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Your search keyword '"Corbett, Elizabeth L."' showing total 22 results
Start Over Author "Corbett, Elizabeth L." Publisher oxford university press (oup)
22 results on '"Corbett, Elizabeth L."'

1. Impact of community-wide tuberculosis active case finding and HIV testing on tuberculosis trends in Malawi

Author

Burke, Rachael M, primary, Nliwasa, Marriott, additional, Dodd, Peter J, additional, Feasey, Helena R, additional, Khundi, McEwen, additional, Choko, Augustine, additional, Nzawa-Soko, Rebecca, additional, Mpunga, James, additional, Webb, Emily L, additional, Fielding, Katherine, additional, MacPherson, Peter, additional, and Corbett, Elizabeth L, additional

Published
2023
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2. Utility of Xpert MTB/RIF Ultra and digital chest radiography for the diagnosis and treatment of TB in people living with HIV: a randomised controlled trial (XACT-TB)

Author

Mukoka, Madalo, primary, Twabi, Hussein H, additional, Msefula, Chisomo, additional, Semphere, Robina, additional, Ndhlovu, Gabriel, additional, Lipenga, Trancizeo, additional, Sikwese, Tionge Daston, additional, Malisita, Kenneth, additional, Choko, Augustine, additional, Corbett, Elizabeth L, additional, MacPherson, Peter, additional, and Nliwasa, Marriott, additional

Published
2022
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3. High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis

Author

McCallum, Andrew D, primary, Pertinez, Henry E, additional, Chirambo, Aaron P, additional, Sheha, Irene, additional, Chasweka, Madalitso, additional, Malamba, Rose, additional, Shani, Doris, additional, Chitani, Alex, additional, Mallewa, Jane E, additional, Meghji, Jamilah Z, additional, Ghany, Jehan F, additional, Corbett, Elizabeth L, additional, Gordon, Stephen B, additional, Davies, Geraint R, additional, Khoo, Saye H, additional, Sloan, Derek J, additional, and Mwandumba, Henry C, additional

Published
2022
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5. Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis

Author

Kloprogge, Frank, primary, Mwandumba, Henry C, additional, Banda, Gertrude, additional, Kamdolozi, Mercy, additional, Shani, Doris, additional, Corbett, Elizabeth L, additional, Kontogianni, Nadia, additional, Ward, Steve, additional, Khoo, Saye H, additional, Davies, Geraint R, additional, and Sloan, Derek J, additional

Published
2020
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6. Tuberculosis in Hospitalized Patients With Human Immunodeficiency Virus: Clinical Characteristics, Mortality, and Implications From the Rapid Urine-based Screening for Tuberculosis to Reduce AIDS Related Mortality in Hospitalized Patients in Africa

Author

Gupta-Wright, Ankur, primary, Fielding, Katherine, additional, Wilson, Douglas, additional, van Oosterhout, Joep J, additional, Grint, Daniel, additional, Mwandumba, Henry C, additional, Alufandika-Moyo, Melanie, additional, Peters, Jurgens A, additional, Chiume, Lingstone, additional, Lawn, Stephen D, additional, and Corbett, Elizabeth L, additional

Published
2019
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7. A Bayesian Approach to Understanding Sex Differences in Tuberculosis Disease Burden

Author

Horton, Katherine C, Sumner, Tom, Houben, Rein M G J, Corbett, Elizabeth L, and White, Richard G

Subjects
Adult, Male, Malawi, Bayes theorem, Adolescent, Practice of Epidemiology, time to treatment, Incidence, Antitubercular Agents, Middle Aged, Global Health, Time-to-Treatment, Young Adult, tuberculosis, Vietnam, access to health care, gender, Prevalence, sex, Humans, Female, Sex Distribution, Tuberculosis, Pulmonary, mathematical model, Aged
Abstract

Globally, men have a higher epidemiologic burden of tuberculosis (incidence, prevalence, mortality) than women do, possibly due to differences in disease incidence, treatment initiation, self-cure, and/or untreated-tuberculosis mortality rates. Using a simple, sex-stratified compartmental model, we employed a Bayesian approach to explore which factors most likely explain men’s higher burden. We applied the model to smear-positive pulmonary tuberculosis in Vietnam (2006–2007) and Malawi (2013–2014). Posterior estimates were consistent with sex-specific prevalence and notifications in both countries. Results supported higher incidence in men and showed that both sexes faced longer durations of untreated disease than estimated by self-reports. Prior untreated disease durations were revised upward 8- to 24-fold, to 2.2 (95% credible interval: 1.7, 2.9) years for men in Vietnam and 2.8 (1.8, 4.1) years for men in Malawi, approximately a year longer than for women in each country. Results imply that substantial sex differences in tuberculosis burden are almost solely attributable to men’s disadvantages in disease incidence and untreated disease duration. The latter, for which self-reports provide a poor proxy, implies inadequate coverage of case-finding strategies. These results highlight an urgent need for better understanding of gender-related barriers faced by men and support the systematic targeting of men for screening.

Published
2018

9. Screening for Tuberculosis With Xpert MTB/RIF Assay Versus Fluorescent Microscopy Among Adults Newly Diagnosed With Human Immunodeficiency Virus in Rural Malawi: A Cluster Randomized Trial (Chepetsa)

Author

Ngwira, Lucky G, primary, Corbett, Elizabeth L, additional, Khundi, McEwen, additional, Barnes, Grace L, additional, Nkhoma, Austin, additional, Murowa, Michael, additional, Cohn, Silvia, additional, Moulton, Lawrence H, additional, Chaisson, Richard E, additional, and Dowdy, David W, additional

Published
2018
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11. The Role of Human Immunodeficiency Virus–Associated Vasculopathy in the Etiology of Stroke

Author

Benjamin, Laura A, primary, Allain, Theresa J, additional, Mzinganjira, Henry, additional, Connor, Myles D, additional, Smith, Colin, additional, Lucas, Sebastian, additional, Joekes, Elizabeth, additional, Kampondeni, Sam, additional, Chetcuti, Karen, additional, Turnbull, Ian, additional, Hopkins, Mark, additional, Kamiza, Steve, additional, Corbett, Elizabeth L, additional, Heyderman, Robert S, additional, and Solomon, Tom, additional

Published
2017
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13. Age- and Sex-Specific Social Contact Patterns and Incidence ofMycobacterium tuberculosisInfection

Author

Dodd, Peter J., primary, Looker, Clare, additional, Plumb, Ian D., additional, Bond, Virginia, additional, Schaap, Ab, additional, Shanaube, Kwame, additional, Muyoyeta, Monde, additional, Vynnycky, Emilia, additional, Godfrey-Faussett, Peter, additional, Corbett, Elizabeth L., additional, Beyers, Nulda, additional, Ayles, Helen, additional, and White, Richard G., additional

Published
2015
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14. Cardiac disease in adolescents with delayed diagnosis of vertically acquired HIV infection

Author

Miller, Robert F, Kaski, Juan P, Hakim, James, Matenga, Jonathan, Nathoo, Kusum, Munyati, Shungu, Desai, Sujal R, Corbett, Elizabeth L, and Ferrand, Rashida A

Abstract

BACKGROUND: At least one-third of human immunodeficiency virus (HIV)-infected infants survive to adolescence even without antiretroviral therapy (ART), but are at high risk of complications including cardiac disease. We investigated the characteristics of cardiac disease among adolescents with HIV infection diagnosed in late childhood who were receiving ambulatory HIV care in Harare, Zimbabwe. METHODS: Consecutive adolescents with vertically acquired HIV attending 2 HIV outpatient treatment clinics were studied. Assessment included clinical history and examination, and 2-dimensional, M-mode, pulsed- and continuous-wave Doppler echocardiography. RESULTS: Of 110 participants (47% male; median age, 15 years; interquartile range, 12-17 years), 78 (71%) were taking ART. Exertional dyspnea, chest pain, palpitations, and ankle swelling were reported by 47 (43%), 43 (39%), 10 (9%), and 7 (6%), respectively. The New York Heart Association score was ≥ 2 in 41 participants (37%). Echocardiography showed that 74 participants (67%) had left ventricular (LV; septal and/or free wall) hypertrophy and 27 (24%) had evidence of impaired LV relaxation or restrictive LV physiology. The estimated pulmonary artery systolic pressure (ePASP) was >30 mm Hg in 4 participants (3.6%); of these 2 also had right ventricular (RV) dilatation. Another 32 participants (29%), without elevated ePASP, had isolated RV dilatation. CONCLUSIONS: A significant burden of cardiac disease was seen among adolescents with vertically acquired HIV infection. More than half were asymptomatic yet had significant echocardiographic abnormalities. These findings highlight the need to screen this population in order to better define the geography, natural history, etiopathogenic mechanisms, and management (including the timing and choice of optimal therapeutic ART and cardiac drug interventions) to prevent development and/or progression of HIV-associated cardiac disease.

Published
2013

15. Chronic lung disease in adolescents with delayed diagnosis of vertically acquired HIV infection

Author

Ferrand, Rashida A, Desai, Sujal R, Hopkins, Charlotte, Elston, Caroline M, Copley, Susan J, Nathoo, Kusum, Ndhlovu, Chiratidzo E, Munyati, Shungu, Barker, Richard D, Miller, Robert F, Bandason, Tsitsi, Wells, Athol U, and Corbett, Elizabeth L

Abstract

BACKGROUND: Long-term survivors of vertically acquired human immunodeficiency virus (HIV) infection are reaching adolescence in large numbers in Africa and are at high risk of delayed diagnosis and chronic complications of untreated HIV infection. Chronic respiratory symptoms are more common than would be anticipated based on the HIV literature. METHODS: Consecutive adolescents with presumed vertically acquired HIV attending 2 HIV care clinics in Harare, Zimbabwe, were recruited and assessed with clinical history and examination, CD4 count, pulmonary function tests, Doppler echocardiography, and chest radiography (CXR). Those with suspected nontuberculous chronic lung disease (CLD) were scanned using high-resolution computed tomography (HRCT). RESULTS: Of 116 participants (43% male; mean age, 14 ± 2.6 years, mean age at HIV diagnosis, 12 years), 69% were receiving antiretroviral therapy. Chronic cough and reduced exercise tolerance were reported by 66% and 21% of participants, respectively; 41% reported multiple respiratory tract infections in the previous year, and 10% were clubbed. More than 40% had hypoxemia at rest (13%) or on exercise (29%), with pulmonary hypertension (mean pulmonary artery pressure >25 mm Hg) in 7%. Forced expiratory volume in 1 second (FEV(1)) was 40% of unselected adolescent clinic attendees meeting criteria for severe hypoxic CLD. This condition is not obvious at rest. Etiology, prognosis, and response to treatment are currently unknown.

Published
2012

18. Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis

Author

Sloan, Derek J., primary, Mwandumba, Henry C., additional, Garton, Natalie J., additional, Khoo, Saye H., additional, Butterworth, Anthony E., additional, Allain, Theresa J., additional, Heyderman, Robert S., additional, Corbett, Elizabeth L., additional, Barer, Mike R., additional, and Davies, Geraint R., additional

Published
2015
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19. Development and Validation of a Global Positioning System–based “Map Book” System for Categorizing Cluster Residency Status of Community Members Living in High-Density Urban Slums in Blantyre, Malawi

Author

MacPherson, Peter, primary, Choko, Augustine T., additional, Webb, Emily L., additional, Thindwa, Deus, additional, Squire, S. Bertel, additional, Sambakunsi, Rodrick, additional, van Oosterhout, Joep J., additional, Chunda, Treza, additional, Chavula, Kondwani, additional, Makombe, Simon D., additional, Lalloo, David G., additional, and Corbett, Elizabeth L., additional

Published
2013
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