1. The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants
- Author
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Jessica Barochiner, José Boggia, Antti Jula, Jan Filipovský, Yan Li, Zhenyu Zhang, Kalina Kawecka-Jaszcz, Augustine N. Odili, Jesus D. Melgarejo, Dong-Mei Wei, Natasza Gilis-Malinowska, Chang-Sheng Sheng, Gavin R. Norton, Edoardo Casiglia, Aletta E. Schutte, Qi-Fang Huang, Lucas S Aparicio, Angela J. Woodiwiss, Teemu J. Niiranen, Krzysztof Narkiewicz, Wen-Yi Yang, Lutgar de Thijs, Valérie Tikhonoff, Jan A. Staessen, Ji-Guang Wang, Katarzyna Stolarz-Skrzypek, Daniel Ackermann, Fang-Fei Wei, Murielle Bochud, International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators, Aparicio, L.S., Barochiner, J., Wei, D.M., Melgarejo, J.D., Thijs, L., Staessen, J.A., Wei, F.F., Yang, W.Y., Zhang, Z.Y., An, D.W., Cheng, Y.B., Guo, Q.H., Huang, J.F., Huang, Q.F., Li, Y., Sheng, C.S., Wang, J.G., Filipovský, J., Seidlerová, J., Juhanoja, E.P., Jula, A.M., Lindroos, A.S., Niiranen, T.J., Sivén, S.S., Casiglia, E., Pizzioli, A., Tikhonoff, V., Chori, B.S., Danladi, B., Odili, A.N., Oshaju, H., Kucharska, W., Kunicka, K., Gilis-Malinowska, N., Narkiewicz, K., Sakiewicz, W., Swierblewska, E., Kawecka-Jaszcz, K., Stolarz-Skrzypek, K., Rajzer, M., Mels, C., Kruger, R., Mokwatsi, G., Schutte, A.E., Norton, G.R., Woodiwiss, A.J., Ackermann, D., Bochud, M., Ehret, G., Álvarez-Vaz, R., Américo, C., Baccino, C., Borgarello, L., Florio, L., Moliterno, P., Noboa, A., Noboa, O., Olascoaga, A., Parnizari, P., and Pécora, M.
- Subjects
Male ,Ajhype/Ajh-08 ,medicine.medical_specialty ,Percentile ,cardiovascular outcome ,hypertension ,Epidemiology ,Original Contributions ,pulse wave velocity ,central blood pressure ,Hemodynamics ,Disease ,030204 cardiovascular system & hematology ,hemodynamics ,Cardiovascular outcome ,pulse wave analysis ,blood pressure ,03 medical and health sciences ,0302 clinical medicine ,International database ,Diabetes mellitus ,Internal Medicine ,Medicine ,Humans ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,610 Medicine & health ,Pulse wave velocity ,business.industry ,Middle Aged ,medicine.disease ,3. Good health ,Blood pressure ,Cross-Sectional Studies ,Cardiovascular Diseases ,Emergency medicine ,AcademicSubjects/SCI00960 ,Female ,business ,Cohort study - Abstract
OBJECTIVE To address to what extent central hemodynamic measurements, improve risk stratification, and determine outcome-based diagnostic thresholds, we constructed the International Database of Central Arterial Properties for Risk Stratification (IDCARS), allowing a participant-level meta-analysis. The purpose of this article was to describe the characteristics of IDCARS participants and to highlight research perspectives. METHODS Longitudinal or cross-sectional cohort studies with central blood pressure measured with the SphygmoCor devices and software were included. RESULTS The database included 10,930 subjects (54.8% women; median age 46.0 years) from 13 studies in Europe, Africa, Asia, and South America. The prevalence of office hypertension was 4,446 (40.1%), of which 2,713 (61.0%) were treated, and of diabetes mellitus was 629 (5.8%). The peripheral and central systolic/diastolic blood pressure averaged 129.5/78.7 mm Hg and 118.2/79.7 mm Hg, respectively. Mean aortic pulse wave velocity was 7.3 m per seconds. Among 6,871 participants enrolled in 9 longitudinal studies, the median follow-up was 4.2 years (5th–95th percentile interval, 1.3–12.2 years). During 38,957 person-years of follow-up, 339 participants experienced a composite cardiovascular event and 212 died, 67 of cardiovascular disease. CONCLUSIONS IDCARS will provide a unique opportunity to investigate hypotheses on central hemodynamic measurements that could not reliably be studied in individual studies. The results of these analyses might inform guidelines and be of help to clinicians involved in the management of patients with suspected or established hypertension., Graphical Abstract Graphical Abstract
- Published
- 2022