1. Impact of nucleos(t)ide reverse transcriptase inhibitors on blood telomere length changes in a prospective cohort of aviremic HIV-infected adults
- Author
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Instituto de Salud Carlos III, European Commission, Montejano, Rocío, Stella-Ascariz, Natalia, Monge, Susana, Bernardino, José I., Pérez-Valero, Ignacio, Montes, Mª L., Valencia, Eulalia, Martín-Carbonero, Luz, Moreno, Victoria, González-García, Juan, Rodriguez-Centeno, Javier, Rodes, Berta, Esteban Cantos, Andrexs, Alejos, Belen, Miguel, Rosa de, Arnalich, Francisco, Perona Abellón, Rosario, Arribas, José R., Instituto de Salud Carlos III, European Commission, Montejano, Rocío, Stella-Ascariz, Natalia, Monge, Susana, Bernardino, José I., Pérez-Valero, Ignacio, Montes, Mª L., Valencia, Eulalia, Martín-Carbonero, Luz, Moreno, Victoria, González-García, Juan, Rodriguez-Centeno, Javier, Rodes, Berta, Esteban Cantos, Andrexs, Alejos, Belen, Miguel, Rosa de, Arnalich, Francisco, Perona Abellón, Rosario, and Arribas, José R.
- Abstract
[Background]: Tenofovir is a potent inhibitor of human telomerase. The clinical relevance of this inhibition is unknown., [Methods]: A prospective cohort of human immunodeficiency virus (HIV)–infected participants with suppressed virological replication was recruited to compare whole-blood telomere length (measured by quantitative multiplex polymerase chain reaction analysis) in participants with current exposure to tenofovir disoproxil fumarate (TDF) to that in participants never exposed to TDF., [Results]: A total of 172 participants were included: 67 were in the TDF group, and 105 were in the non-TDF group (75 were receiving 2 nucleosides [of whom 69 were receiving abacavir], 25 were receiving a nucleos[t]ide reverse transcriptase inhibitor [N{t}RTI]–sparing regimen, and 5 were receiving lamivudine as the only nucleoside). After 2 years, the mean blood telomere length increased significantly in the whole cohort. The TDF group had significantly smaller gains in telomere length than the non-TDF group. In the analysis restricted to participants receiving N(t)RTIs, TDF exposure was not associated with an independent negative effect. In the non-TDF group, participants treated with 2 nucleosides also had significantly smaller gains in telomere length than those receiving N(t)RTI-sparing regimens or lamivudine as the only nucleoside., [Discussion]: In HIV-infected adults with prolonged virological suppression, treatment with TDF or abacavir was associated with smaller gains in blood telomere length after 2 years of follow-up.
- Published
- 2018