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Your search keyword '"Santulli, Gaetano"' showing total 36 results
Start Over Author "Santulli, Gaetano" Publisher ovid technologies (wolters kluwer health)
36 results on '"Santulli, Gaetano"'

1. Sortilin and hypertension

Author

Avvisato, Roberta, Jankauskas, Stanislovas S, Varzideh, Fahimeh, Kansakar, Urna, Mone, Pasquale, Santulli, Gaetano, Avvisato, Roberta, Jankauskas, Stanislovas S, Varzideh, Fahimeh, Kansakar, Urna, Mone, Pasquale, and Santulli, Gaetano

Subjects
hypertension, sphingolipids, endothelium, Nephrology, Internal Medicine, oxidative stress, ceramide, Article
Abstract

Purpose of review: The current review aims to present the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension. Recent findings: The main focus of this systematic overview is on the functional contribution of Sortilin to the pathogenesis of hypertension. Sortilin is a glycoprotein mostly known for its actions as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. Emerging evidence indicates that Sortilin is associated with pathological conditions, including inflammation, arteriosclerosis, dyslipidemia, insulin resistance, and vascular calcification. Most recently, Sortilin has been shown to finely control endothelial function and to drive hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress. Summary: The latest findings linking Sortilin and hypertension that are herein discussed can inspire novel areas of research which could eventually lead to the discovery of new therapeutic strategies in cardiovascular medicine.

Published
2022

5. Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart

Author

Santulli, Gaetano, primary, Varzideh, Fahimeh, additional, Forzano, Imma, additional, Wilson, Scott, additional, Salemme, Luigi, additional, de Donato, Antonio, additional, Lombardi, Angela, additional, Rainone, Antonio, additional, Nunziata, Luigi, additional, Jankauskas, Stanislovas S., additional, Tesorio, Tullio, additional, Guerra, Germano, additional, Kansakar, Urna, additional, and Mone, Pasquale, additional

Published
2023
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7. Abstract P315: Nogo-a Reduces Ceramide De Novo Biosynthesis To Protect From Heart Failure

Author

Sasset, Linda, primary, Manzo, Onorina, additional, Zhang, Yi, additional, Marino, Alice, additional, Rubinelli, Luisa, additional, Riemma, Maria Antonietta, additional, Chalasani, Madhavi Latha S., additional, Dasoveanu, Dragos C., additional, Roviezzo, Fiorentina, additional, Jankauskas, Stanislovas, additional, Santulli, Gaetano, additional, Bucci, Mariarosaria, additional, Lu, Theresa, additional, and Di Lorenzo, Annarita, additional

Published
2022
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19. Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema

Author

Gambardella, Jessica, primary, Sorriento, Daniela, additional, Bova, Maria, additional, Rusciano, Mariarosaria, additional, Loffredo, Stefania, additional, Wang, Xujun, additional, Petraroli, Angelica, additional, Carucci, Laura, additional, Mormile, Ilaria, additional, Oliveti, Marco, additional, Bruno Morelli, Marco, additional, Fiordelisi, Antonella, additional, Spadaro, Giuseppe, additional, Campiglia, Pietro, additional, Sala, Marina, additional, Trimarco, Bruno, additional, Iaccarino, Guido, additional, Santulli, Gaetano, additional, and Ciccarelli, Michele, additional

Published
2020
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26. CaMK4 Gene Deletion Induces Hypertension

Author

Santulli, Gaetano, primary, Cipolletta, Ersilia, additional, Sorriento, Daniela, additional, Del Giudice, Carmine, additional, Anastasio, Antonio, additional, Monaco, Sara, additional, Maione, Angela Serena, additional, Condorelli, Gianluigi, additional, Puca, Annibale, additional, Trimarco, Bruno, additional, Illario, Maddalena, additional, and Iaccarino, Guido, additional

Published
2012
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32. Ischemic Neoangiogenesis Enhanced by β 2 -Adrenergic Receptor Overexpression

Author

Iaccarino, Guido, primary, Ciccarelli, Michele, additional, Sorriento, Daniela, additional, Galasso, Gennaro, additional, Campanile, Alfonso, additional, Santulli, Gaetano, additional, Cipolletta, Ersilia, additional, Cerullo, Vincenzo, additional, Cimini, Vincenzo, additional, Altobelli, Giovanna Giuseppina, additional, Piscione, Federico, additional, Priante, Ornella, additional, Pastore, Lucio, additional, Chiariello, Massimo, additional, Salvatore, Francesco, additional, Koch, Walter J., additional, and Trimarco, Bruno, additional

Published
2005
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33. AKT Participates in Endothelial Dysfunction in Hypertension

Author

Iaccarino, Guido, primary, Ciccarelli, Michele, additional, Sorriento, Daniela, additional, Cipolletta, Ersilia, additional, Cerullo, Vincenzo, additional, Iovino, Gianni Luigi, additional, Paudice, Alessandro, additional, Elia, Andrea, additional, Santulli, Gaetano, additional, Campanile, Alfonso, additional, Arcucci, Oreste, additional, Pastore, Lucio, additional, Salvatore, Francesco, additional, Condorelli, Gianluigi, additional, and Trimarco, Bruno, additional

Published
2004
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34. High HDL (High-Density Lipoprotein) Cholesterol Increases Cardiovascular Risk in Hypertensive Patients

Author

Valentina Trimarco, Raffaele Izzo, Carmine Morisco, Pasquale Mone, Maria Virginia Manzi, Angela Falco, Daniela Pacella, Paola Gallo, Maria Lembo, Gaetano Santulli, Bruno Trimarco, Trimarco, Valentina, Izzo, Raffaele, Morisco, Carmine, Mone, Pasquale, Manzi, MARIA VIRGINIA, Falco, Angela, Pacella, Daniela, Gallo, Paola, Lembo, Maria, Santulli, Gaetano, and Trimarco, Bruno

Subjects
Male, hypercholesterolemia, Cholesterol, HDL, dyslipidemia, cholesterol, population, heart disease risk factors, mortality, Article, Cardiovascular Diseases, Risk Factors, dyslipidemias, hydroxymethylglutaryl-CoA reductase inhibitors, sex characteristics, Hypertension, Internal Medicine, Humans, Female
Abstract

Background: Emerging evidence suggests that elevated circulating levels of HDL-C (high-density lipoprotein cholesterol) could be linked to an increased mortality risk. However, to the best of our knowledge, the relationship between HDL-C and specific cardiovascular events has never been investigated in patients with hypertension. Methods: To fill this knowledge gap, we analyzed the relationship between HDL-C levels and cardiovascular events in hypertensive patients within the Campania Salute Network in Southern Italy. Results: We studied 11 987 patients with hypertension, who were followed for 25 534 person-years. Our population was divided in 3 groups according to the HDL-C plasma levels: HDL-C80 mg/dL (high HDL-C). At the follow-up analysis, adjusting for potential confounders, we observed a total of 245 cardiovascular events with a significantly increased risk of cardiovascular events in the low HDL-C group and in the high HDL-C arm compared with the medium HDL-C group. The spline analysis revealed a nonlinear U-shaped association between HDL-C levels and cardiovascular outcomes. Interestingly, the increased cardiovascular risk associated with high HDL-C was not confirmed in female patients. Conclusions: Our data demonstrate that there is a U-shaped association between HDL-C and the risk of cardiovascular events in male patients with hypertension.

Published
2022

35. The PlA1/A2 polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients

Author

Bruno Trimarco, Gaetano Santulli, Francesca Lanni, Massimo Volpe, Raffaele Izzo, Guido Iaccarino, Bastianina Zanda, Speranza Rubattu, Francesca, Lanni, Santulli, Gaetano, Izzo, Raffaele, Speranza, Rubattu, Bastianina, Zanda, Massimo, Volpe, Iaccarino, Guido, and Trimarco, Bruno

Subjects
Male, medicine.medical_specialty, Physiology, Population, complications/genetics, Blood Pressure, Polymorphism, Single Nucleotide, Brain Ischemia, Brain ischemia, Risk Factors, Internal medicine, Odds Ratio, Internal Medicine, medicine, Humans, genetics, Polymorphism, education, genetics/physiology, Stroke, Aged, Retrospective Studies, Genetic association, blood/genetics, education.field_of_study, business.industry, Integrin beta3, Retrospective cohort study, Single Nucleotide, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Surgery, Blood pressure, Italy, Female, Hypertension, blood/complications, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

OBJECTIVE: The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk factor for stroke in hypertensive patients. METHODS: We studied two populations. In loco, we genotyped 140 hypertensive control individuals and 28 hypertensive patients with ischemic stroke. Furthermore, we performed an analysis of previously published data of 451 Sardinian hypertensive patients, already characterized and genotyped. RESULTS: Association analysis revealed that the Pl(A2) distribution was similar between hypertensive patients with and without stroke, but when considering a more homogeneous population of high-risk hypertensive patients, defined according to ESH/ESC 2003 guidelines, we observed that the frequency of the Pl(A2) allele was higher among stroke versus nonstroke patients (stroke, 46.4\%; nonstroke, 22.6\%; P = 0.01). The multiple regression analysis taking into account this polymorphism among other factors known to contribute to ischemic stroke confirmed the Pl(A2) allele as an additive risk factor for stroke (B = 0.986, Wald = 4.943, P < 0.03), increasing the risk of stroke by 2.9 (95\% confidence interval = 1.23-6.85, P < 0.02). Similar results were obtained in the Sardinian population: in hypertensive patients with three or more risk factors, Pl(A2) increases the risk (odds ratio = 2.8, 95\% confidence interval = 1.3-6.0, P < 0.001) and is an additive risk factor for stroke (B = 1.073, Wald = 6.920, P < 0.01). CONCLUSIONS: Our data suggest that the Pl(A2) polymorphism is a genetic determinant of ischemic stroke in a selected high-risk hypertensive population.

Published
2007

36. Adrenal Signaling in Heart Failure

Author

Gaetano Santulli and Santulli, Gaetano

Subjects
Male, Cardiac function curve, Agonist, Cardiac output, Sympathetic nervous system, medicine.medical_specialty, Arrestins, medicine.drug_class, Adrenal Gland, Myocardial Infarction, Stimulation, Article, Internal medicine, Adrenal Glands, Internal Medicine, medicine, Animals, Receptor, beta-Arrestins, Heart Failure, G protein-coupled receptor kinase, Arrestin, Animal, business.industry, medicine.disease, medicine.anatomical_structure, Endocrinology, Heart failure, business, Neuroscience
Abstract

βarrestin (βarr)-1 and -2 (βarrs) are universal G protein-coupled receptor adapter proteins that negatively regulate cardiac β–adrenergic receptor (βAR) function via βAR desensitization & downregulation. In addition, they mediate G protein-independent βAR signaling, which might be beneficial, e.g. antiapoptotic, for the heart. However, the specific role(s) of each βarr isoform in cardiac βAR dysfunction, the molecular hallmark of chronic heart failure (HF), remain unknown. Furthermore, adrenal βarr1 exacerbates HF by chronically enhancing adrenal production, and hence circulating levels of aldosterone and catecholamines. Herein, we sought to delineate specific roles of βarr1 in post-myocardial infarction (MI) HF by testing the effects of βarr1 genetic deletion on normal and post-MI cardiac function and morphology. We studied βarr1 knockout (βarr1KO) mice alongside wild type (WT) controls under normal conditions and after surgical MI. Normal (sham-operated) βarr1KO’s display enhanced βAR-dependent contractility and post-MI βarr1KO’s enhanced overall cardiac function (and βAR-dependent contractility) compared to WT’s. Post-MI βarr1KO’s also show increased survival, and decreased cardiac infarct size, apoptosis, and adverse remodeling, as well as circulating catecholamines & aldosterone, compared to post-MI WT’s. The underlying mechanisms are on one hand improved cardiac βAR signaling and function, as evidenced by increased βAR density and pro-contractile signaling, via reduced cardiac βAR desensitization due to cardiac βarr1 absence, and on the other hand decreased production leading to lower circulating levels of catecholamines & aldosterone due to adrenal βarr1 absence. Thus, βarr1, via both cardiac and adrenal effects, is detrimental for cardiac structure and function and significantly exacerbates post-MI HF.

Published
2014

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