1. In vitro isolation and characterization of a calicivirus causing a vesicular disease of the hands and feet.
- Author
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Smith AW, Berry ES, Skilling DE, Barlough JE, Poet SE, Berke T, Mead J, and Matson DO
- Subjects
- Adult, Amino Acid Sequence, Animals, Base Sequence, Caliciviridae Infections immunology, Caliciviridae Infections pathology, Caliciviridae Infections veterinary, DNA, Viral, Foot pathology, Hand pathology, Humans, Male, Molecular Sequence Data, Seals, Earless, Caliciviridae Infections virology, Foot virology, Hand virology
- Abstract
We report that a calicivirus of oceanic origin, San Miguel sea lion virus serotype 5 (SMSV-5), is a human pathogen. This biotype was isolated originally from blisters on the flippers of northern fur seals (Callorhinus ursinus) and replicates readily in primate and human cell lines. It infects a phylogenetically diverse array of hosts (poikilotherms to primates) and induces type-specific neutralizing antibodies in exposed humans. Group antibody against a pooled antigen of SMSV-5 and two other serotypes was also observed in 18% of 300 blood donors from a population in the northwestern United States. The human calicivirus isolate designated SMSV-5 Homosapien-1 (SMSV-5 Hom-1) was recovered from a laboratory worker with systemic illness, including vesicular lesions on all four extremities. We believe this newly described human disease represents a paradigmatic shift in calicivirus disease recognition.
- Published
- 1998
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