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ObjectiveTo determine whether race is associated with the development of epilepsy after subdural hematoma (SDH), we identified adult survivors of SDH in a statewide administrative dataset and followed them up for at least 1 year for revisits associated with epilepsy.MethodsWe performed a retrospective cohort study using claims data on all discharges from emergency departments (EDs) and hospitals in California. We identified adults (age ≥18 years) admitted from 2005 to 2011 with first-time traumatic and nontraumatic SDH. We used validated diagnosis codes to identify a primary outcome of ED or inpatient revisit for epilepsy. We used multivariable Cox regression for survival analysis to identify demographic and medical risk factors for epilepsy.ResultsWe identified 29,342 survivors of SDH (mean age 71.2 [SD 16.4] years, female sex 11,954 [41.1%]). Three thousand two hundred thirty (11.0%) patients had revisits to EDs or hospitals with a diagnosis of epilepsy during the study period. Black patients (n = 1,684 [5.7%]) had significantly increased risk compared to White patients (n = 16,945 [57.7%]; hazard ratio [HR] 1.45, 95% confidence interval [CI] 1.28–1.64, p < 0.001). Status epilepticus during the index SDH admission, although infrequent (n = 94 [0.3%]), was associated with a nearly 4-fold risk of epilepsy (HR 3.75, 95% CI 2.80–5.03, p < 0.001). Alcohol use, drug use, smoking, renal disease, and markers of injury severity (i.e., intubation, surgical intervention, length of stay, disposition other than home) were also associated with epilepsy (all p < 0.05).ConclusionsWe found an association between Black race and ED and hospital revisits for epilepsy after SDH, establishing the presence of a racial subgroup that is particularly vulnerable to post-SDH epileptogenesis.

ObjectiveTo estimate the risk of intracerebral hemorrhage (ICH) recurrence in a large, diverse, US-based population and to identify racial/ethnic and socioeconomic subgroups at higher risk.MethodsWe performed a longitudinal analysis of prospectively collected claims data from all hospitalizations in nonfederal California hospitals between 2005 and 2011. We used validated diagnosis codes to identify nontraumatic ICH and our primary outcome of recurrent ICH. California residents who survived to discharge were included. We used log-rank tests for unadjusted analyses of survival across racial/ethnic groups and multivariable Cox proportional hazards regression to determine factors associated with risk of recurrence after adjusting for potential confounders.ResultsWe identified 31,355 California residents with first-recorded ICH who survived to discharge, of whom 15,548 (50%) were white, 6,174 (20%) were Hispanic, 4,205 (14%) were Asian, and 2,772 (9%) were black. There were 1,330 recurrences (4.1%) over a median follow-up of 2.9 years (interquartile range 3.8). The 1-year recurrence rate was 3.0% (95% confidence interval [CI] 2.8%–3.2%). In multivariable analysis, black participants (hazard ratio [HR] 1.22; 95% CI 1.01–1.48; p = 0.04) and Asian participants (HR 1.29; 95% CI 1.10–1.50; p = 0.001) had a higher risk of recurrence than white participants. Private insurance was associated with a significant reduction in risk compared to patients with Medicare (HR 0.60; 95% CI 0.50–0.73; p < 0.001), with consistent estimates across racial/ethnic groups.ConclusionsBlack and Asian patients had a higher risk of ICH recurrence than white patients, whereas private insurance was associated with reduced risk compared to those with Medicare. Further research is needed to determine the drivers of these disparities.

Background: Race/ethnicity is associated with risk of first-ever spontaneous intracerebral hemorrhage (ICH), but the influence of race/ethnicity on risk of ICH recurrence has not been well studied in a large, diverse population. Methods: We used claims data on all discharges from community hospital inpatient stays in California between January 1, 2005 and December 31, 2011 to identify patients who were hospitalized for ICH. California residents who survived to discharge were included. We used validated diagnosis codes to identify a primary outcome of recurrent ICH. We then used survival curves and log-rank tests for unadjusted analyses of survival across race/ethnic groups and multivariable Cox proportional-hazards regression to determine factors associated with risk of ICH recurrence after adjusting for potential confounders. Results: Between 2005-2011, we identified 31,554 first-ever ICH patients who survived to discharge, of which 15,828 (50%) were white, 6,254 (20%) Hispanic, 4,268 (14%) Asian, and 2,820 (9%) black. There were 1339 recurrences (4.2%) over a median follow-up time of 2.9 years (IQR 3.8). The 1-year recurrence rate was 3.0% (95% CI 2.8%-3.2%). In univariable and multivariable analysis, blacks (HR 1.22, 95% CI 1.01-1.48; p=0.035) and Asians (HR 1.29, 95% CI 1.10-1.50; p=0.001) had a higher risk of ICH recurrence than whites (reference categories). Private insurance was associated with a significant reduction in the risk of ICH recurrence compared to subjects with Medicare (HR 0.60, 95% CI 0.50-0.73, p Conclusions: Black and Asian subjects had a higher risk of ICH recurrence than white or Hispanic subjects. Further research is needed to determine drivers of these disparities.

Introduction: Stroke is a leading cause of morbidity and mortality in the United States, affecting an estimated 15 million people each year. Native Americans (NAs) account for 1.5% of the population. Several recent studies have focused on how stroke affects minority groups. However, existing data on stroke in NAs are extremely limited. We aimed to characterize the demographic and clinical characteristics of this population and identify predictors of in-patient mortality. Methods: We evaluated claims data from acute care hospitals in California between 2005-2011. California has the largest NA population in the United States. Validated ICD-9 codes were used to identify first time primary ischemic (AIS) and hemorrhagic stroke (ICH) admissions and ascertain comorbidities and in-hospital mortality. We used univariate and multivariate logistic regression to compare baseline characteristics across race/ethnic groups and to identify independent predictors of in hospital mortality. Results: We identified 283,107 first time strokes in California between 2005 and 2011, including 234,471 AIS (83%) and 48,636 ICH (17%). Of these, 851 (0.3%) were NAs (Age 66 [SD14], female sex 444 [53%]), including 698 AISs (82%) and 153 (18%) ICHs. For AIS, NAs had intermediate prevalence of relevant vascular risk factors, including history of smoking (15% vs 18% in Blacks and 11% in Whites, p0.2). In both AIS and ICH, predictors of in hospital mortality were similar to other minority groups. Conclusions: Native Americans constitute an important yet understudied minority population in stroke. NA have high prevalence of modifiable risk factors including diabetes and smoking.