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7 results on '"Helen Vlassara"'

1. Protein-energy wasting

Author

Vivek Bansal, Hyun Ho Ryu, Eduardo Perez, Nuria S. Pérez, Ahmet Kiykim, Alice Santos-Silva, Takayuki Hamano, Emre Tutal, Gülay Ulusal Okyay, Len Usyvat, Kazumasa Aoyagi, Antonio Santoro, Salih Inal, Ryosuke Shimizu, Naoyuki Kobayashi, Soraya Abad, Masamitsu Fujii, Nick Richards, Hirofumi Matsui, Adalbert Schiller, Mirela Modilca, Bolesław Rutkowski, Patricia Herrera, Flávio Reis, Miha Benedik, Serpil Muge Deger, Silvia Maria Franciscato Cozzolino, Loredana Postiglione, Zubaida Al Ismaili, Sun Hyu Kim, Yumi Kamada, Yousef Al-Abed, Cristian Balgradean, Emilia Barzuca, Maite Villaverde, Bassam Bernieh, Almudena Vega, Turgay Arinsoy, Hermann Haller, Denise Mafra, Miroslava Khil, Won-Min Hwang, Elisabet Masso, Carina Andrei, Violeta Roman, Ozge Tugce Pasaoglu, Marie Hilderman, Koray Uludag, Atsushi Ueda, Rita Guerra, Cristina Marelli, Frank M. van der Sande, Adelina Mihaescu, German Perez Suarez, Reinhard Kramar, Ayako Akiyama, Abdul Rashid Qureshi, Paloma Gallar, Ibuki Moriguchi, Ufuk Tot, M. Dolores Checa Andres, Borys Sheiman, Yuri Gonchar, Vasco Miranda, Juan M. López-Gómez, Mohamad Hassan, Bernard Canaud, Helen Vlassara, Elísio Costa, Stefan Pilz, Ligia Petrica, Hyun Lee Kim, Ilaria Serriello, Hiroshi Mikami, Inge Eidemak, Julius J. Schmidt, Vera Krane, Elisa Loiacono, Jorge B. Cannata-Andía, Michaela Kohlova, Yeon Soon Jung, Ryohei Watanabe, Gary E. Striker, Adel Ismael, Mitsunobu Toki, Hark Rim, Jesper L. Andersen, Hormazdiar Dastoor, Markus Ketteler, Stig Molsted, Len A. Usvyat, Eberhard Ritz, Inés Palomares, Winfried März, Jochen G. Raimann, Zeynep Bal, Vladimir Khil, Fatma Ayerden Ebinç, Sung Ro Yun, Takahiro Tanaka, Javier Reque, Stephan Thijssen, Maria do Sameiro-Faria, Zsofia Ivacson, Inga Bayh, Shigeru Owada, Gabriela Cobo, Francisco Maduell, Rosa Ramos, Mircea Munteanu, Bernhard M W Schmidt, Bruno Memoli, M. Mar Lago Alonso, Kenan Turgutalp, Michael Etter, Jeroen P. Kooman, Carsten Hafer, Kazuki Hotta, Carmine Zoccali, Christoph Wanner, Christian Clajus, Yasemin Erten, Adrian P. Harrison, A. Toledo, Ana Vigil, Nicu Olariu, Gennaro Argentino, Roberta Camilla, Sandra Ribeiro, Burak Sayin, Alexandre Quintanilha, Yumiko Nagano, Maristella Minco, Ana Ramírez Puga, Kentaro Kamiya, Toru Inoue, Yoko Ito, Aki Hirayama, Osama Iba, César García Cantón, Marta Arias-Guillén, Pim van der Harst, Andreas Tomaschitz, Sandra Castellano Gasch, Nobuaki Hamazaki, Esra Köse, Cristina Gluhovschi, María Di Gioia, Fatma Celik, Ye Na Kim, Carmen Anton, Daisuke Kamekawa, Ebru Gok Oguz, Johannes Hadem, Ho Sik Shin, Rudolf A. de Boer, David Goldsmith, Ana Pérez de José, Satoshi Mikami, Jon Dominguez, O. Guliyev, Mehtap Erkmen Uyar, Shinya Tanaka, Adriana Kaycsa, Francesca Righetti, Claudia Yuste, Haruka Ishii, Michitaka Kato, Luís Belo, Drasko Pavlovic, Rakesh Malhotra, Henrique Nascimento, Nathan W. Levin, José Luis Górriz, Jose Ignacio Ramirez, Milena B. Stockler-Pinto, Giuliana Guido, Olaf Malm, Elsa Bronze-da-Rocha, Hatice Pasaoglu, Annette Bruchfeld, Iván Cabezas-Rodríguez, F. Valente, Christiane Drechsler, Giuliano Brunori, Yoshihiro Takamitsu, Jan T. Kielstein, José Luis Fernández-Martín, Jaime Uribarri, Marco Veronesi, Mihaela Margineanu, Lucia Grumetto, Suellen Dornelles, Petronila Rocha-Pereira, Isabel Rodríguez, Suzana Berca, Peter Kotanko, Daniele Marcelli, Sohji Nagase, Eleonora Riccio, Kürşad Öneç, Julie Hinostroza, Juan Jesus Carrero, Siren Sezer, Gheorghe Gluhovschi, Barbara Romano, Corina Vernic, Mayu Katagiri, Aileen Grassmann, João Fernandes, Elena M. Yubero-Serrano, Takashi Masuda, Borja Quiroga, Aniana Oliet, Silvia Velciov, Oana Schiller, Alessandro Amore, Laura Scatizzi, Rosanna Coppo, Iryna Dudar, Elvira Bosch Benitez-Parodi, Vladimir Teplan, Björn Anderstam, Daniel Barraca, Katja Blouin, Eduardo Baamonde Laborda, and Elena Mancini

Subjects
Transplantation, medicine.medical_specialty, Endocrinology, Nephrology, business.industry, Internal medicine, medicine, Protein energy wasting, business
Published
2013
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2. Managing Chronic Inflammation in the Aging Diabetic Patient With CKD by Diet or Sevelamer Carbonate: A Modern Paradigm Shift

Author

Helen Vlassara, E. J. Serrano, Mark Woodward, Weijing Cai, Jaime Uribarri, X. Chen, M. S. Shobha, and Gary E. Striker

Subjects
Glycation End Products, Advanced, Drug, Aging, medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, Sevelamer, Inflammation, Type 2 diabetes, Bioinformatics, Special Article, Internal medicine, Diabetes mellitus, Polyamines, medicine, Animals, Humans, Diabetic Nephropathies, Renal Insufficiency, Chronic, Chelating Agents, media_common, Aged, 80 and over, chemistry.chemical_classification, Reactive oxygen species, business.industry, Disease Management, medicine.disease, Treatment Outcome, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Disease Progression, Hemodialysis, Geriatrics and Gerontology, medicine.symptom, Reactive Oxygen Species, business, Kidney disease, medicine.drug
Abstract

The maintenance of normal metabolism and body defenses depends on the balance between cellular antioxidant and anti-inflammatory factors. This balance can be disrupted by agents/mechanisms in the extracellular milieu that induce excess reactive oxygen species (ROS) and inflammation. Cytopathic advanced glycation endproducts, present in ever increasing amounts in the modern diet, are one of the major environmental factors that cause excess ROS and/or inflammation at all ages and induce complications in aging, such as chronic kidney disease (CKD) and type 2 diabetes. Increased ROS and/or inflammation are present in both aging and CKD, and are associated with reduced cellular defenses against ROS and/or inflammation. Affected individuals have reduced defenses against further stress and are predisposed to organ failure, now a well-known phenomenon in aging. Thus, new methods are urgently needed to safely reduce ROS and/or inflammation in the aging type 2 diabetes patient with CKD. Studies of both normal aging and diabetic patients with kidney disease underline the fact that increased ROS and/or inflammation can be managed in these conditions by economical, safe, and effective interventions that reduce the uptake of advanced glycation endproducts by either modifying preparation of food or an oral drug. This communication reviews these data and adds new information on the efficacy of a drug, sevelamer carbonate, required to reduce ROS and/or inflammation in the aging type 2 diabetes patient complicated by CKD. If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD.

Published
2012
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3. Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging

Author

Luigi Ferrucci, Gary E. Striker, Jaime Uribarri, Helen Vlassara, Melpomeni Peppa, Susan M. Goodman, and Weijing Cai

Subjects
Adult, Glycation End Products, Advanced, Male, Aging, medicine.medical_specialty, Calorie, Inflammation, Dinoprost, medicine.disease_cause, Article, chemistry.chemical_compound, Insulin resistance, Internal medicine, Diabetes mellitus, Humans, Medicine, Aged, Aged, 80 and over, biology, business.industry, Lysine, C-reactive protein, Methylglyoxal, Middle Aged, Pyruvaldehyde, medicine.disease, Diet, Oxidative Stress, C-Reactive Protein, Endocrinology, chemistry, biology.protein, Female, Insulin Resistance, Geriatrics and Gerontology, medicine.symptom, Energy Intake, business, Body mass index, Oxidative stress
Abstract

Background—Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons. Methods—We examined 172 young ( 60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N e -carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation. Results—Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8isoprostanes (r =0.448, p =.0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p = .044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r =0.415, p = .0001 and MG: r = 0.282, p = .002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p = .042). Conclusions—Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.

Published
2007
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4. The role of advanced glycosylation end-products in the pathogenesis of atherosclerosis

Author

Zenji Makita, Helen Vlassara, Satoru Kuwajima, Richard Bucala, Katsuyuki Yanagisawa, and Takao Koike

Subjects
Glycation End Products, Advanced, medicine.medical_specialty, Glycosylation, Apolipoprotein B, Arteriosclerosis, Coronary Disease, Coronary artery disease, Pathogenesis, chemistry.chemical_compound, Lipid oxidation, Internal medicine, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, Apolipoproteins B, Cause of death, Transplantation, biology, business.industry, medicine.disease, Lipoproteins, LDL, Cerebrovascular Disorders, Endocrinology, chemistry, Nephrology, biology.protein, Kidney Failure, Chronic, Advanced glycation end-product, lipids (amino acids, peptides, and proteins), business, Diabetic Angiopathies
Abstract

Coronary artery disease and cerebrovascular disease due to the rapid progression of atherosclerosis is the principal cause of death in diabetes mellitus. Modification of low-density lipoproteins (LDL) by advanced glycosylation end-products (AGE) may play a central role in the development of atherosclerosis, especially in diabetic patients. An AGE-modified form of LDL (AGE-LDL) has been found to circulate in human plasma, and AGE modifications have been identified as being present on both the apoprotein (ApoB) and the phospholipid components of LDL. By utilizing an AGE-specific ELISA, we measured the AGE attached to the ApoB and lipid components of LDL from normal controls and diabetic patients with or without end-stage renal disease (ESRD), as well as lipid oxidation. AGE-ApoB, AGE-lipid and oxidized LDL (Ox-LDL) in diabetic patients were significantly higher than those in patients without diabetes. The correlation between AGE-ApoB and AGE-lipid were highly significant. An especially marked elevation of AGE-LDL was found in diabetic patients with ESRD. The correlation between the serum total cholesterol and the AGE-LDL (AGE-ApoB and AGE-lipid) was significant. In addition, based on the known biological properties of AGE-modified peptide (AGE-peptide), we have proposed that these chemically reactive circulating AGE-peptides contribute to tissue injury by reattaching to susceptible target proteins both within and outside the vasculature, and that this process accelerates vascular pathology in diabetic patients. These data indicate that AGE-modified LDLs may represent a particularly atherogenic form of LDL, and AGE-LDLs as well as AGE-peptides are likely to contribute to the development of atherosclerosis in diabetic patients.

Published
1996
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5. Malnutrition & inflammation in CKD 1-5

Author

Valerio Ferretti, Silvia Regina Manfredi, Milenka Sain, Karsten Krüger, Eythimia Mourvati, Josep Teixidó, Felipe Barreto, George Eisele, Raymond Vanholder, Flávio Carrasco, Marie Quinto, Lilia Solomatina, Antonio Bellasi, Piegiorgio Poisetti, G. Pratt, Eugeny Gusev, Pierpaolo DiNicolo, Masaki Iwasaki, Maribel Troya, Serhat Karadag, Darren W. Grabe, Marina M. Parastayeva, R.G. Hughes, Toshihiko Yamaka, Emre Tutal, Maricruz Pastor, Renata Pyzik, Dimitrios Tziakas, Aki Hirayama, A. Shpilsky, Zulfikar Yilmaz, Miguel C. Riella, Yasemin Doventas, Leonardo Pazarin, Olga N. Berseneva, Stefan Arsov, Josipa Radic, Helen Vlassara, Bengt Lindholm, Amy Barton Pai, Pelagia Kriki, Jordi Bonal, Marcelo Costa Batista, Theodora Gioka, Ivan Kayukov, Claudio Orsi, Colin A. Hutchison, Sami Uzun, Ariane Duval-Sabatier, Bertrand Gondouin, Saso Gelev, Mihaela Oleniuc, Meltem Gursu, Frank Cristop Mooren, Stavros Konstantinides, Laura Cañas, Gary E. Striker, Ali Kemal Kadiroglu, Claire Cerini, M. Emin Yilmaz, Sebnem Karakan, Marcelo Mazza do Nascimento, Marcora Mandreoli, N. Schlesinger, Antonio Santoro, Giovanna Pasquariello, Stavros Apostolakis, Dimitrios Stakos, Nicolette C. Bishop, Zeki Aydin, Vasilios Vargemezis, Jaime Uribarri, Daniela V. Barreto, Hasan Kayabasi, Françoise Dignat-George, George Kosmadakis, Anatoly Kucher, Beatriu Bayés, Lada Trajceska, Serdar Esmer, Lars-Åke Brodin, Mattia Corradini, Maria Aparecida Dalboni, Changying Xing, Sophie Liabeuf, Isabella Petrone, Susana Aguerrevere, Eliana Nogueira, Ramon Romero, Macit Koldas, Alan Bevington, Georgios K. Chalikias, P. Lukacik, Siren Sezer, Adamasco Cupisti, Jan Menne, Guangyu Bi, Michael Seimetz, Leopolodo Baldrati, Francesco Caruso, Tae Yamamoto, Ionut Nistor, Rumeyza Kazancioglu, F. Nurhan Ozdemir Acar, Shirley Yumi Hayashi, A. Gimona, Hiroki Hase, Mihai Onofriescu, Ana Sancho, Weijing Cai, Caren Cristina Grabulosa, Sabri Ogul, Claudia D’Alessandro, Mislav Radic, Kazumasa Aoyagi, Fabiola Martin del Campo, Astrid Seeberger, Alessandro Capitanini, Loretta Zambianchi, Christina Tsigalou, Clarice Origaça, Rui Chen, Philippe Brunet, Nobuhiko Joki, Angelo Rigotti, Miguel Cendoroglo, Julia Zhuravleva, A. So, Galina T. Ivanova, Emma L. Clapp, John Feehally, Liliana González-Espinoza, João L. Viana, Savas Ozturk, Hermann Haller, Norbert Weissmann, Irina Florentina Secara, Alvaro Silva, Stéphane Poitevin, Griet Glorieux, Sunny Eloot, Adrian Covic, Vili Amitov, Aleksy V. Smirnov, Vedran Kovacic, Takashi Shigematsu, Adem Kiris, Margarete Mouro, Giulio Malmusi, Abdul Rashid Qureshi, Marisa Granada, Laetitia Dou, Fabiola Jacobo-Arias, Fábia Salvador, T. Kiechle, Atsushi Ueda, A. Bevins, Brita Lind, Eva Schepers, Susan M. Goodman, Alma Romero-Garcia, Alba Fabbri, Alice C. Smith, Aleksandar Sikole, Pavlina Dzekova, Dragan Ljutic, Shigeru Owada, Stéphane Burtey, Pascal Meier, Ricardo Lauzurica, Stylianos Panagoutsos, Niels Silva, Hirofumi Matsui, Salvatore David, Fabrizio Grosjean, Gjulsen Selim, Yumiko Nagano, Giorgia Russo, Edgar Ferreira da Cruz, Yuri Tanaka, Ziad A. Massy, and Alfonso M. Cueto-Manzano

Subjects
Transplantation, medicine.medical_specialty, Malnutrition, Nephrology, business.industry, Internal medicine, medicine, Inflammation, medicine.symptom, medicine.disease, business
Published
2011
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6. Diabetes / Basic research

Author

Karl J. Jepsen, Julio Pascual, Zac Varghese, Tadao Akizawa, Ying Li, Valerie Williams, Massimo Torreggiani, Lei Zhao, Eva Marquez, Yaxi Chen, Anna Kakehashi, María José Soler, Yanqing Chi, Feng Zheng, Masaaki Inaba, Judit Rigol, John F. Moorhead, Hideki Wanibuchi, Vittoria Esposito, Takanori Shibata, Yuki Hirai, Masayuki Iyoda, Shinya Nakatani, Marta Riera, Gary E. Striker, Katuhito Mori, Eiji Ishimura, Helen Vlassara, Xiong Ruan, Jonathan Madek, Min Wei, Yoshihiro Kuno, Fabrizio Grosjean, Yang Yuan, Jie Liu, Maodong Liu, Baoxing Wang, and Zi-Lin Sun

Subjects
Transplantation, medicine.medical_specialty, Nephrology, Basic research, business.industry, Diabetes mellitus, Family medicine, medicine, medicine.disease, business
Published
2011
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7. An Ultrastructural Study of Chronic Sodium Cyanate-Induced Neuropathy

Author

Helen Vlassara, Jan K. Korthals, Anthony Cerami, and Isabel Tellez-Nagel

Subjects
Pathology, medicine.medical_specialty, Schwann cell, General Medicine, Anatomy, Biology, medicine.disease, Axolemma, Pathology and Forensic Medicine, Lesion, Cellular and Molecular Neuroscience, Myelin, Peripheral neuropathy, medicine.anatomical_structure, nervous system, Neurology, Vacuolization, medicine, Neurology (clinical), Sciatic nerve, medicine.symptom, Remyelination
Abstract

Fifteen rats were given a sodium cyanate-rich diet for 18 months and at the end of that period, all of them had developed motor weakness and were perfused for ultrastructural study. A peripheral neuropathy involving mostly the roots and sciatic nerves was found and the main ultrastructural lesion was vacuolization of myelin. There was marked distinction of the myelin sheaths and phagocytosis of myelin. Axoplasmic changes were minimal and consisted of accumulation of glycogen within vacuoles. Invaginations of adaxonal Schwann cell membranes and axolemma forming loops and separate chambers were also present. There was active participation of macrophages in the splitting of myelin as well as in phagocytosis of myelin remnants. There was evidence of remyelination with the toxic damage. We concluded that cyanate induced neuropathy is due mostly to a myelinotoxic effect of the drug, although parallel but less intense axonal damage cannot be excluded.

Published
1977
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