1. Epidural Oscillating Cardiac-Gated Intracranial Implant Modulates Cerebral Blood Flow
- Author
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Syed Khalid, Sara Qvarlander, Ian Suk, Francis Loth, Suraj Thyagaraj, Jun Yang, Amir Manbachi, Serge El-Khoury, Mark G. Luciano, and Stephen M. Dombrowski
- Subjects
Intracranial Pressure ,Pulsatile flow ,Blood Pressure ,Balloon ,Dogs ,Medicine ,Animals ,Humans ,Arterial Pressure ,Intracranial pressure ,integumentary system ,Pulse (signal processing) ,business.industry ,musculoskeletal, neural, and ocular physiology ,Balloon catheter ,Laser Doppler velocimetry ,Research—Animal ,humanities ,nervous system diseases ,Blood pressure ,Cerebral blood flow ,Cerebrovascular Circulation ,Surgery ,Neurology (clinical) ,Intracranial Hypertension ,business ,Biomedical engineering - Abstract
BACKGROUND: We have previously reported a method and device capable of manipulating ICP pulsatility while minimally effecting mean ICP. OBJECTIVE: To test the hypothesis that different modulations of the intracranial pressure (ICP) pulse waveform will have a differential effect on cerebral blood flow (CBF). METHODS: Using an epidural balloon catheter attached to a cardiac-gated oscillating pump, 13 canine subjects underwent ICP waveform manipulation comparing different sequences of oscillation in successive animals. The epidural balloon was implanted unilaterally superior to the Sylvian sulcus. Subjects underwent ICP pulse augmentation, reduction and inversion protocols, directly comparing time segments of system activation and deactivation. ICP and CBF were measured bilaterally along with systemic pressure and heart rate. CBF was measured using both thermal diffusion, and laser doppler probes. RESULTS: The activation of the cardiac-gate balloon implant resulted in an ipsilateral/contralateral ICP pulse amplitude increase with augmentation (217%/202% respectively, P
- Published
- 2020