1. SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.
- Author
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Reeves RK, Evans TI, Gillis J, Wong FE, Kang G, Li Q, and Johnson RP
- Subjects
- Animals, Biopsy, Flow Cytometry, Gastrointestinal Tract pathology, Gene Expression, Immunohistochemistry, Integrins biosynthesis, Intestinal Mucosa pathology, Macaca mulatta, Microscopy, Fluorescence, Rectum immunology, Rectum pathology, Simian Acquired Immunodeficiency Syndrome pathology, Dendritic Cells immunology, Gastrointestinal Tract immunology, Intestinal Mucosa immunology, Simian Acquired Immunodeficiency Syndrome immunology, Simian Immunodeficiency Virus immunology
- Abstract
Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut-the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3--fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa.
- Published
- 2012
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