Search

Your search keyword '"Bastiaens, Guido J. H."' showing total 5 results
Start Over Author "Bastiaens, Guido J. H." Publisher oxford university press (oup)
5 results on '"Bastiaens, Guido J. H."'

2. Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission : A WWARN individual patient meta-analysis.

Author

Stepniewska, Kasia, Humphreys, Georgina S, Gonçalves, Bronner P, Craig, Elaine, Gosling, Roly, Guerin, Philippe J, Price, Ric N, Barnes, Karen I, Raman, Jaishree, Smit, Menno R, D'Alessandro, Umberto, Stone, Will J R, Bjorkman, Anders, Samuels, Aaron M, Arroyo-Arroyo, Maria I, Bastiaens, Guido J H, Brown, Joelle M, Dicko, Alassane, El-Sayed, Badria B, Elzaki, Salah-Eldin G, Eziefula, Alice C, Kariuki, Simon, Kwambai, Titus K, Maestre, Amanda E, Mårtensson, Andreas, Mosha, Dominic, Mwaiswelo, Richard O, Ngasala, Billy E, Okebe, Joseph, Roh, Michelle E, Sawa, Patrick, Tiono, Alfred B, Chen, Ingrid, Drakeley, Chris J, Bousema, Teun, Stepniewska, Kasia, Humphreys, Georgina S, Gonçalves, Bronner P, Craig, Elaine, Gosling, Roly, Guerin, Philippe J, Price, Ric N, Barnes, Karen I, Raman, Jaishree, Smit, Menno R, D'Alessandro, Umberto, Stone, Will J R, Bjorkman, Anders, Samuels, Aaron M, Arroyo-Arroyo, Maria I, Bastiaens, Guido J H, Brown, Joelle M, Dicko, Alassane, El-Sayed, Badria B, Elzaki, Salah-Eldin G, Eziefula, Alice C, Kariuki, Simon, Kwambai, Titus K, Maestre, Amanda E, Mårtensson, Andreas, Mosha, Dominic, Mwaiswelo, Richard O, Ngasala, Billy E, Okebe, Joseph, Roh, Michelle E, Sawa, Patrick, Tiono, Alfred B, Chen, Ingrid, Drakeley, Chris J, and Bousema, Teun

Abstract

BACKGROUND: Since the World Health Organization recommended single low-dose (0.25mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant P. falciparum, several single-site studies have been conducted to assess its efficacy. METHODS: An individual patient meta-analysis to assess the gametocytocidal and transmission-blocking efficacy of PQ used in combination with different ACTs was conducted. Random effects logistic regression was used to quantify PQ effect on (i) gametocyte carriage in the first two weeks post-treatment; (ii) the probability of infecting at least one mosquito or of a mosquito becoming infected. RESULTS: In 2,574 participants from fourteen studies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients presenting with gametocytaemia on day 0 (Odds Ratio (OR)=0.22; 95%CI 0.17-0.28 and OR=0.12; 95%CI 0.08-0.16, respectively). The rate of decline in gametocyte carriage was faster when PQ was combined with artemether-lumefantrine (AL) compared to dihydroartemisinin-piperaquine (DP) (p=0.010 for day 7). Addition of 0.25mg/kg PQ was associated with near complete prevention of transmission to mosquitoes. CONCLUSION: Primaquine's transmission-blocking effects are achieved with 0.25 mg/kg PQ. Gametocyte persistence and infectivity are lower when PQ is combined with AL compared to DP.

Published
2020
Full Text
View/download PDF

3. Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

Author

Stepniewska, Kasia, primary, Humphreys, Georgina S, additional, Gonçalves, Bronner P, additional, Craig, Elaine, additional, Gosling, Roly, additional, Guerin, Philippe J, additional, Price, Ric N, additional, Barnes, Karen I, additional, Raman, Jaishree, additional, Smit, Menno R, additional, D’Alessandro, Umberto, additional, Stone, Will J R, additional, Bjorkman, Anders, additional, Samuels, Aaron M, additional, Arroyo-Arroyo, Maria I, additional, Bastiaens, Guido J H, additional, Brown, Joelle M, additional, Dicko, Alassane, additional, El-Sayed, Badria B, additional, Elzaki, Salah-Eldin G, additional, Eziefula, Alice C, additional, Kariuki, Simon, additional, Kwambai, Titus K, additional, Maestre, Amanda E, additional, Martensson, Andreas, additional, Mosha, Dominic, additional, Mwaiswelo, Richard O, additional, Ngasala, Billy E, additional, Okebe, Joseph, additional, Roh, Michelle E, additional, Sawa, Patrick, additional, Tiono, Alfred B, additional, Chen, Ingrid, additional, Drakeley, Chris J, additional, and Bousema, Teun, additional

Published
2020
Full Text
View/download PDF

4. Serologic Markers of Previous Malaria Exposure and Functional Antibodies Inhibiting Parasite Growth Are Associated With Parasite Kinetics Following a Plasmodium falciparum Controlled Human Infection

Author

Achan, Jane, primary, Reuling, Isaie J, primary, Yap, Xi Zen, primary, Dabira, Edgard, primary, Ahmad, Abdullahi, primary, Cox, Momodou, primary, Nwakanma, Davis, primary, Tetteh, Kevin, primary, Wu, Lindsey, primary, Bastiaens, Guido J H, primary, Abebe, Yonas, primary, Manoj, Anita, primary, Kaur, Harparkash, primary, Miura, Kazutoyo, primary, Long, Carole, primary, Billingsley, Peter F, primary, Sim, B Kim Lee, primary, Hoffman, Stephen L, primary, Drakeley, Chris, primary, Bousema, Teun, primary, and D’Alessandro, Umberto, primary

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results