1. Therapeutic effect of monophosphoryl lipid A administration on Paracoccidioides brasiliensis-infected mice.
- Author
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Landgraf TN, Fernandes FF, Peron G, and Panunto-Castelo A
- Subjects
- Animals, Disease Models, Animal, Lipid A administration & dosage, Male, Mice, Inbred BALB C, Therapeutic Uses, Treatment Outcome, Immunologic Factors administration & dosage, Lipid A analogs & derivatives, Paracoccidioidomycosis drug therapy
- Abstract
The lack of antifungals with low toxicity and short-term therapy for patients with paracoccidioidomycosis (PCM) led us to evaluate adjuvants in immunotherapeutic intervention. We have previously shown complete Freund's adjuvant (CFA) to be therapeutic on experimental PCM. Owing to CFA toxicity, here we tested adjuvants approved for clinical use or in preclinical phase in experimental mouse PCM. Of all, only monophosporyl lipid A (MPLA) demonstrates a beneficial effect, by reducing the fungal burden and increasing the concentrations of IFN-γ and TNF-α, which are immunoprotective in PCM. These results suggest that MPLA might improve intervention in PCM., (© The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2017
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