1. Validation of inflammation-based prognostic models in patients with hepatitis B-associated hepatocellular carcinoma
- Author
-
Kai Qu, Huichun Liu, Hao Jin, Lei Zhou, Ruixia Cui, and Qing Pang
- Subjects
Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Time Factors ,Neutrophils ,Kaplan-Meier Estimate ,Risk Assessment ,Gastroenterology ,Disease-Free Survival ,Decision Support Techniques ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Carcinoma ,Humans ,Lymphocyte Count ,Lymphocytes ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,Hepatitis ,Chi-Square Distribution ,Hepatology ,Platelet Count ,Proportional hazards model ,business.industry ,Liver Neoplasms ,Cancer ,Retrospective cohort study ,Middle Aged ,Hepatitis B ,medicine.disease ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Multivariate Analysis ,Disease Progression ,Female ,030211 gastroenterology & hepatology ,Neoplasm Recurrence, Local ,business ,Liver cancer - Abstract
BACKGROUND AND OBJECTIVE The objective of this study was to investigate the prognostic significance of several inflammation-based models in hepatitis B-associated hepatocellular carcinoma (HCC). PATIENTS AND METHODS We retrospectively reviewed 470 cases of hepatitis B-associated HCC. Preoperative data were collected to calculate the inflammation-based markers, including systemic immune-inflammation index (neutrophil×platelets/lymphocyte), platelets-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio (NLR). Overall survival and recurrence-free survival were estimated by the Kaplan-Meier method and Cox analysis. RESULTS During a median follow-up time of 29 months, 34.0% (160/470) of patients died and 36.0% (169/470) experienced recurrence. Compared with patients with lower scores of inflammation models, patients in the higher group had larger tumor diameter and higher risk of vascular invasion (both P
- Published
- 2018