Search

Your search keyword '"Manzone, D"' showing total 3 results
Start Over Author "Manzone, D" Publisher oxford university press
3 results on '"Manzone, D"'

1. Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: Patterns and differences

Author

Cavalca, V, Tremoli, E, Porro, B, Veglia, F, Myasoedova, V, Squellerio, I, Manzone, D, Zanobini, M, Trezzi, M, Di Minno, M, Werba, J, Tedesco, C, Alamanni, F, Parolari, A, Parolari, A., MANZONE, DANIELA MADDALENA, Cavalca, V, Tremoli, E, Porro, B, Veglia, F, Myasoedova, V, Squellerio, I, Manzone, D, Zanobini, M, Trezzi, M, Di Minno, M, Werba, J, Tedesco, C, Alamanni, F, Parolari, A, Parolari, A., and MANZONE, DANIELA MADDALENA

Abstract

OBJECTIVES: We investigated whether oxidative stress and the arginine/nitric oxide pathway differ in control subjects and in adult patients who are candidates for the three most common cardiac surgical operations: coronary bypass surgery, aortic valve replacement for calcific non-rheumatic aortic stenosis or mitral valve repair for degenerative mitral insufficiency. METHODS: In this prospective observational study, we studied 165 consecutive patients undergoing surgery from January to June 2011 (coronary bypass surgery, n = 63; aortic valve replacement for calcific non-rheumatic aortic stenosis, n = 51; mitral valve repair for degenerative mitral insufficiency, n = 51). Thirty-three healthy subjects with cardiovascular risk factors similar to surgery patients were also studied (Controls). Oxidative stress (the ratio of reduced and oxidized glutathione and urinary isoprostane), antioxidants (alpha- and gamma tocopherol) and factors involved in nitric oxide synthesis (arginine, symmetric and asymmetric dimethylarginine) were measured before surgery. Analysis of variance general linear models and principal component analysis were used for statistical analysis. RESULTS: Surgical patients had increased levels of oxidative stress and decreased levels of antioxidants. Increased levels of nitric oxide inhibitor asymmetric dimethylarginine were detected in surgical candidates, suggesting arginine/nitric oxide pathway impairment. Concerning the differences among surgical procedures, higher oxidative stress and a major imbalance of the ratio between substrate and inhibitors of nitric oxide synthesis were evidenced in patients who were candidates for mitral valve repair with respect to coronary bypass surgery patients and patients with calcific non-rheumatic aortic stenosis. CONCLUSIONS: Patients undergoing cardiac surgery have increased oxidative stress and a trend towards an impaired arginine/nitric oxide pathway with respect to Controls. Patients affected by mitral valve reg

Published
2013

2. Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: Patterns and differences

Author

Marco Zanobini, Benedetta Porro, Francesco Alamanni, Matteo Trezzi, Alessandro Parolari, Elena Tremoli, Viviana Cavalca, Fabrizio Veglia, José Pablo Werba, Veronika A. Myasoedova, Matteo Nicola Dario Di Minno, Daniela Manzone, Calogero C. Tedesco, Isabella Squellerio, Cavalca, V, Tremoli, E, Porro, B, Veglia, F, Myasoedova, V, Squellerio, I, Manzone, D, Zanobini, M, Trezzi, M, Di Minno, M, Werba, J, Tedesco, C, Alamanni, F, Parolari, A, Cavalca, Viviana, Tremoli, Elena, Porro, Benedetta, Veglia, Fabrizio, Myasoedova, Veronika, Squellerio, Isabella, Manzone, Daniela, Zanobini, Marco, Trezzi, Matteo, DI MINNO, Matteo, Werba, José Pablo, Tedesco, Calogero, Alamanni, Francesco, and Parolari, Alessandro

Subjects
Aortic valve, Male, medicine.medical_treatment, Coronary Artery Disease, Antioxidants, Coronary artery bypass surgery, chemistry.chemical_compound, Aortic valve replacement, Principal Component Analysi, Prospective Studies, Coronary Artery Bypass, Heart Valve Prosthesis Implantation, Principal Component Analysis, Calcinosis, Mitral Valve Insufficiency, Middle Aged, medicine.anatomical_structure, Bypass surgery, Aortic valve stenosis, Aortic Valve, Cardiology, Calcinosi, Linear Model, Female, Antioxidant, Mitral valve regurgitation, Case-Control Studie, Cardiology and Cardiovascular Medicine, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Aortic valve stenosi, Nitric Oxide, Internal medicine, medicine, Humans, Aged, Mitral valve repair, Chi-Square Distribution, business.industry, Coronary Artery Bypa, Oxidative Stre, Aortic Valve Stenosis, Original Articles, Biomarker, medicine.disease, Oxidative Stress, Prospective Studie, chemistry, Case-Control Studies, Biological Marker, Linear Models, Surgery, Asymmetric dimethylarginine, business, Biomarkers
Abstract

OBJECTIVES: We investigated whether oxidative stress and the arginine/nitric oxide pathway differ in control subjects and in adult patients who are candidates for the three most common cardiac surgical operations: coronary bypass surgery, aortic valve replacement for calcific non-rheumatic aortic stenosis or mitral valve repair for degenerative mitral insufficiency. METHODS: In this prospective observational study, we studied 165 consecutive patients undergoing surgery from January to June 2011 (coronary bypass surgery, n = 63; aortic valve replacement for calcific non-rheumatic aortic stenosis, n = 51; mitral valve repair for degenerative mitral insufficiency, n = 51). Thirty-three healthy subjects with cardiovascular risk factors similar to surgery patients were also studied (Controls). Oxidative stress (the ratio of reduced and oxidized glutathione and urinary isoprostane), antioxidants (alpha- and gamma tocopherol) and factors involved in nitric oxide synthesis (arginine, symmetric and asymmetric dimethylarginine) were measured before surgery. Analysis of variance general linear models and principal component analysis were used for statistical analysis. RESULTS: Surgical patients had increased levels of oxidative stress and decreased levels of antioxidants. Increased levels of nitric oxide inhibitor asymmetric dimethylarginine were detected in surgical candidates, suggesting arginine/nitric oxide pathway impairment. Concerning the differences among surgical procedures, higher oxidative stress and a major imbalance of the ratio between substrate and inhibitors of nitric oxide synthesis were evidenced in patients who were candidates for mitral valve repair with respect to coronary bypass surgery patients and patients with calcific non-rheumatic aortic stenosis. CONCLUSIONS: Patients undergoing cardiac surgery have increased oxidative stress and a trend towards an impaired arginine/nitric oxide pathway with respect to Controls. Patients affected by mitral valve regurgitation show more pronounced perturbations in these pathways. The clinical implications of these findings need to be investigated. © The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Published
2013

3. Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: patterns and differences.

Author

Cavalca V, Tremoli E, Porro B, Veglia F, Myasoedova V, Squellerio I, Manzone D, Zanobini M, Trezzi M, Di Minno MN, Werba JP, Tedesco C, Alamanni F, and Parolari A

Subjects
Aged, Antioxidants metabolism, Aortic Valve metabolism, Aortic Valve surgery, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis metabolism, Biomarkers blood, Biomarkers urine, Calcinosis diagnosis, Calcinosis metabolism, Case-Control Studies, Chi-Square Distribution, Coronary Artery Disease diagnosis, Coronary Artery Disease metabolism, Female, Humans, Linear Models, Male, Middle Aged, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency metabolism, Principal Component Analysis, Prospective Studies, Aortic Valve pathology, Aortic Valve Stenosis surgery, Calcinosis surgery, Coronary Artery Bypass, Coronary Artery Disease surgery, Heart Valve Prosthesis Implantation, Mitral Valve Insufficiency surgery, Nitric Oxide metabolism, Oxidative Stress
Abstract

Objectives: We investigated whether oxidative stress and the arginine/nitric oxide pathway differ in control subjects and in adult patients who are candidates for the three most common cardiac surgical operations: coronary bypass surgery, aortic valve replacement for calcific non-rheumatic aortic stenosis or mitral valve repair for degenerative mitral insufficiency., Methods: In this prospective observational study, we studied 165 consecutive patients undergoing surgery from January to June 2011 (coronary bypass surgery, n = 63; aortic valve replacement for calcific non-rheumatic aortic stenosis, n = 51; mitral valve repair for degenerative mitral insufficiency, n = 51). Thirty-three healthy subjects with cardiovascular risk factors similar to surgery patients were also studied (Controls). Oxidative stress (the ratio of reduced and oxidized glutathione and urinary isoprostane), antioxidants (alpha- and gamma tocopherol) and factors involved in nitric oxide synthesis (arginine, symmetric and asymmetric dimethylarginine) were measured before surgery. Analysis of variance general linear models and principal component analysis were used for statistical analysis., Results: Surgical patients had increased levels of oxidative stress and decreased levels of antioxidants. Increased levels of nitric oxide inhibitor asymmetric dimethylarginine were detected in surgical candidates, suggesting arginine/nitric oxide pathway impairment. Concerning the differences among surgical procedures, higher oxidative stress and a major imbalance of the ratio between substrate and inhibitors of nitric oxide synthesis were evidenced in patients who were candidates for mitral valve repair with respect to coronary bypass surgery patients and patients with calcific non-rheumatic aortic stenosis., Conclusions: Patients undergoing cardiac surgery have increased oxidative stress and a trend towards an impaired arginine/nitric oxide pathway with respect to Controls. Patients affected by mitral valve regurgitation show more pronounced perturbations in these pathways. The clinical implications of these findings need to be investigated.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results