1. Low bone mineral density in adult patients with moderate to severe atopic dermatitis.
- Author
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Haeck IM, Hamdy NA, Timmer-de Mik L, Lentjes EG, Verhaar HJ, Knol MJ, de Bruin-Weller MS, and Bruijnzeel-Koomen CA
- Subjects
- Adult, Aged, Aged, 80 and over, Bone Density physiology, Dermatitis, Atopic complications, Dose-Response Relationship, Drug, Female, Humans, Life Style, Male, Middle Aged, Osteoporosis physiopathology, Prevalence, Risk Factors, Severity of Illness Index, Surveys and Questionnaires, Young Adult, Absorptiometry, Photon methods, Adrenal Cortex Hormones adverse effects, Bone Density drug effects, Dermatitis, Atopic drug therapy, Osteoporosis chemically induced
- Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease commonly treated with topical corticosteroids. The inflammatory nature of this disorder and the use of topical corticosteroids represent potential risk factors for bone loss., Objectives: The aim was to assess the prevalence of osteoporosis and osteopenia in adult patients with moderate to severe AD. In addition, the associations between topical/oral corticosteroid use and bone mineral density (BMD) and between disease activity and BMD were studied., Patients and Methods: We studied 125 adult patients with moderate to severe AD. Using dual-energy X-ray absorptiometry, BMD was measured at lumbar spine and hips. The cumulative dose of topical and oral corticosteroids was calculated from pharmacy prescription records. Lifestyle parameters were collected by a questionnaire. Biochemical parameters of bone metabolism and disease activity [serum concentration of thymus and activation-regulated chemokine (TARC) levels] were also measured., Results: Osteoporosis was documented in six patients (4.8%) and osteopenia in 41 patients (32.8%); 30.4% of the patients had a Z-score
- Published
- 2009
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