1. SLC17A7 Gene May Be the Indicator of Selective Serotonin Reuptake Inhibitor Treatment Response in the Chinese Han Population
- Author
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Fengping Yang, Xueli Sun, Xingwang Li, Guang He, Lin He, Xin Li, Zaiquan Dong, Yanfei Cao, Guoyin Feng, Xinzhi Zhao, Xiaoye Huang, Yi Lin, Xirong Li, Baocheng Liu, Weidong Li, Tao Yu, and Xu Zhang
- Subjects
Adult ,Male ,Oncology ,False discovery rate ,medicine.medical_specialty ,Genotype ,Serotonin reuptake inhibitor ,Vesicular glutamate transporter 1 ,Polymorphism, Single Nucleotide ,behavioral disciplines and activities ,Young Adult ,Asian People ,Polymorphism (computer science) ,Internal medicine ,mental disorders ,medicine ,Humans ,Pharmacology (medical) ,International HapMap Project ,Psychiatric Status Rating Scales ,Depressive Disorder, Major ,biology ,business.industry ,Genetic Variation ,Hamilton Rating Scale for Depression ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Treatment Outcome ,Vesicular Glutamate Transport Protein 1 ,biology.protein ,Major depressive disorder ,Female ,business ,Selective Serotonin Reuptake Inhibitors ,Pharmacogenetics - Abstract
Selective serotonin reuptake inhibitors (SSRIs) are widely used drugs for major depressive disorder (MDD), although the treatment outcomes vary in different people. The vesicular glutamate transporter 1 coded by SLC17A7 gene has been reported associated with MDD. According to its role in glutamate transmission, it is reasonable to consider it as a potential pharmacogenetic candidate in SSRI treatment. A total of 290 MDD patients who had been taking SSRIs for 6 weeks were recruited. Their genotypes were assessed for the presence of 4 single-nucleotide polymorphisms, which were selected from either the HapMap Chinese ethnic group or the literature report. Treatment effects were evaluated by the change rate of Hamilton Rating Scale for Depression. After the adjustment for the false discovery rate, 1 single-nucleotide polymorphism (rs74174284, false discovery rate; P = 0.032) demonstrated significant association with SSRI treatment response at week 6. Our results suggest that genetic variants in the SLC17A7 gene may be indicators of treatment response in MDD patients treated by SSRIs.
- Published
- 2014
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