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The gel test, as developed by Lapierre, is an innovative approach to blood group serology. This technology addresses the issue of standardization and incorporates sensitivity, specificity, and efficiency; it is accessible to laboratories of all sizes and levels of expertise. By employing gels premixed with reagents, specific volumes, and a no-wash antiglobulin test that eliminates resuspension of red cell buttons, the gel test reduces the variation inherent in conventional techniques. Applicable to a broad range of tests routinely performed in the blood bank, such as antibody screening, antigen typing, and crossmatching, gel test procedures are easy to perform and yield clearcut end points that are stable, plus they can be reviewed at a later time. Applications for the technology reach beyond the routine and potentially into other areas of diagnostic testing.