6 results on '"Dieter Lütjohann"'
Number of results to display per page
Search Results
2. P0676CHOLESTEROL ABSORPTION JUGDED BY CAMPESTEROL / LATHOSTEROL RATIO AND OUTCOMES IN CHRONIC KIDNEY DISEASE
- Author
-
Emrich, Insa Elena, primary, Heine, Gunnar Henrik, primary, Christian, Schulze, primary, Rogacev, Kyrill S, primary, Fliser, Danilo, primary, Stefan, Wagenpfeil, primary, Böhm, Michael, primary, Dieter, Lütjohann, primary, and Oliver, Weingärtner, primary
- Published
- 2020
- Full Text
- View/download PDF
3. Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice
- Author
-
Volker Meske, Dieter Lütjohann, Frauke Glöckner, and Thomas G. Ohm
- Subjects
Apolipoprotein E ,medicine.medical_specialty ,Genotype ,Oxysterol ,Protein Conformation ,Transgene ,Tau protein ,Cell Count ,Mice, Transgenic ,tau Proteins ,High cholesterol ,Pathology and Forensic Medicine ,Cholesterol, Dietary ,Mice ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Apolipoproteins E ,Internal medicine ,medicine ,Animals ,Humans ,Phosphorylation ,Brain Chemistry ,Mice, Knockout ,biology ,Cholesterol ,General Medicine ,medicine.disease ,Immunohistochemistry ,Lipids ,Sterol ,Diet ,Endocrinology ,Neurology ,chemistry ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Neurology (clinical) ,Alzheimer's disease - Abstract
Apolipoprotein E (ApoE) is the major cholesterol transporter in the brain. There is epidemiological and experimental evidence for involvement of cholesterol metabolism in the development and progression of Alzheimer disease. A dietary effect on tau phosphorylation or aggregation, or a role of apoE in tau metabolism, has been studied experimentally, but the data are ambiguous. To elucidate the relationship between cholesterol and tau, we studied mice expressing P301L mutant human tau but not apoE (htau-ApoE) and P301L mice with wild-type ApoE (htau- ApoE); both genotypes develop neuron cytoskeletal changes similar to those found in Alzheimer disease. Mice were kept on a cholesterol-enriched diet or control diet for 15 weeks. The numbers of neurons with hyperphosphorylated and conformationally changed tau in the cerebral cortex were assessed by immunohistochemistry, and sterol levels were determined. Highly elevated dietary serum cholesterol levels enhanced ongoing tau pathology in htau-ApoE mice; this effect correlated with elevated brain cholesterol metabolite 27-hydroxycholesterol levels. Apolipoprotein E deficiency promoted significant increases of tau phosphorylation and conformational changes in mice on a control diet. In htau-ApoE mice on the high cholesterol regimen, brain oxysterol levels were less than in htau-ApoE mice, and the numbers of neurons with pathologically altered tau were similar to those in htau-ApoE mice on the high-cholesterol diet.
- Published
- 2011
- Full Text
- View/download PDF
4. Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice
- Author
-
Isabel Lastres-Becker, Dieter Lütjohann, Annette Schürmann, Konrad Sandhoff, Susanne Brodesser, Mekhman Azizov, Jana Buchmann, Joachim Nowock, Edith Hintermann, and Georg Auburger
- Subjects
Blood Glucose ,Leptin ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Nerve Tissue Proteins ,Motor Activity ,Mice ,Insulin resistance ,Blood serum ,Cerebellum ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Insulin ,Obesity ,Molecular Biology ,Genetics (clinical) ,Mice, Knockout ,biology ,Pancrelipase ,Lipid metabolism ,General Medicine ,Polyglutamine tract ,Lipid Metabolism ,medicine.disease ,Receptor, Insulin ,Sphingomyelins ,Insulin receptor ,Cholesterol ,Fertility ,Endocrinology ,Ataxins ,Liver ,Ataxin ,Knockout mouse ,biology.protein ,Female ,Gene Deletion - Abstract
Ataxin-2 is a cytoplasmic protein, product of the SCA2 gene. Expansion of the normal polyglutamine tract in the protein leads to the neurodegenerative disorder Spino-Cerebellar Ataxia type 2 (SCA2). Although ataxin-2 has been related to polyribosomes, endocytosis and actin-cytoskeleton organization, its biological function remains unknown. In the present study, an ataxin-2 deficient mouse (Sca2(-/-)) was generated to investigate the functional role of this protein. Homozygous mice exhibited reduced fertility and locomotor hyperactivity. In analyses up to the age of 6 months, the absence of ataxin-2 led to abdominal obesity and hepatosteatosis. This was associated with reduced insulin receptor expression in liver and cerebellum, although the mRNA levels were increased indicating a post-transcriptional effect of ataxin-2 on the insulin receptor status. As in insulin resistance syndromes, insulin levels were increased in pancreas and blood serum. In the cerebellum, increased levels of gangliosides and sulfatides, as well as decreased cholesterol dynamics, may be relevant for cellular membrane functions, and alterations in the sphingomyelin cycle may affect second messengers. Thus, the data suggest altered signaling in ataxin-2 deficient organisms.
- Published
- 2008
- Full Text
- View/download PDF
5. General & clinical epidemiology CKD 1-5 (1)
- Author
-
Pietro Dattolo, Antonio Santoro, Shahrzad Shahidi, Ioannis Vakianos, Angelo Rigotti, Liviu Segall, Belén Marrón, Mojgan Mortazavi, Wim Van Biesen, Guido Giordana, Attila Mohácsi, Maren Mieth, Raymond Vanholder, Investigadores Proyecto Hygia, Marianna Eleftheroudi, Anne-Lise Kamper, Vasile Cepoi, Toshifumi Sakaguchi, Renke Mass, Sandra Wagner, Margareta Fistrek, Jelena Kos, Thalia M. Blicher, M.S. MacGregor, José Hermógenes Rocco Suassuna, Leopoldo Baldrati, Castillo Paez, Kunihiro Yamagata, Shona Methven, Mario Prieto, Panagiotis Chondrogiannis, Pedro González-Carro, Pedro Quiros, F. Gifford, Olivier Moranne, Takashi Fujii, Akira Hishida, Marcora Mandreoli, Mercedes Salgueira, Amanda G.M.R. Sousa, Markus K. Gerhart, Marie-Ange Paget, Paola Smanio, Elham Kalantari, Mihai Onofriescu, Takeshi Horio, Ivana Vuković Lela, Hiroki Hase, Christian Pradier, Kathleen Eeckhaut, Petros Skapinakis, Carolina C. Gonzaga, Molly Tomlin, Gregory Pavlides, Bernhard Banas, Michał Nowicki, Shouichi Fujimoto, Albanita Viana, Alba Fabbri, Guy Berkenboom, Ronaldo Moreira, Vanja Ivković, Mykola Shved, S. Methven, Masao Moroi, Bernhard K. Krämer, Maria José Espigares, Fumihiko Koiwa, Eftyxia Kyroglou, J.R. Fernandez, J.J. Crespo, A. Mojon, Nicanor Vega, Seiichi Matsuo, Jose Luis Lerma, Christina Varvara, Dieter Lütjohann, Kostas C. Siamopoulos, Satoko Nakamura, Marco A.C. Oliveira, Sami Aoufi, Cécile Vigneau, Gunnar H. Heine, Aurora Polo, Yuji Sato, Alison Severn, Olga Balafa, José María Tenías, E.M. Spalding, Inés Castellano, Ludomir Stefanczyk, Fumiki Yoshihara, Sandra Karanović, Francisco Pérez-Roldán, Antonio Bellasi, Anna Masajtis-Zagajewska, T. Watanabe, Hiroshi Fukuda, D.E. Ayala, Manel Ramirez de Orellana, Enyu Imai, Stefan James, Valdiléa Veloso, Adelaida Morales, Lena Dörhöfer, Daniele Marcelli, Fabrizio Cerino, Cesar Garcia-Cantón, Andreas Menzner, Markos Sygelakis, Sebastian Cerezo, Flávio Borelli, Veronica Duarte, Michael Kirsch, Jens Brüning, Hirofumi Masai, Kostas Asimakopoulos, Zdenek Coufal, Lara Coelho, Manuel Manjón, Ivan Pecin, Sandra Gallego, Marica Miletic-Medved, Hideaki Yoshida, S. Iimuro, Adrian Covic, Ljiljana Fodor, A. Otero, Rebeca García-Agudo, Fernanda C. Amparo, Piotr Grzelak, Yuichiro Yano, Parthena Kyriklidou, Steen Z. Abildstrom, Uwe Zeymer, Pierpaolo Di Nicolò, Ryo Nakazato, Vincent Esnault, Anamarija Kovac-Peic, Cristina Rossi, Markus Schubert, Mattia Corradini, Attilio Di Benedetto, Bojan Jelaković, Vedran Premuzic, Luigi Ferrucci, Anatoliy Gozhenko, Tsuyoshi Watanabe, M.C. Castiñeira, Takashi Shigematsu, Taeko Kunimasa, Danilo Fliser, Mette Madsen, Antonio C. Cordeiro Silva Junior, Masato Ikeda, Cynthia Cunha, D.E. Boag, Francisco Ahijado, Yuhei Kawano, Kai van Bentum, Magdalena Kaczmarska, Alan G. Jardine, Cristina Ruiz, Toshiki Moriyama, Kunitoshi Iseki, Y. Ohashi, Athanasia Banioti, Mark S. MacGregor, Ryoichi Ando, Elena Welzel, Piergiorgio Poisetti, Tobias Pinsdorf, Gabriel de Arriba, Giulio Malmusi, Rigas Kalaitzidis, Carmine Zoccali, Toshihiko Yamaka, Nobuhiko Joki, Margarita Ikonomou, Sam Chakraverty, Achyut Valluri, Cecile Couchoud, Celso Amodeo, Oliver Weingärtner, Francesco Caruso, Venetsanos Mavreas, Giovanni Tripepi, Andreas Chardalias, Ana Ramos, Ruth Friedman, Dimitrios Tsakiris, Juan Carlos Martinez-Ocaña, Leda D. Lotaif, Kaoru Sugi, Halyna Susla, Yoshio Iwashima, Kristine Hommel, Frieder Keller, M. Dominguez-Sardiña, R.C. Hermida, Guy De Groote, Hirofumi Makino, Oleksandr Susla, Fuensanta Moreno, Toshio Shinoda, Kazuhiko Tsuruya, Patricia Santiago da Silva, Claudio Orsi, Loretta Zanbianchi, Carsten A. Böger, Daijo Inaguma, Paul Verbeke, Tsuneo Konta, Marcio G. Sousa, Giorgia Russo, Emanuele Gatti, Francisco Ruiz-Carrillo, Ilona Kurnatowska, Beatriz Grinsztejn, Kyrill S. Rogacev, Philipp Hoffmann, Abdolamir Atapour, Ihor Mysula, Koichi Asahi, A. Ferreras, Salvatore David, Oswaldo Passarelli, Francesco Pizzarelli, Yohei Doi, Magali Sartral, Kirsi Norrbacka, Dragana Juric, Ante Cvitkovic, Stefania Bandinelli, Ewa Rutkowska-Majewska, Hideaki Takata, Alberto Ortiz, Tatsuhiko Furuhashi, Ramiro Palma, K. Nitta, Yasuhiro Komatsu, Tadao Akizawa, Dimitrios Goumenos, Jean Ferrières, and Arjan van der Tol
- Subjects
Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Clinical epidemiology ,Intensive care medicine ,business - Published
- 2011
- Full Text
- View/download PDF
6. Brain cholesterol and suicidal behaviour
- Author
-
Dieter Lütjohann
- Subjects
Central Nervous System ,Apolipoprotein E ,medicine.medical_specialty ,Very low-density lipoprotein ,Sterol O-acyltransferase ,Blood lipids ,Cholesterol 7 alpha-hydroxylase ,Mice ,Internal medicine ,Animals ,Humans ,Medicine ,Pharmacology (medical) ,Liver X receptor ,Brain Chemistry ,Pharmacology ,biology ,Mood Disorders ,business.industry ,Reverse cholesterol transport ,Suicide ,Psychiatry and Mental health ,Cholesterol ,Endocrinology ,HMG-CoA reductase ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business - Abstract
Cholesterol is required for growth and replication of all mammalian cells (Yeagle, 1985) and is an obligate precursor of steroid hormones and bile acids. The chemistry and biochemistry of this molecule have attracted much interest due to its role in membrane integrity and function, and in particular due to its association with human diseases. Cholesterol homeostasis in man is regulated by well-balanced mechanisms of synthesis, uptake, esterification and metabolism. Most of the circulating total body cholesterol is of endogenous origin and a considerable amount is synthesized in the liver. The dietary cholesterol is absorbed in the intestine and then transported to the liver. Cholesterol is mainly eliminated by biliary secretion of cholesterol itself or as bile acids, the latter being responsible for absorption of intestinal cholesterol (Lin and Connor, 1980). Plasma lipoproteins transport cholesterol to different target tissues, but also return cholesterol to the liver (Brown and Goldstein, 1986). The discovery of the LDL receptor and its presence in mammalian cells, particularly the liver, revolutionized our understanding in whole-body cholesterol and lipoprotein metabolism (Brown and Goldstein, 1986; Motulsky, 1986).
- Published
- 2006
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.