1. Syphilitic Spinal Disease: An Old Nemesis Revisited. A Case Series and Review of Literature
- Author
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Shermyn Xiumin Neo, Hui Jin Chiew, Pei Xuan Koh, Zhiyong Chen, Monica Saini, and Dinesh Singh
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Cord ,business.industry ,Public Health, Environmental and Occupational Health ,Meninges ,Penicillins ,Dermatology ,Tertiary Syphilis ,Spinal disease ,medicine.disease ,Myelopathy ,Infectious Diseases ,medicine.anatomical_structure ,Tabes dorsalis ,Gumma ,medicine ,Humans ,Spinal Diseases ,Syphilis ,Treponema pallidum ,business ,Vertebral column - Abstract
Syphilitic spinal disease is a rare condition caused by the spirochete Treponema pallidum, either from direct spirochete involvement of the cord, or as a consequence of indirect spirochete involvement of the meninges, blood vessels, or the vertebral column. Following the introduction of penicillin therapy in the 1940s, it has become an increasingly rare condition. We report three challenging cases of syphilitic spinal disease presenting as myelopathy - one with an extra-axial gumma of tertiary syphilis causing cord compression, and two with tabes dorsalis complicated by tabetic spinal neuroarthropathy - each presenting a diagnostic dilemma to their treating physicians. We also review the literature for updates on modern investigative modalities, and discuss pitfalls physicians need to avoid in order to arrive at the diagnosis.
- Published
- 2021