1. Mycophenolate mofetil in low-risk renal transplantation in patients receiving no cyclosporine: a single-centre experience.
- Author
-
Raheem OA, Daly PJ, O'Kelly P, Shields WP, Zimmerman AJ, Mohan P, Power R, Little DM, Conlon PJ, and Hickey DP
- Subjects
- Adult, Cohort Studies, Cyclosporine, Female, Follow-Up Studies, Graft Rejection, Humans, Ireland, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic mortality, Kidney Transplantation adverse effects, Kidney Transplantation mortality, Male, Middle Aged, Mycophenolic Acid therapeutic use, Postoperative Care methods, Retrospective Studies, Risk Assessment, Severity of Illness Index, Survival Rate, Treatment Outcome, Azathioprine administration & dosage, Graft Survival drug effects, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Mycophenolic Acid analogs & derivatives, Transplantation Immunology
- Abstract
Background: We assess our long-term experience with regards the safety and efficacy of Mycophenolate Mofetil (MMF) in our low risk renal transplant population and compared it retrospectively to Azathioprine (AZA) immunosuppressive regimen. Patients and methods. Between January 1999 and December 2005, 240 renal transplants received MMF as part of their immunosuppressive protocol (MMF group). AZA group of 135 renal transplants was included for comparative analysis (AZA group). Patients received Cyclosporine was excluded from this study., Results: The incidence of biopsy proven 3-month acute rejections was 30 (12.5%) in MMF group and 22 (16%) in AZA group respectively (P = 0.307). Patient survival rates at 1 and 5 years for the MMF group were 97 and 94%, respectively, compared to 100% and 91% at 1 and 5 years respectively for the AZA group (P = 0.61). Graft survival rates at 1 and 5 years for the MMF group were 95 and 83%, respectively, compared to 97 and 84% at 1 and 5 years, respectively for the AZA group (P = 0.62)., Conclusion: There was no difference in acute rejection episodes between MMF and AZA based immunotherapy. Additionally, we observed no significant difference concerning graft survival in the MMF group when compared to AZA group.
- Published
- 2012
- Full Text
- View/download PDF