1. Induction of anti-nuclear antibodies by mercuric chloride in mice.
- Author
-
Robinson CJ, Abraham AA, and Balazs T
- Subjects
- Animals, Cell Nucleolus immunology, Dose-Response Relationship, Drug, Female, Kidney immunology, Liver immunology, Male, Mice, Mice, Inbred A, Stimulation, Chemical, Time Factors, Antibodies, Antinuclear biosynthesis, Mercuric Chloride pharmacology
- Abstract
Mercuric chloride (HgCl2) was administered parenterally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4. Inbred A/J male mice were resistant to the induction of ANA by HgCl2.
- Published
- 1984