1. Acro-dermato-ungual-lacrimal-tooth-like syndrome: report of a family with variable expression
- Author
-
Melissa Bellini, Federica Natacci, Fabienne Escande, Ugo Cavallari, Maria Francesca Bedeschi, and Faustina Lalatta
- Subjects
Adult ,Male ,medicine.medical_specialty ,Ectodermal dysplasia ,Nails, Malformed ,Oligodactyly ,Acro dermato ungual lacrimal tooth ,Cutaneous syndactyly ,Pathology and Forensic Medicine ,Variable Expression ,stomatognathic system ,Ectodermal Dysplasia ,Anal stenosis ,medicine ,Humans ,Abnormalities, Multiple ,Maxillary central incisor ,Child ,Genetics (clinical) ,Tooth Abnormalities ,business.industry ,Tumor Suppressor Proteins ,Syndrome ,General Medicine ,medicine.disease ,Dermatology ,Acro–dermato–ungual–lacrimal–tooth syndrome ,DNA-Binding Proteins ,stomatognathic diseases ,Phenotype ,Pediatrics, Perinatology and Child Health ,Trans-Activators ,Syndactyly ,Anatomy ,business ,Nasolacrimal Duct ,Hair ,Transcription Factors - Abstract
We report the case of a young boy with fine hair, mild nail dysplasia, blocked nasolacrimal ducts, absence of central incisors, bilateral oligodactyly of feet and anal stenosis. His father showed the same spectrum of anomalies with mild expression. He had mild nail dysplasia, blocked nasolacrimal ducts, inferior dental cysts with consequent premature tooth loss, frequent dental decays consequent to enamel abnormality and cutaneous syndactyly of the second and third right toe. The acro-dermato-ungual-lacrimal-tooth syndrome was suspected and molecular analysis of the P63 gene was performed, but no mutation was found. Although P63 gene analysis was negative, we think that both cases show clinical overlap with the acro-dermato-ungual-lacrimal-tooth syndrome and confirm the wide expression of this condition, even in the same family.
- Published
- 2006