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Your search keyword '"Yoshimitsu Fukasawa"' showing total 2 results
Start Over Author "Yoshimitsu Fukasawa" Publisher ovid technologies (wolters kluwer health)
2 results on '"Yoshimitsu Fukasawa"'

1. Mutational Patterns in Pancreatic Juice of Intraductal Papillary Mucinous Neoplasms and Concomitant Pancreatic Cancer

Author

Yoshimitsu Fukasawa, Hiroshi Hayakawa, Makoto Kadokura, Shinichi Takano, Jun Itakura, Nobuyuki Enomoto, Daisuke Ichikawa, Sumio Hirose, Tadashi Sato, Hiroshi Kono, Ei Takahashi, Mitsuharu Fukasawa, Hiroko Shindo, Satoshi Kawakami, Hiromichi Kawaida, Kunio Mochizuki, and Shinya Maekawa

Subjects
Pathology, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pancreatic Juice, Pancreatic cancer, Biomarkers, Tumor, Internal Medicine, medicine, Carcinoma, Humans, Pancreatic carcinoma, Aged, Aged, 80 and over, Hepatology, Intraductal papillary mucinous neoplasm, business.industry, High-Throughput Nucleotide Sequencing, Middle Aged, medicine.disease, Adenocarcinoma, Mucinous, Carcinoma, Papillary, Pancreatic Neoplasms, 030220 oncology & carcinogenesis, Concomitant, Mutation, Pancreatic juice, Adenocarcinoma, 030211 gastroenterology & hepatology, Tumor Suppressor Protein p53, business, Carcinoma, Pancreatic Ductal
Abstract

The aims of this study were to identify genetic characteristics of intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic ductal carcinoma (PDC) and to detect these markers using pancreatic juice.From 76 cases, 102 tissues were obtained: 29 cases were noninvasive IPMN, 18 were PDC derived from IPMN (D-PDC; noninvasive part, n = 16; invasive part, n = 18), and 29 were PDC concomitant with IPMN (C-PDC; IPMN part, n = 10; PDC part, n = 29). Moreover, pancreatic juice samples from 28 cases were obtained (noninvasive IPMN, n = 13; D-PDC, n = 7; C-PDC, n = 8). Fifty-one cancer-related genes were analyzed by next-generation sequencing.TP53 mutation rates in D-PDC, C-PDC, and noninvasive IPMN were 67%, 66%, and 10%, respectively. Moreover, KRAS mutational patterns between 2 simultaneous tumors differed in 1 (6.3%) of the 16 D-PDC cases and in 8 (80%) of the 10 C-PDC cases (P = 0.0006). TP53 or multiple KRAS mutations were detected using pancreatic juice more frequently in C-PDC cases than in noninvasive IPMN cases (75% and 23%, respectively, P = 0.03).Multiple KRAS mutations along with TP53 mutation are genetic markers for C-PDC, which could be detected using pancreatic juice preoperatively.

Published
2019
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2. Diffusion-weighted image improves detectability of magnetic resonance cholangiopancreatography for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm

Author

Shintaro Ichikawa, Mitsuharu Fukasawa, Hiroshi Onishi, Nobuyuki Enomoto, Taisuke Inoue, Sumio Hirose, Tatsuya Shimizu, Shinichi Takano, Tatsuya Yamaguchi, Utaroh Motosugi, Tadashi Sato, Makoto Kadokura, Ei Takahashi, Shinya Maekawa, Yoshimitsu Fukasawa, Hiroshi Hayakawa, Hiroko Shindo, Satoshi Kawakami, Hiromichi Kawaida, and Yasuhiro Nakayama

Subjects
diffusion-weighted imaging (DWI), Adult, Male, endocrine system diseases, Cholangiopancreatography, Magnetic Resonance, Pancreatic Intraductal Neoplasms, Observational Study, magnetic resonance cholangiopancreatography (MRCP), Neoplasms, Multiple Primary, 03 medical and health sciences, 0302 clinical medicine, Text mining, intraductal papillary mucinous neoplasm (IPMN), medicine, Carcinoma, Humans, 030212 general & internal medicine, Aged, Retrospective Studies, Aged, 80 and over, Pancreatic duct, Magnetic resonance cholangiopancreatography, Intraductal papillary mucinous neoplasm, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Pancreatic Neoplasms, Diffusion Magnetic Resonance Imaging, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Concomitant, pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm (PDAC concomitant with IPMN), Female, business, Nuclear medicine, Research Article, Carcinoma, Pancreatic Ductal
Abstract

The present study is aimed to clarify the utility of magnetic resonance cholangiopancreatography (MRCP) and the additional value of diffusion-weighted imaging (DWI) in diagnosing pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN). This retrospective study involved 38 patients with PDAC concomitant with IPMN and 114 patients (control) who were randomly selected from 320 patients with IPMN without PDAC and were matched with cases for magnetic resonance imaging (MRI) strength (1.5 T/3.0 T). Two radiologists reviewed the 2 MR image sets with relevant clinical information blinded, first MRCP alone and then combined MRI set including DWI. Diagnostic capability and interobserver agreement were assessed by using receiver operating characteristics curve (Az) analysis and weighted κ statistics. Az values for the 2 observers were 0.834 and 0.821 for MRCP alone and 0.964 and 0.926 for the combined MRI (P

Published
2019
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