16 results on '"Haglind, E."'
Search Results
2. Laparoscopic lavage for perforated diverticulitis in the LapLav study: population-based registry study.
- Author
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Samuelsson A, Bock D, Prytz M, Block M, Ehrencrona C, Wedin A, Ahlstedt M, Angenete E, and Haglind E
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- Aged, Diverticulitis, Colonic complications, Female, Humans, Intestinal Perforation etiology, Length of Stay, Male, Middle Aged, Patient Readmission, Peritoneal Lavage adverse effects, Postoperative Complications, Propensity Score, Registries, Reoperation, Retrospective Studies, Sweden, Treatment Outcome, Diverticulitis, Colonic surgery, Intestinal Perforation surgery, Laparoscopy adverse effects, Peritoneal Lavage methods
- Abstract
Background: The standard treatment for Hinchey III perforated diverticulitis with peritonitis was resection with or without a stoma, but recent trials have shown that laparoscopic lavage is a reasonable alternative. This registry-based Swedish study investigated results at a national level to assess safety in real-world scenarios., Methods: Patients in Sweden who underwent emergency surgery for perforated diverticulitis between 2016 and 2018 were studied. Inverse probability weighting by propensity score was used to adjust for confounding factors., Results: A total of 499 patients were included in this study. Laparoscopic lavage was associated with a significantly lower 90-day Comprehensive Complication Index (20.9 versus 32.0; odds ratio 0.77, 95 per cent compatibility interval (c.i.) 0.61 to 0.97) and overall duration of hospital stay (9 versus 15 days; ratio of means 0.84, 95 per cent c.i. 0.74 to 0.96) compared with resection. Patients had 82 (95 per cent c.i. 39 to 140) per cent more readmissions following lavage than resection (27.2 versus 21.0 per cent), but similar reoperation rates. More co-morbidity was noted among patients who underwent resection than those who had laparoscopic lavage., Conclusion: Laparoscopic lavage is safe in routine care beyond trial evaluations., (© The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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3. Author response to: Recovery after breast cancer surgery following a recommendation of physical activity pre- and postoperatively (PhysSURG-B)-a randomized clinical trial.
- Author
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Heiman J, Haglind E, and Olofsson Bagge R
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- Breast, Exercise, Female, Humans, Mastectomy, Breast Neoplasms surgery
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- 2021
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4. Recovery after breast cancer surgery following recommended pre and postoperative physical activity: (PhysSURG-B) randomized clinical trial.
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Heiman J, Onerup A, Wessman C, Haglind E, and Olofsson Bagge R
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- Adult, Aged, Aged, 80 and over, Female, Humans, Mastectomy, Mastectomy, Segmental, Middle Aged, Postoperative Care, Preoperative Care, Recovery of Function, Breast Neoplasms surgery, Exercise Therapy
- Abstract
Background: The effect of preoperative physical activity on recovery and complications after primary breast cancer surgery is unknown. The objective of this trial was to evaluate whether a recommendation of non-supervised physical activity improved recovery after breast cancer surgery., Methods: This parallel, unblinded, multicentre interventional trial randomized women in whom breast cancer surgery was planned. The intervention consisted of an individual recommendation of added aerobic physical activity (30 min/day), before and 4 weeks after surgery. The control group did not receive any advice regarding physical activity. The primary outcome was patient-reported physical recovery at 4 weeks after surgery. Secondary outcomes included mental recovery, complications, reoperations, and readmissions., Results: Between November 2016 and December 2018, 400 patients were randomized, 200 to each group. Some 370 participants (180 intervention, 190 control) remained at 4 weeks, and 368 at 90 days. There was no significant difference in favour of the intervention for the primary outcome physical recovery (risk ratio (RR) 1.03, 95 per cent c.i. 0.95 to 1.13). There was also no difference for mental recovery (RR 1.05, 0.93 to 1.17) nor in mean Comprehensive Complication Index score (4.2 (range 0-57.5) versus 4.7 (0-58.3)) between the intervention and control groups., Conclusion: An intervention with recommended non-supervised physical activity before and after breast cancer surgery did not improve recovery at 4 weeks after surgery. Registration number: NCT02560662 (http://www.clinicaltrials.gov)., (© The Author(s) 2020. Published by Oxford University Press on behalf of BJS Society Ltd.)
- Published
- 2021
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5. Two-year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis.
- Author
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Kohl A, Rosenberg J, Bock D, Bisgaard T, Skullman S, Thornell A, Gehrman J, Angenete E, and Haglind E
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- Adult, Aged, Diverticulitis, Colonic complications, Feasibility Studies, Female, Follow-Up Studies, Humans, Intestinal Perforation complications, Length of Stay trends, Male, Middle Aged, Peritonitis etiology, Prospective Studies, Rupture, Spontaneous, Time Factors, Treatment Outcome, Colon surgery, Diverticulitis, Colonic surgery, Intestinal Perforation surgery, Laparoscopy methods, Peritoneal Lavage methods, Peritonitis therapy
- Abstract
Background: Traditionally, perforated diverticulitis with purulent peritonitis was treated with resection and colostomy (Hartmann's procedure), with inherent complications and risk of a permanent stoma. The DILALA (DIverticulitis - LAparoscopic LAvage versus resection (Hartmann's procedure) for acute diverticulitis with peritonitis) and other randomized trials found laparoscopic lavage to be a feasible and safe alternative. The medium-term follow-up results of DILALA are reported here., Methods: Patients were randomized during surgery after being diagnosed with Hinchey grade III perforated diverticulitis at diagnostic laparoscopy. The primary outcome was the proportion of patients with one or more secondary operations from 0 to 24 months after the index procedure in the laparoscopic lavage versus Hartmann's procedure groups. The trial was registered as ISRCTN82208287., Results: Forty-three patients were randomized to laparoscopic lavage and 40 to Hartmann's procedure. Patients in the lavage group had a 45 per cent reduced risk of undergoing one or more operations within 24 months (relative risk 0·55, 95 per cent c.i. 0·36 to 0·84; P = 0·012) and had fewer operations (ratio 0·51, 95 per cent c.i. 0·31 to 0·87; P = 0·024) compared with those in the Hartmann's group. No difference was found in mean number of readmissions (1·37 versus 1·50; P = 0·221) or mortality between patients randomized to laparoscopic lavage or Hartmann's procedure. Three patients in the lavage group and nine in the Hartmann's group had a colostomy at 24 months., Conclusion: Laparoscopic lavage is a better option for perforated diverticulitis with purulent peritonitis than open resection and colostomy., (© 2018 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.)
- Published
- 2018
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6. Quality of life in a randomized trial of early closure of temporary ileostomy after rectal resection for cancer (EASY trial).
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Park J, Danielsen AK, Angenete E, Bock D, Marinez AC, Haglind E, Jansen JE, Skullman S, Wedin A, and Rosenberg J
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- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Health Status Indicators, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications prevention & control, Time Factors, Ileostomy, Quality of Life, Rectal Neoplasms surgery, Rectum surgery
- Abstract
Background: A temporary ileostomy may reduce symptoms from anastomotic leakage after rectal cancer resection. Earlier results of the EASY trial showed that early closure of the temporary ileostomy was associated with significantly fewer postoperative complications. The aim of the present study was to compare health-related quality of life (HRQOL) following early versus late closure of a temporary ileostomy., Methods: Early closure of a temporary ileostomy (at 8-13 days) was compared with late closure (at more than 12 weeks) in a multicentre RCT (EASY) that included patients who underwent rectal resection for cancer. Inclusion of participants was made after index surgery. Exclusion criteria were signs of anastomotic leakage, diabetes mellitus, steroid treatment, and signs of postoperative complications at clinical evaluation 1-4 days after rectal resection. HRQOL was evaluated at 3, 6 and 12 months after resection using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires QLQ-C30 and QLQ-CR29 and Short Form 36 (SF-36®)., Results: There were 112 patients available for analysis. Response rates of the questionnaires were 82-95 per cent, except for EORTC QLQ-C30 at 12 months, to which only 54-55 per cent of the patients responded owing to an error in questionnaire distribution. There were no clinically significant differences in any questionnaire scores between the groups at 3, 6 or 12 months., Conclusion: Although the randomized study found that early closure of the temporary ileostomy was associated with significantly fewer complications, this clinical advantage had no effect on the patients' HRQOL. Registration number: NCT01287637 (https://www.clinicaltrials.gov)., (© 2017 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.)
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- 2018
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7. Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II).
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Andersson J, Abis G, Gellerstedt M, Angenete E, Angerås U, Cuesta MA, Jess P, Rosenberg J, Bonjer HJ, and Haglind E
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- 2016
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8. Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial.
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Andersson J, Angenete E, Gellerstedt M, Angerås U, Jess P, Rosenberg J, Fürst A, Bonjer J, and Haglind E
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- 2016
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9. Health economic analysis of laparoscopic lavage versus Hartmann's procedure for diverticulitis in the randomized DILALA trial.
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Gehrman J, Angenete E, Björholt I, Bock D, Rosenberg J, and Haglind E
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- Acute Disease, Aged, Colostomy economics, Costs and Cost Analysis, Diverticulitis, Colonic economics, Female, Humans, Length of Stay economics, Male, Middle Aged, Peritonitis economics, Peritonitis etiology, Peritonitis surgery, Reoperation economics, Treatment Outcome, Diverticulitis, Colonic surgery, Intestinal Perforation surgery, Laparoscopy economics, Therapeutic Irrigation economics
- Abstract
Background: Open surgery with resection and colostomy (Hartmann's procedure) has been the standard treatment for perforated diverticulitis with purulent peritonitis. In recent years laparoscopic lavage has emerged as an alternative, with potential benefits for patients with purulent peritonitis, Hinchey grade III. The aim of this study was to compare laparoscopic lavage and Hartmann's procedure with health economic evaluation within the framework of the DILALA (DIverticulitis - LAparoscopic LAvage versus resection (Hartmann's procedure) for acute diverticulitis with peritonitis) trial., Methods: Clinical effectiveness and resource use were derived from the DILALA trial and unit costs from Swedish sources. Costs were analysed from the perspective of the healthcare sector. The study period was divided into short-term analysis (base-case A), within 12 months, and long-term analysis (base-case B), from inclusion in the trial throughout the patient's expected life., Results: The study included 43 patients who underwent laparoscopic lavage and 40 who had Hartmann's procedure in Denmark and Sweden during 2010-2014. In base-case A, the difference in mean cost per patient between laparoscopic lavage and Hartmann's procedure was €-8983 (95 per cent c.i. -16 232 to -1735). The mean(s.d.) costs per patient in base-case B were €25 703(27 544) and €45 498(38 928) for laparoscopic lavage and Hartmann's procedure respectively, resulting in a difference of €-19 794 (95 per cent c.i. -34 657 to -4931). The results were robust as demonstrated in sensitivity analyses., Conclusion: The significant cost reduction in this study, together with results of safety and efficacy from RCTs, support the routine use of laparoscopic lavage as treatment for complicated diverticulitis with purulent peritonitis., (© 2016 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.)
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- 2016
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10. Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II).
- Author
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Andersson J, Abis G, Gellerstedt M, Angenete E, Angerås U, Cuesta MA, Jess P, Rosenberg J, Bonjer HJ, and Haglind E
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- Aged, Female, Follow-Up Studies, Humans, Male, Patient Satisfaction, Quality of Life, Laparoscopy adverse effects, Rectal Neoplasms surgery, Rectum surgery, Sexual Dysfunction, Physiological etiology, Urination Disorders etiology
- Abstract
Background: This article reports on patient-reported sexual dysfunction and micturition symptoms following a randomized trial of laparoscopic and open surgery for rectal cancer., Methods: Patients in the COLOR II randomized trial, comparing laparoscopic and open surgery for rectal cancer, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-CR38 questionnaire before surgery, and after 4 weeks, 6, 12 and 24 months. Adjusted mean differences on a 100-point scale were calculated using changes from baseline value at the various time points in the domains of sexual functioning, sexual enjoyment, male and female sexual problems, and micturition symptoms., Results: Of 617 randomized patients, 385 completed this phase of the trial. Their mean age was 67·1 years. Surgery caused an anticipated reduction in genitourinary function after 4 weeks, with no significant differences between laparoscopic and open approaches. An improvement in sexual dysfunction was seen in the first year, but some male sexual problems persisted. Before operation 64·5 per cent of men in the laparoscopic group and 55·6 per cent in the open group reported some degree of erectile dysfunction. This increased to 81·1 and 80·5 per cent respectively 4 weeks after surgery, and 76·3 versus 75·5 per cent at 12 months, with no significant differences between groups. Micturition symptoms were less affected than sexual function and gradually improved to preoperative levels by 6 months. Adjusting for confounders, including radiotherapy, did not change these results., Conclusion: Sexual dysfunction is common in patients with rectal cancer, and treatment (including surgery) increases the proportion of patients affected. A laparoscopic approach does not change this., Registration Number: NCT00297791 (http://www.clinicaltrials.gov)., (© 2014 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.)
- Published
- 2014
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11. Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial.
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Andersson J, Angenete E, Gellerstedt M, Angerås U, Jess P, Rosenberg J, Fürst A, Bonjer J, and Haglind E
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- Aged, Body Image, Female, Humans, Male, Treatment Outcome, Laparoscopy psychology, Quality of Life, Rectal Neoplasms surgery, Rectum surgery
- Abstract
Background: Previous studies comparing laparoscopic and open surgical techniques have reported improved health-related quality of life (HRQL). This analysis compared HRQL 12 months after laparoscopic versus open surgery for rectal cancer in a subset of a randomized trial., Methods: The setting was a multicentre randomized trial (COLOR II) comparing laparoscopic and open surgery for rectal cancer. Involvement in the HRQL study of COLOR II was optional. Patients completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-CR38, and EuroQol - 5D (EQ-5D™) before surgery, and 4 weeks, 6, 12 and 24 months after operation. Analysis was done according to the manual for each instrument., Results: Of 617 patients in hospitals participating in the HRQL study of COLOR II, 385 were included. The HRQL deteriorated to moderate/severe degrees after surgery, gradually returning to preoperative values over time. Changes in EORTC QLQ-C30 and QLQ-CR38, and EQ-5D™ were not significantly different between the groups regarding global health score or any of the dimensions or symptoms at 4 weeks, 6 or 12 months after surgery., Conclusion: In contrast to previous studies in patients with colonic cancer, HRQL after rectal cancer surgery was not affected by surgical approach., Registration Number: NCT00297791 (http://www.clinicaltrials.gov)., (© 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons Ltd.)
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- 2013
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12. Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer.
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Lindholm E, Brevinge H, and Haglind E
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- Cohort Studies, Colorectal Neoplasms diagnosis, Enema methods, Enema mortality, Follow-Up Studies, Humans, Incidence, Middle Aged, Sigmoidoscopy methods, Sigmoidoscopy mortality, Survival Analysis, Sweden epidemiology, Colorectal Neoplasms mortality, Mass Screening methods, Occult Blood
- Abstract
Background: Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population., Methods: All 68,308 citizens in Göteborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60-64 years. All were screened two to three times with rehydrated Hemoccult-II. Compliance was 70.0 per cent (23,916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer., Results: After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0.84 (95 per cent confidence interval 0.71 to 0.99). The groups did not differ in incidence of colorectal cancer or in overall mortality., Conclusion: FOBT screening significantly reduces colorectal cancer mortality., ((c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.)
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- 2008
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13. Randomized clinical trial of the costs of open and laparoscopic surgery for colonic cancer.
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Janson M, Björholt I, Carlsson P, Haglind E, Henriksson M, Lindholm E, and Anderberg B
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- Aged, Colonic Neoplasms economics, Costs and Cost Analysis, Female, Health Resources economics, Health Resources statistics & numerical data, Humans, Male, Prospective Studies, Colonic Neoplasms surgery, Laparoscopy economics
- Abstract
Background: There has been no randomized clinical trial of the costs of laparoscopic colonic resection (LCR) compared with those of open colonic resection (OCR) in the treatment of colonic cancer., Methods: A subset of Swedish patients included in the Colon Cancer Open Or Laparoscopic Resection (COLOR) trial was included in a prospective cost analysis; costs were calculated up to 12 weeks after surgery. All relevant costs to society were included. No effects of the procedures, such as quality of life or survival, were taken into account., Results: Two hundred and ten patients were included in the primary analysis, 98 of whom had LCR and 112 OCR. Total costs to society did not differ significantly between groups (difference in means for LCR versus OCR euro1846; P = 0.104). The cost of operation was significantly higher for LCR than for OCR (difference in means euro1171; P < 0.001), as was the cost of the first admission (difference in means euro1556; P = 0.015) and the total cost to the healthcare system (difference in means euro2244; P = 0.018)., Conclusion: Within 12 weeks of surgery for colonic cancer, there was no difference in total costs to society incurred by LCR and OCR. The LCR procedure, however, was more costly to the healthcare system., (Copyright 2004 British Journal of Surgery Society Ltd.)
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- 2004
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14. Value of retesting subjects with a positive Hemoccult in screening for colorectal cancer.
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Kewenter J, Engarås B, Haglind E, and Jensen J
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- Barium Sulfate, Colorectal Neoplasms diagnosis, Enema, Humans, Probability, Sensitivity and Specificity, Sigmoidoscopy, Time Factors, Colorectal Neoplasms prevention & control, Mass Screening methods, Occult Blood, Reagent Kits, Diagnostic
- Abstract
Within a prospective randomized screening study for early detection of colorectal cancer with rehydrated Hemoccult II test, the possibility of increasing the specificity of the test by retesting patients with an initially positive Hemoccult II test was investigated. Of those offered the test 3561 (62.6 per cent) returned it and it was positive in 210 cases (5.9 per cent). The repeat test was performed by 184 patients and was positive in 68 (1.9 per cent). All those with a positive initial test had rectosigmoidoscopy to 60 cm and a double contrast enema. A carcinoma was found in one in seven patients with a positive retest but in only one in 100 patients with a negative retest (P less than 0.001). The specificity of the test was, therefore, increased from 95 per cent to 98 per cent and the sensitivity was unchanged. Rescreening was offered at a later date and increased numbers were available: 7147 patients returned the test and 369 (5.2 per cent) were positive. The test was repeated in 360 patients and 118 (1.7 per cent) were positive. A colorectal neoplasm was found in one in three of those with a positive repeat test, compared with one in seven of those with a negative repeat test. In conclusion, screening for early detection of colorectal cancer with a rehydrated Hemoccult II test may be followed by investigation of only those patients with a positive retest. Such a procedure will reduce the work-load by 60 per cent without reducing sensitivity.
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- 1990
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15. Value of a risk questionnaire in screening for colorectal neoplasm.
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Kewenter J, Haglind E, and Smith L
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- Adenoma diagnosis, Colonic Neoplasms diagnosis, Humans, Middle Aged, Occult Blood, Quality of Health Care, Reagent Kits, Diagnostic, Rectal Neoplasms diagnosis, Risk Factors, Self Care, Surveys and Questionnaires, Sweden, Adenoma prevention & control, Colonic Neoplasms prevention & control, Mass Screening methods, Rectal Neoplasms prevention & control
- Abstract
The value of a postal questionnaire and of Hemoccult II (Smith Klein Diagnostic Inc., Sunnyvale, California, USA) testing in screening for colorectal neoplasms was compared. In the questionnaire, the subjects were asked about previous treatment for colorectal neoplasm and rectal bleeding during the previous 6 months, specified as to type. All participants were asked to perform Hemoccult II blood testing over 3 days. Of 13,759 randomly selected subjects 9040 (66 per cent) performed the test and returned the questionnaire. Three hundred and fifty-four subjects with a positive Hemoccult II test and/or a proven previous colorectal neoplasm had a full assessment including double-contrast enema and rectosigmoidoscopy to 60 cm. Eighteen carcinomas and 61 adenomas were thus diagnosed. The population was followed for from 20 to 29 months, during which time rescreening was undertaken. An additional 34 subjects with carcinomas and 90 with adenomas were identified during this period. A significant correlation between the presence of a colorectal neoplasm and a previous history of colorectal neoplasm, a positive Hemoccult II and a previous history of bright red bleeding but not dark bleeding was found. The possibility of diagnosing a neoplasm was two, four and 19 times higher in a subject with a previous history of bleeding, a history of colorectal neoplasm, or a positive Hemoccult II respectively. Screening by faecal occult blood testing, therefore, at the moment seems to be the best and only practicable method.
- Published
- 1989
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16. Diagnostic accuracy of double-contrast enema and rectosigmoidoscopy in connection with faecal occult blood testing for the detection of rectosigmoid neoplasms.
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Jensen J, Kewenter J, Haglind E, Lycke G, Svensson C, and Ahrén C
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- Adenoma diagnostic imaging, Barium Sulfate, Carcinoma diagnostic imaging, Endoscopy, Enema, Humans, Middle Aged, Occult Blood, Prospective Studies, Radiography, Rectal Neoplasms diagnostic imaging, Sigmoid Neoplasms diagnostic imaging, Adenoma diagnosis, Carcinoma diagnosis, Rectal Neoplasms diagnosis, Sigmoid Neoplasms diagnosis
- Abstract
Four hundred and fifty-eight consecutive subjects with a positive faecal guaiac test when screened for early detection of colorectal neoplasms were investigated with double-contrast enemas and rectosigmoidoscopy (60 cm). The results of these two methods were compared. The radiologists and endoscopists were unaware of the result of each others' examination at the time of their own investigation. Altogether ten subjects with carcinoma in the rectosigmoid area were found. The radiologists and endoscopists each overlooked four of these ten carcinomas and only four of the carcinomas were diagnosed with both methods. Fifty-six of one hundred and seven adenomas were 1 cm or larger in diameter and located in the rectum or the sigmoid colon. Thirteen of the fifty-six adenomas were missed by double contrast enema and ten by endoscopy and only thirty-three adenomas were diagnosed with both methods. Neoplasms in the rectum and the sigmoid colon are sometimes difficult to diagnose with both radiology and endoscopy. Rectosigmoidoscopy (60 cm) should therefore be used as a complement to double contrast enemas if this method is chosen for investigation of a patient with rectal bleeding.
- Published
- 1986
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