, Human, medicine, Humans, Poisson regression, Aged, Retrospective Studies, business.industry, Medicare beneficiary, Retrospective cohort study, United States, Vaccination, Infectious Diseases, Vaccines, Inactivated, Influenza Vaccines, symbols, Seasons, business, Adjuvant, Demography
Abstract

Background Approximately 50 000 influenza-associated deaths occur annually in the United States, overwhelmingly among individuals aged ≥65 years. Although vaccination is the primary prevention tool, investigations have shown low vaccine effectiveness (VE) in recent years, particularly among the elderly. We analyzed the relative VE (RVE) of all influenza vaccines among Medicare beneficiaries aged ≥65 years to prevent influenza hospital encounters during the 2019–2020 season. Methods Retrospective cohort study using Poisson regression and inverse probability of treatment weighting (IPTW). Exposures included egg-based high-dose trivalent (HD-IIV3), egg-based adjuvanted trivalent (aIIV3), egg-based standard dose (SD) quadrivalent (IIV4), cell-based SD quadrivalent (cIIV4), and recombinant quadrivalent (RIV4) influenza vaccines. Results We studied 12.7 million vaccinated beneficiaries. Following IPTW, cohorts were well balanced for all covariates and health-seeking behavior indicators. In the adjusted analysis, RIV4 (RVE, 13.3%; 95% CI, 7.4–18.9%), aIIV3 (RVE, 8.2%; 95% CI, 4.2–12.0%), and HD-IIV3 (RVE, 6.8%; 95% CI, 3.3–10.1%) were significantly more effective in preventing hospital encounters than the reference egg-based SD IIV4, while cIIV4 was not significantly more effective than IIV4 (RVE, 2.8%; 95% CI, −2.8%, 8.2%). Our results were consistent across all analyses. Conclusions In this influenza B-Victoria and A(H1N1)–dominated season, RIV4 was moderately more effective than other vaccines, while HD-IIV3 and aIIV3 were more effective than the IIV4 vaccines, highlighting the contributions of antigen amount and adjuvant use to VE. Egg adaptation likely did not substantially affect our RVE evaluation. Our findings, specific to the 2019–2020 season, should be evaluated in other studies using virological case confirmation.

Published
2020

15. Effect of Age on Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines Among US Medicare Beneficiaries Aged ≥65 Years

Author

Yun, Lu, Yoganand, Chillarige, Hector S, Izurieta, Yuqin, Wei, Wenjie, Xu, Michael, Lu, Heng-Ming, Sung, Arnstein, Lindaas, Michael, Wernecke, Thomas, Macurdy, Jeffrey, Kelman, and Richard A, Forshee

Subjects
Aged, 80 and over, Male, 0301 basic medicine, Age Factors, United States, Hospitalization, 03 medical and health sciences, Treatment Outcome, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, Influenza Vaccines, Influenza, Human, Humans, Immunology and Allergy, Female, 030212 general & internal medicine, Aged, Retrospective Studies
Abstract

BackgroundStudies have found that the high-dose influenza vaccine has a higher relative vaccine effectiveness (RVE) versus standard-dose vaccines in some seasons. We evaluated the effect of age on the RVE of high-dose versus standard-dose influenza vaccines among Medicare beneficiaries.MethodsA 6-season retrospective cohort study from 2012 to 2018 among Medicare beneficiaries aged ≥65 years was performed. Poisson regression was used to evaluate the effect of age on the RVE of high-dose versus standard-dose influenza vaccines in preventing influenza-related hospitalizations.ResultsThe study included >19 million vaccinated beneficiaries in a community pharmacy setting. The Poisson models indicated a slightly increasing trend in RVE with age in all seasons. The high-dose vaccine was more effective than standard-dose vaccines in preventing influenza-related hospital encounters (ie, influenza-related inpatient stays and emergency department visits) in the 2012–2013 (RVE, 23.1%; 95% confidence interval [CI], 17.6%–28.3%), 2013–2014 (RVE, 15.3%; 95% CI, 7.8%–22.3%), 2014–2015 (RVE, 8.9%; 95% CI, 5.6%–12.1%), and 2016–2017 (RVE, 12.6%; 95% CI, 6.3%–18.4%) seasons and was at least as effective in all other seasons. We also found that the high-dose vaccine was consistently more effective than standard-dose vaccines across all seasons for people aged ≥85 years. Similar trends were observed for influenza-related inpatient stays.ConclusionsThe RVE of high-dose versus standard-dose influenza vaccines increases with age.

Published
2019

16. Relative Effectiveness of Cell-Cultured and Egg-Based Influenza Vaccines Among Elderly Persons in the United States, 2017–2018

Author

Yun Lu, Hector S. Izurieta, Yoganand Chillarige, Yuqin Wei, Michael Lu, Jeffrey A. Kelman, Steve Chu, Wenjie Xu, Thomas E. MaCurdy, Michael Wernecke, Richard A. Forshee, and Douglas Pratt

Subjects
Male, 0301 basic medicine, Influenza vaccine, Chick Embryo, Medicare, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Elderly persons, Influenza, Human, Animals, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Poisson regression, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Vaccination, Age Factors, Medicare beneficiary, Vaccine virus, Retrospective cohort study, Interim analysis, United States, Confidence interval, Hospitalization, Influenza B virus, Treatment Outcome, 030104 developmental biology, Infectious Diseases, Batch Cell Culture Techniques, Influenza A virus, Influenza Vaccines, symbols, Female, business, Demography
Abstract

Background The low influenza vaccine effectiveness (VE) observed during the A(H3N2)-dominated 2017–2018 season may be due to vaccine virus adaptation to growth in eggs. We compared the effectiveness of cell-cultured and egg-based vaccines among Medicare beneficiaries. Methods Retrospective cohort study on Medicare beneficiaries aged ≥65 years who received an influenza vaccine (cell-cultured, egg-based quadrivalent; egg-based high-dose, adjuvanted, or standard-dose trivalent) during the 2017–2018 season. We used Poisson regression to evaluate relative VE (RVE) in preventing influenza-related hospital encounters. Results Of >13 million beneficiaries, RVE for cell-cultured vaccines relative to egg-based quadrivalent vaccines was 10% (95% confidence interval [CI], 7%–13%). In a midseason interim analysis, this estimate was 16.5% (95% CI, 10.3%–22.2%). In a 5-way comparison, cell-cultured (RVE, 11%; 95% CI, 8%–14%) and egg-based high-dose (RVE, 9%; 95% CI, 7%–11%) vaccines were more effective than egg-based quadrivalent vaccines. Conclusions The modest VE difference between cell-cultured and egg-based vaccines only partially explains the low overall VE reported by the Centers for Disease Control and Prevention, suggesting that egg adaptation was not the main contributor to the low VE found among individuals aged ≥65 years. The midseason interim analysis we performed demonstrates that our methods can be used to evaluate VE actively during the influenza season.

Published
2018

17. Recombinant Zoster Vaccine (Shingrix): Real-World Effectiveness in the First 2 Years Post-Licensure

Author

Izurieta, Hector S, primary, Wu, Xiyuan, additional, Forshee, Richard, additional, Lu, Yun, additional, Sung, Heng-Ming, additional, Agger, Paula Ehrlich, additional, Chillarige, Yoganand, additional, Link-Gelles, Ruth, additional, Lufkin, Bradley, additional, Wernecke, Michael, additional, MaCurdy, Thomas E, additional, Kelman, Jeffrey, additional, and Dooling, Kathleen, additional

Published
2021
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18. PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma

Author

Benitez, Jorge A, primary, Finlay, Darren, additional, Castanza, Anthony, additional, Parisian, Alison D, additional, Ma, Jianhui, additional, Longobardi, Ciro, additional, Campos, Alex, additional, Vadla, Raghavendra, additional, Izurieta, Alejandro, additional, Scerra, Gianluca, additional, Koga, Tomoyuki, additional, Long, Tao, additional, Chavez, Lukas, additional, Mesirov, Jill P, additional, Vuori, Kristiina, additional, and Furnari, Frank, additional

Published
2021
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19. Natural History of Coronavirus Disease 2019: Risk Factors for Hospitalizations and Deaths Among &gt;26 Million US Medicare Beneficiaries

Author

Izurieta, Hector S, primary, Graham, David J, additional, Jiao, Yixin, additional, Hu, Mao, additional, Lu, Yun, additional, Wu, Yue, additional, Chillarige, Yoganand, additional, Wernecke, Michael, additional, Menis, Mikhail, additional, Pratt, Douglas, additional, Kelman, Jeffrey, additional, and Forshee, Richard, additional

Published
2020
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20. Comparative Effectiveness of Influenza Vaccines Among US Medicare Beneficiaries Ages 65 Years and Older During the 2019–2020 Season

Author

Izurieta, Hector S, primary, Lu, Michael, additional, Kelman, Jeffrey, additional, Lu, Yun, additional, Lindaas, Arnstein, additional, Loc, Julie, additional, Pratt, Douglas, additional, Wei, Yuqin, additional, Chillarige, Yoganand, additional, Wernecke, Michael, additional, MaCurdy, Thomas E, additional, and Forshee, Richard, additional

Published
2020
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22. Effectiveness and Duration of Protection Provided by the Live-attenuated Herpes Zoster Vaccine in the Medicare Population Ages 65 Years and Older

Author

Sarah Wong, Hector S. Izurieta, Christopher Jankosky, Rafael Harpaz, Qin Sun, Richard A. Forshee, Chris Worrall, Douglas Pratt, Jeffrey A. Kelman, Michael Wernecke, Yun Lu, Philip R. Krause, and Tom MaCurdy

Subjects
Male, 0301 basic medicine, Microbiology (medical), Herpesvirus 3, Human, medicine.medical_specialty, Herpes Zoster Vaccine, 030106 microbiology, Comorbidity, Medicare, Vaccines, Attenuated, Herpes Zoster, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Secondary analysis, Outcome Assessment, Health Care, medicine, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Postherpetic neuralgia, Vaccination, Retrospective cohort study, medicine.disease, United States, Surgery, Ophthalmic zoster, Infectious Diseases, Medicare population, Pneumococcal vaccination, Female, business, Follow-Up Studies
Abstract

Background Tens of millions of seniors are at risk of herpes zoster (HZ) and its complications. Live attenuated herpes zoster vaccine (HZV) reduces that risk, although questions regarding effectiveness and durability of protection in routine clinical practice remain. We used Medicare data to investigate HZV effectiveness (VE) and its durability. Methods This retrospective cohort study included beneficiaries ages ≥65 years during January 2007 through July 2014. Multiple adjustments to account for potential bias were made. HZV-vaccinated beneficiaries were matched to unvaccinated beneficiaries (primary analysis) and to HZV-unvaccinated beneficiaries who had received pneumococcal vaccination (secondary analysis). HZ outcomes in community and hospital settings were analyzed, including ophthalmic zoster (OZ) and postherpetic neuralgia (PHN). Results Among eligible beneficiaries (average age 77 years), the primary analysis found VE for community HZ of 33% (95% CI: 32%-35%) and 19% (95% CI: 17%-22%), for the first 3, and subsequent 4+ years postvaccination, respectively. In the secondary analysis, VE was, respectively, 37% (95% CI: 36%-39%) and 22% (95% CI: 20%-25%). In the primary analysis, VE for PHN was 57% (95% CI: 52%-61%) and 45% (95% CI: 36%-53%) in the first 3 and subsequent 4+ years, respectively; VE for hospitalized HZ was, respectively, 74% (95% CI: 67%-79%) and 55% (95% CI: 39%-67%). Differences in VE by age group were not significant. Conclusions In both the primary and secondary analyses, HZV provided protection against HZ across all ages, but effectiveness declined over time. VE was higher and better preserved over time for PHN and HZ-associated hospitalizations than for community HZ.

Published
2017

23. Poster Session 1The imaging examination and quality assessmentP185Why did the normal values of the left and right atrial volumes increase in the recent chamber quantification guidelines update?P186Atrial electromechanical delay, Left Atrial mechanical functions and longitudinal left ventricular strain in pre-diabetic patientsP187A web-based platform for e-training in echocardiographyP188Righ atrial size as a marker of success in electrical cardioversion in patients with persistent atrial fibrillationP189Echocardiographic assessment of left atrial dimensions and function in a healthy populationP190Impact of carotid artery revascularization on the cognitive and functional outcome and cerebral flow on TCD and brain MRI in patients with symptomatic carotid artery stenosis: a preliminary reportP191Aortic elasticity is impaired in hypereosinophilic syndromeP192Disturbed intracardiac flow transit prognosticates early decompensation in dilated cardiomyopathyP193Ultrasound guided treatment in acute heart failureP194Determinants of impaired global longitudinal function in middle-aged subjects free of cardiovascular diseaseP195Left ventricular remodeling in asymptomatic heart failure: classification and prognostic evaluationP196Restricted displacement of lateral right ventricular wall: a physiopathological explanation of geometrical and functional cardiac changes after cardiac surgeryP197A novel method to image intracardiac flow stagnation for the risk stratification for thrombosisP198Magnetic resonance imaging of anomalous origin of the left coronary artery from the pulmonary artery in children older than 4 monthsP199Coronary flow reserve is improved by LDL apheresis in patients with familial hypercholesterolemia and chronic ischemic heart diseaseP200 High velocities in the proximal part of the coronary arteries during routine echocardiography can predict nearest prognosisP201Recovery potential of the right ventricular function in the setting of a first STEMI treated by primary PCI: an echocardiographic studyP202Severe aortic stenosis patients with preserved ejection fraction according to flow and gradient classification: prevalence and outcomesP203Is basal left ventricular ejection time able to predict the severity of aortic stenosis in patients with depressed ejection fraction?P204Acceleration time in aortic stenosis: a new echocardiographic diagnostic parameterP205Application of novel Doppler indices of stenosis severity in the assessment of rheumatic mitral stenosis beyond conventional valve area and transvalvular gradientsP206Comparison of conventional echo score in patients with symptomatic rheumatic mitral stenosis: transesophageal echocardiography versus transthoracic echocardiographyP207Speckle-tracking echocardiography in evaluation early left ventricular systolic dysfunction in asymptomatic aortic regurgitation patients with good left ventricular ejection fractionP208Expansible aortic ring annuloplasty: mid-term results of aortic valve repairP209Papillary muscle dysfunction: insights into mitral valve prolapse using speckle tracking imaging

Author

L. Ring, Z. Hlubocka, V. Mizariene, YH. Park, A. Chong, D. Ruiz Fernandez, AS. Lazaro Mendes, JM. Monteagudo Ruiz, M. Stoian, A. Zagatina, E. Pasanisi, AJR Jurko, H. Nishikawa, A. Garcia Martin, I. Fabiani, I. Ceponiene, J. Oehman, T. Uejima, A. Nemes, R. Badacz, R W J Van Grootel, C. Doering, R. Conte, TAMER Moustafa, K. Kebed, E. Kruse, K. Addetia, B. Ciszek, M. Thykattil, B. Guile, RM. Lang, V. Mor-Avi, RAGAB Mahfouz, AHMED Elzayat, MOHAMD Goda, MARWA Gad, F. Sansone, F. Napoli, A. Tonacci, M. Raciti, P. Landi, A. Grande, L. Ait-Ali, K. Sveric, U. Richter, RH. Strasser, C. Wunderlich, ME. Menting, JS. Mcghie, M. Strachinaru, WB. Vletter, ML. Geleijnse, JW. Roos-Hesselink, AE. Van Den Bosch, A. Kablak-Ziembicka, M. Urbanczyk-Zawadzka, RP. Banys, P. Musialek, P. Pieniazek, S. Mleczko, K. Zmudka, T. Przewlocki, I. Marton, P. Domsik, A. Kalapos, E. Posfai, S. Modok, Z. Borbenyi, T. Forster, L. Takahashi, H. Semba, H. Sawada, T. Yamashita, R. Jurkevicius, J. Petkeviciene, O. Gustiene, E. Tamuleviciute-Prasciene, J. Motiejunaite, R. Slapikas, NR. Pugliese, S. La Carrubba, F. Antonini Canterin, P. Colonna, P. Caso, F. Benedetto, R. Citro, S. Carerj, V. Di Bello, JL. Moya Mur, C. Lazaro Rivera, LM. Rincon Diaz, J. Miguelena Hycka, A. Garcia Lledo, JJ. Jimenez Nacher, C. Fernandez-Golfin, J. Rodriguez-Roda, JL. Zamorano, A. Jurko, T. Jurko, J. Mistinova-Polakova, F. Sbrana, C. Petersen, F. Bigazzi, B. Dal Pino, M. Coceani, A. Ripoli, M. Pianelli, R. Luciani, T. Sampietro, N. Zhuravskaya, Y. Vareldzhyan, M. Kamenskikh, D. Shmatov, D. Zamfir, A. Vijiiac, D. Pitic, G. Tamasescu, S. Onciul, R. Onut, C. Stefan, M. Dorobantu, A. Gonzalez-Gomez, C. Izurieta, A. Marco, GL. Alonso Salinas, R. Hinojar Baydes, E. Casas Rojo, AR. Ferreira, J. Moura Ferreira, L. Leite, AP. Oliveira, N. Ribeiro, AJ. Barbosa, R. Mata Martins, D. Ramos, M. Pego, S. Gamaza Chulian, E. Diaz Retamino, S. Camacho Freire, A. Gutierrez Barrios, J. Oneto Otero, M. Bansal, HK. Grewal, RR. Kasliwal, S. Wahi, SH. Lee, DS. Lee, JM. Hwang, JS. Kim, JH. Kim, KJ. Chun, M. Bieseviciene, R. Verseckaite, R. Jonkaitiene, J. Janenaite, G. Dostalova, J. Hlubocky, R. Novotny, V. Vondracek, J. Lindner, A. Linhart, and NK. Preston

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, Follow up studies, Radiology, Nuclear Medicine and imaging, Regression analysis, General Medicine, Longitudinal function, Disease, Cardiology and Cardiovascular Medicine, business, Cohort study
Published
2016

24. P650Influence of fetunin-a level on progression of calcific aortic valve stenosis The COFRASA - GENERAC StudyP651Common carotid artery remodeling 1 year after aortic valve surgeryP652Low gradient aortic stenosis with preserved ejection fraction: reclassification of severity by 3D transesophageal echocardiography. P653Results of balloon aortic valvuloplasty in patients with impaired left ventricle ejection fraction.P654Burden of associated aortic regurgitation in patients with mitral regurgitationP655Differences in right ventricular mechanics in acute and chronic ischemic mitral regurgitation after inferoposterior myocardial infarctionP656Tricuspid regurgitation in patients operated for severe symptomatic native aortic stenosis: pre-operative determinantsP657Echocardiographic diagnosis in patients with prosthetic or annuloplasty ring dysfunction: correlation with surgical findingsP659Agreement analisys of different three-dimensional transoesophageal echocardiographic modalities and cardiac CT scan in aortic annulus sizing for transapical heart valve implantationP660Elevated gradients after TAVR are associated with increased rehospitalization, but have no impact on mortality and major adverse cardiac eventsP661Echocardiographic characteristics of post-TAVI thrombosis and endocarditis: single-centre experienceP662Impact of mixed aortic valve disease in long-term mortality after transcatheter aortic valve implantationP663Quantification of mitral regurgitation during interventional valve repair: correlation between haemodynamic parameters and 3D color Doppler echocardiographyP664Mitraclip in functional mitral regurgitation: are immediate results the same in ischemic and non ischemic etiology?P665Left ventricular contractile reserve by stress echocardiography as a predictor of response to cardiac resynchronization therapy in heart failure: a meta-analysisP666Regardless of the definition used, left ventricular reverse remodeling is not different in fibrosis positive and negative dilated cardiomyopathy patientsP667Heterogeneity of LV contractile function by multidimensional strain in patients with EF<35%: Insights for the hemodynamic burdenP668Ability of 99mTc-DPD scintigraphy to predict conduction disorders requiring permanent pacemaker in patients with transthyretin-related cardiac amyloidosisP669Provocation of left ventricular outflow tract obstruction using nitrate inhalation in hypertrophic cardiomyopathy: relation to electromechanical delayP670Could echocardiographic features differentiate Fabry cardiomyopathy from sarcomeric forms of hypertrophic cardiomyopathy?P671Pregnancy is well tolerated in women with arrhythmogenic right ventricular cardiomyopathy P672Glycogen storage cardiomyopathy (PRKAG2): do particular echocardiography findings in established and advanced techniques are helpful in suggesting the diagnosis?P673Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medication

Author

I. Ikonomidis, W. Costa Santos, AI. Castrini, S. Militaru, W. Hamed, S. Brun, LE. Sade, S. Wisniowska-Smialek, Q. Ciampi, MD. Mesa Rubio, B. Goebel, K. Stathogiannis, M. Spartera, M. Ali, V. Polizzi, B. De Chiara, C. Dumont, E. Tamulenaite, JM. Monteagudo Ruiz, DS. Sorysz, A. Gonzalez Gomez, J. Petrini, N. Kubota, DMZ David Messika-Zeitoun, M. Ring, K. Caidahl, MJ. Eriksson, JM. Monteagudo, C. Fernandez-Golfin, C. Izurieta, R. Hinojar, A. Garcia, E. Casas, A. Marco, JJ. Jimenez-Nacher, JL. Zamorano, M. Daniec, M. Stapor, M. Tomala, B. Nawrotek, L. Rzeszutko, P. Kleczynski, A. Dziewierz, M. Bagienski, K. Zmudka, D. Dudek, D. Mesa, T. Gonzalez-Alujas, M. Sitges, F. Carrasco-Chinchilla, CH. Li, A. Grande-Trillo, A. Martinez, J. Matabuena, D. Alonso-Rodriguez, I. Aquila, A. Gonzalez-Gomez, Z. Valuckiene, R. Jurkevicius, E. Galli, E. Oger, A. Hubert, C. Leclercq, E. Donal, S. Quattrocchi, L. Botta, F. Casadei, A. Peritore, O. Belli, F. Musca, C. Russo, C. Giannattasio, A. Moreo, ML. Lo Presti, PG. Pino, A. Madeo, D. Bellavia, V. Buffa, R. Fiorilli, G. Luzi, F. Musumeci, VT. Nkomo, PA. Pellikka, HM. Connolly, CG. Scott, GS. Sandhu, DR. Holmes, CS. Rihal, KL. Greason, SV. Pislaru, M. Barletta, F. Ancona, I. Rosa, S. Stella, C. Marini, M. Montorfano, A. Latib, O. Alfieri, A. Margonato, A. Colombo, E. Agricola, K. Toutouzas, M. Drakopoulou, A. Michelongona, G. Latsios, A. Synetos, O. Kaitozis, F. Mitropoulou, S. Brili, D. Tousoulis, I. Rohm, A. Hamadanchi, S. Otto, C. Jung, HR. Figulla, PC. Schulze, TC. Poerner, G. Gutierrez Ballesteros, C. Aristizabal Duque, M. Ruiz Ortiz, M. Delgado Ortega, J. Fernandez Cabeza, M. Pan Alvarez-Osorio, A. Lopez Granados, M. Romero Moreno, J. Suarez De Lezo Cruz-Conde, C. Carpegiani, C. Michelassi, B. Villari, E. Picano, P. Rubis, B. Biernacka-Fijalkowska, E. Dziewiecka, L. Khachatryan, P. Faltyn, A. Lesniak-Sobelga, M. Hlawaty, M. Kostkiewicz, P. Podolec, U. Bal, D. Oguz, S. Eroglu, B. Pirat, H. Muderrisoglu, S. Pradel, P. Mondoly, G. Victor, P. Pascal, M. Galinier, D. Carrie, P. Maury, I. Berry, O. Lairez, HMB Badran, RIY Yaseen, MAGDY Yacoub, RD. Adam, A. Mursa, M. Chivulescu, M. Rosca, L. Mandes, E. Rusu, L. Dima, A. Fruntelata, BA. Popescu, CD. Ginghina, RO. Jurcut, IS. Leren, ME. Estensen, LG. Klaeboe, T. Edvardsen, KH. Haugaa, JLB Pena, IH. Sampaio, MHA Siqueira, MC. Alves, EB. Sternick, G. Pavlidis, V. Lambadiari, F. Kousathana, H. Triantafyllidi, M. Varoudi, D. Vlastos, S. Vlachos, G. Dimitriadis, and J. Lekakis

Subjects
medicine.medical_specialty, business.industry, Hemodynamics, Calcific aortic valve stenosis, General Medicine, medicine.disease, Pathophysiology, Stenosis, Ectopic calcification, Internal medicine, Cohort, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Aortic valve calcification, Cardiology and Cardiovascular Medicine, Prospective cohort study, business
Abstract

Background. In recent years, pathophysiology of aortic stenosis (AS) has been considered as a possibly active inflammatory process, but its determinants remain unclear. Calcium tissue deposition observed in dilaysis patients have been linked to low level of Fetuin-A, a powerful inhibitor of ectopic calcification. It is thus suspected to play a role in development of aortic stenosis. Purpose. To assess correlation between Fetuin-A level and AS progression in a prospective cohort of AS patients, COFRASA (clinicalTrial.gov_number_NCT00338676) and GENERAC (clinicalTrial.gov_number_NCT00647088). Methods. A comprehensive clinical evaluation and Fetuin-A plasma level measurement was performed at baseline. AS severity was evaluated at baseline and yearly thereafter using echocardiography (mean pressure gradient (MPG)) and computed tomography (degree of aortic valve calcification or AVC). Annual progression was calculated as [(final measurement - baseline measurement)/follow-up duration] for both MPG and AVC measurements. Results. We enrolled 296 patients with at least 1 year of follow-up. Mean age was 74±10 years, 217 (73%) were men. Mean Fetuin-A level was 0.55±0.15 g/L. After a mean follow-up of 3.0±1.7 years, no correlation was found between AS progression and Fetuin-A level, using either MPG (r=0.015, p=0.82) or AVC (r=0.014, p=0.82). This was also true when comparing patients with lower level of Fetuin-A (≤0.53 g/L, the median in our cohort) with patients with higher level(+3±5 mmHg/year (median 2, [0-5] vs +4±4 mmHg/year (median 2, [1-6]) p=0.06, and +205±290 AUC/year (median 122, [32-269]) vs +240±310 AUC/year (median 145, [50-313], p=0.24). This was true also after adjustment for baseline severity and valve antomy. Conclusions. In our prospective cohortot of AS patients we found no impact of Fetuin-A on both hemodynamic and anatomic AS progression. Despite strong capacity to inhibit ectopic calcium deposition, Fetuin-A plasma level seems to have minor influence on AS progression.

Published
2016

25. P673Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medicationP674Clinical presentation, echocardiographic findings and complications in patients with typical and atypical form of takotsubo cardiomyopathyP675Left ventricular mass/end-diastolic volume ratio with tridimensional echocardiography in newly-diagnosed hypertensive patients: which relation between left ventricular geometry and stroke volume?P676Endothelial dysfunction: the link between arterial hypertension, diabetes mellitus and heart diseaseP677Dynamic of changes of arterial stiffness evaluated by cardio-ankle vascular index(CAVI) during the growth and development of children and adolescentsP678Peripheral arterial stiffness in pulmonary hypertension and pulmonary embolism: assessment with cardio ankle vascular index, noninvasive markers of vascular diseaseP679Early detection and prediction of CHOP-induced cardiotoxicity in nonHodgkin lymphoma by 4D echocardiography, vascular ultrasound, and cardiac biomarkersP680Right ventricular remodeling in children engaged in endurance sports: a longitudinal study in preadolescent athletesP681Electrocardiographic criteria for atria enlargement are not useful in the evaluation of junior high-dynamic high-static athletesP682Prognostic value of right ventricle, pulmonary arterial pressure and biomarkers in patients with acute heart failure: one year follow upP683One-point carotid stiffness parameters by echo-tracking method in a wide-age range of healthy population. A single center experienceP684Role of bidimensional speckle tracking longitudinal strain in the evaluation of right and left ventricular function in adult patients with transposition of the great arteriesP685Interfaces between FBN1 gene polymorphism and biomechanical parameters estimated by speckle-tracking echocardiography of dilative pathology of ascending aorta P686Layer-specific speckle tracking analysis for the detection of coronary artery disease during dipyridamole stress echoP687Stress echo in Italy: state-of-the art 2015P688The declining frequency of Inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983-2009)P689Global longitudinal strain can unmask inducible myocardial ischemia at submaximal heart rate during dobutamine stress echocardiography.P690Low risk syntax score predicted by wall motion score index during dobutamine stress echocardiographyP691Outdoor stress echo by lung ultrasound for subclinical detection of high altitude pulmonary edema with B-linesP692Predictors and consequences of infective endocarditis with perivalvular extension - a subgroup with worse short and medium-term prognosisP693Analysis of left atrial auricle morphology and function to detect considerable risk factors regarding the prevention of strokeP694LAA closure - does size really matter?P695Real assessment of mitral regurgitation by three-dimensional transesophageal echocardiographyP696Myocardial contrast dobutamine stress echocardiography for detection of coronary artery disease

Author

O. Tereshina, G. Perea, JM. Ribeiro, S. Stoebe, M. Coutinho Cruz, L. Pratali, HA. Zainal Abidin, CM. Van De Heyning, C. Carpeggiani, Q. Ciampi, M. Cameli, M. Bieseviciene, AT. Timoteo, O. Vriz, M. Deljanin Ilic, M. Konopka, F. D'ascenzi, D. Mihalcea, FL. Ciciarello, T. Jurko, A-M Vintila, M. Lembo, M. Budnik, I. Ikonomidis, G. Pavlidis, V. Lambadiari, F. Kousathana, H. Triantafyllidi, M. Varoudi, D. Vlastos, S. Vlachos, G. Dimitriadis, J. Lekakis, J. Kochanowski, R. Piatkowski, K. Wojtera, G. Opolski, F. Lo Iudice, R. Esposito, C. Santoro, D. Gerardi, G. De Simone, B. Trimarco, M. Galderisi, V. Vintila, I. Bruckner, AJR Jurko, A. Jurko, M. Mestanik, A. Mestanikova, I. Tonhajzerova, VS. Valeria Silvestri, RB. Roberto Badagliacca, DV. Dario Vizza, FF. Francesco Fedele, LA. Luciano Agati, M. Florescu, AM. Vladareanu, D. Vinereanu, M. Solari, BM. Natali, A. Malandrino, F. Valentini, M. Focardi, M. Bonifazi, A. Pelliccia, S. Mondillo, K. Burkhard-Jagodzinska, A. Jakubiak, W. Krol, A. Klusiewicz, R. Zdanowicz, D. Sitkowski, M. Dluzniewski, W. Braksator, D. Petrovic, S. Stojanovic, S. Ilic, G. Kocic, M. Pirisi, J. Magne, V. Aboyans, R. Minisini, E. Bossone, L. Moura Branco, SA. Rosa, A. Galrinho, L. Sousa, JA. Oliveira, A. Agapito, RC. Ferreira, V. Mizariene, JJ. Vaskelyte, V. Lesauskaite, R. Sepetiene, GE. Mandoli, D. Menci, E. Capitani, C. Albizzi, F. Crudele, R. Citro, S. Severino, G. Labanti, L. Cortigiani, R. Sicari, P. Colonna, E. Picano, P. Landi, C. Michelassi, B. Ectors, H. Heuten, B. Shivalkar, JOHAN Ismail, SAZZLI Kasim, G. Giardini, M. Cavana, R. Ilhao Moreira, L. Coutinho Miranda, J. Abreu, P. Modas Daniel, J. Fragata, R. Cruz Ferreira, G. Farese, A. Tarr, D. Jurisch, D. Pfeiffer, A. Hagendorff, R. Teixeira, L. Puga, M. Costa, J. Silva, L. Paiva, L. Goncalves, M. Lombardero, R. Henquin, C. Izurieta, and MC. Corneli

Subjects
medicine.medical_specialty, Aorta, business.industry, Diastole, General Medicine, Type 2 diabetes, medicine.disease, Blood pressure, medicine.artery, Internal medicine, medicine, Cardiology, Arterial stiffness, Radiology, Nuclear Medicine and imaging, Systole, Brachial artery, Cardiology and Cardiovascular Medicine, business, Pulse wave velocity
Abstract

Background Arterial stiffness is associated with increased risk for cardiovascular disease. The purpose of this study is to investigate the arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 before and after glycemic control by optimal medication. Methods In 50 patients with uncontrolled type 2 diabetes(age:52±10years)and 25 controls of similar age and sex and no atherosclerotic risk factors we measured at baseline and 6 months after glycemic control a) carotid-femoral pulse wave velocity(PWVc m/sec-Complior SP ALAM),central systolic blood pressure(cSBP -mmHg),augmentation index(AI%), of the aortic pulse wave(ArteriographTensioMed) b)S',E'(m/sec)andE'/A'of mitral annulus by Tissue Doppler c)LV longitudinal strain(GLS-%),systolic(LongSr-l/sec)and diastolic(LongSrE-l/sec)strain rate, twisting(Tw-deg),peak twisting(Tw)and untwisting(unTw-deg/sec)velocity using speckle tracking echocardiography.The degree of LV untwisting was calculated as the percentage difference between peak twisting and untwisting at MVO(%dp PeakTw-UntwMVO)and between peak twisting and untwisting at peak and end of the mitral inflow E wave d)perfusion boundary region(PBR- micrometers)of the sublingual arterial microvessels(ranged from 5-25 micrometers)using Sideview,Darkfield imaging(Microscan,Glycocheck).Increased PBR is considered an accurate index of reduced endothelial glucocalyx thickness because of a deeper RBC penetration in the glucocalyx e) Flow mediated dilatation(FMD) of the brachial artery and percentage difference of FMD (FMD%). Results Compared to controls,diabetics had higher PWVa(10.3±2.2 vs. 8.1±1.9), AI(27.9±15 vs. 19.4±14.7), PWVc(11.8±3.2 vs. 8.8±1.3),cSBP(136±20 vs. 119±18),PBR (2.1±0.2 vs 1.89±0.1)and lower GLS(-15±3 vs. -18±3),LongSr(-0.78±0.1 vs. -0.96±0.2),LongSrE(0.77±0.29 vs. 1.2±0.3),S',E' and E/A(p

Published
2016

26. Giant ovarian cystadenocarcinoma in an adult patient, a rare finding in modern times

Author

Lenin J Guzmán, Gabriel A Molina, William G. Aguayo, Alison Nicole Izurieta, Miguel A Moyon, Ruben Alejandro Parra, Fernando X Moyon, and Jorge F Tufiño

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, General surgery, Late stage, Cancer, Case Report, medicine.disease, Broad spectrum, Papillary serous, Ovarian Cystadenocarcinoma, medicine, Surgery, business, Cystadenocarcinoma, Ovarian cancer
Abstract

Ovarian cancer (OC) is one of the most commonly diagnosed cancers among women. Regretfully due to its a broad spectrum of clinical behavior and challenging diagnosis most cases are diagnosed at a late stage. On rare occasions, these tumors can grow to massive sizes if left untreated, worsening the prognosis of the patient. Thanks to the advancement of medicine and diagnostic techniques, these rare cases are less frequent. Timely detection and surgery could avoid all these potentially troublesome scenarios. We report the case of a 64-year-old female with a giant 13 kg high-grade papillary serous ovarian cystadenocarcinoma, the tumor grew during a four year period and was adequately treated with surgery and is under close follow up with the oncologist. To our knowledge, this is the first case of a giant ovarian cystadenocarcinoma ever reported in Ecuador.

Published
2019

27. Erratum to: Effect of Age on Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines Among US Medicare Beneficiaries Aged ≥65 Years

Author

Lu, Yun, primary, Chillarige, Yoganand, additional, Izurieta, Hector S, additional, Wei, Yuqin, additional, Xu, Wenjie, additional, Lu, Michael, additional, Sung, Heng-Ming, additional, Lindaas, Arnstein, additional, Wernecke, Michael, additional, Macurdy, Thomas, additional, Kelman, Jeffrey, additional, and Forshee, Richard A, additional

Published
2019
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28. Effect of Age on Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines Among US Medicare Beneficiaries Aged ≥65 Years

Author

Lu, Yun, primary, Chillarige, Yoganand, additional, Izurieta, Hector S, additional, Wei, Yuqin, additional, Xu, Wenjie, additional, Lu, Michael, additional, Sung, Heng-Ming, additional, Lindaas, Arnstein, additional, Wernecke, Michael, additional, Macurdy, Thomas, additional, Kelman, Jeffrey, additional, and Forshee, Richard A, additional

Published
2019
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30. Relative Effectiveness of Cell-Cultured and Egg-Based Influenza Vaccines Among Elderly Persons in the United States, 2017–2018

Author

Izurieta, Hector S, primary, Chillarige, Yoganand, additional, Kelman, Jeffrey, additional, Wei, Yuqin, additional, Lu, Yun, additional, Xu, Wenjie, additional, Lu, Michael, additional, Pratt, Douglas, additional, Chu, Steve, additional, Wernecke, Michael, additional, MaCurdy, Thomas, additional, and Forshee, Richard, additional

Published
2018
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33. P2402Low flow aortic stenosis: early improvement in left ventricular function after TAVI

Author

J.L. Zamorano, L. Salido Tahoces, José Julio Jiménez-Nacher, A Garcia Martin, Valentina Barletta, A. Carbonell San Román, C. Izurieta, R Hinojar Baydes, Covadonga Fernández-Golfín, Rosana Hernández-Antolín, and A Gonzalez Gomez

Subjects
medicine.medical_specialty, Stenosis, Ventricular function, Flow (mathematics), business.industry, Internal medicine, Aortic valve stenosis, medicine, Cardiology, Ventricular pressure, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2017

34. Heterologous Prime-Boost Vaccination Using an AS03B-Adjuvanted Influenza A(H5N1) Vaccine in Infants and Children <3 Years of Age

Author

Terry Nolan, Robert Booy, Mamadou Dramé, Bee Wah Lee, David W. Vaughn, Patricia Izurieta, Poh Chong Chan, and Helen Marshall

Subjects
Male, Vaccination schedule, Immunization, Secondary, Antibodies, Viral, medicine.disease_cause, Major Articles and Brief Reports, Adjuvants, Immunologic, children, Influenza, Human, Pandemic, booster, Humans, Immunology and Allergy, Medicine, media_common.cataloged_instance, Live attenuated influenza vaccine, European union, media_common, Singapore, Heterologous vaccine, Influenza A Virus, H5N1 Subtype, business.industry, pandemic, Vaccination, Infant, virus diseases, H5N1, Hemagglutination Inhibition Tests, Virology, Influenza A virus subtype H5N1, 3. Good health, Infectious Diseases, Influenza Vaccines, Child, Preschool, Viruses, Human mortality from H5N1, Female, influenza, business
Abstract

Avian influenza A(H5N1) was identified as a cause of death in poultry in 1996, with the first human cases of infection recorded in 1997 [1]. From 2003 until January 2014, influenza A(H5N1) has caused 650 cases of influenza in humans [2]. Around 90% of cases have occurred in individuals

Published
2014

35. Statin Use and Risks of Influenza-Related Outcomes Among Older Adults Receiving Standard-Dose or High-Dose Influenza Vaccines Through Medicare During 2010–2015

Author

Izurieta, Hector S, primary, Chillarige, Yoganand, additional, Kelman, Jeffrey A, additional, Forshee, Richard, additional, Qiang, Yandong, additional, Wernecke, Michael, additional, Ferdinands, Jill M, additional, Lu, Yun, additional, Wei, Yuqin, additional, Xu, Wenjie, additional, Lu, Michael, additional, Fry, Alicia, additional, Pratt, Douglas, additional, and Shay, David K, additional

Published
2018
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36. Coregulation and modulation of NF B-related genes in celiac disease: uncovered aspects of gut mucosal inflammation

Author

Ainara Castellanos-Rubio, Amaia Jauregi-Miguel, Leticia Plaza-Izurieta, Nora Fernandez-Jimenez, Marian M. de Pancorbo, Xabier Elcoroaristizabal, Iñaki Irastorza, Tamara Lopez-Euba, Carlos Tutau, Jose Ramon Bilbao, and Juan Carlos Vitoria

Subjects
Gene Expression, Biology, Downregulation and upregulation, Intestinal mucosa, Gene expression, Genetics, Cluster Analysis, Humans, Gene Regulatory Networks, Intestinal Mucosa, Promoter Regions, Genetic, Molecular Biology, Genetics (clinical), Inflammation, Regulation of gene expression, Gene Expression Profiling, NF-kappa B, Articles, General Medicine, DNA Methylation, Paracaspase, NFKB1, Celiac Disease, Gene Expression Regulation, DNA methylation, Immunology, biology.protein, Gliadin, Signal Transduction
Abstract

It is known that the NFκB route is constitutively upregulated in celiac disease (CD), an immune-mediated disorder of the gut caused by intolerance to ingested gluten. Our aim was to scrutinize the expression patterns of several of the most biologically relevant components of the NFκB route in intestinal biopsies from active and treated patients and after in vitro gliadin challenge, and to assess normalization of the expression using an inhibitor of the MALT1 paracaspase. The expression of 93 NFκB genes was measured by RT-PCR in a set of uncultured active and treated CD and control biopsies, and in cultured biopsy series challenged with gliadin, the NFκB modulator, both compounds and none. Methylation of eight genes involved in NFκB signaling was analyzed by conventional pyrosequencing. Groups were compared and Pearson's correlation matrixes were constructed to check for coexpression and co-methylation. Our results confirm the upregulation of the NFκB pathway and show that constitutively altered genes usually belong to the core of the pathway and have central roles, whereas genes overexpressed only in active CD are more peripheral. Additionally, this is the first work to detect methylation level changes in celiac intestinal mucosa. Coexpression is very common in controls, whereas gliadin challenge and especially chronic inflammation present in untreated CD result in the disruption of the regulatory equilibrium. In contrast, co-methylation occurs more often in active CD. Importantly, NFκB modulation partially restores coregulation, opening the door to future therapeutic possibilities and targets.

Published
2013

37. Characterizing Vaccine-associated Risks Using Cubic Smoothing Splines

Author

Laura L. Polakowski, Hector Izurieta, Corrie Paeglow, Gregory W. Daniel, M. Alan Brookhart, Yun Lu, Tosmai Puenpatom, Alexander M. Walker, and Jie Li

Subjects
Pediatrics, medicine.medical_specialty, Time Factors, Fever, Epidemiology, Measles Vaccine, Mumps Vaccine, Risk Assessment, Measles, Rubella, Chickenpox Vaccine, Smoothing spline, Rubella vaccine, Humans, Medicine, Rubella Vaccine, Cumulative incidence, Poisson Distribution, Vaccines, Models, Statistical, business.industry, Incidence, Vaccination, Infant, Exanthema, medicine.disease, Mumps vaccine, Child, Preschool, Data Interpretation, Statistical, Immunology, Regression Analysis, Measles vaccine, business, medicine.drug
Abstract

Estimating risks associated with the use of childhood vaccines is challenging. The authors propose a new approach for studying short-term vaccine-related risks. The method uses a cubic smoothing spline to flexibly estimate the daily risk of an event after vaccination. The predicted incidence rates from the spline regression are then compared with the expected rates under a log-linear trend that excludes the days surrounding vaccination. The 2 models are then used to estimate the excess cumulative incidence attributable to the vaccination during the 42-day period after vaccination. Confidence intervals are obtained using a model-based bootstrap procedure. The method is applied to a study of known effects (positive controls) and expected noneffects (negative controls) of the measles, mumps, and rubella and measles, mumps, rubella, and varicella vaccines among children who are 1 year of age. The splines revealed well-resolved spikes in fever, rash, and adenopathy diagnoses, with the maximum incidence occurring between 9 and 11 days after vaccination. For the negative control outcomes, the spline model yielded a predicted incidence more consistent with the modeled day-specific risks, although there was evidence of increased risk of diagnoses of congenital malformations after vaccination, possibly because of a "provider visit effect." The proposed approach may be useful for vaccine safety surveillance.

Published
2012

38. Source of Piped Drinking Water Supply and Soil Transmitted Helminth Infections (STHI) in School Children in El Salvador

Author

Lakshminarayan Rajaram, Miguel Angel Minero, Thomas R. Unnasch, Linda M. Whiteford, Miguel Aragon, Ricardo Izurieta, Sharad Malavade, and Malinee Neelamegam

Subjects
Low income, Potable water, Infectious Diseases, Oncology, Descriptive statistics, Soil-transmitted helminth, business.industry, Environmental protection, Environmental health, Water supply, Medicine, Developing country, business
Published
2017

39. Safety of Varicella Vaccine after Licensure in the United States: Experience from Reports to the Vaccine Adverse Event Reporting System, 1995–2005

Author

Jane F. Seward, Penina Haber, D. Scott Schmid, Sandra S. Chaves, Hector S. Izurieta, Robert P. Wise, and Kimp Walton

Subjects
Herpesvirus 3, Human, Pediatrics, medicine.medical_specialty, Adolescent, Varicella vaccine, viruses, Disease, Herpes Zoster, Chickenpox Vaccine, Adverse Event Reporting System, Chickenpox, medicine, Adverse Drug Reaction Reporting Systems, Humans, Immunology and Allergy, Child, Adverse effect, Licensure, integumentary system, business.industry, Infant, virus diseases, medicine.disease, Meningitis, Viral, United States, Infectious Diseases, Child, Preschool, Immunology, Viral disease, Centers for Disease Control and Prevention, U.S, business, Meningitis
Abstract

Widespread use of varicella vaccine in the United States could enable detection of rare adverse events not identified previously. We reviewed data from 1995 to 2005 from the Vaccine Adverse Event Reporting System, including data from laboratory analyses, to distinguish adverse events associated with wild-type varicella-zoster virus (VZV) versus those associated with vaccine strain. Almost 48 million doses of varicella vaccine were distributed between 1995 and 2005. There were 25,306 adverse events reported (52.7/100,000 doses distributed); 5.0% were classified as serious (2.6/100,000 doses distributed). Adverse events associated with evidence of vaccine-strain VZV included meningitis in patients with concurrent herpes zoster. Patients with genetic predispositions may rarely have disease triggered by receipt of varicella vaccine. Overall, serious adverse events reported after varicella vaccination continue to be rare and must be considered relative to the substantial benefits of varicella vaccination. Ongoing safety surveillance and further studies may shed light on some of the hypothesized associations.

Published
2008

42. Effectiveness and Duration of Protection Provided by the Live-attenuated Herpes Zoster Vaccine in the Medicare Population Ages 65 Years and Older

Author

Izurieta, Hector S., primary, Wernecke, Michael, additional, Kelman, Jeffrey, additional, Wong, Sarah, additional, Forshee, Richard, additional, Pratt, Douglas, additional, Lu, Yun, additional, Sun, Qin, additional, Jankosky, Christopher, additional, Krause, Philip, additional, Worrall, Chris, additional, MaCurdy, Tom, additional, and Harpaz, Rafael, additional

Published
2017
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43. Comparative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines Among US Medicare Beneficiaries in Preventing Postinfluenza Deaths During 2012–2013 and 2013–2014

Author

Shay, David K., primary, Chillarige, Yoganand, additional, Kelman, Jeffrey, additional, Forshee, Richard A., additional, Foppa, Ivo M., additional, Wernecke, Michael, additional, Lu, Yun, additional, Ferdinands, Jill M., additional, Iyengar, Arjun, additional, Fry, Alicia M., additional, Worrall, Chris, additional, and Izurieta, Hector S., additional

Published
2017
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45. P569Diastolic dyssynchrony is associated with exercise intolerance in hypertensive patients with left ventricular hypertrophyP570Echocardiographic pattern of acute pulmonary embolism, analysis of consecutive 511 patientsP571Clinical significance of ventricular interdependence and left ventricular function in patients with pulmonary hypertension receiving specific vasodilator therapyP572Haemodynamic characteristics and ventricular mechanics in post-capillary and combined pre- and post-capillary pulmonary hypertensionP573Relationship between hematological response and echocardiographic features in patients with light chains systemic amyloidosisP574Myocardial changes in patients with anorexia nervosaP575Giant cell arteritis presenting as fever of unknown origin: role of clinical history, early positron emission tomography and ultrasound screeningP576Subclinical systolic dysfunction in systemic sclerosis is not influenced by standard rheumatologic therapy - a 4D echocardiographic studyP577Cardiac index correlates with the degree of hepatic steathosis in obese patients with obstructive sleep apneaP578Myocardial mechanics in top-level endurance athletes: a three-dimensional speckle tracking studyP579The athlete heart: what happens to myocardial deformation in physiological adaptation to sportsP580Association between left ventricle intrinsic function and urine protein-creatinine ratio in preeclampsia before and after deliveryP581Dilatation of the aorta in children with bicuspid aortic valveP582Cardiovascular functional abnormalities in patients with osteogenesis imperfectaP583Dobutamine stress test fast protocol: diagnostic accuracy and securityP584Prognostic value of non-positive exercise echocardiography in the patients submitted to percutaneous coronary interventionP585The use of myocardial strain imaging in the detection of coronary artery disease during stress echocardiographyP586Preserved O2 extraction exercise response in heart failure patients with chronotropic insufficiency: evidence for a central cardiac rather than peripheral oxygen uptake limitationP587Major determinant of O2 artero-venous difference at peak exercise in heart failure and healthy subjectsP588Stress echocardiography with contrast perfusion analysis for a more sensitive test for ischemic heart diseaseP589Assessment of mitral annular physiology in myxomatous mitral disease with 3D transesophageal echocardiography: comparison between early severe mitral regurgitation and decompensated groupP590Three-dimensional transesophageal echocardiographic assessment of the mitral valve geometry in patients with mild, moderate and severe chronic ischemic mitral regurgitationP591Left atrial appendage closure. Multimodality imaging in device size selectionP592Contributions of three-dimensional transesophageal echocardiography in the evaluation of aortic atherosclerotic plaquesP593Agitated blood-saline is superior to agitated air-saline for echocardiographic shunt studies

Author

Jung, IH., primary, Kurnicka, K., primary, Enache, R., primary, Nagy, AI., primary, Martins, E., primary, Cereda, A., primary, Vitiello, G., primary, Magda, SL., primary, Styczynski, G., primary, Lo Iudice, F., primary, De Barros Viegas, H., primary, Shahab, F., primary, Trunina, I., primary, Mata Caballero, R., primary, Marques, A., primary, Shimoni, S., primary, Generati, G., primary, Bendix Salkvist Jorgensen, T., primary, Chen, TE., primary, Andrianova, A., primary, Fernandez-Golfin, C., primary, Corneli, MC., primary, Ali, M., primary, Seo, HS., additional, Kim, MJ., additional, Lichodziejewska, B., additional, Goliszek, S., additional, Dzikowska-Diduch, O., additional, Zdonczyk, O., additional, Kozlowska, M., additional, Kostrubiec, M., additional, Ciurzynski, M., additional, Palczewski, P., additional, Pruszczyk, P., additional, Popa, E., additional, Coman, IM., additional, Badea, R., additional, Platon, P., additional, Calin, A., additional, Beladan, CC., additional, Rosca, M., additional, Ginghina, C., additional, Popescu, BA., additional, Jurcut, R., additional, Venkateshvaran, AI., additional, Sola, SC., additional, Govind, SC., additional, Dash, PK., additional, Lund, L., additional, Manouras, AI., additional, Merkely, B., additional, Magne, J., additional, Aboyans, V., additional, Boulogne, C., additional, Lavergne, D., additional, Jaccard, A., additional, Mohty, D., additional, Casadei, F., additional, Spano, F., additional, Santambrogio, G., additional, Musca, F., additional, Belli, O., additional, De Chiara, B., additional, Bokor, D., additional, Giannattasio, C., additional, Corradi, E., additional, Colombo, CA., additional, Moreo, A., additional, Vicario, ML., additional, Castellani, S., additional, Cammelli, D., additional, Gallini, C., additional, Needleman, L., additional, Cruz, BK., additional, Maggi, E., additional, Marchionni, N., additional, Bratu, VD., additional, Mincu, RI., additional, Mihai, CM., additional, Gherghe, AM., additional, Florescu, M., additional, Cinteza, M., additional, Vinereanu, D., additional, Sobieraj, P., additional, Bielicki, P., additional, Krenke, R., additional, Szmigielski, CA., additional, Petitto, M., additional, Ferrone, M., additional, Esposito, R., additional, Vaccaro, A., additional, Buonauro, A., additional, Trimarco, B., additional, Galderisi, M., additional, Mendes, L., additional, Dores, H., additional, Melo, I., additional, Madeira, V., additional, Patinha, J., additional, Encarnacao, C., additional, Ferreia Santos, J., additional, Habib, F., additional, Soesanto, AM., additional, Sedyawan, J., additional, Abdurrazak, G., additional, Sharykin, A., additional, Popova, NE., additional, Karelina, EV., additional, Telezhnikova, ND., additional, Hernandez Jimenez, V., additional, Saavedra, J., additional, Molina, L., additional, Alberca, MT., additional, Gorriz, J., additional, L Pais, J., additional, Pavon, I., additional, Navea, C., additional, Alonso, JJ., additional, Sonia, S., additional, Cruz, I., additional, Joao, I., additional, Gomes, AC., additional, Caldeira, D., additional, Lopes, L., additional, Fazendas, P., additional, Pereira, H., additional, Edri, O., additional, Schneider, N., additional, Abaye, N., additional, Goerge, J., additional, Gandelman, G., additional, Bandera, F., additional, Alfonzetti, E., additional, Guazzi, M., additional, Villani, S., additional, Ferraro, O., additional, Ramberg, E., additional, Bhardwaj, P., additional, Nepper, ML., additional, Binko, TS., additional, Olausson, M., additional, Fink-Jensen, T., additional, Andersen, AM., additional, Roland, J., additional, Gleerup Fornitz, G., additional, Ong, K., additional, Suri, RM., additional, Enrique-Sarano, M., additional, Michelena, HI., additional, Burkhart, HM., additional, Gillespie, SM., additional, Cha, S., additional, Mankad, SV., additional, Saidova, MA., additional, Bolotova, MN., additional, Salido Tahoces, L., additional, Izurieta, C., additional, Villareal, G., additional, Esteban, A., additional, Urena Vacas, A., additional, Ayala, A., additional, Jimenez Nacher, JJ., additional, Hinojar Baydes, R., additional, Gonzalez Gomez, A., additional, Garcia, A., additional, Mestre, JL., additional, Hernandez Antolin, R., additional, Zamorano Gomez, JJ., additional, Perea, G., additional, Covelli, Y., additional, Henquin, R., additional, Ronderos, R., additional, Hepinstall, MJ., additional, Cassidy, CS., additional, Pellikka, PA., additional, Pislaru, SV., additional, and Kane, G., additional

Published
2016
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46. Poster Session 6Assessment of morphology and functionP1222Multimodality imaging for left atrial appendage occluder sizingP1223Longitudinal left atrial strain is a main predictor for long term prognosis on atrial fibrillation after CABG operation patientsP1224Comparison of 2D and 3D left ventricular volumes measurements: results from the SKIPOGH II studyP1225Adjusting for thoracic circumference is superior to body surface area in the assessment of neonatal cardiac dimensions in foetal growth abnormalityP1226Maximal vortex suction pressure: an equivocal marker for optimization of atrio-ventricular delayP1227Volume-time curve of cardiac magnetic resonance assessed left ventricular dysfunction in coronary artery disease patients with type 2 diabetes mellitusP1228Thickness matters, but not in the same way for all strain parametersP1229Digging deeper in postoperative modifications of right ventricular function: impact of pericardial approach and cardioplegiaP1230Left atrial function evaluated by 2D-speckle tracking echocardiography in diabetes mellitus populationP1231The influence of arterial hypertension duration on left ventricular diastolic parameters in patients with well regulated arterial blood pressureP1232Investigation of factors affecting left ventricular diastolic dysfunction determined using mitral annulus velocityP1233High regulatory T-lymphocytes after ST-elevation myocardial infarction relate with adverse left ventricular remodelling assessed by 3D-echocardiographyP1234Prevalence of paradoxical low flow/low gradient severe aortic stenosis measure with 3 dimensional transesophageal echocardiographyP1235Coronary microvascular and diastolic dysfunctions after aortic valve replacement: comparison between mechanical and biological prosthesesP1236Normal-flow, low gradient aortic stenosis is common in a population of patients with severe aortic valve stenosis undergoing aortic valve replacementP1237Analysis of validity and reproducibility of calcium burden visual estimation by echocardiographyP12383D full automatic software in the evaluation of aortic stenosis severity in TAVI patients. Preliminary resultsP1239Differential impact of net atrioventricular compliance on clinical outcomes in patients with mitral stenosis according to cardiac rhythmP1240Aortic regurgitation affects the intima-media thickness of the right and left common carotid artery differentlyP1241Global longitudinal strain: an hallmark of cardiac damage in mitral valve regurgitation. Experience from the european registry of mitral regurgitationP1242Echocardiographic characterisation of Barlow's disease versus fibroelastic deficiencyP1243Echocardiographic screening for rheumatic heart disease in a ugandan orphanage - feasibility and outcomesP1244Alterations in right ventricular mechanics upon follow-up period in patients with persistent ischemic mitral regurgitation after inferoposterior myocardial infarctionP1245Ten-years conventional mitral surgery in patients with mitral regurgitation and left ventricular dysfunction: clinical and echocardiographic outcomes

Author

Wassmuth, R., primary, Hristova, K., primary, Monney, P., primary, Olander, RFW, primary, Rodriguez Munoz, D., primary, Huayan, X., primary, Pagourelias, E., primary, Loardi, C., primary, Moreno, J., primary, Miljkovic, T., primary, Takase, H., primary, Latet, SC., primary, Henquin, R., primary, America, R., primary, Carter-Storch, R., primary, Panelo, ML., primary, Fernandez-Golfin, C., primary, Cho, IJ., primary, Petrini, J., primary, Buonauro, A., primary, Liu, B., primary, Mapelli, M., primary, Tamulenaite, E., primary, De Chiara, B., primary, Minden, H., additional, Kostova, V., additional, Nesheva, N., additional, Katova, TZ., additional, Bojadzhiev, L., additional, Crisinel, V., additional, Reverdin, S., additional, Conti, L., additional, Mach, F., additional, Mueller, H., additional, Jeanrenaud, X., additional, Bochud, M., additional, Ehret, G., additional, Sundholm, JKM, additional, Ojala, T., additional, Andersson, S., additional, Sarkola, T., additional, Moya Mur, JL., additional, Berlot, B., additional, Fernandez-Golfin, C., additional, Moreno Planas, J., additional, Casas Rojo, E., additional, Garcia Martin, A., additional, Jimenez Nacher, JJ., additional, Hernandez-Madrid, A., additional, Franco Diez, E., additional, Matia Frances, R., additional, Zamorano, JL., additional, Zhigang, YANG, additional, Yingkun, GUO, additional, Jing, CHEN, additional, Duchenne, J., additional, Mirea, O., additional, Triantafyllis, A., additional, Michalski, B., additional, Vovas, G., additional, Delforge, M., additional, Van Cleemput, J., additional, Bogaert, J., additional, Voigt, JU., additional, Saccocci, M., additional, Tamborini, G., additional, Veglia, F., additional, Pepi, M., additional, Alamanni, F., additional, Zanobini, M., additional, Zuniga Sedano, JJ., additional, Alexanderson, E., additional, Martinez, C., additional, Bjelobrk, M., additional, Pavlovic, K., additional, Ilic, A., additional, Colakovic, S., additional, Dodic, S., additional, Tanaka, T., additional, Machii, M., additional, Nonaka, D., additional, Van Herck, PL., additional, Claeys, MJ., additional, Haine, SE., additional, Miljoen, HP., additional, Segers, VF., additional, Vandendriessche, TR., additional, De Winter, BY., additional, Hoymans, VY., additional, Vrints, CJ., additional, Lombardero, M., additional, Perea, G., additional, Miele, MM., additional, De Amicis, DAV, additional, Mannacio, VAM, additional, Dahl, JS., additional, Christensen, NL., additional, Soendergaard, EV., additional, Marcussen, N., additional, Moeller, JE., additional, Fernandez-Palomeque, C., additional, Garcia-Vega, D., additional, Mont-Girbau, L., additional, Pardo, A., additional, Izurieta, C., additional, Boretti, I., additional, Hinojar, R., additional, Gonzalez-Gomez, A., additional, Casas, E., additional, Salido, L., additional, Barrios, V., additional, Ruiz, S., additional, Moya, JL., additional, Hernandez Antolin, R., additional, Jimenez Nacher, JL., additional, Chang, HJ., additional, Choi, HH., additional, Lee, SY., additional, Shim, CY., additional, Ha, JW., additional, Chung, N., additional, Ring, M., additional, Caidahl, K., additional, Eriksson, MJ., additional, Esposito, R., additional, Santoro, C., additional, Monteagudo, JM., additional, Trimarco, B., additional, Galderisi, M., additional, Baig, S., additional, Hayer, M., additional, Steeds, R., additional, Edwards, N., additional, Fusini, L., additional, Zagni, P., additional, Muratori, M., additional, Agostoni, P., additional, Gripari, P., additional, Ghulam Ali, S., additional, Fiorentini, C., additional, Valuckiene, Z., additional, Jurkevicius, R., additional, Peritore, A., additional, Botta, L., additional, Belli, O., additional, Musca, F., additional, Casadei, F., additional, Russo, C., additional, Giannattasio, C., additional, and Moreo, A., additional

Published
2016
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47. Poster Session 1The imaging examination and quality assessmentP185Why did the normal values of the left and right atrial volumes increase in the recent chamber quantification guidelines update?P186Atrial electromechanical delay, Left Atrial mechanical functions and longitudinal left ventricular strain in pre-diabetic patientsP187A web-based platform for e-training in echocardiographyP188Righ atrial size as a marker of success in electrical cardioversion in patients with persistent atrial fibrillationP189Echocardiographic assessment of left atrial dimensions and function in a healthy populationP190Impact of carotid artery revascularization on the cognitive and functional outcome and cerebral flow on TCD and brain MRI in patients with symptomatic carotid artery stenosis: a preliminary reportP191Aortic elasticity is impaired in hypereosinophilic syndromeP192Disturbed intracardiac flow transit prognosticates early decompensation in dilated cardiomyopathyP193Ultrasound guided treatment in acute heart failureP194Determinants of impaired global longitudinal function in middle-aged subjects free of cardiovascular diseaseP195Left ventricular remodeling in asymptomatic heart failure: classification and prognostic evaluationP196Restricted displacement of lateral right ventricular wall: a physiopathological explanation of geometrical and functional cardiac changes after cardiac surgeryP197A novel method to image intracardiac flow stagnation for the risk stratification for thrombosisP198Magnetic resonance imaging of anomalous origin of the left coronary artery from the pulmonary artery in children older than 4 monthsP199Coronary flow reserve is improved by LDL apheresis in patients with familial hypercholesterolemia and chronic ischemic heart diseaseP200 High velocities in the proximal part of the coronary arteries during routine echocardiography can predict nearest prognosisP201Recovery potential of the right ventricular function in the setting of a first STEMI treated by primary PCI: an echocardiographic studyP202Severe aortic stenosis patients with preserved ejection fraction according to flow and gradient classification: prevalence and outcomesP203Is basal left ventricular ejection time able to predict the severity of aortic stenosis in patients with depressed ejection fraction?P204Acceleration time in aortic stenosis: a new echocardiographic diagnostic parameterP205Application of novel Doppler indices of stenosis severity in the assessment of rheumatic mitral stenosis beyond conventional valve area and transvalvular gradientsP206Comparison of conventional echo score in patients with symptomatic rheumatic mitral stenosis: transesophageal echocardiography versus transthoracic echocardiographyP207Speckle-tracking echocardiography in evaluation early left ventricular systolic dysfunction in asymptomatic aortic regurgitation patients with good left ventricular ejection fractionP208Expansible aortic ring annuloplasty: mid-term results of aortic valve repairP209Papillary muscle dysfunction: insights into mitral valve prolapse using speckle tracking imaging

Author

Kebed, K., primary, Moustafa, TAMER, primary, Conte, R., primary, Doering, C., primary, Van Grootel, R W J, primary, Badacz, R., primary, Nemes, A., primary, Uejima, T., primary, Oehman, J., primary, Ceponiene, I., primary, Fabiani, I., primary, Garcia Martin, A., primary, Nishikawa, H., primary, Jurko, AJR, primary, Pasanisi, E., primary, Zagatina, A., primary, Stoian, M., primary, Monteagudo Ruiz, JM., primary, Lazaro Mendes, AS., primary, Ruiz Fernandez, D., primary, Chong, A., primary, Park, YH., primary, Mizariene, V., primary, Hlubocka, Z., primary, Ring, L., primary, Kruse, E., additional, Addetia, K., additional, Ciszek, B., additional, Thykattil, M., additional, Guile, B., additional, Lang, RM., additional, Mor-Avi, V., additional, Mahfouz, RAGAB, additional, Elzayat, AHMED, additional, Goda, MOHAMD, additional, Gad, MARWA, additional, Sansone, F., additional, Napoli, F., additional, Tonacci, A., additional, Raciti, M., additional, Landi, P., additional, Grande, A., additional, Ait-Ali, L., additional, Sveric, K., additional, Richter, U., additional, Strasser, RH., additional, Wunderlich, C., additional, Menting, ME., additional, Mcghie, JS., additional, Strachinaru, M., additional, Vletter, WB., additional, Geleijnse, ML., additional, Roos-Hesselink, JW., additional, Van Den Bosch, AE., additional, Kablak-Ziembicka, A., additional, Urbanczyk-Zawadzka, M., additional, Banys, RP., additional, Musialek, P., additional, Pieniazek, P., additional, Mleczko, S., additional, Zmudka, K., additional, Przewlocki, T., additional, Marton, I., additional, Domsik, P., additional, Kalapos, A., additional, Posfai, E., additional, Modok, S., additional, Borbenyi, Z., additional, Forster, T., additional, Takahashi, L., additional, Nishikawa, H., additional, Semba, H., additional, Sawada, H., additional, Yamashita, T., additional, Jurkevicius, R., additional, Petkeviciene, J., additional, Gustiene, O., additional, Tamuleviciute-Prasciene, E., additional, Motiejunaite, J., additional, Slapikas, R., additional, Pugliese, NR., additional, La Carrubba, S., additional, Antonini Canterin, F., additional, Colonna, P., additional, Caso, P., additional, Benedetto, F., additional, Citro, R., additional, Carerj, S., additional, Di Bello, V., additional, Moya Mur, JL., additional, Lazaro Rivera, C., additional, Rincon Diaz, LM., additional, Miguelena Hycka, J., additional, Garcia Lledo, A., additional, Jimenez Nacher, JJ., additional, Fernandez-Golfin, C., additional, Rodriguez-Roda, J., additional, Zamorano, JL., additional, Uejima, T., additional, Jurko, A., additional, Jurko, T., additional, Mistinova-Polakova, J., additional, Sbrana, F., additional, Petersen, C., additional, Bigazzi, F., additional, Dal Pino, B., additional, Coceani, M., additional, Ripoli, A., additional, Pianelli, M., additional, Luciani, R., additional, Sampietro, T., additional, Zhuravskaya, N., additional, Vareldzhyan, Y., additional, Kamenskikh, M., additional, Shmatov, D., additional, Zamfir, D., additional, Vijiiac, A., additional, Pitic, D., additional, Tamasescu, G., additional, Onciul, S., additional, Onut, R., additional, Stefan, C., additional, Dorobantu, M., additional, Gonzalez-Gomez, A., additional, Izurieta, C., additional, Marco, A., additional, Alonso Salinas, GL., additional, Hinojar Baydes, R., additional, Garcia Martin, A., additional, Casas Rojo, E., additional, Ferreira, AR., additional, Moura Ferreira, J., additional, Leite, L., additional, Oliveira, AP., additional, Ribeiro, N., additional, Barbosa, AJ., additional, Mata Martins, R., additional, Ramos, D., additional, Pego, M., additional, Gamaza Chulian, S., additional, Diaz Retamino, E., additional, Camacho Freire, S., additional, Gutierrez Barrios, A., additional, Oneto Otero, J., additional, Bansal, M., additional, Grewal, HK., additional, Kasliwal, RR., additional, Wahi, S., additional, Lee, SH., additional, Lee, DS., additional, Hwang, JM., additional, Kim, JS., additional, Kim, JH., additional, Chun, KJ., additional, Bieseviciene, M., additional, Verseckaite, R., additional, Jonkaitiene, R., additional, Janenaite, J., additional, Dostalova, G., additional, Hlubocky, J., additional, Novotny, R., additional, Vondracek, V., additional, Lindner, J., additional, Linhart, A., additional, and Preston, NK., additional

Published
2016
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48. P673Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medicationP674Clinical presentation, echocardiographic findings and complications in patients with typical and atypical form of takotsubo cardiomyopathyP675Left ventricular mass/end-diastolic volume ratio with tridimensional echocardiography in newly-diagnosed hypertensive patients: which relation between left ventricular geometry and stroke volume?P676Endothelial dysfunction: the link between arterial hypertension, diabetes mellitus and heart diseaseP677Dynamic of changes of arterial stiffness evaluated by cardio-ankle vascular index(CAVI) during the growth and development of children and adolescentsP678Peripheral arterial stiffness in pulmonary hypertension and pulmonary embolism: assessment with cardio ankle vascular index, noninvasive markers of vascular diseaseP679Early detection and prediction of CHOP-induced cardiotoxicity in nonHodgkin lymphoma by 4D echocardiography, vascular ultrasound, and cardiac biomarkersP680Right ventricular remodeling in children engaged in endurance sports: a longitudinal study in preadolescent athletesP681Electrocardiographic criteria for atria enlargement are not useful in the evaluation of junior high-dynamic high-static athletesP682Prognostic value of right ventricle, pulmonary arterial pressure and biomarkers in patients with acute heart failure: one year follow upP683One-point carotid stiffness parameters by echo-tracking method in a wide-age range of healthy population. A single center experienceP684Role of bidimensional speckle tracking longitudinal strain in the evaluation of right and left ventricular function in adult patients with transposition of the great arteriesP685Interfaces between FBN1 gene polymorphism and biomechanical parameters estimated by speckle-tracking echocardiography of dilative pathology of ascending aorta P686Layer-specific speckle tracking analysis for the detection of coronary artery disease during dipyridamole stress echoP687Stress echo in Italy: state-of-the art 2015P688The declining frequency of Inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983-2009)P689Global longitudinal strain can unmask inducible myocardial ischemia at submaximal heart rate during dobutamine stress echocardiography.P690Low risk syntax score predicted by wall motion score index during dobutamine stress echocardiographyP691Outdoor stress echo by lung ultrasound for subclinical detection of high altitude pulmonary edema with B-linesP692Predictors and consequences of infective endocarditis with perivalvular extension - a subgroup with worse short and medium-term prognosisP693Analysis of left atrial auricle morphology and function to detect considerable risk factors regarding the prevention of strokeP694LAA closure - does size really matter?P695Real assessment of mitral regurgitation by three-dimensional transesophageal echocardiographyP696Myocardial contrast dobutamine stress echocardiography for detection of coronary artery disease

Author

Ikonomidis, I., primary, Budnik, M., primary, Lembo, M., primary, Vintila, A-M, primary, Jurko, T., primary, Ciciarello, FL., primary, Mihalcea, D., primary, D'ascenzi, F., primary, Konopka, M., primary, Deljanin Ilic, M., primary, Vriz, O., primary, Timoteo, AT., primary, Bieseviciene, M., primary, Cameli, M., primary, Ciampi, Q., primary, Carpeggiani, C., primary, Van De Heyning, CM., primary, Zainal Abidin, HA., primary, Pratali, L., primary, Coutinho Cruz, M., primary, Stoebe, S., primary, Ribeiro, JM., primary, Perea, G., primary, Tereshina, O., primary, Pavlidis, G., additional, Lambadiari, V., additional, Kousathana, F., additional, Triantafyllidi, H., additional, Varoudi, M., additional, Vlastos, D., additional, Vlachos, S., additional, Dimitriadis, G., additional, Lekakis, J., additional, Kochanowski, J., additional, Piatkowski, R., additional, Wojtera, K., additional, Opolski, G., additional, Lo Iudice, F., additional, Esposito, R., additional, Santoro, C., additional, Gerardi, D., additional, De Simone, G., additional, Trimarco, B., additional, Galderisi, M., additional, Vintila, V., additional, Bruckner, I., additional, Jurko, AJR, additional, Jurko, A., additional, Mestanik, M., additional, Mestanikova, A., additional, Tonhajzerova, I., additional, Valeria Silvestri, VS., additional, Roberto Badagliacca, RB., additional, Dario Vizza, DV., additional, Francesco Fedele, FF., additional, Luciano Agati, LA., additional, Florescu, M., additional, Vladareanu, AM., additional, Vinereanu, D., additional, Solari, M., additional, Natali, BM., additional, Malandrino, A., additional, Valentini, F., additional, Cameli, M., additional, Focardi, M., additional, Bonifazi, M., additional, Pelliccia, A., additional, Mondillo, S., additional, Burkhard-Jagodzinska, K., additional, Jakubiak, A., additional, Krol, W., additional, Klusiewicz, A., additional, Zdanowicz, R., additional, Sitkowski, D., additional, Dluzniewski, M., additional, Braksator, W., additional, Petrovic, D., additional, Stojanovic, S., additional, Ilic, S., additional, Kocic, G., additional, Pirisi, M., additional, Magne, J., additional, Aboyans, V., additional, Minisini, R., additional, Bossone, E., additional, Moura Branco, L., additional, Rosa, SA., additional, Galrinho, A., additional, Sousa, L., additional, Oliveira, JA., additional, Agapito, A., additional, Ferreira, RC., additional, Mizariene, V., additional, Vaskelyte, JJ., additional, Lesauskaite, V., additional, Sepetiene, R., additional, Mandoli, GE., additional, Menci, D., additional, Capitani, E., additional, Albizzi, C., additional, Crudele, F., additional, D'ascenzi, F., additional, Citro, R., additional, Severino, S., additional, Labanti, G., additional, Cortigiani, L., additional, Sicari, R., additional, Colonna, P., additional, Picano, E., additional, Landi, P., additional, Michelassi, C., additional, Ectors, B., additional, Heuten, H., additional, Shivalkar, B., additional, Ismail, JOHAN, additional, Kasim, SAZZLI, additional, Giardini, G., additional, Cavana, M., additional, Ilhao Moreira, R., additional, Coutinho Miranda, L., additional, Timoteo, AT., additional, Abreu, J., additional, Modas Daniel, P., additional, Fragata, J., additional, Cruz Ferreira, R., additional, Farese, G., additional, Tarr, A., additional, Jurisch, D., additional, Pfeiffer, D., additional, Hagendorff, A., additional, Teixeira, R., additional, Puga, L., additional, Costa, M., additional, Silva, J., additional, Paiva, L., additional, Goncalves, L., additional, Lombardero, M., additional, Henquin, R., additional, Izurieta, C., additional, and Corneli, MC., additional

Published
2016
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49. P650Influence of fetunin-a level on progression of calcific aortic valve stenosis The COFRASA - GENERAC StudyP651Common carotid artery remodeling 1 year after aortic valve surgeryP652Low gradient aortic stenosis with preserved ejection fraction: reclassification of severity by 3D transesophageal echocardiography. P653Results of balloon aortic valvuloplasty in patients with impaired left ventricle ejection fraction.P654Burden of associated aortic regurgitation in patients with mitral regurgitationP655Differences in right ventricular mechanics in acute and chronic ischemic mitral regurgitation after inferoposterior myocardial infarctionP656Tricuspid regurgitation in patients operated for severe symptomatic native aortic stenosis: pre-operative determinantsP657Echocardiographic diagnosis in patients with prosthetic or annuloplasty ring dysfunction: correlation with surgical findingsP659Agreement analisys of different three-dimensional transoesophageal echocardiographic modalities and cardiac CT scan in aortic annulus sizing for transapical heart valve implantationP660Elevated gradients after TAVR are associated with increased rehospitalization, but have no impact on mortality and major adverse cardiac eventsP661Echocardiographic characteristics of post-TAVI thrombosis and endocarditis: single-centre experienceP662Impact of mixed aortic valve disease in long-term mortality after transcatheter aortic valve implantationP663Quantification of mitral regurgitation during interventional valve repair: correlation between haemodynamic parameters and 3D color Doppler echocardiographyP664Mitraclip in functional mitral regurgitation: are immediate results the same in ischemic and non ischemic etiology?P665Left ventricular contractile reserve by stress echocardiography as a predictor of response to cardiac resynchronization therapy in heart failure: a meta-analysisP666Regardless of the definition used, left ventricular reverse remodeling is not different in fibrosis positive and negative dilated cardiomyopathy patientsP667Heterogeneity of LV contractile function by multidimensional strain in patients with EF<35%: Insights for the hemodynamic burdenP668Ability of 99mTc-DPD scintigraphy to predict conduction disorders requiring permanent pacemaker in patients with transthyretin-related cardiac amyloidosisP669Provocation of left ventricular outflow tract obstruction using nitrate inhalation in hypertrophic cardiomyopathy: relation to electromechanical delayP670Could echocardiographic features differentiate Fabry cardiomyopathy from sarcomeric forms of hypertrophic cardiomyopathy?P671Pregnancy is well tolerated in women with arrhythmogenic right ventricular cardiomyopathy P672Glycogen storage cardiomyopathy (PRKAG2): do particular echocardiography findings in established and advanced techniques are helpful in suggesting the diagnosis?P673Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medication

Author

Kubota, N., primary, Petrini, J., primary, Gonzalez Gomez, A., primary, Sorysz, DS., primary, Monteagudo Ruiz, JM., primary, Tamulenaite, E., primary, Dumont, C., primary, De Chiara, B., primary, Polizzi, V., primary, Ali, M., primary, Spartera, M., primary, Stathogiannis, K., primary, Goebel, B., primary, Mesa Rubio, MD., primary, Ciampi, Q., primary, Wisniowska-Smialek, S., primary, Sade, LE., primary, Brun, S., primary, Hamed, W., primary, Militaru, S., primary, Castrini, AI., primary, Costa Santos, W., primary, Ikonomidis, I., primary, David Messika-Zeitoun, DMZ, additional, Ring, M., additional, Caidahl, K., additional, Eriksson, MJ., additional, Monteagudo, JM., additional, Fernandez-Golfin, C., additional, Izurieta, C., additional, Hinojar, R., additional, Garcia, A., additional, Casas, E., additional, Marco, A., additional, Jimenez-Nacher, JJ., additional, Zamorano, JL., additional, Daniec, M., additional, Stapor, M., additional, Tomala, M., additional, Nawrotek, B., additional, Rzeszutko, L., additional, Kleczynski, P., additional, Dziewierz, A., additional, Bagienski, M., additional, Zmudka, K., additional, Dudek, D., additional, Mesa, D., additional, Gonzalez-Alujas, T., additional, Sitges, M., additional, Carrasco-Chinchilla, F., additional, Li, CH., additional, Grande-Trillo, A., additional, Martinez, A., additional, Matabuena, J., additional, Alonso-Rodriguez, D., additional, Aquila, I., additional, Gonzalez-Gomez, A., additional, Valuckiene, Z., additional, Jurkevicius, R., additional, Galli, E., additional, Oger, E., additional, Hubert, A., additional, Leclercq, C., additional, Donal, E., additional, Quattrocchi, S., additional, Botta, L., additional, Casadei, F., additional, Peritore, A., additional, Belli, O., additional, Musca, F., additional, Russo, C., additional, Giannattasio, C., additional, Moreo, A., additional, Lo Presti, ML., additional, Pino, PG., additional, Madeo, A., additional, Bellavia, D., additional, Buffa, V., additional, Fiorilli, R., additional, Luzi, G., additional, Musumeci, F., additional, Nkomo, VT., additional, Pellikka, PA., additional, Connolly, HM., additional, Scott, CG., additional, Sandhu, GS., additional, Holmes, DR., additional, Rihal, CS., additional, Greason, KL., additional, Pislaru, SV., additional, Barletta, M., additional, Ancona, F., additional, Rosa, I., additional, Stella, S., additional, Marini, C., additional, Montorfano, M., additional, Latib, A., additional, Alfieri, O., additional, Margonato, A., additional, Colombo, A., additional, Agricola, E., additional, Toutouzas, K., additional, Drakopoulou, M., additional, Michelongona, A., additional, Latsios, G., additional, Synetos, A., additional, Kaitozis, O., additional, Mitropoulou, F., additional, Brili, S., additional, Tousoulis, D., additional, Rohm, I., additional, Hamadanchi, A., additional, Otto, S., additional, Jung, C., additional, Figulla, HR., additional, Schulze, PC., additional, Poerner, TC., additional, Gutierrez Ballesteros, G., additional, Aristizabal Duque, C., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Fernandez Cabeza, J., additional, Pan Alvarez-Osorio, M., additional, Lopez Granados, A., additional, Romero Moreno, M., additional, Suarez De Lezo Cruz-Conde, J., additional, Carpegiani, C., additional, Michelassi, C., additional, Villari, B., additional, Picano, E., additional, Rubis, P., additional, Biernacka-Fijalkowska, B., additional, Dziewiecka, E., additional, Khachatryan, L., additional, Faltyn, P., additional, Lesniak-Sobelga, A., additional, Hlawaty, M., additional, Kostkiewicz, M., additional, Podolec, P., additional, Bal, U., additional, Oguz, D., additional, Eroglu, S., additional, Pirat, B., additional, Muderrisoglu, H., additional, Pradel, S., additional, Mondoly, P., additional, Victor, G., additional, Pascal, P., additional, Galinier, M., additional, Carrie, D., additional, Maury, P., additional, Berry, I., additional, Lairez, O., additional, Badran, HMB, additional, Yaseen, RIY, additional, Yacoub, MAGDY, additional, Adam, RD., additional, Mursa, A., additional, Chivulescu, M., additional, Rosca, M., additional, Mandes, L., additional, Rusu, E., additional, Dima, L., additional, Fruntelata, A., additional, Popescu, BA., additional, Ginghina, CD., additional, Jurcut, RO., additional, Leren, IS., additional, Estensen, ME., additional, Klaeboe, LG., additional, Edvardsen, T., additional, Haugaa, KH., additional, Pena, JLB, additional, Sampaio, IH., additional, Siqueira, MHA, additional, Alves, MC., additional, Sternick, EB., additional, Pavlidis, G., additional, Lambadiari, V., additional, Kousathana, F., additional, Triantafyllidi, H., additional, Varoudi, M., additional, Vlastos, D., additional, Vlachos, S., additional, Dimitriadis, G., additional, and Lekakis, J., additional

Published
2016
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50. Measles Eradication in the Americas: Progress to Date

Author

Hector S. Izurieta, Ciro A. de Quadros, Linda Venczel, and Peter Carrasco

Subjects
medicine.medical_specialty, Adolescent, Cost effectiveness, Measles Vaccine, Population, Measles, Indigenous, Environmental protection, Environmental health, medicine, Humans, Immunology and Allergy, Child, education, education.field_of_study, Immunization Programs, Transmission (medicine), business.industry, Public health, Infant, medicine.disease, Vaccination, Pan American Health Organization, Infectious Diseases, Child, Preschool, Population Surveillance, Measles vaccine, Americas, business
Abstract

The region of the Americas has shown extraordinary progress in its fight to interrupt measles transmission. The Pan American Health Organization's recommended strategy includes the following: a 1-time nationwide campaign targeting 1- to 14-year-old children; routine vaccination among 1-year-olds; and nationwide campaigns conducted every 4 years, targeting all 1- to 4-year-olds. Rapid house-to-house monitoring of vaccination and measles surveillance are other essential components of the strategy. During 2001, only 541 cases were confirmed in the region. In 2002, only Venezuela and Colombia had indigenous transmission. After important vaccination efforts in both countries, the last reported case occurred on 20 September 2002, in Venezuela. Since then, no confirmation exists of indigenous measles circulation anywhere else in the region. Nonetheless, important challenges remain, including insufficient coverage during routine and campaign vaccination and inadequate investigation of some cases.

Published
2004

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