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Your search keyword '"Hirsch, H.H."' showing total 4 results
Start Over Author "Hirsch, H.H." Publisher oxford university press
4 results on '"Hirsch, H.H."'

1. Increases in Condomless Sex in the Swiss HIV Cohort Study

Author

Kouyos, R.D., Hasse, B., Calmy, A., Cavassini, M., Furrer, H., Stöckle, M., Vernazza, P.L., Bernasconi, E., Weber, R., Günthard, H.F., Aubert, V., Battegay, M., Böni, J., Bucher, H.C., Burton-Jeangros, C., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Fux, C.A., Gorgievski, M., Günthard, H., Haerry, D., Hirsch, H.H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, B.M., Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schüpbach, J., Speck, R., Tarr, P., Trkola, A., Vernazza, P., Yerly, S., and Swiss HIV Cohort Study

Subjects
Gerontology, medicine.medical_specialty, business.industry, Public health, Human immunodeficiency virus (HIV), 610 Medicine & health, condomless sex, medicine.disease_cause, 3. Good health, Men who have sex with men, HIV transmission, Infectious Diseases, STI transmission, Oncology, STI prevention, Heterosexuality, Medicine, 570 Life sciences, biology, Brief Reports, business, Hiv transmission, Sti prevention, Cohort study, Demography
Abstract

Condomless sex is a key driver of sexually transmitted diseases. In this study, we assess the long-term changes (2000-2013) of the occurrence of condomless sex among human immunodeficiency virus (HIV)-infected individuals enrolled in the Swiss HIV Cohort study. The frequencies with which HIV-infected individuals reported condomless sex were either stable or only weakly increasing for 2000-2008. For 2008-2013, these rates increased significantly for stable relationships among heterosexuals and men who have sex with men (MSM) and for occasional relationships among MSM. Our results highlight the increasing public health challenge posed by condomless sex and show that condomless sex has been increasing even in the most recent years.

Published
2015
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2. Obesity Trends and Body Mass Index Changes After Starting Antiretroviral Treatment: The Swiss HIV Cohort Study

Author

Hasse, B., Iff, M., Ledergerber, B., Calmy, A., Schmid, P., Hauser, C., Cavassini, M., Bernasconi, E., Marzolini, C., Tarr, P.E., Aubert, V., Barth, J., Battegay, M., Böni, J., Bucher, H.C., Burton-Jeangros, C., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Gorgievski, M., Günthard, H., Haerry, D., Hirsch, H.H., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schultze, D., Schüpbach, J., Speck, R., Staehelin, C., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Egger, Mathias, and Swiss HIV Cohort Study

Subjects
Gerontology, Longitudinal study, obesity, Population, antiretroviral therapy, 610 Medicine & health, body mass index, Overweight, Major Articles, medicine, education, ddc:616, 2. Zero hunger, education.field_of_study, immunosuppression, business.industry, longitudinal study, medicine.disease, HIV infection, Obesity, Confidence interval, 3. Good health, Regimen, Infectious Diseases, Oncology, 570 Life sciences, biology, medicine.symptom, business, Body mass index, Cohort study, Demography
Abstract

Increasing obesity rates in Swiss HIV+ persons may partially be due to aging, demographic changes and earlier ART start. Most BMI increase occurred in year 1 of ART. The effect of individual ART regimens was limited., Background The factors that contribute to increasing obesity rates in human immunodeficiency virus (HIV)-positive persons and to body mass index (BMI) increase that typically occurs after starting antiretroviral therapy (ART) are incompletely characterized. Methods We describe BMI trends in the entire Swiss HIV Cohort Study (SHCS) population and investigate the effects of demographics, HIV-related factors, and ART on BMI change in participants with data available before and 4 years after first starting ART. Results In the SHCS, overweight/obesity prevalence increased from 13% in 1990 (n = 1641) to 38% in 2012 (n = 8150). In the participants starting ART (n = 1601), mean BMI increase was 0.92 kg/m2 per year (95% confidence interval, .83–1.0) during year 0–1 and 0.31 kg/m2 per year (0.29–0.34) during years 1–4. In multivariable analyses, annualized BMI change during year 0–1 was associated with older age (0.15 [0.06–0.24] kg/m2) and CD4 nadir 350 (P < .001). Annualized BMI change during years 1–4 was associated with CD4 nadir 350 (P = .001) and black compared to white ethnicity (0.28 [0.16–0.37] kg/m2). Individual ART combinations differed little in their contribution to BMI change. Conclusions Increasing obesity rates in the SHCS over time occurred at the same time as aging of the SHCS population, demographic changes, earlier ART start, and increasingly widespread ART coverage. Body mass index increase after ART start was typically biphasic, the BMI increase in year 0–1 being as large as the increase in years 1–4 combined. The effect of ART regimen on BMI change was limited.

Published
2014
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3. Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort Study

Author

Castillo-Mancilla, Jose R, Cavassini, Matthias, Schneider Voirol, Marie Paule, Furrer, Hansjakob, Calmy, Alexandra, Battegay, Manuel, Scanferla, Giulia, Bernasconi, Enos, Günthard, Huldrych F, Glass, Tracy R, Anagnostopoulos, A, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Calmy, A, Cavassini, M, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Günthard, H F, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Huber, M, Kahlert, C R, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R D, Kovari, H, Ledergerber, B, Martinetti, G, Martinez de Tejada, B, Marzolini, C, Metzner, K J, Müller, N, Nicca, D, Paioni, P, Pantaleo, G, Perreau, M, Rauch, A, Rudin, C, Scherrer, A U, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Weber, R, Yerly, S, Swiss HIV Cohort Study, Anagnostopoulos, A., Battegay, M., Bernasconi, E., Böni, J., Braun, D.L., Bucher, H.C., Calmy, A., Cavassini, M., Ciuffi, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Günthard, H.F., Haerry, D., Hasse, B., Hirsch, H.H., Hoffmann, M., Hösli, I., Huber, M., Kahlert, C.R., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R.D., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Marzolini, C., Metzner, K.J., Müller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Rauch, A., Rudin, C., Scherrer, A.U., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Trkola, A., Vernazza, P., Wandeler, G., Weber, R., and Yerly, S.

Subjects
0301 basic medicine, medicine.medical_specialty, viral suppression, antiretroviral therapy, 610 Medicine & health, Disease, Major Articles, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, cardiovascular disease, Internal medicine, adherence, medicine, 030212 general & internal medicine, Myocardial infarction, Imputation (statistics), Stroke, ddc:615, business.industry, Proportional hazards model, Hazard ratio, Cardiovascular disease, medicine.disease, Viral suppression, 030112 virology, Antiretroviral therapy, Infectious Diseases, AcademicSubjects/MED00290, Oncology, Adherence, business, Cohort study
Abstract

BackgroundIncomplete antiretroviral therapy (ART) adherence, even if sufficient to maintain viral suppression, is associated with enhanced inflammation in persons with HIV (PWH). However, its clinical implications remain unknown.MethodsPWH enrolled in the Swiss HIV Cohort Study without a history of cardiovascular disease (CVD) who initiated ART between 2003 and 2018 and had viral suppression (ResultsA total of 6971 PWH (74% male) were included in the analysis (median age [interquartile range {IQR}], 39 [32–47] years). The median (IQR) follow-up was 8 (4–11) years, with 14 (8–23) adherence questionnaires collected per participant. In total, 205 (3%) participants experienced a CVD event, and 186 (3%) died a non-CVD-related death. In an adjusted competing risk model where missing data were imputed, missing ≥1 ART dose showed an increased, but not statistically significant, risk for CVD events (hazard ratio [HR], 1.23; 95% CI, 0.85–1.79; P = .28). Non-CVD-related mortality showed a statistically significantly increased risk with missing ≥1 ART dose (HR, 1.44; 95% CI, 1.00–2.07; P = .05) and missing ≥2 ART doses (HR, 2.21; 95% CI, 1.37–3.57; P = .001).ConclusionsIncomplete ART adherence was significantly associated with an increased risk for non-CVD-related mortality in PWH with virologic suppression. This highlights the potential role of nonadherence to ART as a driver of non-AIDS clinical outcomes.

Published
2021
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4. Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population

Author

Hasse, Barbara, Tarr, Philip E, Marques-Vidal, Pedro, Waeber, Gerard, Preisig, Martin, Mooser, Vincent, Valeri, Fabio, Djalali, Sima, Rauch, Andri, Bernasconi, Enos, Calmy, Alexandra, Cavassini, Matthias, Vernazza, Pietro, Battegay, Manuel, Weber, Rainer, Senn, Oliver, Vollenweider, Peter, Ledergerber, Bruno, Aubert, V, Barth, J, Battegay, M, Bernasconi, E, Böni, J, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, Hansjakob, Fux, C A, Gorgievski, Meri, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, Martinez de Tejada, B, Metzner, K, Müller, N, Nadal, D, Pantaleo, G, Regenass, S, Rickenbach, M, Rudin, C, Schöni-Affolter, F, Schmid, P, Schultze, D, Schüpbach, J, Speck, R, Stähelin, Cornelia Johanna, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R, Yerly, S, Jean-Michel, Aubry, Murielle, Bochud, Jean Michel, Gaspoz, Christoph, Hock, Thomas, Lüscher, Pedro, Marques Vidal, Vincent, Mooser, Fred, Paccaud, Martin, Preisig, Peter, Vollenweider, Roland, Von Känel, Aidacic, Vladeta, Gerard, Waeber, Jürg, Beriger, Markus, Bertschi, Heinz, Bhend, Martin, Büchi, Hans-Ulrich, Bürke, Ivo, Bugmann, Reto, Cadisch, Isabelle, Charles, Corinne, Chmiel, Sima, Djalali, Peter, Duner, Simone, Erni, Andrea, Forster, Markus, Frei, Claudius, Frey, Jakob, Frey, Ali, Gibreil Musa, Matthias, Günthard, Denis, Haller, Marcel, Hanselmann, Walter, Häuptli, Simon, Heininger, Felix, Huber, Paul, Hufschmid, Eva, Kaiser, Vladimir, Kaplan, Daniel, Klaus, Stephan, Koch, Beat, Köstner, Benedict, Kuster, Heidi, Kuster, Vesna, Ladan, Giovanni, Lauffer, Werner, Leibundgut Hans, Phillippe, Luchsinger, Severin, Lüscher, Christoph, Maier, Jürgen, Martin, Damian, Meli, Werner, Messerli, Titus, Morger, Valentina, Navarro, Jakob, Rizzi, Thomas, Rosemann, Hana, Sajdl, Frank, Schindelek, Georg, Schlatter, Oliver, Senn, Pietro, Somaini, Jacques, Staeger, Alfred, Staehelin, Alois, Steinegger, Claudia, Steurer, Othmar, Suter, Phuoc, Truong The, Marco, Vecellio, Alessandro, Violi, René, Von Allmen, Hans, Waeckerlin, Fritz, Weber, Johanna, Weber-Schär, Joseph, Widler, Marco, Zoller, Burton-Jeangros, Claudine, Kaiser, Laurent, Aubry, Jean-Michel, Bochud, Murielle, Gaspoz, Jean-Michel, Frei, Markus, CoLaus Cohort, Aubert, V., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Bucher, H.C., Burton-Jeangros, C., Calmy, A., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H.H., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schultze, D., Schüpbach, J., Speck, R., Staehelin, C., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Jean-Michel, A., Murielle, B., Jean Michel, G., Christoph, H., Thomas, L., Pedro, M.V., Vincent, M., Fred, P., Martin, P., Peter, V., Roland, V.K., Aidacic, V., Gerard, W., Jürg, B., Markus, B., Heinz, B., Martin, B., Hans-Ulrich, B., Ivo, B., Reto, C., Isabelle, C., Corinne, C., Sima, D., Peter, D., Simone, E., Andrea, F., Markus, F., Claudius, F., Jakob, F., Ali, G.M., Matthias, G., Denis, H., Marcel, H., Walter, H., Simon, H., Felix, H., Paul, H., Eva, K., Vladimir, K., Daniel, K., Stephan, K., Beat, K., Benedict, K., Heidi, K., Vesna, L., Giovanni, L., Werner, L.H., Phillippe, L., Severin, L., Christoph, M., Jürgen, M., Damian, M., Werner, M., Titus, M., Valentina, N., Jakob, R., Thomas, R., Hana, S., Frank, S., Georg, S., Oliver, S., Pietro, S., Jacques, S., Alfred, S., Alois, S., Claudia, S., Othmar, S., Phuoc, T.T., Marco, V., Alessandro, V., René, V.A., Hans, W., Fritz, W., Johanna, W.S., Joseph, W., and Marco, Z.

Subjects
medicine.medical_specialty, multimorbidity, Population, 610 Medicine & health, Rate ratio, Major Articles, ddc:616.89, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Internal medicine, Medicine, 030212 general & internal medicine, Poisson regression, HIV-infection, education, ddc:613, ddc:616, 2. Zero hunger, 0303 health sciences, education.field_of_study, 030306 microbiology, business.industry, Incidence (epidemiology), virus diseases, medicine.disease, Comorbidity, Confidence interval, 3. Good health, comorbidity, Infectious Diseases, Oncology, Immunology, symbols, 570 Life sciences, biology, business, Body mass index, Cohort study
Abstract

AIDS-associated morbidity has diminished due to excellent viral control. Multimorbidity are more prevalent and incident in Swiss HIV-positive persons compared to HIV-negative controls. However, smoking, but not HIV status, had a strong impact on cardiovascular risk and multimorbidity., Background. Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods. We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records. The incidence of the respective endpoints were assessed among SHCS and CoLaus participants. Poisson regression models were adjusted for age, sex, body mass index, and smoking. Results. Overall, 74 291 participants contributed data to prevalence analyses (3230 HIV-infected; 71 061 controls). In CoLaus, FIRE, and SHCS, multimorbidity was present among 26%, 13%, and 27% of participants. Compared with nonsmoking individuals from CoLaus, the incidence of cardiovascular disease was elevated among smoking individuals but independent of HIV status (HIV-negative smoking: incidence rate ratio [IRR] = 1.7, 95% confidence interval [CI] = 1.2–2.5; HIV-positive smoking: IRR = 1.7, 95% CI = 1.1–2.6; HIV-positive nonsmoking: IRR = 0.79, 95% CI = 0.44–1.4). Compared with nonsmoking HIV-negative persons, multivariable Poisson regression identified associations of HIV infection with hypertension (nonsmoking: IRR = 1.9, 95% CI = 1.5–2.4; smoking: IRR = 2.0, 95% CI = 1.6–2.4), kidney (nonsmoking: IRR = 2.7, 95% CI = 1.9–3.8; smoking: IRR = 2.6, 95% CI = 1.9–3.6), and liver disease (nonsmoking: IRR = 1.8, 95% CI = 1.4–2.4; smoking: IRR = 1.7, 95% CI = 1.4–2.2). No evidence was found for an association of HIV-infection or smoking with diabetes mellitus. Conclusions. Multimorbidity is more prevalent and incident in HIV-positive compared with HIV-negative individuals. Smoking, but not HIV status, has a strong impact on cardiovascular risk and multimorbidity.

Published
2015
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