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Start Over Author "Yang, Jing‐Quan" Publisher oxford university press
7 results on '"Yang, Jing‐Quan"'

1. Supplementary Material for Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression and agronomically important loci

Author

Li, Meng-Hua [menghua.li@cau.edu.cn], Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, Li, Meng-Hua [menghua.li@cau.edu.cn], Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., and Li, Meng-Hua

Published
2022

2. Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression, and agronomically important loci

Author

National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., and Li, Meng-Hua

Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3′-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep.

Published
2022

3. Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression, and agronomically important loci

Author

Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, Samuel R., Caetano, Alexandre R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, Nowick, Katja, National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, FENG-HUA LV, China Agricultural University, China, YIN-HONG CAO, Chinese Academy of Sciences (CAS), China, GUANG-JIAN LIU, Novogene Bioinformatics Institute, China, LING-YUN LUO, China Agricultural University, China, RAN LU, China Agricultural University, China, MING-JUN LIU, Xinjiang Academy of Animal Science, China, WEN-RONG LI, Xinjiang Academy of Animal Science, China, PING ZHOU, Xinjiang Academy of Agricultural and Reclamation Sciences, China, XIN-HUA WANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, MIN SHEN, Xinjiang Academy of Agricultural and Reclamation Sciences, China, LEI GAO, Xinjiang Academy of Agricultural and Reclamation Sciences, China, JING-QUAN YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, HUA YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YONG-LIN YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, CHANG-BIN LIU, Xinjiang Academy of Agricultural and Reclamation Sciences, China, PENG-CHENG WAN, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YUN-SHENG ZHANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, WEN-HUI PI, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YAN-LING REN, Shandong Binzhou Academy of Animal Science and Veterinary Medicine, China, ZHI-QIANG SHEN, Shandong Binzhou Academy of Animal Science and Veterinary Medicine, China, FENG WANG, Nanjing Agricultural University, China, YU-TAO WANG, Kashi University, China, JIN-QUAN LI, Inner Mongolia Agricultural University, China, HOSEIN SALEHIAN-DEHKORDI, Chinese Academy of Sciences (CAS), China, EER HEHUA, Ningxia Academy of Agriculture and Forestry Sciences, China, YONG-GANG LIU, Yunnan Agricultural University, China, JIAN-FEI CHEN, China Agricultural University, China, JIAN-KUI WANG, China Agricultural University, China, XUE-MEI DENG, China Agricultural University, China, ALI ESMAILIZADEH, Shahid Bahonar University of Kerman, Iran, MOSTAFA DEHGHANI-QANATQESTANI, Shahid Bahonar University of Kerman, Iran, HADI CHARATI, Shahid Bahonar University of Kerman, Iran, MARYAM NOSRATI, Payame Noor University, Iran, ONDREJ STEPANEK, State Veterinary Institute Jihlava, Czech Republic, HOSSAM E. RUSHDI, Cairo University, Egypt, INGRID OLSAKER, Norwegian University of Life Sciences, Norway, INO CURIK, University of Zagreb, Croatia, NEENA A. GORKHALI, Nepal Agriculture Research Council (NARC), Nepal, SAMUEL REZENDE PAIVA, Cenargen, ALEXANDRE RODRIGUES CAETANO, Cenargen, ELENA CIANI, Universita degli Studi di Bari Aldo 24 Moro, Italy, MARCEL AMILLS, Campus de la Universitat Autonoma de Barcelona, Spain, CHRISTINA WEIMANN, Justus-Liebig-University Giessen, Germany, GEORG ERHARDT, Justus-Liebig-University Giessen, Germany, AGRAW AMANE, Addis Ababa University, Ethiopia, JORAM M. MWACHARO, International Centre for Agricultural Research in the Dry Areas (ICARDA), Ethiopia, JIAN-LIN HAN, Chinese Academy of Agricultural Sciences (CAAS), China, OLIVIER HANOTTE, International Livestock Research Institute, Ethiopia, KATHIRAVAN PERIASAMY, International Atomic Energy Agency (IAEA), Austria, ANNA M. JOHANSSON, Swedish University of Agricultural Sciences, Sweden, JON H. HALLSSON, Agricultural University of Iceland, Iceland, JUHA KANTANEN, Natural Resources Institute Finland (Luke), Finland, DAVID W. COLTMAN, University of Alberta, Edmonton, Canada, MICHAEL W. BRUFORD, Cardiff University, United Kingdom, JOHANNES A. LENSTRA, Utrecht University, The Netherlands, and MENG-HUA LI, China Agricultural University, China.

Subjects
Asia, Genome, Sheep, Whole-genome sequences, Genetic Variation, Genetic selection, Sequence Analysis, DNA, Iran, Polymorphism, Single Nucleotide, Genetic diversity, whole-genome sequences, genetic diversity, adaptive introgression, genetic selection, agronomic traits, migration, Europe, Adaptive introgression, Genetics, Animals, Agronomic traits, Molecular Biology, Sheep, Domestic, Ecology, Evolution, Behavior and Systematics, Migration
Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3′-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep., This study was financially supported by grants from the National Natural Science Foundation of China (Nos. 32061133010, 31825024, 31661143014, and 31972527), the National Key Research and Development Program-Key Projects of International Innovation Cooperation between Governments (2017YFE0117900), the External Cooperation Program of Chinese Academy of Sciences (152111KYSB20150010), and the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) (No. 2019QZKK0501), and the Special Funds of the State Key Laboratory of Sheep Genetic Improvement and Healthy Production (Nos. 2018CA001, and 2019CA009, 2020CA001).

Published
2022

4. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep

Author

One Health Toxicologie, Afd Pharmacology, Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, Li, Meng-Hua, One Health Toxicologie, Afd Pharmacology, Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, and Li, Meng-Hua

Published
2021

5. Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci.

Author

Lv FH, Cao YH, Liu GJ, Luo LY, Lu R, Liu MJ, Li WR, Zhou P, Wang XH, Shen M, Gao L, Yang JQ, Yang H, Yang YL, Liu CB, Wan PC, Zhang YS, Pi WH, Ren YL, Shen ZQ, Wang F, Wang YT, Li JQ, Salehian-Dehkordi H, Hehua E, Liu YG, Chen JF, Wang JK, Deng XM, Esmailizadeh A, Dehghani-Qanatqestani M, Charati H, Nosrati M, Štěpánek O, Rushdi HE, Olsaker I, Curik I, Gorkhali NA, Paiva SR, Caetano AR, Ciani E, Amills M, Weimann C, Erhardt G, Amane A, Mwacharo JM, Han JL, Hanotte O, Periasamy K, Johansson AM, Hallsson JH, Kantanen J, Coltman DW, Bruford MW, Lenstra JA, and Li MH

Subjects
Animals, Asia, Europe, Genetic Variation, Iran, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Sheep genetics, Genome, Sheep, Domestic genetics
Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3'-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)

Published
2022
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6. Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep.

Author

Cao YH, Xu SS, Shen M, Chen ZH, Gao L, Lv FH, Xie XL, Wang XH, Yang H, Liu CB, Zhou P, Wan PC, Zhang YS, Yang JQ, Pi WH, Hehua E, Berry DP, Barbato M, Esmailizadeh A, Nosrati M, Salehian-Dehkordi H, Dehghani-Qanatqestani M, Dotsev AV, Deniskova TE, Zinovieva NA, Brem G, Štěpánek O, Ciani E, Weimann C, Erhardt G, Mwacharo JM, Ahbara A, Han JL, Hanotte O, Miller JM, Sim Z, Coltman D, Kantanen J, Bruford MW, Lenstra JA, Kijas J, and Li MH

Subjects
Animals, Biological Evolution, Climate Change, Genetic Variation, Phylogeography, Pneumonia immunology, Sheep immunology, Adaptation, Biological genetics, Disease Resistance genetics, Genetic Introgression, Sheep genetics
Abstract

How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600K and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667-248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication., (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)

Published
2021
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7. Expression profile analysis of microRNAs during hair follicle development in the sheep foetus.

Author

Yang HY, Yang H, Shi GQ, Shen M, Yang JQ, Yang YL, and Liu XJ

Subjects
Animals, Computational Biology, Down-Regulation, Female, High-Throughput Nucleotide Sequencing, Platelet Activation, Prolactin metabolism, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Sequence Analysis, RNA methods, Signal Transduction, Up-Regulation, Wool, Fetal Development genetics, Gene Expression Profiling, Hair Follicle growth & development, MicroRNAs genetics, Sheep embryology
Abstract

MicroRNAs (miRNAs) regulate the development and growth cycle of hair follicles (HFs). The molecular mechanism by which miRNAs determine the development of HFs in the sheep foetus remains elusive. In this study, the expression profiles of miRNAs at 11 development periods (45, 55, 65, 75, 85, 95, 105, 115, 125, 135 and 145 d) in sheep foetus skin were analysed by high-throughput sequencing and bioinformatics analysis. A total of 72 conserved miRNAs, 44 novel miRNAs and 32 known miRNAs were significantly differentially expressed. qRT-PCR results for 18 miRNAs were consistent with the sequencing data. 85 d of foetal development was the starting point for secondary hair follicle (SF) development according to tissue morphology and cluster analysis. In SF development, the prolactin signalling pathway and platelet activation played important roles, and 10 miRNAs were potential candidate miRNAs in SF initiation.

Published
2019
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