1. OP16 Characterization of the Clinical Features and Outcomes of Paediatric Patients with Isolated Colonic Crohn’s Disease: A Multi-center Study from the Porto Group of ESPGHAN
- Author
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B. Weiss, J Meredith, A Yerushalmi, L Ramasamy Padmanaban, Nicholas M. Croft, L Scarrallo, Valeria Dipasquale, Patrizia Alvisi, D Urlep, Claudio Romano, M Knudsen, Daniela Elena Serban, M Gasparetto, Paolo Lionetti, Raanan Shamir, M Matar, Erasmo Miele, D Yogev, Eytan Wine, Lorenzo Norsa, Annamaria Staiano, J Bronski, T Berger, Iva Hojsak, Oren Ledder, V Manuel Navas-López, Marina Aloi, H Miin Lee, Kaija-Leena Kolho, and Dror S. Shouval
- Subjects
0303 health sciences ,Pediatrics ,medicine.medical_specialty ,Crohn's disease ,Colonic Crohn's disease ,business.industry ,Gastroenterology ,General Medicine ,medicine.disease ,Ulcerative colitis ,Inflammatory bowel disease ,Hematochezia ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Multi center study ,medicine ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Irritable bowel syndrome ,030304 developmental biology ,Paediatric patients - Abstract
Background Isolated colonic (L2) Crohn’s disease (CD) in adults is thought to have unique clinical and genetic features compared with ileal (L1) CD and ulcerative colitis (UC). Similar studies in paediatrics are scarce. Our goal was to characterize the clinical features of paediatric patients with isolated colonic CD and compare them to patients with ileo-cecal CD and those with UC. Methods This was a multi-center retrospective study including 21 sites affiliated with the Porto IBD group and IBD interest group of ESPGHAN. Data of paediatric patients diagnosed between 2014–2017 with L1 or L2 CD, or with UC, was collected, including information on demographic, clinical and laboratory parameters at diagnosis, end of induction, 1 year and 3 years after diagnosis (or at last follow-up). Results Data was collected on 300 children (102 L1, 94 L2, 104 UC) with similar demographic features. At diagnosis, bloody stools were identified in 45% of L2 patients, compared with 15% and 95% of L1 and UC patients, respectively (P Conclusion Paediatric patients with isolated colonic CD exhibit several clinical features which differentiate them from ileo-cecal CD and UC. Prospective studies are required to understand the pathogenesis of this unique entity and define short- and long-term outcomes.
- Published
- 2021