1. Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
- Author
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Michael A Sundberg, Aurélia F. Porto, Silvane B. Santos, Edgar M. Carvalho, Márcia Lima, Glória Orge, Mirla Amorim, Andrea Bacellar, and Fernanda Salles
- Subjects
Adult ,Male ,Treatment outcome ,Strongyloides stercoralis ,medicine ,Animals ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,IL-2 receptor ,Anthelmintics ,Human T-lymphotropic virus 1 ,biology ,Coinfection ,Tumor Necrosis Factor-alpha ,Public Health, Environmental and Occupational Health ,Receptors, Interleukin-2 ,General Medicine ,Original Articles ,Middle Aged ,biology.organism_classification ,medicine.disease ,Virology ,HTLV-I Infections ,Leukemia ,Infectious Diseases ,Strongyloidiasis ,Treatment Outcome ,Immunology ,Disease Progression ,Parasitology ,Tumor necrosis factor alpha ,Female - Abstract
Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection.Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p0.05). The one patient who developed ATLL was coinfected with S. stercoralis.These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.
- Published
- 2013