1. Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52–Variant Lineages
- Author
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Yin Ling Woo, Robert D. Burk, Ryo Konno, Zigui Chen, María Alejandra Picconi, Lucia Giovannelli, Anna-Barbara Moscicki, Samantha Jayne Hibbitts, Martin C.S. Wong, Tang-Yuan Chu, Tsitsi Magure, Joel M. Palefsky, Ivan Sabol, Patricia Piña-Sánchez, Wendy C. S. Ho, Magdalena Grce, Martin C.W. Chan, Wannapa Settheetham-Ishida, Alison Nina Fiander, Tak Hong Cheung, Mike Chirenje, Paul K.S. Chan, Federico De Marco, Jong-Sup Park, François Coutlée, Chuqing Zhang, and Karen Smith-McCune
- Subjects
Male ,Topography ,cervical cancer ,Uterine Cervical Neoplasms ,Disease ,Global Health ,phylogeny ,Medical and Health Sciences ,0302 clinical medicine ,Genotype ,Prevalence ,80 and over ,Immunology and Allergy ,2.1 Biological and endogenous factors ,Young adult ,Papillomaviridae ,Aetiology ,Cancer ,Cervical cancer ,Genetics ,Aged, 80 and over ,0303 health sciences ,Middle Aged ,Biological Sciences ,3. Good health ,Phylogeography ,Infectious Diseases ,030220 oncology & carcinogenesis ,Topography, Medical ,Female ,Adult ,HPV ,Lineage (genetic) ,Asia ,Adolescent ,Biology ,Risk Assessment ,Microbiology ,oncogenic risk ,Vaccine Related ,03 medical and health sciences ,Major Articles and Brief Reports ,Young Adult ,Phylogenetics ,Clinical Research ,Medical ,medicine ,Humans ,030304 developmental biology ,Aged ,Papillomavirus Infections ,Basic Medical Sciences ,medicine.disease ,biology.organism_classification ,Virology ,Good Health and Well Being ,Sexually Transmitted Infections ,Immunization - Abstract
Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%-5.5%; P(corrected) < .001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name "Asian lineage" be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.
- Published
- 2014