1. Oxidative profile, inflammatory responses and δ-aminolevulinate dehydratase enzyme activity in influenza B virus infection.
- Author
-
Bulegon JS, Weber AAP, de Souza MD, Viero FT, Pillat MM, and Gonçalves TL
- Subjects
- Humans, Antioxidants, Porphobilinogen Synthase metabolism, Influenza B virus metabolism, Oxidative Stress, Ascorbic Acid, Iron, Cytokines metabolism, Influenza, Human, Herpesviridae Infections
- Abstract
The aim of the current study was to determine the activity of the delta-aminolevulinate dehydratase (δ-ALA-D) enzyme, oxidative stress biomarkers and the expression of cytokines in those infected with influenza B virus (IBV). To evaluate the activity of the δ-ALA-D enzyme, lipid peroxidation was estimated as levels of thiobarbituric acid reactive substances, protein and non-protein thiol groups, ferric-reducing antioxidant power (FRAP), vitamin C concentration and cytokine levels in IBV-infected individuals (n = 50) and a control group (n = 30). δ-ALA-D activity was significantly lower in IBV-infected individuals compared with controls, as well as levels of thiols, vitamin C and FRAP. Lipid peroxidation and cytokine levels of IL-6, IL-10, IL-17A and IFN-y were statistically higher in the IBV group. In conclusion, we found evidence of the generation of oxidants, the depletion of the antioxidant system, decrease in the activity of the δ-ALA-D enzyme and an increase in the synthesis of cytokines, thus contributing to a better understanding of oxidative and inflammatory pathways during IBV infection., (© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.)
- Published
- 2023
- Full Text
- View/download PDF