1. Enhanced therapeutic potential of naringenin-phospholipid complex in rats.
- Author
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Maiti K, Mukherjee K, Gantait A, Saha BP, and Mukherjee PK
- Subjects
- Animals, Antioxidants chemistry, Antioxidants pharmacokinetics, Antioxidants therapeutic use, Carbon Tetrachloride, Catalase metabolism, Chemical and Drug Induced Liver Injury, Chemistry, Pharmaceutical, Delayed-Action Preparations, Flavanones blood, Flavanones chemistry, Flavanones pharmacokinetics, Flavanones therapeutic use, Glutathione Peroxidase metabolism, Lipid Peroxidation drug effects, Liver drug effects, Liver metabolism, Liver Diseases metabolism, Liver Function Tests, Male, Phospholipids chemistry, Phospholipids pharmacokinetics, Phospholipids therapeutic use, Rats, Rats, Wistar, Superoxide Dismutase metabolism, Antioxidants pharmacology, Flavanones pharmacology, Liver Diseases prevention & control, Phospholipids pharmacology
- Abstract
Naringenin is a naturally occurring flavanone, possessing a variety of biological activity. Due to its rapid elimination, naringenin needs frequent administration to maintain an effective plasma concentration. We have evaluated the therapeutic potential of naringenin-phospholipid complex under oxidative stress conditions compared with free naringenin. Naringenin-phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Liver function tests were studied by assessing serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase and total bilirubin. Marker enzymes of liver, namely glutathione peroxidase, superoxide dismutase, catalase and thiobarbituric acid reactive substances, were measured to evaluate the antioxidant potential at the same dose level. The plasma concentration of naringenin was also measured. It was observed that the naringenin-phospholipid complex enhanced the antioxidant activity of the biomolecule and protected the liver significantly for a longer time as compared with free naringenin at the same dose level. Phospholipid complex of naringenin produced better antioxidant activity than the free compound with a prolonged duration of action, which may be helpful in reducing the fast elimination of the molecule from body.
- Published
- 2006
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