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Start Over Author "Salcido, A." Publisher ovid technologies (wolters kluwer health)
419 results on '"Salcido, A."'

1. Bag-Valve-Mask Ventilation and Survival from Out-of-Hospital Cardiac Arrest: A Multicenter Study.

Author

Idris, Ahamed H., primary, Aramendi Ecenarro, Elisabete, additional, Leroux, Brian, additional, Jaureguibeitia, Xabier, additional, Yang, Betty Y., additional, Shaver, Sarah, additional, Chang, Mary P., additional, Rea, Tom, additional, Kudenchuk, Peter, additional, Christenson, Jim, additional, Vaillancourt, Christian, additional, Callaway, Clifton W, additional, Salcido, David, additional, Carson, Jonas, additional, Blackwood, Jennifer, additional, and Wang, Henry E., additional

Published
2023
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2. Assessment of the Effects of Sodium Nitroprusside Administered Via Intracranial Subdural Catheters on the Cerebral Blood Flow and Lactate Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy in a Pig Cardiac Arrest Model

Author

Lee, Hyoung Youn, primary, Jung, Yong Hun, additional, Mamadjonov, Najmiddin, additional, Jeung, Kyung Woon, additional, Lee, Byung Kook, additional, Kim, Tae‐Hoon, additional, Kim, Hyung Joong, additional, Gumucio, Jorge Antonio, additional, and Salcido, David D., additional

Published
2023
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4. Abstract 14171: Prehospital Outcomes and Patient Characteristics Associated With PulsePoint Dispatches for Out-of-Hospital Cardiac Arrest in Pittsburgh, Pennsylvania

Author

David Salcido, Christian Martin-Gill, LEONARD WEISS, and David D Salcido

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Background: Mobile phone-based dispatch of volunteers to out-of-hospital cardiac arrest (OHCA) has been shown to increase the likelihood of early chest compressions and AED application. In the United States, limited characterization of patients encountered as a result of such systems exists, including PulsePoint Respond, a smartphone-based volunteer dispatch system. Objective: Examine prehospital case characteristics and outcomes from a multi-year deployment of PulsePoint in Pittsburgh, Pennsylvania. Methods: Case data, including PulsePoint determinant triggers and timing, prehospital electronic health records (EHRs), and computer aided dispatch records were obtained for suspected EMS-treated OHCA cases that did and did not generate PulsePoint alerts within the service area of Pittsburgh EMS for the period July 2016 to October 2020. EHRs were reviewed to determine true OHCA status, and OHCA case characteristics were extracted according to the Utstein template. Key characteristics and the outcome of prehospital return of spontaneous circulation (ROSC) were summarized and compared between cases with and without PulsePoint dispatches. Chi-squared tests were used to determine statistical significance of relationships. Results: There were 1229 OHCA cases overall in the capture period, with an estimated 29.6% occurring in public. Of 840 total PulsePoint dispatches, 68 (8.1%) were for true OHCA. Forty-five (66.2%) of these were witnessed, 43 (63.2%) received bystander CPR, and 17 (25%) had an AED applied prior to first responder arrival. Twenty-seven (39.7%) had an initial shockable rhythm, and 34 (50%) achieved ROSC in the field. Compared to non-PulsePoint dispatch generating OHCA, PulsePoint alert-associated patients were significantly more likely to be male (p=0.024), have bystander CPR/AED application performed (p Conclusions: A minority of PulsePoint dispatches in Pittsburgh were triggered by true OHCA. Among cases that did generate a PulsePoint dispatch, case characteristics were prognostically favorable.

Published
2021
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5. Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab

Author

Hagström, Emil, primary, Steg, P. Gabriel, additional, Szarek, Michael, additional, Bhatt, Deepak L., additional, Bittner, Vera A., additional, Danchin, Nicolas, additional, Diaz, Rafael, additional, Goodman, Shaun G., additional, Harrington, Robert A., additional, Jukema, J. Wouter, additional, Liberopoulos, Evangelos, additional, Marx, Nikolaus, additional, McGinniss, Jennifer, additional, Manvelian, Garen, additional, Pordy, Robert, additional, Scemama, Michel, additional, White, Harvey D., additional, Zeiher, Andreas M., additional, Schwartz, Gregory G., additional, Tricoci, Pierluigi, additional, Roe, Matthew T., additional, Mahaffey, Kenneth W., additional, Edelberg, Jay M., additional, Hanotin, Corinne, additional, Lecorps, Guillaume, additional, Moryusef, Angèle, additional, Sasiela, William J., additional, Tamby, Jean-François, additional, Aylward, Philip E, additional, Drexel, Heinz, additional, Sinnaeve, Peter, additional, Dilic, Mirza, additional, Lopes, Renato D., additional, Gotcheva, Nina N, additional, Prieto, Juan-Carlos, additional, Yong, Huo, additional, López-Jaramillo, Patricio, additional, Pećin, Ivan, additional, Reiner, Zeljko, additional, Ostadal, Petr, additional, Poulsen, Steen Hvitfeldt, additional, Viigimaa, Margus, additional, Nieminen, Markku S, additional, Chumburidze, Vakhtang, additional, Carlos, Pablo, additional, Valdovinos, Montenegro, additional, Tse, Hung-Fat, additional, Kiss, Robert Gabor, additional, Xavier, Denis, additional, Zahger, Doron, additional, Valgimigli, Marco, additional, Kimura, Takeshi, additional, Kim, Hyo Soo, additional, Kim, Sang-Hyun, additional, Erglis, Andrejs, additional, Laucevicius, Aleksandras, additional, Kedev, Sasko, additional, Yusoff, Khalid, additional, Ramos López, Gabriel Arturo, additional, Alings, Marco, additional, Halvorsen, Sigrun, additional, Correa Flores, Roger M, additional, Sy, Rody G., additional, Budaj, Andrzej, additional, Morais, Joao, additional, Dorobantu, Maria, additional, Karpov, Yuri, additional, Ristic, Arsen D., additional, Chua, Terrance, additional, Murin, Jan, additional, Fras, Zlatko, additional, Dalby, Anthony J, additional, Tuñón, José, additional, de Silva, H. Asita, additional, Hagström, Emil, additional, Landmesser, Ulf, additional, Müller, Christian, additional, Chiang, Chern-En, additional, Sritara, Piyamitr, additional, Guneri, Sema, additional, Parkhomenko, Alexander, additional, Ray, Kausik K., additional, Moriarty, Patrick M., additional, Vogel, Robert, additional, Chaitman, Bernard, additional, Kelsey, Sheryl F., additional, Olsson, Anders G., additional, Rouleau, Jean-Lucien, additional, Simoons, Maarten L., additional, Alexander, Karen, additional, Meloni, Chiara, additional, Rosenson, Robert, additional, Sijbrands, Eric J.G., additional, Alexander, John H., additional, Armaganijan, Luciana, additional, Bagai, Akshay, additional, Bahit, Maria Cecilia, additional, Brennan, J. Matthew, additional, Clifton, Shaun, additional, DeVore, Adam D., additional, Deloatch, Shalonda, additional, Dickey, Sheila, additional, Dombrowski, Keith, additional, Ducrocq, Grégory, additional, Eapen, Zubin, additional, Endsley, Patricia, additional, Eppinger, Arleen, additional, Harrison, Robert W., additional, Hess, Connie Ng, additional, Hlatky, Mark A., additional, Jordan, Joseph Dedrick, additional, Knowles, Joshua W., additional, Kolls, Bradley J., additional, Kong, David F., additional, Leonardi, Sergio, additional, Lillis, Linda, additional, Maron, David J., additional, Marcus, Jill, additional, Mathews, Robin, additional, Mehta, Rajendra H., additional, Mentz, Robert J., additional, Moreira, Humberto Graner, additional, Patel, Chetan B., additional, Pereira, Sabrina Bernardez, additional, Perkins, Lynn, additional, Povsic, Thomas J., additional, Puymirat, Etienne, additional, Jones, William Schuyler, additional, Shah, Bimal R., additional, Sherwood, Matthew W., additional, Stringfellow, Kenya, additional, Sujjavanich, Darin, additional, Toma, Mustafa, additional, Trotter, Charlene, additional, van Diepen, Sean F.P., additional, Wilson, Matthew D., additional, Tze-Kay Yan, Andrew, additional, Schiavi, Lilia B, additional, Garrido, Marcelo, additional, Alvarisqueta, Andrés F, additional, Sassone, Sonia A, additional, Bordonava, Anselmo P, additional, Alves De Lima, Alberto E, additional, Schmidberg, Jorge M, additional, Duronto, Ernesto A, additional, Caruso, Orlando C, additional, Novaretto, Leonardo P, additional, Hominal, Miguel Angel, additional, Montaña, Oscar R, additional, Caccavo, Alberto, additional, Gomez Vilamajo, Oscar A, additional, Lorenzatti, Alberto J, additional, Cartasegna, Luis R, additional, Paterlini, Gustavo A, additional, Mackinnon, Ignacio J, additional, Caime, Guillermo D, additional, Amuchastegui, Marcos, additional, Salomone, Oscar, additional, Codutti, Oscar R, additional, Jure, Horacio O, additional, Bono, Julio OE, additional, Hrabar, Adrian D, additional, Vallejos, Julio A, additional, Ahuad Guerrero, Rodolfo A, additional, Novoa, Federico, additional, Patocchi, Cristian A, additional, Zaidman, Cesar J, additional, Giuliano, Maria E, additional, Dran, Ricardo D, additional, Vico, Marisa L, additional, Carnero, Gabriela S, additional, Guzman, Pablo N, additional, Medrano Allende, Juan C, additional, Garcia Brasca, Daniela F, additional, Bustamante Labarta, Miguel H, additional, Nani, Sebastian, additional, Blumberg, Eduardo DS, additional, Colombo, Hugo R, additional, Liberman, Alberto, additional, Fuentealba, Victorino, additional, Luciardi, Hector L, additional, Waisman, Gabriel D, additional, Berli, Mario A, additional, Garcia Duran, Ruben O, additional, Cestari, Horacio G, additional, Luquez, Hugo A, additional, Giordano, Jorge A, additional, Saavedra, Silvia S, additional, Zapata, Gerardo, additional, Costamagna, Osvaldo, additional, Llois, Susana, additional, Waites, Jonathon H, additional, Collins, Nicholas, additional, Soward, Allan, additional, Hii, Chris LS, additional, Shaw, James, additional, Arstall, Margaret A, additional, Horowitz, John, additional, Ninio, Daniel, additional, Rogers, James F, additional, Colquhoun, David, additional, Oqueli Flores, Romulo E, additional, Roberts-Thomson, Philip, additional, Raffel, Owen, additional, Lehman, Sam J, additional, Aroney, Constantine, additional, Coverdale, Steven GM, additional, Garrahy, Paul J, additional, Starmer, Gregory, additional, Sader, Mark, additional, Carroll, Patrick A, additional, Dick, Ronald, additional, Zweiker, Robert, additional, Hoppe, Uta, additional, Huber, Kurt, additional, Berger, Rudolf, additional, Delle-Karth, Georg, additional, Frey, Bernhard, additional, Weidinger, Franz, additional, Faes, Dirk, additional, Hermans, Kurt, additional, Pirenne, Bruno, additional, Leone, Attilio, additional, Hoffer, Etienne, additional, Vrolix, Mathias CM, additional, Wolf, Luc De, additional, Wollaert, Bart, additional, Castadot, Marc, additional, Dujardin, Karl, additional, Beauloye, Christophe, additional, Vervoort, Geert, additional, Striekwold, Harry, additional, Convens, Carl, additional, Roosen, John, additional, Barbato, Emanuele, additional, Claeys, Marc, additional, Cools, Frank, additional, Terzic, Ibrahim, additional, Barakovic, Fahir, additional, Midzic, Zlatko, additional, Pojskic, Belma, additional, Fazlibegovic, Emir, additional, Durak-Nalbantic, Azra, additional, Kulić, Mehmed, additional, Vulic, Dusko, additional, Muslibegovic, Adis, additional, Goronja, Boris, additional, Reis, Gilmar, additional, Sousa, Luciano, additional, Nicolau, Jose C, additional, Giorgeto, Flavio E, additional, Silva, Ricardo P, additional, Maia, Lilia Nigro, additional, Rech, Rafael, additional, Rossi, Paulo RF, additional, Cerqueira, Maria José AG, additional, Duda, Norberto, additional, Kalil, Renato, additional, Kormann, Adrian, additional, Abrantes, José Antonio M, additional, Filho, Pedro Pimentel, additional, Soggia, Ana Priscila, additional, de Santos, Mayler ON, additional, Neuenschwander, Fernando, additional, Bodanese, Luiz C, additional, Michalaros, Yorghos L, additional, Eliaschewitz, Freddy G, additional, Vidotti, Maria H, additional, Leaes, Paulo E, additional, Botelho, Roberto V, additional, Kaiser, Sergio, additional, Manenti, Euler Roberto F Fernandes, additional, Precoma, Dalton B, additional, Moura Jorge, Jose C, additional, Silva, Pedro, additional, Silveira, Jose A, additional, Saporito, Wladmir, additional, Neto, Jose A Marin, additional, Feitosa, Gilson S, additional, Ritt, Luiz Eduardo F, additional, de Souza, Juliana A, additional, Costa, Fernando, additional, Souza, Weimar KSB, additional, Reis, Helder JL, additional, Machado, Leandro, additional, Aidar Ayoub, José Carlos, additional, Todorov, Georgi V, additional, Nikolov, Fedya P, additional, Velcheva, Elena S, additional, Tzekova, Maria L, additional, Benov, Haralambi O, additional, Petranov, Stanislav L, additional, Tumbev, Haralin S, additional, Shehova-Yankova, Nina S, additional, Markov, Dimitar T, additional, Raev, Dimitar H, additional, Mollov, Mihail N, additional, Kichukov, Kostadin N, additional, Ilieva- Pandeva, Katya A, additional, Ivanova, Raya, additional, Gospodinov, Maryana, additional, Mincheva, Valentina M, additional, Lazov, Petar V, additional, Dimov, Bojidar I, additional, Senaratne, Manohara, additional, Stone, James, additional, Kornder, Jan, additional, Pearce, Stephen, additional, Dion, Danielle, additional, Savard, Daniel, additional, Pesant, Yves, additional, Pandey, Amritanshu, additional, Robinson, Simon, additional, Gosselin, Gilbert, additional, Vizel, Saul, additional, Hoag, Gordon, additional, Bourgeois, Ronald, additional, Morisset, Anne, additional, Sabbah, Eric, additional, Sussex, Bruce, additional, Kouz, Simon, additional, MacDonald, Paul, additional, Diaz, Ariel, additional, Michaud, Nicolas, additional, Fell, David, additional, Leung, Raymond, additional, Vuurmans, Tycho, additional, Lai, Christopher, additional, Nigro, Frank, additional, Davies, Richard, additional, Nogareda, Gustavo, additional, Vijayaraghavan, Ram, additional, Ducas, John, additional, Lepage, Serge, additional, Mehta, Shamir, additional, Cha, James, additional, Dupuis, Robert, additional, Fong, Peter, additional, Lutchmedial, Sohrab, additional, Rodes-Cabau, Josep, additional, Fadlallah, Hussein, additional, Cleveland, David, additional, Huynh, Thao, additional, Bata, Iqbal, additional, Hameed, Adnan, additional, Pincetti, Cristian, additional, Potthoff, Sergio, additional, Prieto, Juan C, additional, Acevedo, Monica, additional, Aguirre, Arnoldo, additional, Vejar, Margarita, additional, Yañez, Mario, additional, Araneda, Guillermo, additional, Fernandez, Mauricio, additional, Perez, Luis, additional, Varleta, Paola, additional, Florenzano, Fernando, additional, Huidobro, Laura, additional, Raffo, Carlos A, additional, Olivares, Claudia, additional, Nahuelpan, Leonardo, additional, Montecinos, Humberto, additional, Chen, Jiyan, additional, Dong, Yugang, additional, Huang, Weijian, additional, Wang, Jianzhong, additional, Huang, Shi’An, additional, Yao, Zhuhua, additional, Li, Xiang, additional, Cui, Lan, additional, Lin, Wenhua, additional, Sun, Yuemin, additional, Wang, Jingfeng, additional, Li, Jianping, additional, Zhang, Xuelian, additional, Zhu, Hong, additional, Chen, Dandan, additional, Huang, Lan, additional, Dong, Shaohong, additional, Su, Guohai, additional, Xu, Biao, additional, Su, Xi, additional, Cheng, Xiaoshu, additional, Lin, Jinxiu, additional, Zong, Wenxia, additional, Li, Huanming, additional, Feng, Yi, additional, Xu, Dingli, additional, Yang, Xinchun, additional, Ke, Yuannan, additional, Lin, Xuefeng, additional, Zhang, Zheng, additional, Zheng, Zeqi, additional, Luo, Zhurong, additional, Chen, Yundai, additional, Ding, Chunhua, additional, Zhong, Yi, additional, Zheng, Yang, additional, Li, Xiaodong, additional, Peng, Daoquan, additional, Zhao, Shuiping, additional, Li, Ying, additional, Liu, Xuebo, additional, Wei, Meng, additional, Liu, Shaowen, additional, Yu, Yihua, additional, Qu, Baiming, additional, Jiang, Weihong, additional, Zhou, Yujie, additional, Zhao, Xingsheng, additional, Yuan, Zuyi, additional, Guo, Ying, additional, Xu, Xiping, additional, Shi, Xubo, additional, Ge, Junbo, additional, Fu, Guosheng, additional, Bai, Feng, additional, Fang, Weiyi, additional, Shou, Xiling, additional, Yang, Xiangjun, additional, Wang, Jian’An, additional, Xiang, Meixiang, additional, Sun, Yingxian, additional, Lu, Qinghua, additional, Zhang, Ruiyan, additional, Zhu, Jianhua, additional, Xu, Yizhou, additional, Fan, Zhongcai, additional, Li, Tianchang, additional, Wu, Chun, additional, Jaramillo, Nicolas, additional, Vallejo, Gregorio Sanchez, additional, Luna Botia, Diana C, additional, Lopez, Rodrigo Botero, additional, De Salazar, Dora I Molina, additional, Bonfanti, Alberto J Cadena, additional, Aroca, Carlos Cotes, additional, Higuera, Juan Diego, additional, Blanquicett, Marco, additional, Barrera Silva, Sandra I, additional, Garcia Lozada, Henry J, additional, Coronel Arroyo, Julian A, additional, Accini Mendoza, Jose L, additional, Fernandez Ruiz, Ricardo L, additional, Quintero Ossa, Alvaro M., additional, Manzur Jatin, Fernando G, additional, Sotomayor Herazo, Aristides, additional, Parada, Jeffrey Castellanos, additional, Arambula, Rafael Suarez, additional, Urina Triana, Miguel A, additional, Trujillo, Angela M Fernandez, additional, Strozzi, Maja, additional, Car, Siniša, additional, Miličić, Davor, additional, Lovrić Benčić, Martina, additional, Pintarić, Hrvoje, additional, Prvulović, Đeiti, additional, Šikić, Jozica, additional, Peršić, Viktor, additional, Mileta, Dean, additional, Štambuk, Kresimir, additional, Babić, Zdravko, additional, Tomulic, Vjekoslav, additional, Lukenda, Josip, additional, Mejic-Krstulovic, Stanka, additional, Starcevic, Boris, additional, Spinar, Jindrich, additional, Horak, David, additional, Velicka, Zdenek, additional, Alan, David, additional, Machova, Vilma, additional, Linhart, Ales, additional, Novotny, Vojtech, additional, Kaucak, Vladimir, additional, Rokyta, Richard, additional, Naplava, Robert, additional, Coufal, Zdenek, additional, Adamkova, Vera, additional, Podpera, Ivo, additional, Zizka, Jiri, additional, Motovska, Zuzana, additional, Marusincova, Ivana, additional, Heinc, Petr, additional, Kuchar, Jiri, additional, Povolny, Petr, additional, Matuska, Jiri, additional, Poulsen, Steen H, additional, Raungaard, Bent, additional, Clemmensen, Peter, additional, Bang, Lia E, additional, May, Ole, additional, Bøttcher, Morten, additional, Hove, Jens D, additional, Frost, Lars, additional, Gislason, Gunnar, additional, Larsen, John, additional, Johansen, Peter Betton, additional, Hald, Flemming, additional, Johansen, Peter, additional, Jeppesen, Jørgen, additional, Nielsen, Tonny, additional, Kristensen, Kjeld S, additional, Walichiewicz, Piotr Maria, additional, Lomholdt, Jens D, additional, Klausen, Ib C, additional, Nielsen, Peter Kaiser, additional, Davidsen, Flemming, additional, Videbaek, Lars, additional, Soots, Mai, additional, Vahula, Veiko, additional, Hedman, Anu, additional, Soopõld, Üllar, additional, Märtsin, Kaja, additional, Jurgenson, Tiina, additional, Kristjan, Arved, additional, Vikman, Saila, additional, Huikuri, Heikki, additional, Airaksinen, Juhani, additional, Coste, Pierre, additional, Ferrari, Emile, additional, Morel, Olivier, additional, Montalescot, Gilles, additional, Machecourt, Jacques, additional, Barone-Rochette, Gilles, additional, Mansourati, Jacques, additional, Cottin, Yves, additional, Steg, Ph. Gabriel, additional, Leclercq, Florence, additional, Belhassane, Abdelkader, additional, Delarche, Nicolas, additional, Boccara, Franck, additional, Paganelli, Franck, additional, Clerc, Jérôme, additional, Schiele, Francois, additional, Aboyans, Victor, additional, Probst, Vincent, additional, Berland, Jacques, additional, Lefèvre, Thierry, additional, Khintibidze, Irakli, additional, Shaburishvili, Tamaz, additional, Pagava, Zurab, additional, Ghlonti, Ramaz, additional, Lominadze, Zaza, additional, Khabeishvili, George, additional, Hemetsberger, Rayyan, additional, Edward, Kemala, additional, Rauch-Kröhnert, Ursula, additional, Stratmann, Matthias, additional, Appel, Karl-Friedrich, additional, Schmidt, Ekkehard, additional, Omran, Heyder, additional, Stellbrink, Christoph, additional, Dorsel, Thomas, additional, Lianopoulos, Emmanouil, additional, Vöhringer, Hans Friedrich, additional, Marx, Roger, additional, Zirlik, Andreas, additional, Schellenberg, Detlev, additional, Heitzer, Thomas, additional, Laufs, Ulrich, additional, Werner, Christian, additional, Gielen, Stephan, additional, Nuding, Sebastian, additional, Winkelmann, Bernhard, additional, Behrens, Steffen, additional, Sydow, Karsten, additional, Karakas, Mahir, additional, Simonis, Gregor, additional, Muenzel, Thomas, additional, Werner, Nikos, additional, Leggewie, Stefan, additional, Böcker, Dirk, additional, Braun- Dullaeus, Rüdiger, additional, Toursarkissian, Nicole, additional, Jeserich, Michael, additional, Weißbrodt, Matthias, additional, Schaeufele, Tim, additional, Weil, Joachim, additional, Völler, Heinz, additional, Waltenberger, Johannes, additional, Natour, Mohammed, additional, Schmitt, Susanne, additional, Müller-Wieland, Dirk, additional, Steiner, Stephan, additional, Heidenreich, Lothar, additional, Offers, Elmar, additional, Gremmler, Uwe, additional, Killat, Holger, additional, Rieker, Werner, additional, Patsilinakos, Sotiris, additional, Kartalis, Athanasios, additional, Manolis, Athanassios, additional, Sionis, Dimitrios, additional, Chachalis, Geargios, additional, Skoumas, Ioannis, additional, Athyros, Vasilios, additional, Vardas, Panagiotis, additional, Parthenakis, Frangkiskos, additional, Hahalis, Georgios, additional, Lekakis, John, additional, Hatzitolios, Apostolos, additional, Fausto Ovando, Sergio R, additional, Montenegro Valdovinos, Pablo Carlos, additional, Arango Benecke, Juan L, additional, Rodriguez De Leon, Edgar R, additional, Yan, Bryan PY, additional, Siu, David CW, additional, Turi, Tibor, additional, Merkely, Bela, additional, Gabor Kiss, Robert, additional, Ungi, Imre, additional, Lupkovics, Geza, additional, Nagy, Lajos, additional, Katona, András, additional, Édes, István, additional, Müller, Gábor, additional, Horvath, Iván, additional, Kapin, Tibor, additional, Szigeti, Zsolt, additional, Faluközy, József, additional, Kumbla, Mukund, additional, Sandhu, Manjinder, additional, Annam, Sharath, additional, Reddy Proddutur, Naveen, additional, Regella, Reddy, additional, Premchand, Rajendra K, additional, Mahajan, Ajaykumar, additional, Pawar, Sudhir, additional, Abhyanakar, Atul D, additional, Kerkar, Prafulla, additional, Govinda, Ravishankar A, additional, Oomman, Abraham, additional, Sinha, Dhurjati, additional, Patil, Sachin N, additional, Kahali, Dhiman, additional, Sawhney, Jitendra, additional, Joshi, Abhijeet B, additional, Chaudhary, Sanjeev, additional, Harkut, Pankaj, additional, Guha, Santanu, additional, Porwal, Sanjay, additional, Jujjuru, Srimannarayana, additional, Pothineni, Ramesh B, additional, Monteiro, Minguel R, additional, Khan, Aziz, additional, Iyengar, Shamanna S, additional, Grewal, Jasprakash Singh, additional, Chopda, Manoj, additional, Fulwani, Mahesh C, additional, Patange, Dr. Aparna, additional, Sachin, Patil, additional, Chopra, Vijay K, additional, Goyal, Naresh K, additional, Shinde, Rituparna, additional, Manakshe, Gajendra V, additional, Patki, Nitin, additional, Sethi, Sumeet, additional, Munusamy, Vengatesh, additional, Sunil Thanvi, Sunil Karnaand, additional, Adhyapak, Srilakshmi, additional, Patil, Chandrakant, additional, Pandurangi, Ulhas, additional, Mathur, Rishabh, additional, Gupta, Jugal, additional, Kalashetti, Suhas, additional, Bhagwat, Ajit, additional, Raghuraman, Bagirath, additional, Kumar Yerra, Shiv, additional, Bhansali, Prasant, additional, Borse, Rohidas, additional, Rahul, Patil, additional, Das, Srihari, additional, Kumar, Vinay, additional, Abdullakutty, Jabir, additional, Saathe, Shireesh, additional, Palimkar, Priya, additional, Abdullkutty, Jabir, additional, Sathe, Shireesh, additional, Atar, Shaul, additional, Shechter, Michael, additional, Mosseri, Morris, additional, Arbel, Yaron, additional, Ehud, Chorin, additional, Ofer, Havakuk, additional, Lotan, Chaim, additional, Rosenschein, Uri, additional, Katz, Amos, additional, Henkin, Yaakov, additional, Francis, Adi, additional, Klutstein, Marc, additional, Nikolsky, Eugenia, additional, Zukermann, Robert, additional, Turgeman, Yoav, additional, Halabi, Majdi, additional, Marmor, Alon, additional, Kornowski, Ran, additional, Jonas, Michael, additional, Amir, Offer, additional, Hasin, Yonathan, additional, Rozenman, Yoseph, additional, Fuchs, Shmuel, additional, Zvi, Vered, additional, Hussein, Osamah, additional, Gavish, Dov, additional, Vered, Zvi, additional, Caraco, Yoseph, additional, Elias, Mazen, additional, Tov, Naveh, additional, Wolfovitz, Efrat, additional, Lishner, Michael, additional, Elias, Nizar, additional, Piovaccari, Giancarlo, additional, Pellegrin, Annamaria De, additional, Garbelotto, Raffaella, additional, Guardigli, Gabriele, additional, Marco, Valgimigli, additional, Licciardello, Giovanni, additional, Auguadro, Carla, additional, Scalise, Filippo, additional, Cuccia, Claudio, additional, Salvioni, Alessandro, additional, Musumeci, Giuseppe, additional, Senni, Michelle, additional, Calabrò, Paolo, additional, Novo, Salvatore, additional, Faggiano, Pompilio, additional, Metra, Marco, additional, De Cesare, Nicoletta B, additional, Berti, Sergio, additional, Puccioni, Enrico, additional, Galvani, Marcello, additional, Tespili, Maurizio, additional, Piatti, Piermarco, additional, Palvarini, Michela, additional, Luca, Giuseppe De, additional, Violini, Roberto, additional, Leo, Alessandro De, additional, Olivari, Zoran, additional, Filardi, Pasquale Perrone, additional, Ferratini, Maurizio, additional, Racca, Vittorio, additional, Dai, Kazuoki, additional, Shimatani, Yuji, additional, Kamiya, Haruo, additional, Ando, Kenji, additional, Takeda, Yoshihiro, additional, Morino, Yoshihiro, additional, Hata, Yoshiki, additional, Kimura, Kazuo, additional, Kishi, Koichi, additional, Michishita, Ichiro, additional, Uehara, Hiroki, additional, Higashikata, Toshinori, additional, Hirayama, Atsushi, additional, Hirooka, Keiji, additional, Doi, Yasuji, additional, Sakagami, Satoru, additional, Taguchi, Shuichi, additional, Koike, Akihiro, additional, Fujinaga, Hiroyuki, additional, Koba, Shinji, additional, Kozuma, Ken, additional, Kawasaki, Tomohiro, additional, Ono, Yujiro, additional, Shimizu, Masatoshi, additional, Katsuda, Yousuke, additional, Wada, Atsuyuki, additional, Shinke, Toshiro, additional, Ako, Junya, additional, Fujii, Kenshi, additional, Takahashi, Toshiyuki, additional, Nakao, Koichi, additional, Furukawa, Yutaka, additional, Sugino, Hiroshi, additional, Tamura, Ritsu, additional, Mano, Toshiaki, additional, Uematsu, Masaaki, additional, Utsu, Noriaki, additional, Ito, Kashima, additional, Haraguchi, Takuya, additional, Sato, Katsuhiko, additional, Ueda, Yasunori, additional, Nishibe, Akira, additional, Fujimoto, Kazuteru, additional, Masutani, Motomaru, additional, Yoon, Jung Han, additional, Kim, Hack-Lyoung, additional, Sik Park, Hun, additional, Chae, In-Ho, additional, Kim, Moo Hyun, additional, Jeong, Myung Ho, additional, Rha, Seungwoon, additional, Kim, Chongjin, additional, Kim, Hyo-Soo, additional, Kim, Hae Young, additional, Hong, Taekjong, additional, Tahk, Seung-Jea, additional, Kim, Youngkwon, additional, Busmane, Arija, additional, Pontaga, Natalija, additional, Strelnieks, Aldis, additional, Mintale, Iveta, additional, Sime, Iveta, additional, Petrulioniene, Zaneta, additional, Kavaliauskiene, Roma, additional, Jurgaitiene, Ruta, additional, Sakalyte, Gintare, additional, Slapikas, Rimvydas, additional, Norkiene, Sigute, additional, Misonis, Nerijus, additional, Kibarskis, Aleksandras, additional, Kubilius, Raimondas, additional, Bojovski, Stojko, additional, Lozance, Nensi, additional, Kjovkaroski, Aleksandar, additional, Doncovska, Snezana, additional, Ong, Tiong Kiam, additional, Kasim, Sazzli, additional, Maskon, Oteh, additional, Kandasamy, Balachandran, additional, Liew, Houng B, additional, Wan Mohamed, Wan Mohd Izani, additional, Castillo, Armando García, additional, Calvillo, Jorge Carrillo, additional, Campos, Pedro Fajardo, additional, Núñez Fragoso, Juan Carlos, additional, Bayram Llamas, Edmundo Alfredo, additional, Alcocer Gamba, Marco Antonio, additional, Madrigal, Jaime Carranza, additional, González Salas, Luis Gerardo, additional, Rosas, Enrique López, additional, González Díaz, Belinda, additional, Vázquez, Eduardo Salcido, additional, Nacoud Ackar, Alfredo, additional, Llamas Esperón, Guillermo Antonio, additional, Martínez Sánchez, Carlos Rodolfo, additional, De Leon, María Guerrero, additional, Suarez Otero, Rodrigo, additional, Salmón, Guillermo Fanghänel, additional, Pérez Ríos, Jesús Antonio, additional, Garza Ruíz, José Angel, additional, Breedveld, Robert W, additional, Feenema-Aardema, Margriet, additional, Borger-Van Der Burg, Alida, additional, Hoogslag, Pieter AM, additional, Suryapranata, Harry, additional, Oomen, Antonius, additional, Van Haelst, Paulus, additional, Feenema-Aradema, Margriet, additional, Wiersma, Jacobijne J, additional, Basart, Dirk, additional, Van Der Wal, Ruud MA, additional, Zwart, Peter, additional, Monraats, Pascalle, additional, Van Kesteren, Henricus, additional, Karalis, Ioannis, additional, Jukema, Johan, additional, Verdel, Gerardus JE, additional, Brueren, Bart RG, additional, Troquay, Roland PTh, additional, Viergever, Eric P, additional, Al-Windy, Nadea YY, additional, Bartels, Gerard L, additional, Cornel, Jan H, additional, Hermans, Walter RM, additional, Herrman, Johannes PR, additional, Bos, Robert J, additional, Groutars, Reginald GEJ, additional, Van Der Zwaan, Coenraad C, additional, Kaplan, Refik, additional, Ronner, Eelko, additional, Groenemeijer, Bjorn E, additional, Bronzwaer, Patrick NA, additional, Liem, Anho AH, additional, Rensing, Bernard JWM, additional, Bokern, Marcel JJA, additional, Nijmeijer, Remco, additional, Hersbach, Ferry MRJ, additional, Willems, Frank F, additional, Gosselink, Antonius TM, additional, Rasoul, Saman, additional, Elliott, John, additional, Wilkins, Gerard, additional, Fisher, Raewyn, additional, Scott, Douglas, additional, Hart, Hamish, additional, Stewart, Ralph, additional, Harding, Scott, additional, Ternouth, Ian, additional, Fisher, Nicholas, additional, Wilson, Samuel, additional, Aitken, Denise, additional, Anscombe, Russell, additional, Davidson, Laura, additional, Tomala, Tadeusz, additional, Nygård, Ottar, additional, Sparby, Jon Arne, additional, Andersen, Kjell, additional, Gullestad, Lars, additional, Jortveit, Jarle, additional, Munk, Peter S, additional, Singsaas, Erlend gyllensten, additional, Hurtig, Ulf, additional, Calderon Ticona, Jorge R, additional, Durand Velasquez, Julio R, additional, Negron Miguel, Sandra A, additional, Sanabria Perez, Enrique S, additional, Carrion Chambilla, Jesus M, additional, Chavez Ayala, Carlos A, additional, Castillo Leon, Reynaldo P, additional, Vargas GonzalesC, Rolando J, additional, Hernandez Zuniga, Jose D, additional, Camacho Cosavalente, Luis A, additional, Bravo Mannucci, Jorge E, additional, Landeo, Javier Heredia, additional, Llerena Navarro, Nassip C, additional, Roldan Concha, Yudy M, additional, Rodriguez Chavez, Víctor E, additional, Anchante Hernandez, Henry A, additional, Zea Nunez, Carlos A, additional, Ramos, Walter Mogrovejo, additional, Ferrolino, Arthur, additional, Sy, Rosa Allyn G, additional, Tirador, Louie, additional, Matiga, Generoso, additional, Coching, Raul Martin, additional, Bernan, Alisa, additional, Rogelio, Gregorio, additional, Morales, Dante D., additional, Tan, Edgar, additional, Sulit, Dennis Jose, additional, Wlodarczak, Adrian, additional, Skonieczny, Grzegorz, additional, Pawlowicz, Lidia, additional, Wojewoda, Pawel, additional, Busz-Papiez, Benita, additional, Bednarski, Janusz, additional, Goch, Aleksander, additional, Staneta, Pawel, additional, Dulak, Elzbieta, additional, Saminski, Krzysztof, additional, Krasowski, Wlodzimierz, additional, Sudnik, Wanda, additional, Zurakowski, Aleksander, additional, Skorski, Marcin, additional, Lysek, Roman, additional, Miklaszewicz, Beata, additional, Lipko, Jan Andrzej, additional, Kostarska-Srokosz, Edyta, additional, Piepiorka, Marek, additional, Drzewiecka, Anna, additional, Stasiewski, Arkadiusz, additional, Blicharski, Tomasz, additional, Bystryk, Leszek, additional, Szpajer, Michal, additional, Korol, Marek, additional, Czerski, Tomasz, additional, Gniot, Jacek, additional, Lubinski, Andrzej, additional, Gorny, Jerzy, additional, Franek, Edward, additional, Raczak, Grzegorz, additional, Szwed, Hanna, additional, Monteiro, Pedro, additional, Mesquita Bastos, Jose, additional, Pereira, Helder H, additional, Seixo, Filipe, additional, Mendonça, Carlos, additional, Botelho, Ana, additional, Caetano, Francisca, additional, Minescu, Bogdan, additional, Istratoaie, Octavian, additional, Tesloianu, Dan N, additional, Cristian, Gabriel, additional, Dumitrescu, Silviu, additional, Podoleanu, Cristian GC, additional, Constantinescu, Mircea CA, additional, Bengus, Cristina M, additional, Militaru, Constantin, additional, Rosu, Doina, additional, Parepa, Irinel R, additional, Matei, Adrian V, additional, Alexandru, Tom M, additional, Malis, Mihaela, additional, Coman, Ioan, additional, Shvarts, Yury, additional, Orlikova, Olga, additional, Kobalava, Zhanna, additional, Barbarash, Olga L, additional, Markov, Valentin, additional, Lyamina, Nadezhda, additional, Gordienko, Alexander, additional, Zrazhevsky, Konstantin, additional, Vishnevsky, Alexander Y, additional, Gurevich, Victor, additional, Stryuk, Raisa, additional, Lomakin, Nikita V, additional, Bokarev, Igor, additional, Khlevchuk, Tatiana, additional, Shalaev, Sergey, additional, Khaisheva, Larisa, additional, Chizhov, Petr, additional, Viktorova, Inna, additional, Osokina, Natalya, additional, Shchekotov, Vladimir, additional, Akatova, Evgenia, additional, Chumakova, Galina, additional, Libov, Igor, additional, Voevoda, Mikhail I, additional, Tretyakova, Tatyana V, additional, Baranov, Evgeny, additional, Shustov, Sergey, additional, Yakushin, Sergey, additional, Gordeev, Ivan, additional, Khasanov, Niiaz, additional, Reshetko, Olga, additional, Sotnikova, Tatiana, additional, Molchanova, Olga, additional, Nikolaev, Konstantin, additional, Gapon, Liudmila, additional, Baranova, Elena, additional, Kosmachova, Elena, additional, Karpov, Yuriy, additional, Povzun, Anton, additional, Egorova, Liudmila, additional, Tyrenko, Vadim V, additional, Ivanov, Igor G, additional, Ilya, Masterov, additional, Kanorsky, Sergey, additional, Simic, Dragan, additional, Ivanovic, Nikola, additional, Davidovic, Goran, additional, Tasic, Nebojsa, additional, Asanin, Milika R., additional, Stojic, Stevo, additional, Apostolovic, Svetlana R., additional, Ilic, Stevan, additional, Tosic, Biljana Putnikovic, additional, Stankovic, Aleksandar, additional, Arandjelovic, Aleksandra, additional, Radovanovic, Slavica, additional, Todic, Branislava, additional, Balinovac, Jovan, additional, Dincic, Dragan V., additional, Seferovic, Petar, additional, Karadzic, Ana, additional, Dodic, Slobodan, additional, Dimkovic, Sinisa, additional, Jakimov, Tamara, additional, Poh, Kian-Keong, additional, Yee Ong, Hean, additional, Tang I-Shing, Justin, additional, Micko, Karol, additional, Nociar, Jan, additional, Pella, Daniel, additional, Fulop, Peter, additional, Hranai, Marian, additional, Palka, Juraj, additional, Mazur, Juraj, additional, Majercák, Ivan, additional, Dzupina, Andrej, additional, Fazekas, František, additional, Gonsorcik, Jozef, additional, Bugan, Viliam, additional, Selecky, Juraj, additional, Kamensky, Gabriel, additional, Strbova, Jaroslava, additional, Smik, Rudolf, additional, Dukat, Andrej, additional, Olexa, Peter, additional, Žuran, Ivan, additional, Poklukar, Janez, additional, Šuligoj, Nataša Černič, additional, Cevc, Matija, additional, Cyster, Henry P, additional, Ranjith, Naresh, additional, Corbett, Clive, additional, Bayat, Junaid, additional, Makoali Makotoko, Ellen, additional, du Toit Theron, Hendrik, additional, Kapp, Ilse E, additional, de V Basson, Matthys M, additional, Lottering, Hanlie, additional, Aswegen, Dina Van, additional, Van Zyl, Louis J, additional, Sebastian, Peter J, additional, Pillay, Thayabran, additional, Saaiman, Jan A, additional, Commerford, Patrick J, additional, Cassimjee, Soraya, additional, Riaz, Garda, additional, Ebrahim, Iftikhar O, additional, Sarvan, Mahomed, additional, Mynhardt, Joseph H, additional, Reuter, Helmuth, additional, Moodley, Rajendran, additional, Vida, Manuel, additional, Fillat, Angel R. Cequier, additional, Peris, Vicente Bodí, additional, Jimenez, Francisco Fuentes, additional, Marín, Francisco, additional, Cruz Fernández, Jose M, additional, Hidalgo Urbano, Rafael Jesus, additional, Gil-Extremera, Blas, additional, Toledo, Pablo, additional, Worner Diz, Fernando, additional, Garcia-Dorado, David, additional, Iñiguez, Andres, additional, Gonzalez-Juanatey, Jose R, additional, Portales, Javier Fernandez, additional, Murillo, Fernando Civeira, additional, Pericas, Laia Matas, additional, Zamorano, Jose Luis, additional, De Mora Martin, Manuel, additional, Cortada, Jordi Bruguera, additional, Alonso Martin, Joaquin J, additional, Serrano Antolin, Jose Maria, additional, De Berrazueta Fernández, José R, additional, Vázquez de Prada, José Antonio, additional, Díaz Fernández, Jose Francisco, additional, García Lledó, José Alberto, additional, Cosín Sales, Juan, additional, Rodriguez, Javier Botas, additional, Tragant, Gabriel Gusi, additional, Benedicto, Amparo, additional, Gonzalez-Juanatey, Carlos, additional, Camprubí Potau, Mercedes, additional, Perez, Ignacio Plaza, additional, De La Tassa, César Morís, additional, Rincon, Pablo Loma-Osorio, additional, Recena, Javier Balaguer, additional, Escudier, Juan M, additional, Payeras, Antonio Coca, additional, Orcajo, Norberto Alonso, additional, Constantine, Godwin, additional, Haniffa, Ruvaiz, additional, Tissera, Nirmali, additional, Amarasekera, Stanley, additional, Ponnamperuma, Chandrike, additional, Fernando, Nimali, additional, Fernando, Kaputella, additional, Jayawardena, Jayanthimala, additional, Wijeyasingam, Santharaj, additional, Ranasinghe, Gotabhaya, additional, Ekanayaka, Ruvan, additional, Mendis, Sepalika, additional, Senaratne, Vajira, additional, Mayurathan, Gnanamoorthy, additional, Rajapaksha, Ajantha, additional, Sirisena, Thilak, additional, Herath, Jagath I, additional, Amarasena, Naomali, additional, Berglund, Stefan, additional, Rasmanis, Gundars, additional, Vedin, Ola, additional, Witt, Nils, additional, Mourtzinis, Georgios, additional, Nicol, Peter, additional, Hansen, Ole, additional, Romeo, Stefano, additional, Jensen, Steen Agergaard, additional, Torstensson, Ingemar, additional, Ahremark, Ulf, additional, Sundelin, Torbjörn, additional, Moccetti, Tiziano, additional, Mach, Francois, additional, Binde, Ronald, additional, Gämperli, Oliver, additional, Tsai, Wei- Chuan, additional, Ueng, Kwo-Chang, additional, Lai, Wen-Ter, additional, Liu, Ming-En, additional, Hwang, Juey- Jen, additional, Yin, Wei-Hsian, additional, Hsieh, I-Chang, additional, Hsieh, Ming-Jer, additional, Hsiang Lin, Wei, additional, Kuo, Jen-Yuan, additional, Huang, Tsuei-Yuan, additional, Fang, Chih-Yuan, additional, Kaewsuwanna, Pinij, additional, Soonfuang, Wasant, additional, Jintapakorn, Woravut, additional, Sukonthasarn, Apichard, additional, Wongpraparut, Nattawut, additional, Sastravaha, Krisada, additional, Sansanayudh, Nakarin, additional, Kehasukcharoen, Wirash, additional, Piyayotai, Dilok, additional, Chotnoparatpat, Paiboon, additional, Camsari, Ahmet, additional, Kultursay, Hakan, additional, Mutlu, Bulent, additional, Ersanli, Murat, additional, Demirtas, Mustafa, additional, Kirma, Cevat, additional, Ural, Ertan, additional, Koldas, Lale, additional, Karpenko, Oleksandr, additional, Prokhorov, Alexander, additional, Vakaluyk, Ihor, additional, Myshanych, Halyna, additional, Reshotko, Dmytro, additional, Batushkin, Valeriy, additional, Rudenko, Leonid, additional, Kovalskyi, Ihor, additional, Kushnir, Mykola, additional, Tseluyko, Vira, additional, Mostovoy, Yuriy, additional, Stanislavchuk, Mykola, additional, Kyiak, Yulian, additional, Karpenko, Yuriy, additional, Malynovsky, Yaroslav, additional, Klantsa, Andriy, additional, Kutniy, Oles, additional, Amosova, Ekaterina, additional, Tashchuk, Viktor, additional, Leshchuk, Oleh, additional, Rishko, Mykola, additional, Kopytsya, Mykola, additional, Yagensky, Andriy, additional, Vatutin, Mykola, additional, Bagriy, Andriy, additional, Barna, Olga M, additional, Ushakov, Olexiy, additional, Dzyak, Georgiy, additional, Goloborodko, Borys, additional, Rudenko, Anatolii, additional, Zheleznyy, Volodymyr, additional, Trevelyan, Jasper, additional, Zaman, Azfar, additional, Lee, Kaeng, additional, Moriarty, Andrew, additional, Aggarwal, Rajesh K, additional, Clifford, Piers, additional, Wong, Yuk- Ki, additional, Iqbal, Syed MR, additional, Subkovas, Eduardas, additional, Braganza, Denise, additional, Sarkar, David, additional, Storey, Robert, additional, Griffiths, Huw, additional, Mcclure, Sam, additional, Muthusamy, Rangasamy, additional, Smith, Simon, additional, Kurian, John, additional, Levy, Terry, additional, Barr, Craig, additional, Kadr, Honer, additional, Gerber, Robert, additional, Simaitis, Audrius, additional, Soran, Handrean, additional, Brodison, Adrian, additional, Ayaz, Mohammad, additional, Cheema, Muhammad, additional, Oliver, Richard, additional, Thackray, Simon, additional, Mudawi, Telal, additional, Rahma, Gohar, additional, Sultan, Ayyaz, additional, Reynolds, Timothy, additional, Sharman, David, additional, Spriging, david, additional, Butler, Rob, additional, Wilkinson, Peter, additional, Lip, Gregory YH, additional, Ossei-Gerning, Nicholas, additional, Vardi, Gil, additional, Baldari, Duccio, additional, Brabham, David, additional, Treasure II, Charles, additional, Dahl, Charles, additional, Palmer, Bruce, additional, Wiseman, Alan, additional, Khan, Abul, additional, Puri, Sanjeev, additional, Mohart, Ann Elizabeth, additional, Ince, Carlos, additional, Flores, Enrique, additional, Wright, Scott, additional, Cheng, Shi-Chi, additional, Rosenberg, Michael, additional, Rogers, William, additional, Kosinski, Edward, additional, Forgosh, Les, additional, Waltman, Jonathan, additional, Shoukfeh, Mohammad, additional, Dagher, Georges, additional, Cambier, Patrick, additional, Lieber, Ira, additional, Kumar, Priya, additional, East, Cara, additional, Krichmar, Perry, additional, Hasan, Mian, additional, White, Lindsey, additional, Knickelbine, Thomas, additional, Haldis, Thomas, additional, Gillespie, Eve, additional, Amidon, Thomas, additional, Suh, David, additional, Arif, Imran, additional, Abdallah, mouhamad, additional, Akhter, Faiq, additional, Carlson, Eric, additional, D’Urso, Michael, additional, El- Ahdab, Fadi, additional, Nelson, William, additional, Moriarty, Katie, additional, Harris, Barry, additional, Cohen, Steven, additional, Carter, Luther, additional, Doty, Daniel, additional, Sabatino, Kenneth, additional, Haddad, Tariq, additional, Rao, Sunder, additional, Mulkay, Angel, additional, Jovin, Ion, additional, Klancke, Kim, additional, Malhotra, Vinay, additional, Devarapalli, Sai K, additional, Koren, Michael, additional, Chandna, Harish, additional, Dodds III, George, additional, Goraya, Tauqir, additional, Bengston, James, additional, Janik, Matthew, additional, Moran, Joseph, additional, Sumner, Andrew, additional, Kobayashi, John, additional, Davis, William, additional, Yazdani, Shahram, additional, Pasquini, John, additional, Thakkar, Maitreya, additional, Vedere, Amarnath, additional, Leimbach, Wayne, additional, Rider, James, additional, fenton, Sarah, additional, Singh, Narendra, additional, Shah, Anil V, additional, Janosik, Denise, additional, Pepine, Carl, additional, Berman, Brett, additional, Gelormini, Joseph, additional, Daniels, Christopher, additional, Richard, Kerensky, additional, Keating, Friederike, additional, Kondo, Nicholas I, additional, Shetty, Sanjay, additional, Levite, Howard, additional, Waider, Winfried, additional, Takata, Theodore, additional, Abu-Fadel, Mazen, additional, Shah, Vipul, additional, Aggarwal, Rahul, additional, Kumar, Anil, additional, Hattler, Brack, additional, Do, Rose, additional, Link, Chad, additional, Bortnick, Anna, additional, Kinzfogl III, George, additional, Ghitis, Arnold, additional, Larry, John, additional, Teufel, Edward, additional, Kuhlman, Peter, additional, Mclaurin, Brent, additional, Zhang, Wenwu, additional, Thew, Stephen, additional, Abbas, Jalal, additional, White, Matthew, additional, Islam, Othman, additional, Subherwal, Sumeet, additional, Ranadive, Nandkishore, additional, Vakili, Babak, additional, Gring, Christian, additional, Henderson, David, additional, Schuchard, Timothy, additional, Farhat, Naim, additional, Kline, Geoffrey, additional, Mahal, Sharan, additional, Whitaker, Jack, additional, Speirs, Shawn, additional, Andersen, Rolf, additional, Daboul, Nizar, additional, Horwitz, Phillip, additional, Zahr, Firas, additional, Ponce, George, additional, Jafar, Zubair, additional, Mcgarvey, Joseph, additional, Panchal, Vipul, additional, Voyce, Stephen, additional, Blok, Thomas, additional, Sheldon, William, additional, Azizad, Masoud M, additional, Schmalfuss, Carsten, additional, Picone, Mark, additional, Pederson, Robert, additional, Herzog, William, additional, Friedman, Keith, additional, Lindsey, Jason, additional, Timothy, Eichenlaub, additional, Leonard, Parilak, additional, Lepor, Norman, additional, El Shahawy, Mahfouz, additional, Weintraub, Howard, additional, Irimpen, Anand, additional, Alonso, Alvaro, additional, May, Wade, additional, Christopher, Daniels, additional, Galski, Thomas, additional, Chu, Alan, additional, Mody, Freny, additional, Ramin, Ebrahimi, additional, Hodes, Zachary, additional, Rossi, Joseph, additional, Rose, Gregory, additional, Fairlamb, James, additional, Lambert, Charles, additional, Raisinghani, Ajit, additional, Abbate, Antonio, additional, Vetrovec, George, additional, King, Marilyn, additional, Carey, Charles, additional, Gerber, Jaime, additional, Younis, Liwa, additional, Park, Hyeun (Tom), additional, Vidovich, Mladen, additional, Knutson, Thomas, additional, Friedman, Dennis, additional, Chaleff, Fred, additional, Loussararian, Arthur, additional, Rozeman, Phillip, additional, Kimmelstiel, Carey, additional, Kuvin, Jeffrey, additional, Silver, Kevin, additional, Foster, Malcolm, additional, Tonnessen, Glen, additional, Espinoza, Andrey, additional, Amlani, Mohamadali, additional, Wali, Andreas, additional, Malozzi, Christopher, additional, Jong, Geert T, additional, Massey, Clara, additional, Wattanakit, Keattiyoat, additional, O’Donnell, Philip J., additional, Singal, Dinesh, additional, Jaffrani, Naseem, additional, Banuru, Sridhar, additional, Fisher, Daniel, additional, Xenakis, Mark, additional, Perlmutter, Neal, additional, Bhagwat, Ravi, additional, Strader, James, additional, Blonder, Ronald, additional, Akyea-Djamson, Ayim, additional, Labroo, Ajay, additional, Lee, Kwan, additional, Marais, H. John, additional, Claxton, Edmund, additional, Weiss, Robert, additional, Kathryn, Rohr, additional, Berk, Martin, additional, Rossi, Peter, additional, Joshi, Parag, additional, Khera, Amit, additional, Khaira, Ajit S, additional, Kumkumian, Greg, additional, Lupovitch, Steven, additional, Purow, Joshua, additional, Welka, Stephen, additional, Hoffman, David, additional, Fischer, Stuart, additional, Soroka, Eugene, additional, Eagerton, Donald, additional, Pancholy, Samir, additional, Ray, Michael, additional, Erenrich, Norman, additional, Farrar, Michael, additional, Pollock, Stewart, additional, French, William J, additional, Diamantis, Steve, additional, Guy, Douglas, additional, Gimple, Lawrence, additional, Neustel, Mark, additional, Schwartz, Steven, additional, Pereira, Edward, additional, Albert, Seals, additional, Spriggs, Douglas, additional, Strain, Janet, additional, Mittal, Suneet, additional, Vo, Anthony, additional, Chane, Majed, additional, Hall, Jason, additional, Vijay, Nampalli, additional, Lotun, Kapildeo, additional, Lester, F. Martin, additional, Nahhas, Ahed, additional, Pope, Theodore, additional, Nager, Paul, additional, Vohra, Rakesh, additional, Sharma, Mukesh, additional, Bashir, Riyaz, additional, Ahmed, Hinan, additional, Berlowitz, Michael, additional, Fishberg, Robert, additional, Barrucco, Robert, additional, Yang, Eric, additional, Radin, Michael, additional, Sporn, Daniel, additional, Stapleton, Dwight, additional, Eisenberg, Steven, additional, Landzberg, Joel, additional, Mcgough, Martin, additional, Turk, Samir, additional, Schwartz, Michael, additional, Sundram, P. Sandy, additional, Jain, Diwakar, additional, Zainea, Mark, additional, Bayron, Carlos, additional, Karlsberg, Ronald, additional, Dohad, Suhail, additional, Lui, Henry, additional, Keen, William, additional, Westerhausen, Donald, additional, Khurana, Sandeep, additional, Agarwal, Himanshu, additional, Birchem, Jessica, additional, Penny, William, additional, Chang, Mark, additional, Murphy, Sherrill, additional, Henry, John, additional, Schifferdecker, Branislav, additional, Gilbert, John M, additional, Chalavarya, Gopal, additional, Eaton, Charles, additional, Schmedtje, John F, additional, Christenson, Stuart, additional, Dotani, Imran, additional, Denham, Douglas, additional, Macdonell, Alexander, additional, Gibson, Paul, additional, Rahman, Aref, additional, Al Joundi, Tammam, additional, Assi, Nizar, additional, Conrad, Gary, additional, Kotha, Purushotham, additional, Love, Michael, additional, Giesler, Gregory, additional, Rubenstein, Howard, additional, Gamil, Dawood, additional, Akright, Laura, additional, Krawczyk, Justine, additional, Cobler, Joanne, additional, Wells, Terry, additional, Welker, James, additional, Foster, Robert, additional, Gilmore, Richard, additional, Anderson, Jay, additional, Jacoby, Douglas, additional, Harris, Bill, additional, Gardner, Geraldine, additional, Dandillaya, Ramprasad, additional, Vora, Kishor, additional, Kostis, John, additional, Hunter, John, additional, Laxson, David, additional, Ball, Eric, additional, Egydio, Flavia, additional, Kawakami, Anelise, additional, Oliveira, Janaina, additional, Wozniak, Julianna, additional, Matthews, Alexander, additional, Ratky, Caroline, additional, Valiris, Janine, additional, Berdan, Lisa, additional, Hepditch, Anita, additional, Quintero, Kirby, additional, Rorick, Tyrus, additional, Westbrook, Melissa, additional, Bezault, Madeleine, additional, Drouet, Elodie, additional, Simon, Tabassome, additional, Alsweiler, Caroline, additional, Luyten, Anne, additional, Butters, Julie, additional, Griffith, Liddy, additional, Shaw, Michelle, additional, Grunberg, Lena, additional, Islam, Shahidul, additional, Brégeault, Marie-France, additional, Bougon, Nathalie, additional, Faustino, Douglas, additional, Fontecave, Sylvie, additional, Murphy, Judith, additional, Tamby, Jean- Francois, additional, Verrier, Melanie, additional, Agnetti, Veronique, additional, Andersen, Dorthe, additional, Badreddine, Emmy, additional, Bekkouche, Mhamed, additional, Bouancheau, Cecile, additional, Brigui, Imane, additional, Brocklehurst, Maddy, additional, Cianciarulo, Joseph, additional, Devaul, Dawn, additional, Domokos, Szilvia, additional, Gache, Cecile, additional, Gobillot, Caroline, additional, Guillou, Severine, additional, Healy, Jan, additional, Heath, Megan, additional, Jaiwal, Gayatri, additional, Javierre, Carine, additional, Labeirie, Julien, additional, Monier, Myriam, additional, Morales, Ulises, additional, Mrabti, Asmaa, additional, Mthombeni, Bicky, additional, Okan, Betim, additional, Smith, Lucile, additional, Sheller, Jennifer, additional, Sopena, Sebastien, additional, Pellan, Valerie, additional, Benbernou, Fadela, additional, Bengrait, Nafissa, additional, Lamoureux, Maud, additional, Kralova, Katarina, additional, Bejuit, Raphael, additional, Coulange, Anthony, additional, Berthou, Christelle, additional, Repincay, Jérôme, additional, Lorenzato, Christelle, additional, Etienne, Alexis, additional, Gouet, Valerie, additional, Loizeau, Virginie, additional, Normand, Mickael, additional, Ourliac, Anne, additional, Rondel, Christelle, additional, Adamo, Antony, additional, Beltran, Pascale, additional, Barraud, Pauline, additional, Dubois-Gache, Helene, additional, Halle, Benjamin, additional, Metwally, Lamia, additional, Mourgues, Maxime, additional, Sotty, Marc, additional, Vincendet, Marion, additional, Cotruta, Raluca, additional, Chengyue, Zhu, additional, Fournie-Lloret, Dominique, additional, Morrello, Christine, additional, Perthuis, Aurelie, additional, Picault, Patrick, additional, Zobouyan, Isabelle, additional, Colhoun, Helen M., additional, Dempsey, Michael A., additional, and McClanahan, Mark A., additional

Published
2022
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8. The authors reply

Author

Ibarra-Estrada, Miguel Á., primary, Mireles-Cabodevila, Eduardo, additional, García-Salas, Yessica, additional, López-Pulgarín, José A., additional, Chávez-Peña, Quetzalcóatl, additional, García-Salcido, Roxana, additional, Mijangos-Méndez, Julio C., additional, and Aguirre-Avalos, Guadalupe, additional

Published
2022
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10. 222: OBESITY AND COVID-19: A SINGLE-CENTER STUDY

Author

Mijangos-Méndez, Julio, primary, Vargas-Obieta, Alexandra, additional, Garcia-Salcido, Roxana, additional, Ibarra-estrada, Miguel, additional, López-Pulgarín, Jose, additional, Chavez-Peña, Quetzalcoatl, additional, Alvarez-Hernandez, Esther, additional, Lopez-Aguirre, Paulina, additional, Cruz-Muñoz, Beatriz, additional, and Aguirre-Avalos, Guadalupe, additional

Published
2021
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11. Abstract 14213: Injury Characteristics of Chest Compressions in a Swine Model of Infant Asphyxial Cardiac Arrest Using Either 1.5 inch or 1/3 Anterior-Posterior Diameter Depth Targets

Author

David D Salcido, Allison C Koller, Ericka L Fink, Robert A Berg, and James J Menegazzi

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Background: Current AHA guidelines for the delivery of chest compressions (CC) for infants and children are largely consensus based, and recommended depths of 1.5 inches or 1/3 anterior-posterior chest diameter (APD). It is unclear whether these have equal potential for injury. Objectives: We sought to examine and compare injury characteristics of CC delivered at 1.5 inches or 1/3 APD in an infant-sized model of asphyxial OHCA. Methods: Thirty-six juvenile swine weighing 10.6kg +/- 0.84 (approximating the 50 th percentile for a 12-month-old) were anesthetized, paralyzed, intubated, and mechanically ventilated (FiO2 21%). APD was measured and by two investigators via a sliding T-square. After instrumentation, the endotracheal tube was manually occluded to induce asphyxia, and occlusion was maintained for 9 minutes. Animals with an organized rhythm after 8 minutes 45 seconds of asphyxia received a single, 3-second transthoracic shock to induce ventricular fibrillation. At 9 minutes, each was then randomized to receive CC with a depth of 1.5 inches (Group 1) or 1/3 APD (Group 2), both with a rate of 100 per minute. ALS drugs were administered after 13 minutes, followed by initial defibrillation attempt at 14 minutes. Resuscitation continued until return of spontaneous circulation (ROSC) or 20 minutes of failed resuscitation. Survivors were sacrificed with KCl after 20 minutes of observation. Veterinary staff blinded to group assignment conducted necropsies to assess lung injury, rib fracture, hemothorax, airway bleeding, great vessel dissection, and heart/liver/spleen contusion. Characteristics were compared via Chi-Squared test or Mann-Whitney U-test using an alpha = 0.05. Results: Group 1 had n=18 and Group 2 had n=18 animals. Mean (SD) APD overall was 5.58 (0.22) inches, yielding a mean 1/3 APD depth of 1.86 inches. APD did not differ between groups. ROSC rates did not differ between groups (Group 1: 66.7% vs Group 2: 83.33%; p = 0.248. No injury characteristics differed significantly between groups. Airway bleeding rates were noteworthy though not different between groups (Group 1: 18.8% vs Group 2: 42.1%; p = 0.219). Conclusions: In a swine model of infant OHCA and resuscitation, both CC depth strategies had similar injury characteristics.

Published
2021
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14. The authors reply

Author

Miguel Á. Ibarra-Estrada, Eduardo Mireles-Cabodevila, Yessica García-Salas, José A. López-Pulgarín, Quetzalcóatl Chávez-Peña, Roxana García-Salcido, Julio C. Mijangos-Méndez, and Guadalupe Aguirre-Avalos

Subjects
Critical Care and Intensive Care Medicine
Published
2022
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17. Abstract 372: Regional Cerebral Saturation in a Swine Model of Goal-directed Resuscitation of Prolonged Ventricular Fibrillation Cardiac Arrest

Author

Caelie Kern, David D Salcido, Allison C Koller, James J. Menegazzi, and Cornelia Genbrugge

Subjects
Resuscitation, medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, education, Ventricular fibrillation, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Saturation (chemistry)
Abstract

Introduction: The characteristics and limitations of near-infrared spectroscopy (NIRS) measurement of regional cerebral saturation (rSO2) for reflecting key moment-to-moment physiological changes needed to guide cardiopulmonary resuscitation (CPR) have yet to be fully determined. Objective: Examine the impact of NIRS sensor placement and resuscitation process variation on rSO2 measurements during prolonged cardiac arrest. Methods: Thirty mixed-breed domestic pigs (mean weight: 25.0kg+/-2.0) were sedated (ketamine / xylazine), anesthetized (fentanyl), paralyzed (vecuronium) and mechanically ventilated. Micromanometer pressure transducers were placed in the aorta and right atrium via femoral cutdown to measure central pressures, including mean arterial pressure (MAP) and coronary perfusion pressure (CPP). Two NIRS sensors were placed on the cranium: one on the skin surface and one on the bare skull. Ventricular fibrillation was induced electrically and untreated for 8 minutes followed by CPR. Initial BLS phase: 4 minutes of CPR at 100 compressions per minute (CPM) and 2 inches depth with manual ventilations (30:2). Randomized ALS phase: CPR with a pressor-titrated (Group A) or a compression rate/depth-titrated (Group B) strategy targeting 25mmHg CPP. Group A animals received pressor doses q1min and fixed rate/depth CPR. Group B animals received increasing rates and depth of CPR with epinephrine q3min. Defibrillation was attempted at 6min CPR q2min. rSO2 was compared between skin and skull across phases of resuscitation with t-tests and generalized estimating equations (GEE). Results: Mean skin and skull rSO2 differed marginally overall (63.8 vs 62.0, p < 0.001), at baseline (69.9 vs 64.9, p < 0.001), during BLS CPR (56.9 vs 48.7, p < 0.001), during ALS CPR (59.5 vs 51.0, p < 0.001), and following ROSC (70.0 vs 60.5, p Conclusion: rSO2 measures differ between skin and skull though both correlate with MAP.

Published
2020
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18. 222: OBESITY AND COVID-19: A SINGLE-CENTER STUDY

Author

Julio Mijangos-Méndez, Alexandra Vargas-Obieta, Roxana Garcia-Salcido, Miguel Ibarra-estrada, Jose López-Pulgarín, Quetzalcoatl Chavez-Peña, Esther Alvarez-Hernandez, Paulina Lopez-Aguirre, Beatriz Cruz-Muñoz, and Guadalupe Aguirre-Avalos

Subjects
Critical Care and Intensive Care Medicine
Published
2021
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22. Abstract 125: Automated External Defibrillator Shock Advisement Performance Among Multiple Human Electrocardiographic Rhythms and Devices

Author

Dylan A Defilippi, James J. Menegazzi, David D Salcido, Xavier J Szigethy, and Connor Willson

Subjects
medicine.medical_specialty, Rhythm analysis, business.industry, Defibrillation, medicine.medical_treatment, medicine.disease, Physical medicine and rehabilitation, Rhythm, External defibrillators, Physiology (medical), Shock (circulatory), Ventricular fibrillation, medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Automated external defibrillator
Abstract

Background: Automated external defibrillators (AEDs) perform rhythm analysis in order to facilitate defibrillation. The effectiveness of AEDs is dependent on the accuracy of their rhythm classification, which includes differentiation of shockable rhythms from non-shockable rhythms Independent (i.e. non-industry) evaluation of the performance of AEDs against real-world ECG could lead to improvements in their performance. Objective: To evaluate the sensitivity and specificity characteristics of commercial AEDs with respect to quantitative properties of the ECG waveform in several rhythm presentations using real world ECG data. Methods: We conducted a prospective simulation study evaluating three commercially available AEDs from Defibtech, Phillips, and Zoll on the determination of ECG rhythm shockability. Performance was evaluated for 181 human ECG recordings (101 ventricular fibrillation-VF, 55 PEA, and 25 asystole) ranging widely in signal characteristics, obtained from the Pittsburgh site of the Resuscitation Outcomes Consortium. We used a commercially available digital-to-analog converter (National Instruments USB-6001) to inject the recordings into each AED through a direct lead-wire interface, recording shock advisement decisions in a best-out-of-three approach for each device/rhythm pairing. We calculated the sensitivity and specificity for discriminating VF and non-VF rhythms for each device and overall. VF signal characteristics were calculated, including peak frequency, median amplitude, and peak amplitude, and the VF quantitative waveform measures AMSA and median slope. Results: The 101 VF trials featured signals with mean peak frequency 10.02 Hz(IQR 4.80 Hz), mean AMSA 9.13(IQR 7.29), mean median slope 6.72 (IQR 3.66). The sensitivities were: Defibtech 99.0%; Philips 97.0%; Zoll 98.0%. The specificities were: Defibtech 98.7%; Philips 96.2%; Zoll 97.4%. Defibtech recorded 5 discordant advisements and Philips and Zoll recorded eight each. The overall sensitivity was 98.0%, and the specificity 97.4%. Conclusion: Evaluated against a wide variety of real-world signal presentations, commercial AEDs demonstrated a high degree of sensitivity and specificity for shockable ECG rhythms.

Published
2019
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23. Abstract 427: Sudden ECG Rhythm Changes After Return of Spontaneous Circulation in Porcine Models of Cardiac Arrest

Author

Cornelia Genbrugge, Allison C Koller, James J. Menegazzi, and David D Salcido

Subjects
medicine.medical_specialty, Resuscitation, Rhythm, medicine.diagnostic_test, business.industry, Physiology (medical), Internal medicine, Cardiology, Medicine, Return of spontaneous circulation, Cardiology and Cardiovascular Medicine, business, Electrocardiography
Abstract

Background: Observation of the electrocardiogram (ECG) immediately following return of spontaneous circulation (ROSC) in resuscitated swine has revealed the interesting phenomenon of sudden ECG rhythm changes (SERC) that occur in the absence of pharmacological, surgical, or other medical interventions. Objective: We sought to identify, quantify, and characterize post-ROSC SERCs in successfully resuscitated swine. Methods: We reviewed all LabChart data from resuscitated approximately four-month-old swine used for various experimental protocols from 2006 to 2019. We identified those that achieved sustained ROSC and analyzed the entire post-ROSC period for evidence of a SERC in the ECG, arterial and venous pressure tracings. Presence or absence of a SERC was confirmed independently by two reviewers (ACK, DDS). We measured the time from ROSC to first SERC, analyzed the following metrics and calculated the change from 60 sec pre-SERC (or from ROSC if less than 60 sec) to 60 sec post-SERC: heart rate, central arterial pressure (CAP), and central venous pressure (CVP). Results: A total of 52 pigs achieved and sustained ROSC. Of these, we confirmed at least one SERC in 25 (48.1%). Two pigs (8%) had two unique SERC events. Median (IQR) time from ROSC to first SERC was 3.8 (1.0-6.9) min (range: 16 sec to 67.5 min). Mean (SE) heart rate changed by 51.7 (6.22) bpm. Mean heart rate decreased in 60% of cases. Mean (SE) CAP changed by 20.9 mmHg and mean (SE) CVP changed by 1.1 (0.24) mmHg. Mean CAP decreased in 72% of cases and mean CVP increased in 68%. Figure 1 shows an illustrative case with: red channel CAP (top), blue channel CVP (second from top), green channel CPP (second from bottom), and pink channel ECG (bottom). Conclusions: SERC occurs in nearly half of all cases with sustained ROSC and can occur multiple times per case. First SERC occurs within the first 4 minutes following ROSC. Heart rate, CAP and CVP change around the moment of SERC. Figure 1. SERC Case

Published
2019
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24. Abstract 434: A Randomized Blinded Trial of Three Chest Compression Strategies in a Porcine Model of Pediatric Cardiac Arrest

Author

Cornelia Genbrugge, Charity G. Patterson, David D Salcido, Robert A. Berg, Allison C Koller, Ericka L. Fink, and James J. Menegazzi

Subjects
Resuscitation, business.industry, Physiology (medical), medicine.medical_treatment, Anesthesia, medicine, Basic life support, Cardiopulmonary resuscitation, Cardiology and Cardiovascular Medicine, Compression (physics), business
Abstract

Background: Current guidelines recommend that chest compressions for children be done at either 1.5 inches depth and 100 per minute, or one-third the chest A-P diameter depth and 100 per minute. Neither of these recommendations is based on scientific evidence. Objective: As part of an ongoing efficacy trial, we sought to compare the safety of three different chest compression strategies in a porcine model of pediatric cardiac arrest. Methods: Following anesthesia, instrumentation, and induction of asphyxial cardiac arrest, we randomly assigned 48 domestic swine to one of three groups (n=16 per group). The mean mass of 25.7 kg approximates the 50 th percentile for a 7 year old. Group 1 had fixed chest compression depth of 1.5 inches/rate 100; group 2 had fixed proportional depth of one-third the A-P diameter/rate 100; group 3 used an adaptive algorithm that incrementally increased chest compression rate and/or depth from baseline 1.5in (max: 2.13in) and 100/min (max; 130/min) every 25s while coronary perfusion pressure was below 25mmHg. Necropsies were independently performed by a veterinarian and veterinary technologist who were blinded to group assignment. The primary safety outcome was unrecoverable injury (i.e. toxicity), which we defined as either a total lung injury score ≥16 (score can range from 0 to 20) plus presence of hemothorax, or disruption of either the aorta or vena cava. Data were analyzed with the Bayesian Beta Binomial to determine if within-group toxicity exceeded an unacceptable level (30%) with a pre-selected posterior predictive threshold of 0.75(ptox). Lung injury scores between groups were compared with Kruskal-Wallis tests. Results: Median total lung injury scores were: 12 for group 1; 18 for group 2; 14 for group 3. Group 2 was significantly different from both groups 1 and 3 (p Conclusions: Chest compressions performed at a depth of one-third the A-P diameter are unsafe. The safety of this approach in children should be carefully evaluated.

Published
2019
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25. Abstract 215: Hemodynamics of Absolute, Proportional, and Adaptive Mechanical Chest Compression Strategies in a Swine Model of Pediatric Out-Of-Hospital Cardiac Arrest

Author

Caelie Kern, James J. Menegazzi, Cornelia Genbrugge, David D Salcido, and Allison C Koller

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Hemodynamics, Compression (physics), Out of hospital cardiac arrest, Pediatric resuscitation, Physiology (medical), Internal medicine, Cardiology, Medicine, Cardiopulmonary resuscitation, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Guidelines for pediatric resuscitation recommend a depth of 1.5in or 1/3 anterior-posterior chest diameter for chest compressions (CC) despite little supporting evidence. Objective: To evaluate the hemodynamic effects of the two recommended depths and an adaptive strategy. Methods: Thirty-eight animals (mass ~25kg) were sedated, anesthetized, intubated, and ventilated. Micromanometer pressure sensors were installed in the aorta and right atrium via the right femoral artery and vein. Coronary perfusion pressure (CPP) was calculated as aortic minus right atrial pressure. An ultrasonic flow probe was secured around the right common carotid. Biosignals were recorded at 1000Hz. Animals were then re-paralyzed, followed by a fentanyl bolus, and the endotracheal tube was occluded for 9min. Each was randomized to absolute (Group 1: 1.5in & 100/min), proportional (Group 2: 1/3 AP diameter & 100/min), or stepwise adaptive (Group 3: 1.5in & 100/min, adding 0.25in or 5/min q25s until CPP > 25mmHg) CC using a robotic compressor. Epinephrine (0.1mg/kg) and sodium bicarbonate (1mEq/kg) were given after 4min, followed by epinephrine (0.15mg/kg) q3min. Defibrillation (150J) was attempted after 5min; CPR discontinued after 20min. Mean arterial pressure (MAP), CPP and carotid blood flow (CBF) were calculated for the first 10 minutes of CPR and compared between groups with generalized estimating equations (GEE). Results: In GEE models, MAP, CBF and CPP did not differ between groups over the first 10 minutes of resuscitation. Each measure differed significantly over time (p Conclusion: In a swine model of asphyxial cardiac arrest, CC methods based on current guidelines and an additional adaptive approach did not differ hemodynamically.

Published
2019
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26. Abstract 470: Understanding the Distribution of CPR Training in Pennsylvania High Schools

Author

Leonard S. Weiss, Vanessa Mejia, David D Salcido, Paige Meskers, and Jessica Salerno

Subjects
business.industry, Physiology (medical), medicine.medical_treatment, Bystander cpr, medicine, Cardiopulmonary resuscitation, Medical emergency, Cardiology and Cardiovascular Medicine, Cpr training, medicine.disease, business, Curriculum
Abstract

Introduction: Bystander CPR may increase out-of-hospital cardiac arrest survival rates. Incorporating CPR education into high school curricula is an efficient way to teach a large number of individuals CPR. Pennsylvania, unlike most states, does not require CPR training prior to graduation, and the prevalence of school training programs is not known. Objective: The goal of this study was to describe the distribution and characteristics of CPR training practices in high schools across Pennsylvania. Methods: As part of an ongoing public health project, we developed and administered a 7-question survey designed to determine if school districts offer CPR training programs, and if so, query key details about those programs. Using the Pennsylvania Education Names and Addresses database, we compiled contact information for all Pennsylvania school districts. Student researchers then contacted district personnel by telephone or email to administered the survey. Survey results were tabulated and summarized, and basic comparative statistics were calculated using Stata (ver. 15). Geographic patterns were assessed using QGIS (ver. 3.0.1) To understand the role of race and economics in availability of CPR training, our analyses incorporated census data on median income, race and ethnicity. Results: Between July 2018 and May 2019, we attempted to contact all 500 school districts in Pennsylvania, 494 of which were determined to have high schools within the district. We received survey responses from 446 (90%) school districts. Of those, 255 (57%) offered some form of CPR education and 141 (32%) of those programs were mandatory. Of the 255 districts that offered programs, 157 (62%) programs certified students as CPR providers. School districts that have CPR training have a median household income on average $4906 higher than school districts without CPR training. Clusters of districts with and without training were observed, however these clusters did not correlate with state geographic divisions, white race or Hispanic ethnicity. Conclusion: In Pennsylvania, where CPR training is not mandatory in high schools, at least half of all schools have training programs. Factors determining program adoption are unclear.

Published
2019
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27. Screening and management of overweight and obesity at a university student health center

Author

Maria Estela Salcido and Diane B. Monsivais

Subjects
Male, medicine.medical_specialty, Quality management, Adolescent, Universities, Student Health Services, Best practice, education, Overweight, Young Adult, ComputingMilieux_COMPUTERSANDEDUCATION, medicine, Humans, Center (algebra and category theory), Obesity, Students, General Nursing, Protocol (science), business.industry, medicine.disease, Family medicine, Female, medicine.symptom, business
Abstract

This article discusses a quality improvement project focused on developing, implementing, and evaluating an evidence-based best practice protocol for screening and management of overweight and obesity in college students in a university-based student health center.

Published
2016
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28. Abstract 146: Association Between Quantitative Waveform Measures of the Ventricular Fibrillation Electrocardiogram and Defibrillation Success in the ROC ALPS Trial

Author

Robert H. Schmicker, Matthew L Sundermann, James J Menegazzi, Allison C Koller, David D Salcido, and Katharyn L Flickinger

Subjects
medicine.medical_specialty, business.industry, Defibrillation, Physiology (medical), Internal medicine, medicine.medical_treatment, Ventricular fibrillation, medicine, Cardiology, Waveform, Cardiology and Cardiovascular Medicine, medicine.disease, business
Abstract

Introduction: During out-of-hospital cardiac arrest (OHCA), features of the ventricular fibrillation electrocardiogram (ECG) have been correlated with outcomes. Understanding factors affecting the variability of these features may elucidate their utility. We examined the association between quantitative waveform measures (QWM) of the VF ECG and defibrillation success in the context of the Resuscitation Outcomes Consortium (ROC) amiodarone, lidocaine and placebo (ALPS) trial. Methods: We retrospectively obtained case data for patients enrolled in the ALPS trial from the ROC data coordinating center (DCC). The primary trial enrolled emergency medical services (EMS) – treated OHCA patients with at least one failed defibrillation from 2012 to 2015 at 10 sites across the ROC network for randomization to amiodarone, lidocaine or placebo. We included all enrolled cases with an ECG file available through the DCC. ECG signals were analyzed with custom, semi-automatic software to identify shocks, parse pre-shock ECG segments, and identify pre- and post- defibrillation rhythms, including post-shock return of organized rhythm (ROOR). Three QWM – AMSA, centroid frequency (CF), and median slope (MS) – were calculated for pre-shock ECG segments. Multivariable logistic regression models accounting for repeated shocks were constructed with outcome ROOR, adjusting for ALPS treatment arm, shock number and relevant case characteristics. Results: A total of 1242 cases were available for analysis, comprising a total of 5,408 defibrillation events with identifiable pre-shock VF. Mean (SD) QWM values for all shocks were: AMSA{6.74 (10.80)}, CF{3.98 (1.68)} , MS{0.02 (0.02)}. CF, but not AMSA or MS, differed significantly between ALPS treatment arms when controlling for shock number (p amio < 0.001; p lido = 0.016). All QWM were significantly directly associated with defibrillation success in multivariable models (OR AMSA =1.03 [95%CI: 1.02 – 1.04]; OR CF =1.35 [95%CI: 1.26 – 1.45]); OR MS =1.05 [95%CI: 1.04 – 1.06]). Conclusions: In the ROC ALPS trial, QWM were associated with defibrillation success independent of shock number or treatment arm.

Published
2018
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29. Abstract 149: Role of Pre and Intra-Arrest Hemodynamics in Evolution of the Ventricular Fibrillation Electrocardiogram Waveform

Author

Caelie E Kern and David D Salcido

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Purpose: Quantitative waveform measures (QWM) of the ventricular fibrillation (VF) waveform have been shown in laboratory and clinical studies to be predictive of return of spontaneous circulation (ROSC) and survival to hospital discharge. During resuscitation, QWM are responsive to hemodynamic changes resulting from CPR. It is not known whether the trajectory of QWM are affected by pre-arrest hemodynamics or intra-arrest arterio-venous pressure equilibration. We sought to investigate the role of hemodynamics on the evolution of VF before and during prolonged VF. Methods: We pooled data from six previous porcine experiments. Each modeled prolonged VF and included electrical induction of VF which was left untreated for up to 10 minutes, followed by attempted resuscitation. All animals were instrumented with pressure transducers (Millar, MikroTip) placed via femoral cutdown in the aorta and right atrium, as well as Lead II surface ECG. Signals were recorded continuously at 1000Hz with a data acquisition unit (PowerLab, ADInstruments). Mean baseline central arterial (CAP) and central venous pressure (CVP) were calculated from 1- minute of immediate pre-VF pressure traces. Coronary perfusion pressure (CPP) during untreated VF was calculated as the continuous difference between the CAP and CVP channels. Median slope (MS), a QWM, was calculated in 1-second windows and interpolated to the full length of the intra-arrest ECG. For trajectory analysis, CPP and MS traces were normalized on a 0-1 scale and grouped by morphological similarity. Pearson’s Correlation coefficient was calculated between corresponding CPP and MS traces. Results: A total of 141 experiments were included in the analysis. Overall mean (SD) correlation between CPP and MS was 0.56 (0.29). CPP-MS correlation strength did not correlate with baseline pressures. However, trajectory analysis revealed multiple patterns of hemodynamic and QWM evolution through untreated VF, with the most well-defined (mean coeff. = 0.58) indicating a shared bimodality temporally offset between CPP and MS. Conclusions: Hemodynamics during untreated VF show some correlation with the trajectory of QWM of the VF signal. More work is needed to understand the mechanism of this relationship.

Published
2018
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30. Abstract 206: Cardiopulmonary Resuscitation Process Measures Associated With Return of Spontaneous Circulation in Non-Shockable Out-of-Hospital Cardiac Arrest

Author

Seo Young Park, David D Salcido, Jose Miguel Juarez, Robert H. Schmicker, James J Menegazzi, and Allison C Koller

Subjects
Resuscitation, medicine.medical_specialty, business.industry, Physiology (medical), medicine.medical_treatment, Emergency medicine, Medicine, Cardiopulmonary resuscitation, Return of spontaneous circulation, Cardiology and Cardiovascular Medicine, business, Out of hospital cardiac arrest, Process Measures
Abstract

Purpose: Survival rates after non-shockable out-of-hospital cardiac arrest (OHCA) remain low despite advances in resuscitation. Cardiopulmonary resuscitation (CPR) process measures may inform treatment strategies. We hypothesized that CPR process measures would be associated with return of spontaneous circulation (ROSC) and patient electrocardiogram (ECG) transitions. Methods: We obtained defibrillator monitor data for emergency medical service (EMS)-treated non-shockable OHCA from the Resuscitation Outcomes Consortium (ROC), an OHCA research network (U.S./Canada). We extracted ECG data from EMS defibrillator files and parsed cases into compression-free analyzable segments using custom MATLAB software. Two data abstractors classified segment rhythms as PEA, asystole, ventricular fibrillation (VF), pulseless ventricular tachycardia (PVT), or ROSC. We calculated CPR process measures (average rate, depth, duration, leaning proportion, chest compression fraction, and duty cycle) for CPR bouts preceding every ECG segment. We used mixed effects models controlling for subject to test associations between individual CPR process measures and the bout-level outcomes ROSC and shockable rhythm. Results: We analyzed 1893 cases consisting of 7981 CPR bouts. Case initial rhythms were asystole (68.2%), PEA (24.9%), or NSA-AED (6.9%). Segment rhythm classifications were asystole (78.1%), PEA (20.4%), ROSC (5.5%), VF (1.4%), and PVT (0.07%). Regression model results are shown in Table 1. Chest compression fraction was most strongly associated with ROSC and shockable rhythm. Depth was also associated with shockable rhythm. Leaning proportion and duty cycle were not associated with either outcome. Conclusions: In cases of non-shockable OHCA, CPR quality measures were associated with ROSC and transition to a shockable rhythm at the bout level.

Published
2018
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31. Abstract 316: Cardiac Arrest Rhythm Transitions in Drug Overdose-Related Resuscitation

Author

James J Menegazzi, Allison C Koller, and David D Salcido

Subjects
medicine.medical_specialty, Resuscitation, business.industry, Physiology (medical), Cardiac arrest rhythm, Emergency medicine, medicine, Etiology, Cardiology and Cardiovascular Medicine, business, Drug overdose, medicine.disease
Abstract

Introduction: The prehospital electrocardiogram (ECG) may inform treatment of out-of-hospital cardiac arrest (OHCA) patients regardless of etiology. While drug overdose (OD)-OHCA is increasingly common, little is known about the characteristics and utility of the intra-resuscitation OD-OHCA ECG signal. In this study, we sought to investigate the evolving ECG rhythm state of OD-OHCA patients to identify potentially informative patterns or phenomena. Methods: Case data, including electronic defibrillator files, for emergency medical services treated OD-OHCA were obtained from the Resuscitation Outcomes Consortium, a multi-site clinical research network in the US and Canada. OD-OHCA case status was previously established by site-level data abstractors reviewing prehospital and in-hospital electronic medical records for evidence of drug involvement. Continuous ECG traces were extracted and chest compression-free ECG segments were parsed with custom MATLAB (vR2017a) software. Each ECG segment was manually rhythm-classified by a research specialist. Rhythm transitions were identified as changes in rhythm between sequential analyzable rhythm segments. Transitions were tabulated and summarized by their rhythms and timing. Results: Complete prehospital ECG data were available for 130 patients, comprising 1,112 ECG segments of which 771 (69.3%) were analyzable. The mean (SD) age was 33.6 (11.3) years and 68.3% were male. The most commonly observed rhythm at the segment level was low amplitude (“fine”) ventricular fibrillation (VF), accounting for 44.1% of all segments, although at the case level asystole was the most common rhythm, present in 47.7% of all cases. We recorded 292 rhythm transitions, with a mean (SD) 2.5 (1.5) transitions per case. Mean (SD) time to first transition was 11.1 (6.9) minutes and mean (SD) time to last transition was 19.8(8.8) minutes. The most frequently observed transition was from asystole to low amplitude ventricular fibrillation (17.1%). Conclusions: The OD-OHCA ECG is varied and dynamic, presenting in numerous rhythms and transitioning between rhythms throughout the course of resuscitation.

Published
2018
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32. Abstract 334: Cardioplegia Defibrillation of Circulatory Phase Ventricular Fibrillation in a Swine Model: Three Randomized Controlled Trials

Author

Keith A Marill, David D Salcido, Matthew L Sundermann, Allison C Koller, and James J Menegazzi

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: We previously found potassium cardioplegia followed by rapid calcium reversal (K plegia) can achieve defibrillation in a swine model of electrical phase ventricular fibrillation (VF) comparable to standard care. Hypothesis: Exploring 3 possible potassium (K) dose and timing protocols, we hypothesize K plegia may benefit resuscitation of circulatory phase VF. Methods: Three separate blinded randomized placebo-controlled trials were performed with electrically-induced VF untreated for durations of 6,9, and 12 minutes in a swine model. All experimental groups received infusion of 1 or 2 boluses of intravenous (IV) K followed by a single calcium reversal bolus. Only K was replaced by saline in the control groups. All other treatments were the same. Outcomes included: amplitude spectrum area (AMSA) during VF, resulting rhythms, number of defibrillations, return of spontaneous circulation (ROSC), and hemodynamics for 1 hour post ROSC. Single nominal and interval outcomes were compared with Fisher’s Exact test and Mann-Whitney U, respectively. Results: Twelve, 12, and 8 animals were included at 6, 9 , and 12 minute VF durations for a total of 32. ROSC, average number of shocks, and post-ROSC norepinephrine requirement are listed below. 4/6 K plegia and 2/6 control animals achieved ROSC in the 9 minute protocol, (p=0.24). Two of 8 animals that achieved ROSC with K plegia did so without electrical defibrillation. Conclusions: The majority of animals achieved ROSC after up to 9 minutes of untreated VF arrest using K plegia protocols. K plegia requires further optimization for both peripheral IV and intraosseous infusion, and to assess for superiority over standard care.

Published
2018
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33. Abstract 287: Simulating the Effects of Sudden Cardiac Arrest Responders Embedded in a Marathon Cohort

Author

Jessica E Salerno, Connor J Willson, Leonard S Weiss, and David D Salcido

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Risk of sudden cardiac arrest may increase during distance running. In marathons, this risk is typically mitigated by deployment of medical resources, e.g. automated external defibrillators (AED), at fixed locations, potentially leaving racers vulnerable for periods of the race. We investigated utilization of marathon runners themselves as mobile emergency resources (R-AEDs). We hypothesized that systematic R-AED deployment would increase AED coverage of a race cohort over baseline coverage from static public AEDs. Methods: A simulation was constructed in MATLAB (vR2018a) incorporating the route of the 2018 Pittsburgh Marathon, detailed publicly available runner performance data from a nearby local marathon (N=1536), and known locations of S-AEDs with 1/8 th mile of any part of the Pittsburgh Marathon course (N = 47). During each simulation run, participants were randomly selected based on several distribution schemes (including age, pace category and pure chance) to carry an R-AED. R-AED coverage was assessed per minute by determining the proportion of racers up to 3 minutes ahead of each R-AED. S-AED coverage was calculated similarly based on whether runners were within 3-minutes of a public AED. All simulation variants were repeated 100 times and aggregated. Results: At baseline, 44% of the Pittsburgh Marathon course was within 3-minute walking distance of a public AED. Full coverage could be achieved with an additional 54 S-AEDs. Of the schemes we tested, when R-AEDs were deployed to random participants, optimal overall coverage was achieved with 1 R-AED per 25 runners (61 total for 57%), with 10% of race time achieving over 95% coverage. Weighted distribution of R-AEDs within age categories or pace categories achieved 72% coverage (155 AEDs) and 71% coverage, and over 95% coverage for 33% and 32% of the race duration, respectively. Conclusion: R-AEDs provided varying levels of additional coverage over baseline public access AED coverage during a simulated marathon. More work is necessary to fully determine the practical utility of this approach.

Published
2018
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40. Abstract 21301: Effect of Chest Compression Parameter Variation on Waveform Characteristics of the Ventricular Fibrillation Electrocardiogram

Author

David D Salcido, Matthew L Sundermann, Allison C Koller, Rena Sufrin, John Kucewicz, Graham Nichol, Adeyinka Adedipe, and James J Menegazzi

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: The ventricular fibrillation (VF) electrocardiogram (ECG) waveform is known to deteriorate over time if untreated, recover with CPR, and to predict defibrillation success. VF ECG measures could inform CPR quality feedback algorithms based on patient physiologic response. Objectives: Investigate the effects of chest compression parameters (rate, depth and duty cycle (DC)) on VF ECG waveform characteristics in a swine cardiac arrest model. Methods: Twelve mixed-breed domestic swine were sedated, anesthetized and paralyzed, followed by endotracheal intubation and mechanical ventilation. Animals were instrumented with a battery of physiological sensors, including multi-lead ECG, recorded continuously with a high-fidelity data acquisition unit at 1000Hz. VF was induced with a 3-second 100mA transthoracic shock. After 7 minutes, animals were randomized to receive continuous CPR with a custom robotic device using 1 of 6 pre-programmed, cross-over 2-phase CPR schemes that varied 1 parameter in 5 x 1-minute intervals per phase while holding the other 2 parameters fixed. Frequency (AMSA) and slope-based (MS) quantitative ECG characteristics of the ECG were calculated at the end of each 1-minute interval and compared between rate, depth and DC schemes, as well as experimental phases. Correlations between CPR parameter settings and ECG characteristics were calculated. Results: Compression rate showed a low-to-moderate correlation (0.454) with change in MS in Phase I, however neither DC nor depth showed a correlation with either AMSA or MS. In ANOVA models, MS differed between CPR groups at the end of Phase I (p = 0.046) but not AMSA, suggesting similar response of quantitative ECG measures after extended time intervals. Conclusions: In this study only chest compression rate in early phase CPR appeared to be related to quantitative characteristics of the VF ECG. Rate may be important clinically in the early phase of CPR.

Published
2017
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41. The Indistinguishable Gluten Vehicle and Placebo in the Diagnosis of NCGS

Author

Cabrera-Chávez Francisco, Ontiveros Noé, and Salcido-Figueroa Oscar Gerardo

Subjects
0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, 030109 nutrition & dietetics, Hepatology, business.industry, Gastroenterology, Placebo, Gluten, 03 medical and health sciences, 0302 clinical medicine, Text mining, chemistry, Internal medicine, Medicine, 030211 gastroenterology & hepatology, business
Published
2018
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