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BackgroundA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak affecting 52 people from a large school community in Santiago, Chile, was identified (12 March) 9 days after the first case in the country. We assessed the magnitude of the outbreak and the role students and staff played using self-administered antibody detection tests and a self-administered survey.MethodsThe school was closed on 13 March, and the entire community was placed under quarantine. We implemented a home-delivery, self-administered, immunoglobin (Ig) G/IgM antibody test and survey to a classroom-stratified sample of students and all staff from 4–19 May. We aimed to determine the overall seroprevalence rates by age group, reported symptoms, and contact exposure, and to explore the dynamics of transmission.ResultsThe antibody positivity rates were 9.9% (95% confidence interval [CI], 8.2–11.8) for 1009 students and 16.6% (95% CI, 12.1–21.9) for 235 staff. Among students, positivity was associated with a younger age (P = .01), a lower grade level (P = .05), prior real-time polymerase chain reaction (RT-PCR) positivity (P = .03), and a history of contact with a confirmed case (P ConclusionsTeachers were more affected during the outbreak and younger children were at a higher risk for infection, likely because index case(s) were teachers and/or parents from the preschool. Self-administered antibody testing, supervised remotely, proved to be a suitable and rapid tool. Our study provides useful information for school reopenings.

Disease-related knowledge can positively influence in the acceptance of the disease, increase treatment compliance and improve quality of life in patients with Inflammatory Bowel Disease (IBD). It also allows the patients to become more involved in decisions regarding the treatment of their disease, achieving a better doctor-patient relationship. The aim of our study was to identify disease-related knowledge in patients with IBD and determine possible factors associated to the knowledge level.We conducted a prospective study including patients presenting to our outpatient IBD Program between October 2014 and July 2015. Adult patients (18 years or older) were invited to participate, answering a demographic and clinical questionnaire. A Spanish-translated version of the 24-item Crohn's and Colitis Knowledge score (CCKNOW) was used to assess disease-related knowledge. Patients also completed a demographic and clinical questionnaire including age, gender, educational level, employment status, history of IBD surgery and current IBD treatment. The study was approved by our Institutional Review Board, and all patients signed an informed consent. For statistical analysis categorical variables were expressed as frequency and percentage, and compare using chi square test. For continuous variables medians and range were used, and compare with Mann Whitney Test (2 groups) or Kruskal-Wallis Test (more than 2 groups). A P value 50 years (median CCKNOW score 8 versus 9.5; P = 0.033), with UC (9 versus 11 in Crohn's Disease patients; P = 0.017), with less than 5 years of disease (9 versus 10; P = 0.045) and patients without IBD surgery (9 versus 11.5; P = 0.004) showed a lower disease-related knowledge. Interestingly, there was no association between CCKNOW scores and the educational level of the patients.Patients attending our IBD Program show a poor disease-related knowledge, which is similar to knowledge levels observed in developed countries. It is necessary to assess patient's knowledge in order to develop educational strategies, and evaluate the impact of these in the compliance and quality of life of IBD patients.