1. Histological and clinical predictors of early and late renal outcome in ANCA-associated vasculitis
- Author
-
Franz Thomas Meisl, Afschin Soleiman, Sandra Kandutsch, Heinz Regele, Irmgard Neumann, and Renate Kain
- Subjects
Adult ,Male ,Vasculitis ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Renal function ,Enzyme-Linked Immunosorbent Assay ,Kidney Function Tests ,Risk Assessment ,Severity of Illness Index ,Gastroenterology ,Antibodies, Antineutrophil Cytoplasmic ,Glomerulonephritis ,Adrenal Cortex Hormones ,Predictive Value of Tests ,Renal Dialysis ,Internal medicine ,Biopsy ,medicine ,Humans ,Dialysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Transplantation ,Kidney ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Immunohistochemistry ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Nephrology ,Female ,Hemodialysis ,Renal biopsy ,business ,Follow-Up Studies ,Kidney disease - Abstract
Background. Renalinvolvementremainsamajordeter-minant in antineutrophil cytoplasmic autoantibody-associated small vessel vasculitis (AASV). While somepatients may develop persistent renal damage, othershave a favourable outcome.Methods. To identify patients at risk for poor renaloutcome, we evaluated 95 renal biopsies (67 initialbiopsies and 28 repeat biopsies) of 67 patients withAASV for the presence and extent of active (AI)and chronic (CI) lesions, retrospectively. AI, CI, levelsof proteinuria and dose of cyclophosphamide (CYC)were related to renal outcome.Results. Recovery of renal function in patients ini-tially dialysis dependent was associated with a lowerCI compared with patients who remained on dialysis(P
- Published
- 2004