1. Tracking the re-emergence of epidemic chikungunya virus in Indonesia.
- Author
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Laras K, Sukri NC, Larasati RP, Bangs MJ, Kosim R, Djauzi, Wandra T, Master J, Kosasih H, Hartati S, Beckett C, Sedyaningsih ER, Beecham HJ 3rd, and Corwin AL
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alphavirus Infections immunology, Antibodies, Viral blood, Chikungunya virus immunology, Child, Child, Preschool, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Indonesia epidemiology, Middle Aged, RNA, Viral analysis, Reverse Transcriptase Polymerase Chain Reaction methods, Risk Factors, Seasons, Alphavirus Infections epidemiology, Chikungunya virus isolation & purification, Disease Outbreaks
- Abstract
Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 +/- 18 years in Bogor and 33 +/- 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.
- Published
- 2005
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