1. Saline Nebulization before Gastric Lavage in the Diagnosis of Pulmonary Tuberculosis in Children and Adolescents
- Author
-
John L. Johnson, Renata Lyrio Peres, Thiago Nascimento do Prado, Moises Palaci, Cristina Ribeiro Macedo, Claudio Jose Struchiner, Reynaldo Dietze, Ethel Leonor Noia Maciel, and Solange Alves Vinhas
- Subjects
Male ,medicine.medical_specialty ,Tuberculosis ,Adolescent ,medicine.medical_treatment ,Sensitivity and Specificity ,Gastroenterology ,Internal medicine ,Statistical significance ,medicine ,Humans ,Child ,Tuberculosis, Pulmonary ,Saline ,Gastric Lavage ,Saline Solution, Hypertonic ,Inhalation ,business.industry ,Nebulizers and Vaporizers ,Stomach ,Respiratory disease ,Mycobacterium tuberculosis ,medicine.disease ,Gastric lavage ,Research Letters ,Surgery ,Hypertonic saline ,Infectious Diseases ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
The main objective is to assess whether nebulization before gastric lavage (GL) improves its sensitivity for the diagnosis of childhood tuberculosis (TB). Children and adolescents suspected of pulmonary TB were randomly assigned (1 : 2) to nebulization with hypertonic saline 30 min before GL (Neb group; n = 36) or GL without prior nebulization (controls; n = 68). The proportion of positive GL smears was greater in Neb group than in the control group; however, no statistical significance was observed (36.3% vs. 22.2%; p = 0.4). Inhalation of nebulized hypertonic saline before GL did not improve TB diagnosis in this study. Nevertheless, the validation of our data will require large longitudinal studies.
- Published
- 2010
- Full Text
- View/download PDF