Author: "Pere, Cardona" / Publisher: ovid technologies (wolters kluwer health) - Searchworks@Jio Institute Digital Library Search Results

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19 results on '"Pere, Cardona"'

1. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas

Author: Alvaro Garcia-Tornel, Monica Millan, Marta Rubiera, Alejandro Bustamante, Manuel Requena, Laura Dorado, Marta Olivé-Gadea, Xavier Jiménez, Angels Soto, Marisol Querol, Maria Hernández-Pérez, Meritxell Gomis, Pere Cardona, Xabier Urra, Francesc Purroy, Yolanda Silva, Xavier Ustrell, Patricia Esteve, Mercè Salvat-Plana, Miquel Gallofré, Carlos Molina, Antoni Dávalos, Tudor Jovin, Sonia Abilleira, Marc Ribo, Natalia Pérez de la Ossa, Marc Ribó Jacobi, Estela Sanjuan, Katherine Santana, Noelia Rodríguez, Jorge Pagola, David Rodriguez-Luna, Olga Maisterra, Estevo Santamarina, Marian Muchada, Jesús Juega, Sandra Boned, Antonio Palasi Franco, Álvaro García -Tornel, Matías Deck, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Sara, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Sergio Amaro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Jerzy Krupinski, Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela (intensivista), Manuel Gómez-Choco, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Mikel Terceño Izarra, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Alan Flores, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Josep Zaragoza, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Iago Payo, Júlia Saura Salvado, Natalia Mas Sala, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Catena, Bárbara Gómez, Vergilin Raileau, Esther Catena Ruíz, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Goran Anastasovski, Oscar Mascaró, Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Dolores Cocho Calderón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Gemma, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Mireia Pallisera, Lluís Gonzalo Oliva, Gemma Sanchez, Xavier Basurto, Ludgi Vivoda, Richard Van der Kleyn, Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, null Anabel, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Cristina, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, de Sostoa Graell, del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Alicia, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Hernandez Sebastia, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Mireia, M Conillera, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Florenc Uku, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Alba Mari, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Javier Francisco, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Fernandez Toledo Edurne Judith, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo.
Subjects: Stroke, Advanced and Specialized Nursing, Treatment Outcome, Endovascular Procedures, Humans, Neurology (clinical), Cardiology and Cardiovascular Medicine, Brain Ischemia, Ischemic Stroke, Thrombectomy, Workflow
Abstract: Background: We aim to compare the outcome of patients from urban areas, where the referral center is able to perform thrombectomy, with patients from nonurban areas enrolled in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion). Methods: Patients with suspected large vessel occlusion stroke, as evaluated by a Rapid Arterial Occlusion Evaluation score of ≥5, from urban catchment areas of thrombectomy-capable centers during RACECAT trial enrollment period were included in the Stroke Code Registry of Catalonia. Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with an ischemic stroke. Secondary outcomes included mortality at 90 days, rate of thrombolysis and thrombectomy, time from onset to thrombolysis, and thrombectomy initiation. Propensity score matching was used to assemble a cohort of patients with similar characteristics. Results: The analysis included 1369 patients from nonurban areas and 2502 patients from urban areas. We matched 920 patients with an ischemic stroke from urban areas and nonurban areas based on their propensity scores. Patients with ischemic stroke from nonurban areas had higher degrees of disability at 90 days (median [interquartle range] modified Rankin Scale score, 3 [2–5] versus 3 [1–5], common odds ratio, 1.25 [95% CI, 1.06–1.48]); the observed average effect was only significant in patients with large vessel stroke (common odds ratio, 1.36 [95% CI, 1.08–1.65]). Mortality rate was similar between groups(odds ratio, 1.02 [95% CI, 0.81–1.28]). Patients from nonurban areas had higher odds of receiving thrombolysis (odds ratio, 1.36 [95% CI, 1.16–1.67]), lower odds of receiving thrombectomy(odds ratio, 0.61 [95% CI, 0.51–0.75]), and longer time from stroke onset to thrombolysis (mean difference 38 minutes [95% CI, 25–52]) and thrombectomy(mean difference 66 minutes [95% CI, 37–95]). Conclusions: In Catalonia, Spain, patients with large vessel occlusion stroke triaged in nonurban areas had worse neurological outcomes than patients from urban areas, where the referral center was able to perform thrombectomy. Interventions aimed at improving organizational practices and the development of thrombectomy capabilities in centers located in remote areas should be pursued. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.
Published: 2022
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2. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author: Álvaro García-Tornel, Alan Flores, Mikel Terceño, Pedro Cardona, Sergi Amaro, Meritxell Gomis, Josep Zaragoza, Jerzy Krupinski, Manuel Gómez-Choco, Natalia Mas, Dolores Cocho, Esther Catena, Francesc Purroy, Matias Deck, Marta Rubiera, Jorge Pagola, David Rodriguez-Luna, Jesús Juega, Noelia Rodríguez-Villatoro, Carlos A. Molina, Cristina Soro, Xavier Jimenez, Mercè Salvat-Plana, Antoni Dávalos, Tudor G Jovin, Sonia Abilleira, Natalia Pérez de la Ossa, Marc Ribó, Estela Sanjuan, Katherine Santana, Olga Maisterra, Estevo Santamarina, Marian Muchada, Sandra Boned, Antonio Palasi Franco, Marta Olivé Gadea, Matías Deck, Manuel Requena, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, Laura Dorado, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Alejandro Bustamante, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Dra Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Yolanda Silva Blas, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Patricia Esteve Belloch, Iago Payo, Júlia Saura Salvado, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Bárbara Gómez, Vergilin Raileau, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, José Carlos Molina, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Vanesa Pascual_Medicina Interna, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Dr Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Dr Goran Anastasovski, Dr Oscar Mascaró, Dr Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Dra Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Dra Mireia Pallisera, Dr Lluís Gonzalo Oliva, Dra Gemma Sanchez, Dr Xavier Basurto, Dr Ludgi Vivoda, Dr Richard Van der Kleyn, Dra Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Miquel, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Anna, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Anna, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, Marc de Sostoa Graell, Laura del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Sebastia Hernandez, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Edurne Judith Fernandez Toledo, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Torello Masa, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo
Subjects: Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Background: We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized trial that did not demonstrate the benefit of direct transportation to a thrombectomy-capable center versus nearest local stroke center for patients with a suspected large vessel stroke triaged in nonurban Catalonia between March 2017 and June 2020. Methods: We performed a post hoc analysis of RACECAT to evaluate if the association between initial transport routing and functional outcome differed according to trial enrollment time: daytime (8:00 am –8:59 pm ) and nighttime (9:00 pm –7:59 am ). Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with ischemic stroke. Subgroup analyses according to stroke subtype were evaluated. Results: We included 949 patients with an ischemic stroke, of whom 258 patients(27%) were enrolled during nighttime. Among patients enrolled during nighttime, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days (adjusted common odds ratio [acOR], 1.620 [95% CI, 1.020–2.551]); no significant difference between trial groups was present during daytime (acOR, 0.890 [95% CI, 0.680–1.163]; P interaction =0.014). Influence of nighttime on the treatment effect was only evident in patients with large vessel occlusion(daytime, acOR 0.766 [95% CI, 0.548–1.072]; nighttime, acOR, 1.785 [95% CI, 1.024–3.112] ; P interaction P interaction >0.1 for all comparisons). We observed longer delays in alteplase administration, interhospital transfers, and mechanical thrombectomy initiation during nighttime in patients allocated to local stroke centers. Conclusions: Among patients evaluated during nighttime for a suspected acute severe stroke in non-urban areas of Catalonia, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days. This association was only evident in patients with confirmed large vessel occlusion on vascular imaging. Time delays in alteplase administration and interhospital transfers might mediate the observed differences in clinical outcome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.
Published: 2023
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3. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author: García-Tornel, Álvaro, primary, Flores, Alan, additional, Terceño, Mikel, additional, Cardona, Pedro, additional, Amaro, Sergi, additional, Gomis, Meritxell, additional, Zaragoza, Josep, additional, Krupinski, Jerzy, additional, Gómez-Choco, Manuel, additional, Mas, Natalia, additional, Cocho, Dolores, additional, Catena, Esther, additional, Purroy, Francesc, additional, Deck, Matias, additional, Rubiera, Marta, additional, Pagola, Jorge, additional, Rodriguez-Luna, David, additional, Juega, Jesús, additional, Rodríguez-Villatoro, Noelia, additional, Molina, Carlos A., additional, Soro, Cristina, additional, Jimenez, Xavier, additional, Salvat-Plana, Mercè, additional, Dávalos, Antoni, additional, Jovin, Tudor G, additional, Abilleira, Sonia, additional, Pérez de la Ossa, Natalia, additional, Ribó, Marc, additional, Sanjuan, Estela, additional, Santana, Katherine, additional, Maisterra, Olga, additional, Santamarina, Estevo, additional, Muchada, Marian, additional, Boned, Sandra, additional, Franco, Antonio Palasi, additional, Gadea, Marta Olivé, additional, Deck, Matías, additional, Requena, Manuel, additional, Sala, Victoria, additional, Muñoz, Lucía, additional, Millán, Mónica, additional, López-Cancio, Elena, additional, Dorado, Laura, additional, Hernández-Pérez, María, additional, Ciurans, Jordi, additional, Samaniego, Daniela, additional, Canento, Tamara, additional, Martin, Lorena, additional, Planas, Anna, additional, Broto, Joaquin, additional, Sorrentino, Agustín, additional, Paré, Martí, additional, Zhu, Nuole, additional, Garrido, Alicia, additional, Grau, Laia, additional, Crespo, Ane Miren, additional, Presas, Silvia, additional, Almendrote, Miriam, additional, Ramos, Alba, additional, Lucente, Giuseppe, additional, Ispierto, Lourdes, additional, Lozano, Manuel, additional, Becerra, Juan Luis, additional, Jiménez, Marta, additional, Rolán, Dolores Vilas, additional, Guanyabens, Nicolas, additional, Sanchez-Ojanguren, Josep, additional, Martínez-Piñeiro, Alicia, additional, Forcén, Sara, additional, Gea, Mireia, additional, Álvarez, Marta, additional, Ramos, Anna, additional, Lizarbe, Manuel Domínguez, additional, Guerra, Rubio, additional, Bragado, Irene, additional, Arbex, Andrea, additional, Rodríguez, Luis, additional, Bustamante, Alejandro, additional, Portela, Pere Cardona, additional, García, Helena Quesada, additional, Rodríguez, Blanca Lara, additional, Cayuela, Nuria, additional, Miró, Julia, additional, Marzal, Clara, additional, Paipa, Andrés, additional, Campoy, Sergio, additional, Núñez, Ana, additional, Arroyo, Pablo, additional, Besora, Sarah, additional, Adell, Vanessa, additional, Campdelacreu, Jaume, additional, Martí, Montse Alemany, additional, González, Belén, additional, Vila, Laura Bau, additional, Crespo, Marta Fiter, additional, Berbel, Anna, additional, Urbaneja, Ma. Cristina Villaescusa, additional, Guillen, Núria, additional, Vidal, Nuria, additional, Santamaria, Patricia Valentina Vérez, additional, Navarro, Diego Herrero, additional, Simó, Marta, additional, Falip, Mercedes, additional, Matas, Elisabeth, additional, Ochoa, Neus Mongay, additional, Gifreu, Ariadna, additional, Muñoz, Albert, additional, Romero, Lucía, additional, Portell, Eduard, additional, Perez, Guillermo Hernández, additional, Esteve, F. Ruiz, additional, Teixidor, Silvia, additional, Talavera, Augusto Salazar, additional, Gómez, Roser, additional, Nuin, Xabier Urra, additional, Vargas, Martha, additional, Chamorro, Ángel, additional, Llull, Laura, additional, Renú, Arturo, additional, Rudilosso, Salvatore, additional, del Valle, Raquel Sánchez, additional, Ariño, Helena, additional, Solà, Nuria, additional, la Puma, Delón, additional, Gil, Francisco, additional, Gómez, Juan Bernardo, additional, Matos, Nuria, additional, Falgàs, Neus, additional, Borrego, Sergi, additional, Sánchez, Almudena, additional, Balasa, Mircea, additional, Montejo, Carmen, additional, Guasp, Mar, additional, Reyes, David, additional, Cervilla, Pablo Sánchez, additional, Contador, Jose Miguel, additional, Monge, Victor Augusto Vera, additional, Ramos, Oscar, additional, Rodríguez, Alejandro, additional, Campello, Ana Rodríguez, additional, Ballester, Gemma Romeral, additional, Trujillano, Mireia Llop, additional, Steinhauer, Eva Giralt, additional, Godia, Elisa Cuadrado, additional, Santiago, Angel Javier Ois, additional, Conde, Jordi Jimenez, additional, Fábregas, Joan Martí, additional, Guisado, Daniel, additional, Prats, Luís, additional, Camps, Pol, additional, Delgado, Raquel, additional, Domeño, Alejandro Martínez, additional, Marín, Rebeca, additional, Cànovas, David, additional, Estela, Jordi, additional, Ros, Marta, additional, Aranceta, Sonsoles, additional, Espinosa, Jordi, additional, Rubio, Marta, additional, Lafuente, Cristina, additional, Barrachina, Oriol, additional, Anguita, Alicia, additional, Reverter, Anna, additional, García, Carmen, additional, Sansa, Gemma, additional, Hervas, Mariona, additional, Crosas, Monica, additional, Delgado, Tania, additional, Folch, Dra Sonia Huertas, additional, Gamito, Gemma Muñoz, additional, Alvarez, Josep Trenado, additional, Subirana, Teresa, additional, Molina, Jessica, additional, Romero, Laura Comes, additional, Valls, Gemma Guardia, additional, Jover, Miriam, additional, Sotova, Javier Joaquín, additional, García Sánchez, Sonia Mª, additional, Valenzuela, Sebastian, additional, Mengual, Juan José, additional, Font, M. Àngels, additional, Gómez Ruiz, Mª Isabel, additional, Zubizarreta, Irati, additional, González, Susana Fernández, additional, Gubieras, Laura, additional, Cobos, Carmen E., additional, Romo, Luis Mena, additional, Caballol, Nuria, additional, Cano, Luis, additional, Leal, Joaquín Serena, additional, Blas, Yolanda Silva, additional, Trigo, Irene Bragado, additional, Viturro, Saima Bashir, additional, Albiñana, Laura Pardo, additional, Garrido, Montserrat Reina, additional, Cazcarra, Carla Marco, additional, Uscamaita, Karol Enrique, additional, Márquez, Fabian, additional, Coll, Cristina, additional, Villlas, Mar Irida Lloret, additional, Vila, Berta Solano, additional, Perna, Berta Alemany, additional, Domínguezl, Daniel López, additional, de Lera, Mercedes, additional, Foraster, Anna Cots, additional, Bojaryn, Urszula, additional, Benabdelhak, Ikram, additional, Capdevila, Gerard Mauri, additional, Montesinos, Jordi Sanahuja, additional, Vázquez, Daniel, additional, Hervás, José Vicente, additional, González, Cristina, additional, Quílez, Alejandro, additional, Pascual, Mikel Vicente, additional, Ruiz, María, additional, Riba, Yolanda, additional, Villar, M. Pilar Gil, additional, García, Cristina, additional, Roig, Xavier Ustrell, additional, Mora, Mònica Baldrich, additional, Guinjoan, Anna Pellisé, additional, Borras, Judit, additional, Martínez, Alba Mañé, additional, Marés, Rafael, additional, Viñas i Gaya, Jaume, additional, Seró, Laia, additional, Rodríguez, Paula, additional, Castilho, Gislaine, additional, Ortega, Angela Monterde, additional, Reverté, Silvia, additional, Baiges, Joan Josep, additional, Ozaeta, Gisela Martín, additional, Escalante, Sonia, additional, Belloch, Patricia Esteve, additional, Payo, Iago, additional, Salvado, Júlia Saura, additional, Soler Insa, Josep M, additional, Vilamala, Ester Tio, additional, Navarro, Josep Abos, additional, Tabuenca, Héctor Cruz, additional, Sánchez, Tamara Canento, additional, Roldán, Elisabet, additional, Rubiol, Elsa Puiggrós, additional, Franquet, Elisabet, additional, Fuentes, Lidia, additional, Donaire, Javier, additional, Martí, Elena, additional, Giménez, Laura, additional, Vázquez, Junior Gil, additional, Ambrós, Eloisa Nieto Clara Gris, additional, Rodríguez, Puri, additional, Oletta, José Félix, additional, Mellado, Pilar Pons, additional, Gómez, Bárbara, additional, Raileau, Vergilin, additional, Pardina, Oscar, additional, Mercadal, Jordi, additional, López-Diéguez, María, additional, Pérez, Pilar, additional, Gabarró, Lourdes, additional, Orriols, María, additional, Molina, José Carlos, additional, Canet, Joan Josep, additional, Roca, Mireia, additional, Álvaro, Muriel, additional, Boneu, Francesc, additional, Giménez, Georgina, additional, Albà, Jaume, additional, Gibert, Francesc, additional, Garcia, Jéssica, additional, Barragan, Patricia, additional, Jurado, Gustavo, additional, Pascual_Medicina Interna, Vanesa, additional, Ortega, Josep Sabaté, additional, Solano, Joan Amaurys Martínez, additional, Fernández, Víctor, additional, Torres, Mónica, additional, Alvaredo, Ana Belén Montero, additional, Parejo, Laura Redondo, additional, Aragonés, Josep Maria, additional, Bullón, Anna, additional, Loste, Cora, additional, González, Paula, additional, Bejarano, Neker, additional, Sanchez, Francisco, additional, Lucchetti, Gianni, additional, Pla, Xavier, additional, Gimeno, Dr Javier, additional, Reynaga, Esteban, additional, Barcons, Montse, additional, Celedón, Gabriel, additional, Ortiz, Juan, additional, Anastasovski, Dr Goran, additional, Mascaró, Dr Oscar, additional, de los Ríos, Dr Javier Diez, additional, Feliu, Meritxell, additional, Ribera, Anna, additional, Ruiz, Cristhian, additional, Corominas, Gerard, additional, Nunes, Dra Daniella, additional, Roca, Claudia, additional, Latorre, Nadina, additional, Yataco, Lizbeth, additional, Cruz, Maricelys, additional, Blanco, Nerea, additional, Castejón, Santiago, additional, Sunyer, Claustre Pont, additional, Garcia, Jordi Espinosa, additional, Martin, Rodrigo Paz, additional, de Luis Sanchez, Albert, additional, Vivas, Dolores Espinosa, additional, Molina, Juan Valencia, additional, Palome, Planels, additional, Chaume, Laia Tomas, additional, Vilella, Ares Villagrasa, additional, Bustamante, Marco, additional, Boltes, Anunciación, additional, Rodríguez, Fernando, additional, Arrieta, Itziar, additional, Molist, Jordi Ciurans, additional, Andreu, Barnés, additional, Soler, Ernest Palomeras, additional, Buscà, Nicolau Guanyabens, additional, López, Manuel Daza, additional, Farreres, Jordi Bigas, additional, Ruiz, Virginia Casado, additional, Batiste, Desiree Muriana, additional, Sanz Cartagena, Mª Pilar, additional, de Vega, Eulalia Cabot, additional, Real, Josep Bassa, additional, Roman, Hector Pelaez, additional, Socolich, César, additional, Alonso Camp, Josep Mª, additional, Orgaz, Antonio Tomás Cano, additional, Fossas Felip, Mª Pilar, additional, Morón, Nicolás, additional, Bacca, Sandra, additional, Molina, Mauricio, additional, Casarramona, Francesc, additional, Elias, Lorena, additional, Bukaei, Muhammad Zidane, additional, Gutierrez, Jose Antonio Martos, additional, Escuin, Judith Lopez, additional, Olaizola, Cristina, additional, Vargas, Yolexis López, additional, Oyonarte, Juan Jiménez, additional, Soultana, Rashida, additional, Golpe, Eduardo Sanjurjo, additional, Salvador, Esther, additional, Vila, Guillem, additional, Serrano, Marcos, additional, Claverol, Matilde Nuria López, additional, Lamolla, Marian, additional, Amate, Miquel, additional, Rodriguez, Adriana, additional, Romero, Ruth, additional, del Carpio, Montgomery, additional, Hernandez, Ana Isabel, additional, Martín, Julián, additional, Rosas, M Carmen, additional, Nogueroles, Antonio, additional, Encarnación, Sorilandy, additional, Robles, Augusto, additional, Herrera, Jose Antonio, additional, Gavilán, Roger, additional, Mameghani, Toghrol, additional, Araujo, Gastón, additional, Morales, M.Angeles Garrido, additional, Segui, Enric Ramon Albert, additional, Climent, Eva Fernandez, additional, Pujol, Francesc Paris, additional, Seira, Mireia Judit Garrofé, additional, Pía, Lucía Gómez, additional, Nuñez, Fernando Salleres, additional, Peñalver, Cristina Aguar, additional, Lopes, Cristina Vaz, additional, Tasa, Elisenda Ribera, additional, Vilchez, Carmen Repullo, additional, Zambrana, Modesto Sánchez, additional, Ribas, Beatriu Suescun, additional, Panés, Inés Vilà, additional, Planavila, Montserrat Vila, additional, Lorenzo, Alicia Vaqueiro, additional, Guixes, Meritxell Sabartés, additional, Medina, Jorge, additional, Sambrano, David, additional, Zamarreño, Javi, additional, Pirela, Carmen, additional, Vélez, Paola, additional, Cajamarca, Luis, additional, Pérez, Honey, additional, Martínez, Yarles, additional, Gonçalves, Jesus Alexander, additional, Regordosa, Carles, additional, Mormeneo, Claudia, additional, Griu, Laura, additional, Colina, Maria Francia, additional, Farik, Enric, additional, Duch, Dolors Carrión, additional, Badenas, Carles, additional, Bernal, Oscar, additional, Agramunt, Núria, additional, Morales, Shyrlei, additional, Reynoso, Victoria, additional, Guerrero, Miguel, additional, Cid, Primitivo Romera, additional, Folqué, Mònica, additional, Pedroza, Claudia, additional, Hachem, Adnan, additional, Martínez, Íñigo Soteras, additional, García, Xavier Verdera, additional, Amorós, Mercè López, additional, Subirós, Xavier Costa, additional, Benet, Marta Cufí, additional, Van Eendenburg, Cecile, additional, Osuna, Teresa, additional, Santos, Dra Gina, additional, Pallisera, Dra Mireia, additional, Oliva, Dr Lluís Gonzalo, additional, Sanchez, Dra Gemma, additional, Basurto, Dr Xavier, additional, Vivoda, Dr Ludgi, additional, Van der Kleyn, Dr Richard, additional, Robles, Dra Laura, additional, Barranco, Ana Cabanelas, additional, Almendros, Mª Cruz, additional, Oliveras, Marc Pérez, additional, Álvarez, Amelia Fernández, additional, Rybyeva, Maria, additional, Viñas, Antoni, additional, Barcons, Maria, additional, Tavera, Joaquim Danès Alberto, additional, Burbano, Pablo, additional, López, Cintie, additional, Cruz, David, additional, Bisbe, Paula, additional, Fernández, Nora, additional, Palacio, Juan Carlos, additional, Fraiz, Eduardo, additional, Aguiló, Oriol, additional, Amorodjo, Rollmy, additional, Velázquez, John, additional, Sánchez, Elena, additional, Español, Jaume, additional, Perez de Celis, Judit, additional, Coll, Anna, additional, Díaz, Glòria, additional, Vergés i Sala, Margarida, additional, Casas Capdevila, Mª Ángels, additional, Ferrini, Yosmairy Yoselin, additional, Gorriz, Aitor, additional, Navarro, Diego-Javier Cucurell, additional, Velásquez, Dulce, additional, Pla Soler, Jaume, additional, González, Josep, additional, Higuera, Julian David, additional, Cuellar, Lina, additional, Miniello, Liza Margarita, additional, Pujol, Lluis, additional, Cracan, Sorin, additional, Vives, Mora, additional, Angela, M, additional, Lopez, Lopez, additional, Molist, Montse Gorchs, additional, Anna, Delofeu, additional, Muñoz, Silvia Solà, additional, Yolanda, Ferreres, additional, Pujalte, Carol, additional, Marín, Elisabeth Téllez, additional, Casas, Yolanda Font, additional, Luque, Sara Hernández, additional, Sendra, Joaquim Mejias, additional, Valero, Francesca Mellado, additional, Escala, Campos, additional, De Lacanal, Galup, additional, Diaz, Lopez, additional, Paramio, Castillo, additional, Estopà, Català, additional, Moreda, Español, additional, Majo, Calafell, additional, Almeida, Carballo, additional, Naval, Castro, additional, Elena, M, additional, Ruiz, Cregut, additional, Lluis, Pere, additional, Font, Deulofeu, additional, Sanjuan, Fabregat, additional, Pere, Joan, additional, Gorchs, Fontquerni, additional, Bellés, Forés, additional, Antoni, Joan, additional, Herrera, Gomez, additional, Carlos, Juan, additional, Prades, Hijazo, additional, Torvisco, Itzaina, additional, Rovira, Marti, additional, Gonzalez, Obiols, additional, Cavero, Olive, additional, Gil, Querol, additional, Soledad, M, additional, Rodriguez, Rico, additional, Sambernardo, Rios, additional, Molina, Ropero, additional, Ramon, Jose, additional, Valero, Sanchez, additional, Arevalo, Santos, additional, Jose, Maria, additional, Garcia, Soto, additional, Angeles, Maria, additional, Escribano, Tebar, additional, Garcia, Torres, additional, José, Pedro, additional, Carrion, Verdes, additional, Isabel, M, additional, Lopez, Verge, additional, Jose, Juan, additional, Canela, Lopez, additional, Angeles, M, additional, Guarque, Lucas, additional, Alvarez, Morales, additional, Arnulfo, Jorge, additional, Fornieles, Morell, additional, Gomez, Subirats, additional, Teresa, Maria, additional, Masa, Miquel, Torello, additional, Lopez, Val, additional, Mercedes, Maria, additional, Reyes, Palmero, additional, Manuel, Juan, additional, Forne, Rodriguez, additional, Turiel, Ruana, additional, Gonzalez, Sanchez, additional, Gornals, Sebastia, additional, Rico, Abrio, additional, Falip, Albert Gual, additional, Oliveros, Aznar, additional, Perotti, Brugues, additional, Molinero, Calvet, additional, Franco, Catells, additional, Medina, Corrales, additional, Miro, Daroca, additional, Marquez, Duran, additional, Pradas, Feliu, additional, Casanova, Figueras, additional, Tortajada, Garcia, additional, Gallego, Grajera, additional, del Mar, Azahara, additional, Arroyo, Las, additional, de Jesus, Dulcenombre, additional, Sanz, Laserreta, additional, Vidal, Llambrich, additional, Corral, Monllao, additional, de la Cruz, Morales, additional, Blanco, Moreno, additional, Orgaz, Orejuela, additional, Suazo, Piñana, additional, Minguillon, Pons, additional, Gómez, Rodríguez, additional, Carlos, José, additional, Pereira, Rodriguez, additional, Porcel, Anna, Sedo, additional, Villar, Sevil, additional, Lopez, Sierra, additional, Romero, Torres, additional, Calveres, Anna, Trepat, additional, Arnella, Ventura, additional, Gil, Acera, additional, Teresa, M, additional, Vico, Biesot, additional, Galea, Castro, additional, Maria, Rosa, additional, Chafer, Escorcia, additional, Antonio, Juan, additional, Faure, Gil, additional, Luque, Hernandez, additional, Delgado, Jimenez, additional, Gay, Mallafre, additional, Angel, M., additional, Sanzo, Olivares, additional, Fondevila, Pubill, additional, Fort, Sabate, additional, Agámez, Segovia, additional, Carlos, Antonio, additional, Longaretti, Turata, additional, Hernandez, Valle, additional, Guixens, Trayner, additional, Valor, Aguilar, additional, Alvarez, Aguirre, additional, Naval, Alastrue, additional, Baquero, Alferez, additional, Marne, Alonso, additional, Orozco, Aloy, additional, Colino, Alvarez, additional, Peñuela, Alvarez, additional, Cirilo, Ameller, additional, Vanessa, Maria, additional, Guerrero, Andujar, additional, Remedios, Estefania, additional, Sillero, Auladell, additional, Sorbet, Azcarate, additional, Genesca, Basany, additional, Barduena, Benavent, additional, Tudela, Benito, additional, Pardo, Blanch, additional, Pla, Boluda, additional, Gonzalez, Bonilla, additional, Serramalera, Bru, additional, Andreu, Burnat, additional, Calvo-Rayo, Caballero, additional, Casellas, Calvo, additional, Mombiela, Camps, additional, Bresme, Cano, additional, Fernandez, Carcelen, additional, Solà, Caro, additional, Matavacas, Casasas, additional, Bolado, Castanedo, additional, Cortina, Cerdeña, additional, Jane, Abella, additional, Borrego, Laia Collado, additional, Orri, Colom, additional, Vilanova, Comellas, additional, Sole, Conillera, additional, Torres, Cots, additional, Estepa, Cuchi, additional, de Sostoa Graell, Marc, additional, del Rio Lopez, Laura, additional, Compte, Delgado, additional, Bueno, Diaz, additional, Maneiro, Diaz, additional, Lucia, Andrea, additional, Palau, Domenech, additional, Carme, M., additional, Carasso, Duran, additional, Javier, Pablo, additional, Abidi, El, additional, Martin, Escoda, additional, Casanovas, Esteve, additional, Perez, Fernandez, additional, Quintero, Ferre, additional, Escobar, Flores, additional, Abad, Fontcuberta, additional, del Valle, Fortes, additional, Luisa, Mª, additional, Quesada, Franco, additional, Maria, Sara, additional, Romero, Franco, additional, Francisco, Gallego, additional, Gala, Gamiz, additional, Castañeda, Garcia, additional, Rodriguez, Garcia, additional, Gemma, Casajuana, additional, Arroyo, Gomez, additional, Girbau, Gomez, additional, Fernandez, Gonzalez, additional, Gonzalez, Gonzalez, additional, Lopez, Gonzalez, additional, Obeso, Gual, additional, Blanco, Guerrero, additional, Roca, Guillemas, additional, Eudaldo, Guillermo, additional, Hernandez, Sebastia, additional, Covas, Homar, additional, Alvarez, Hostench, additional, Royo, Huerta, additional, Barcelo, Ibañez, additional, Cruz, Izquiero, additional, Etxetxikia, Jaione Urdangarin, additional, Gimenez, Juárez, additional, Alami, Khlifi, additional, Gasco, Laparra, additional, Moreales, Lara, additional, Medina, Lasaosa, additional, Lourdes, Maria, additional, Cava, Lazaro, additional, Berrar, Leon, additional, Maturana, López, additional, Ramirez, Lopez, additional, Romero, López, additional, Marco, Lorente, additional, Martin, Lorenzo, additional, Casals, Lozano, additional, Nicola, Lujan, additional, Diaz, Madrid, additional, Antonio, Jose, additional, Morales, Maria Teresa Peris, additional, Clemente, Marti, additional, Castaño, Martinez, additional, Natanael, David, additional, Gamez, Martinez, additional, Gonzalez, Martinez, additional, Quesada, Martinez, additional, de la Cabeza, Maria, additional, Fusté, Marzà, additional, Lasheras, Melendo, additional, Mestre, Miralles, additional, Pastalle, Montserrat Puig, additional, Vidal, Montserrate, additional, Mellado, Mora, additional, Ponce, Morales, additional, Cabre, Morera, additional, Vivet, Morera, additional, Souza, Mundi, additional, Quiles, Muñoz, additional, Rosa, Navea, additional, Iglesias, Neira, additional, Asuncion, M, additional, Manrique, Nuñez, additional, Pilar, Mª, additional, Martinez, Obiols, additional, Reig, Pallares, additional, Torres, Partegas, additional, Berengueras, Pascual, additional, Gamez, Perez, additional, Oset, Perez, additional, Restrepo, Perez, additional, Alejandra, Maria, additional, Yeste, Planas, additional, Mangado, Planells, additional, Carbonell, Puertas, additional, Blanco, Quinteiro, additional, Benavente, Rebollar, additional, Fernandez, Recasens, additional, Gomez, Reyes, additional, del Carmen, Maria, additional, Pou, Roca, additional, Ferrer, Rodriguez, additional, Franco, Rodriguez, additional, Fuertes, Rodriguez, additional, Muñoz, Rodriguez, additional, Navarro, Rodriguez, additional, Iniesta, Roig, additional, Gracia, Romero, additional, Brunet, Rovira, additional, de Eugenio, Rovira, additional, Baena, Rubio, additional, Llorens, Ruiz, additional, Llamazares, Sala, additional, Alaez, San Juan, additional, Segura, Sanchez, additional, Soldevilla, Santasusana, additional, Salmeron, Sanz, additional, Perez, Segura, additional, Balcells, Serra, additional, Dumitras, Sorina, additional, Montoya, Teixidor, additional, Vicente, Tena, additional, Salinas, Tierno, additional, Ines, Ester, additional, Testa, Toledo, additional, Figueras, Tomàs, additional, Ruperez, Tomas, additional, Garcia-Penche, Torrano, additional, Esparza, Torres, additional, Blanco, Vazquez, additional, De la Paz, Vazquez, additional, Gil, Vazquez, additional, Gonzalez, Vazquez, additional, Meler, Vidal, additional, Cots, Vilalta, additional, Jimenez, Vilches, additional, Fernandez, Visser, additional, Gavin, Viu, additional, Vives, Vives, additional, Jimenez, Carmona, additional, Jose, Francisco, additional, Vilches, Galobardes, additional, Gomez, Gonzalez, additional, Manzanera, Jodar, additional, Cortes, Marimon, additional, Orive, Marrodan, additional, Bosch, Martin, additional, Lopez, Martorell, additional, Roca, Millares, additional, Jesus, M, additional, Guri, Miralles, additional, Hernandez, Muliterno, additional, Oliva, Muñoz, additional, Pujol, Pons, additional, Conde, Postius, additional, Arruñada, Prieto, additional, Mathé, Quintana, additional, Mata, Rosell, additional, Alvarez, Alvarin, additional, Flores, Arrufat, additional, Pago, Bañuelos, additional, Vilar, Campo, additional, Hidalgo, Cardus, additional, Gil, Castello, additional, Gloria, Maria, additional, Montsesinos, Castrillo, additional, Garces, Clave, additional, Sanroma, Comes, additional, Sequi, Descalzo, additional, Ricol, Errando, additional, Campillo, Escudero, additional, del Mar, Maria, additional, Alvarez, Fernandez, additional, Gomez, Fernandez, additional, Espinosa, Franch, additional, Graells, Freixes, additional, Plaza, Garcia, additional, Gallego, Garcia-Marron, additional, Simancas, Hernandez, additional, Armas, Jaraba, additional, Ramos, Jimenez, additional, Oganissian, Lopez, additional, Romero, Madrona, additional, Rosa, M, additional, Millan, Martinez, additional, Morón, Martínez, additional, Encinas, Merchan, additional, Jimenez, Moreno, additional, Rico, Muñoz, additional, Rodriguez, Navarro, additional, Ibañez, Nogales, additional, Maria, Rita, additional, Viera, Novillo, additional, Torrabadella, Parella, additional, Alba, Mari, additional, Villar, Pera, additional, Montserrat, Carla, additional, Miralles, Rabella, additional, Trilles, Ramis, additional, Ortiz, Ribera, additional, Perez, Sastre, additional, Borrega, Soro, additional, Fores, Tapia, additional, Bernad, Tellez, additional, Alvarez, Trenado, additional, Martin, Felix, additional, Perez, Herrero, additional, Fuster, Lanau, additional, Gomariz, Lopez, additional, Lozano, Pardo, additional, Altimiras, Quintana, additional, Lopez, Ventosa, additional, Damian, Almodovar, additional, Monterroso, Alvarez, additional, Comas, Arambudo, additional, Garzon, Boullon, additional, Capella, Burgos, additional, Garcia, Campuzano, additional, Del Mar, Maria, additional, Olivas, Capdevila, additional, Marti, Carre, additional, Isabel, Clara, additional, Bacaicoa, Carretero, additional, Calderon, Cazorla, additional, Osuna, Chacon, additional, Planas, Cortes, additional, Olio, Cortit, additional, Estany, Delhomme, additional, Martinez, Fructuos, additional, Lopez, Garcia, additional, Luis, Pascual, additional, Vallve, Genis Amill, additional, Muñoz, Gonzalez, additional, Ventura, Hernaez, additional, Gimenez, Lavernia, additional, Rojo, Martin, additional, Medina, Martínez, additional, Barrera, Mayol, additional, Pi, Mercader, additional, Dalmau, Merino, additional, Campodarbe, Miguel, additional, Sanchez, Moreno, additional, Javier, Francisco, additional, Barrameda, Penela, additional, Ajenjo, Prieto, additional, Pareja, Rodriguez, additional, Piñar, Rodríguez, additional, Tello, Rodriguez, additional, Pereda, Romero, additional, Saborido, Sainz, additional, Martin, Santacana, additional, Martinez, Santos, additional, Chavez, Sierra, additional, Torres, Turbau, additional, Domenech, Vicente, additional, Esteo, Villena, additional, Pertegaz, Vives, additional, Gonzalez, Baena, additional, Pont, Bagaria, additional, Sanchez, Beltran, additional, Alarcon, Bonet, additional, Ballescà, Borch, additional, Clanchet, Buhils, additional, Garcia, Closa, additional, Carril, Colomina, additional, Sanchez, Cristina Fernandez, additional, Toledo, Edurne Judith Fernandez, additional, Rodriguez, Espases, additional, Resa, Espert, additional, Xavier, F, additional, Sol, Fernández, additional, Lugo, Gonzalez, additional, Llesera, Gracia, additional, Lendinez, Herrada, additional, Liesa, Juliench, additional, Alicia, Sandra, additional, Ortega, Lopez, additional, Yuste, Lopez, additional, Villanueva, Lozano, additional, Soto, Lucia Sola, additional, Castellano, Madrid, additional, Cano, Megias, additional, Jesus, Daniel, additional, Ponce, Montasell, additional, Sospedra, Montesinos, additional, Martinez, Moya, additional, Herrera, Muñoz, additional, Fernandez, Ocaña, additional, Bernal, Palau, additional, Sole, Perez, additional, Carbonell, Ramon, additional, Lop, Ribas, additional, López, Rubio, additional, Lopez, Rueda, additional, Castaño, Sabat, additional, Lara, Sabata, additional, Ramírez, Salmerón, additional, Creus, Serra, additional, Dalmau, Serrano, additional, Mainero, Sumasi, additional, Gabriel, Gonzalo, additional, Masa, Torello, additional, Primo, Valencia, additional, Muñoz, Ana Maria Viñuales, additional, Roig, Josep, additional, and Hidalgo, Verònica, additional
Published: 2023
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4. Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice

Author: Mònica Millán, Anna Ramos-Pachón, Laura Dorado, Alejandro Bustamante, María Hernández-Pérez, Luís Rodríguez-Esparragoza, Meritxell Gomis, Sebastia Remollo, Carlos Castaño, Mariano Werner, Denisse Wenger, Sara Rubio, Manuel Domínguez-Lizarbe, Mikel Terceño, Andrés Julián Paipa, Alejandro Rodríguez-Vázquez, Sandra Boned, Pol Camps-Renom, David Cánovas, Eva Giralt, Elena López-Cancio, Antoni Dávalos, Josep Ros-Roig, Natalia Pérez de la Ossa, Pere Cardona, Helena Quesada, Blanca Lara, Ana Nuñez Guillen, Roger Barranco, Lucia Aja, Paloma Mora, Oscar Chirife, Sonia Aixut, Maria Angeles de Miquel, Toni Martínez-Yelamos, Carlos Molina, Marta Rubiera, Jorge Pagola, David Rodríguez-Luna, Marian Muchada, Alejandro Tomasello, Marc Ribó, Carlos Piñana, Manuel Requena, Matías Deck, Alvaro Garcia-Tornel, Marta Olivé, Noelia Rodriguez, Jesus Jueg, Ángel Chamorro, Sergio Amaro, Xabier Urra, Laura Llull, Arturo Renú, Salvatore Rudiloso, Juan M. Macho, Jordi Blasco, Luis San Roman Manzanera, Antonio López, Federico Zarco, Ramón Torné, Ricard Valero, Víctor Obach, Víctor Vera, Martha Vargas, Carlos Laredo, Joan Martí-Fàbregas, Raquel Delgado-Mederos, Alejandro Martínez-Domeño, Luis Prats-Sánchez, Daniel Guisado-Alonso, Marina Guasch-Jiménez, Rebeca Marín Bueno, Jordi Branera-Pujol, José Pablo Martínez, Lavinia Dinia, Anna Pellisé, Xavier Ustrell, Alan Flores, Laia Seró, Joaquín Serena, Yolanda Silva, Saima Bashir, Alan Murillo, Jerzy Krupinski, Sonia Huertas, Jessica Molina, Georgina Figueras, Sarah Besora, Ana Rodríguez-Campello, Jaume Roquer, Ángel Ois, Elisa cuadrado-Godia, Jordi Jiménez-Conde, Elio Vivas, Polo Guimaraens, Maria del Carmen Garcia, Jordi Estela, Joan Perendreu, Nicolas Romero, Roberto Eduardo Correa, Oriol Barrachina, Moisès Broggi, Manuel Gómez-Choco, Sonia M. García, Maria Àngels Font Padrós, Juan José Mengual Chirife, Luis Mena Romo, Ernest Palomeras, Virginia Casado, Nicolau Guanyabens, Marta Álvarez, Esther Catena, José Luis Camacho Velasquez, Francisco Purroy, Gerard Mauri, Cristina Garcia, Jessica García Alhama, Irene Bragado Trigo, Jordi Monedero, Mònica Perecaula, Luis Guillermo Casanovas, Carla Colom, Dolores Cocho, Adela Rios González, Juanjo Baiges, Josep Zaragoza, Gisela Martin, Sonia Escalante, Patricia Esteve, Iago Payo, Lidia Binela, Josep Maria Aragonés, Núria Matos, Josep Maria Soler-Insa, Natalia Mas, Glòria Diaz, Margarida Vergés, Xavier Costa, Liseth Molina, M. Cruz Almendros, Marc Pérez, Ana Cabanelas, Olga Belchi, Maria Rybyeba, Miquel Barceló, Dolors Carrión, Carmen Repullo, Eduard Sanjurjo, Mercè Salvat-Plana, Josep Roig, Verònica Hidalgo, Olga Fagúndez, Victòria Sala, Anabel Alonso, Marisol Querol, Montse Gorchs, Xavier Jiménez, and Maria Àngels Mora
Subjects: Male, medicine.medical_specialty, Treatment outcome, Outcome (game theory), Humans, Medicine, Disabled Persons, In patient, Prospective Studies, Registries, Stroke, Aged, Ischemic Stroke, Thrombectomy, Aged, 80 and over, Advanced and Specialized Nursing, business.industry, Middle Aged, medicine.disease, Mechanical thrombectomy, Clinical Practice, Spain, Ischemic stroke, Physical therapy, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Abstract: Background and Purpose: Mechanical thrombectomy (MT) in ischemic stroke patients with poor prestroke conditions remains controversial. We aimed to analyze the frequency of previously disabled patients treated with MT in clinical practice, the safety and clinical response to MT of patients with preexisting disability, and the disabled patient characteristics associated with a better response to MT. Methods: We studied all consecutive patients with anterior circulation occlusion treated with MT from January 2017 to December 2019 included in the Codi Ictus Catalunya registry—a government-mandated, prospective, hospital-based data set. Prestroke disability was defined as modified Rankin Scale score 2 or 3. Functional outcome at 90 days was centrally assessed by a blinded evaluator of the Catalan Stroke Program. Favorable outcome (to return at least to prestroke modified Rankin Scale at 90 days) and safety and secondary outcomes were compared with patients without previous disability. Logistic regression analysis was used to assess the association between prestroke disability and outcomes and to identify a disabled patient profile with favorable outcome after MT. Results: Of 2487 patients included in the study, 409 (17.1%) had prestroke disability (313 modified Rankin Scale score 2 and 96 modified Rankin Scale score 3). After adjustment for covariates, prestroke disability was not associated with a lower chance of achieving favorable outcome at 90 days (24% versus 30%; odds ratio, 0.79 [0.57–1.08]), whereas it was independently associated with a higher risk of symptomatic intracranial hemorrhage (5% versus 3%; odds ratio, 2.04 [1.11–3.72]) and long-term mortality (31% versus 18%; odds ratio, 1.74 [1.27–2.39]) compared with patients without disability. Prestroke disabled patients without diabetes, Alberta Stroke Program Early CT Score >8 and National Institutes of Health Stroke Scale score Conclusions: Despite a higher mortality and risk of symptomatic intracranial hemorrhage, prestroke-disabled patients return as often as independent patients to their prestroke level of function, especially those nondiabetic patients with favorable early ischemic signs profile. These data support a potential benefit of MT in patients with previous mild or moderate disability after large anterior vessel occlusion stroke.
Published: 2022
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5. Effects of Bihemispheric Transcranial Direct Current Stimulation Combined With Repetitive Peripheral Nerve Stimulation in Acute Stroke Patients

Author: S. Yagüe, Jordi Pedro, Belia García, Hatice Kumru, Josep Valls-Solé, Pere Cardona, Antonio Martínez-Yélamos, Jordi Montero, Misericordia Veciana, Blanca Lara, and Helena Quesada
Subjects: Physiology, medicine.medical_treatment, Central nervous system, Peripheral nerve stimulation, Stimulation, Transcranial Direct Current Stimulation, Placebo, Upper Extremity, Physiology (medical), Humans, Medicine, Peripheral Nerves, Prospective Studies, Transcranial direct-current stimulation, business.industry, Stroke Rehabilitation, Recovery of Function, Neurophysiology, Stroke, Treatment Outcome, medicine.anatomical_structure, Neurology, Somatosensory evoked potential, Anesthesia, Upper limb, Neurology (clinical), business
Abstract: Transcranial direct current stimulation (tDCS) can change the excitability of the central nervous system and contribute to motor recovery of stroke patients. The aim of our study was to examine the short- and long-term effects of real versus sham bihemispheric tDCS combined with repetitive peripheral nerve stimulation in patients with acute stroke and a severe motor impairment.The study was prospective, randomized, double blind, and placebo controlled. Nineteen acute stroke patients (ischemic and hemorrhagic) with upper limb Fugl-Meyer mean score of19 were randomized in two groups: one group received five consecutive daily sessions of anodal tDCS over the affected hemisphere and cathodal over unaffected hemisphere combined with repetitive peripheral nerve stimulation and the other received sham tDCS associated to repetitive peripheral nerve stimulation. Clinical and neurophysiological assessment was applied before tDCS, 5 days after tDCS, and 3, 6, and 12 months after tDCS.There were significant time-related changes in both groups of patients in motor evoked potentials, somatosensory evoked potentials, Hmax:Mmax ratio, upper limb Fugl-Meyer scores, and Modified Ashworth scales scores ( P0.05). However, no significant differences between groups were present at any time ( P0.05).Bihemispheric tDCS and repetitive peripheral nerve stimulation with the parameters of our study did not add significant short- or long-term clinical improvement or change in neurophysiological data in severe acute stroke patients in comparison to sham stimulation. The severity of motor impairment in stroke patients may influence a possible response to an interventional tDCS treatment.
Published: 2021
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6. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke

Author: Alejandro Bustamante, Mikel Terceño, Joaquín Serena, Mónica Millán, Natalia Pérez de la Ossa, María Hernández-Pérez, Xavier Ustrell, Teresa García-Berrocoso, Joan Montaner, Antoni Dávalos, Marta Rubiera, Anna Ramos-Pachón, Elena López-Cancio, Moisés Garcés, and Pere Cardona
Subjects: Male, medicine.medical_specialty, patients, Brain Ischemia, Fibrin Fibrinogen Degradation Products, Predictive Value of Tests, Internal medicine, Atrial Fibrillation, D-dimer, medicine, Humans, Prospective Studies, cardiovascular diseases, Prehospital triage, Stroke, Acute ischemic stroke, Aged, Ischemic Stroke, Retrospective Studies, Thrombectomy, Advanced and Specialized Nursing, business.industry, Endovascular Procedures, biomarkers, Middle Aged, medicine.disease, stroke, reperfusion, thrombectomy, Reperfusion, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Biomarkers, Large vessel occlusion
Abstract: Background and Purpose: Improving prehospital triage of large vessel occlusion (LVO) would reduce time to reperfusion therapies. We aimed to study early predictors of LVO in acute ischemic stroke to identify candidates for endovascular treatment. Methods: The Stroke-Chip was a prospective observational study conducted at 6 Stroke Centers in Catalonia. Blood samples were obtained in the first 6 hours from symptom onset of consecutive patients. Stroke severity was evaluated with National Institutes of Health Stroke Scale (NIHSS) and LVO was assessed. Independent association of multiple blood biomarkers with LVO was evaluated using logistic regression models adjusted by covariates. Sensitivity, specificity, and predictive values were assessed for NIHSS and the combination of NIHSS and selected serum biomarkers levels. Results: One thousand three hundred eight suspected strokes were enrolled for a 17-month period. LVO was not assessed in 131 patients. One thousand one hundred seventy-seven patients were selected for analysis (mean age 69.3 years, 56% men, median baseline NIHSS of 6, and median time to blood collection 2.5 hours). LVO was detected in 262 patients. LVO patients were older, had higher baseline NIHSS, history of atrial fibrillation, and lower time from stroke onset to admission. After logistic regression analysis, D-dimer remained an independent predictor of LVO (odds ratio, 1.59 [1.31–1.92]). Specificity and positive predictive value to exclude or detect LVO were higher when using combined D-dimer levels and NIHSS score assessment rather than NIHSS alone. Conclusions: Early D-dimer levels are an independent predictor of LVO and may be useful to better optimize prehospital patient transport to the appropriate stroke center.
Published: 2021
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7. Abstract 36: Endovascular Thrombectomy Beyond 24 Hours From Last Known Well: A Pooled Multicenter International Cohort

Author: Amrou Sarraj, Ameer E Hassan, Michael G Abraham, Pere Cardona Portela, Nathan W Manning, Dennis Cordato, Timothy J Kleinig, Nitin Goyal, Spiros Blackburn, Margy E McCullough-Hicks, Marc Ribo, Teddy Y Wu, Jordi Blasco, Navdeep Sangha, Juan F Arenillas, Adam Wallace, Deep K Pujara, Faris Shaker, Mercedes de Lera Alfonso, Arturo Renu, Marta Olivé Gadea, Daniel Gibson, Colleen G Lechtenberg, Laith N Maali, Mohammad A Abdulrazzak, Tareq S Almaghrabi, James Beharry, Balaji Krishnaiah, Megan Miller, Najwa Khalil, Gagan J Sharma, Aristeidis H Katsanos, Ali Fadhil, Kelsey R Duncan, Yin Hu, clark W sitton, Sheryl B Martin-schild, Georgios K Tsivgoulis, Peter J Mitchell, Adam S Arthur, Mark Parsons, James C Grotta, Bruce C Campbell, and Gregory W Albers
Subjects: Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Background: Limited data are available on endovascular thrombectomy (EVT) efficacy and safety in large vessel occlusion (LVO) patients presenting >24hr from last known well (LKW). We compared outcomes between patients receiving EVT and best medical management (MM) in a multicenter international cohort. Methods: Consecutive patients with anterior circulation LVO presenting >24h after LKW from 13 centers from 7/2012-4/2021 were analyzed. Multivariable models for 90d mRS distribution and symptomatic ICH were adjusted for age, NIHSS, glucose, IV tPA, transfer status, clot location, time from LKW, CT ASPECTS and ischemic core (rCBF6s volumes. Results: Of 240 patients with a median (IQR) LKW to presentation 28.3h (24.9-38.2), 153 (64%) received EVT. Baseline characteristics were similar except for NIHSS (EVT: 13 (8-20) vs MM: 17 (10-22), p=0.005), CT ASPECTS (EVT: 8(6-9) vs MM: 4(3-6), p Conclusions: EVT may be associated with better functional outcomes, despite numerically increased risk of sICH in patients presenting with anterior circulation LVO beyond 24 hours. Further prospective studies are warranted.
Published: 2022
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8. Abstract P75: Cerebrovascular Events and Outcomes in Hospitalized Patients With Covid-19: The Society of Vascular and Interventional Neurology Multinational Registry

Author: Luis San Roman, Juan F. Arenillas, A. Singla, I. Bach, Alba Chavarría-Miranda, Alicia Zha, Alexandra L Czap, Ameer E Hassan, P. Patel, N. P. De la Ossa, Diogo C Haussen, Ryna Then, O. O. Zaidat, David S Liebeskind, Jesse M. Thon, Santiago Ortega-Gutierrez, Xabi Urra, P. Khandelwal, Saif Bushnaq, Alejandro Vazquez, Marc Ribó, Dinesh V Jillella, Ossama Mansour, Thanh N. Nguyen, Mudassir Farooqui, Raul G Nogueira, Pere Cardona Portela, Artem Kaliaev, Manuel Requena, A. Guillen, Cristina Tiu, James E. Siegler, Mónica Millán, Tudor G Jovin, and M. de Lera
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, 2019-20 coronavirus outbreak, Neurology, Coronavirus disease 2019 (COVID-19), Hospitalized patients, business.industry, Critically ill, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Epidemiology, medicine, Neurology (clinical), Significant risk, Cardiology and Cardiovascular Medicine, Intensive care medicine, business
Abstract: Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aims: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. Methods: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in 4 countries (2/1/2020 - 06/16/2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). Results: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) of whom were female and 96/172 (55.8%) were between the ages 60-79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130 - 280/100,000) and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p Conclusions: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19 associated cerebrovascular complications, therefore aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
Published: 2021
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9. Abstract WP101: Remote Ischemic Perconditioning Among Acute Ischemic Stroke Patients in Catalonia: Remote-Cat Project

Author: Gloria Arque, Sònia Abilleira, Pere Cardona, Joan Martí-Fàbregas, Jorge Pagola, Coral Torres, Cristina García, Manel Portero-Otin, Mikel Vicente-Pascual, Francisco Purroy, Alfonso López-Gomariz, Gerard Mauri, Ana Rodríguez-Campello, and Alex Rovira
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, Internal medicine, Cardiology, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Acute ischemic stroke
Abstract: Rationale: Remote ischemic perconditioning (RIPerC), consisting of brief episodes of transient limb ischemia, represents a new paradigm in neuroprotection with interesting results in ischemic heart disease patients. Aim: We aim to conduct a multicentre study of pre-hospital RIPerC application in acute ischemic stroke (AIS) patients.Sample size estimates: To detect a treatment difference of 14% in the outcome, 286 patients will be included for 5% significance and 80% power. Methods: A total of 572 adult patients diagnosed of suspected clinical stroke within 8 hours of symptom onset and clinical deficit >0 according to prehospital RACE scale will be randomized, in blocks of size 4, to RIC or sham. Patients will be stratified by RACE score scale. RIC will be started in the ambulance before hospital admission. RIPerC will consist of five cycles of electronic tourniquet inflation and deflation (5 min each). Study outcomes: The primary outcome will be the difference in clinical benefit measured by the modified Rankin Scale (mRS) score Discussion: Neuroprotective therapies could not only increase the benefits of available reperfusion therapies among AIS patients but also provide an option for patients who are not candidates for these treatments. REMOTE-CAT will investigate the clinical benefit of RIC as a new neuroprotective strategy in AIS. Clinicaltrials.gov number: NCT03375762. Status: Active
Published: 2020
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10. Abstract WMP70: Etiology of Stroke Based on Early Analysis of Clot Cytometry Obtained Through First Pass Technique for Mechanical Thrombectomy

Author: Sandra Boned, Laura Dorado, Noelia Rodriguez-Villatoro, Carlos Palacio, Elena Martinez, Pere Cardona, Jessica Camacho, Jorge Pagola, Helena Quesada, Carolina De la Torre, Marian Muchada, Alejandro Tomasello, Marc Ribó, Maria del C. Valdés Hernández, Carlos A. Molina, Marta Rubiera, David Rodriguez-Luna, Jesus Juega, Álvaro García-Tornel, and Santiago Ramon y Cajal Agueras
Subjects: Advanced and Specialized Nursing, First pass, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Atrial fibrillation, medicine.disease, Flow cytometry, Mechanical thrombectomy, Internal medicine, medicine, Etiology, Cardiology, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Stroke, Cytometry, Early analysis
Abstract: Introduction: Mechanical thrombectomy is the best treatment for large vessel occlusion in acute strokes, this technique can obtain clots for further analysis. Objective: To evaluate flow cytometry in thrombi obtained in the treatment of hyperacute stroke by mechanical thrombectomy, as a diagnostic tool in the etiological study of stroke Methods: Consecutively, intracranial clots were obtained in the hyperacute phase of stroke with solitaire device. Cell suspensions of thrombi were prepared that were labeled by direct immunofluorescence using conjugated monoclonal antibodies. The labeled samples were acquired in a Naviostm flow cytometer (Beckman-Coulter). The following leukocyte populations were studied: granulocytes, monocytes, total lymphocytes, T lymphocytes (CD3 +), helper T lymphocytes (CD3 +, CD4 +), suppressor-cytotoxic T lymphocytes (CD3 +, CD8 +), TNK lymphocytes (CD3 +, CD56 / 16 +) , NK lymphocytes (CD3-, CD56 / 16 +) and B lymphocytes (CD19 +). The results were expressed as percentages (%). The aetiology of stroke was categorized in secondary to: major structural heart disease, atrial fibrillation, stroke of atherosclerotic etiology (severe stenosis or complicated aortic atheromatosis ulceration) or infrequent causes. Results: 40 samples were analyzed. Clots of atherosclerotic etiology (n = 13) were associated with higher% of CD4 T lymphocytes (24.85% vs 15.83% p = 0.016), and higher% of NK (21.08% vs 17.04) % p = 0.07), also showed a tendency to a higher% LT (23.69% vs 16.46% p = 0.052). Strokes secondary to AF were associated with a higher percentage of CD8 T lymphocytes (20.24 vs 13.56 p = 0.048). Conclussion: Analysis by flow cytometry of clots obtained in the hyperacute phase of stroke showed significant differences in the different lymphocyte populations according to the etiology
Published: 2019
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11. Abstract TP307: Clinical and Neuroimaging Criteria to Improve Transfers to Comprehensive Stroke Centers for Endovascular Reperfusion Treatment Evaluation

Author: Natalia Pérez de la Ossa, Helena Quesada, Manuel Requena, Sònia Abilleira, Pere Cardona, Ángel Chamorro, Sandra Boned, Catalan Stroke Code, Carlos A. Molina, Xabier Urra, Marta Rubiera, Marc Ribó, and Antoni Dávalos
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, Stroke volume, medicine.disease, Treatment evaluation, Neuroimaging, medicine, Neurology (clinical), Endovascular treatment, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, Stroke
Abstract: Transfer protocols from primary (PSC) to comprehensive stroke centers (CSC) are crucial for the success of endovascular treatment (EVT). We aimed to identify clinical and neuroimaging predictors of EVT outcome in patients first assessed at non-capable EVT centers. Methods: Retrospective analysis of consecutive patients included in a prospective, population-based, mandatory registry of acute ischemic strokes (AIS). Inclusion criteria: AIS firstly evaluated at a PSC with suspected large vessel occlusion (LVO) transferred to a CSC for EVT assessment. PSC and CSC-ASPECTS, time-metrics and clinical data were analyzed. Results: Between February 2016 and May 2018, 1185 EVT candidates were transferred from PSC to CSC in our stroke code network (see Graph). Median baseline NIHSS was 13(7-19). 53.4% received iv tPA in the PSC. Upon CSC arrival, LVO was confirmed in 63.1% patients, and 42.8% received EVT. After a median of 130(107-169)min between both CT-acquisitions, the median inter-facilities ASPECTS decay was 1(0-2) and only 11.9% showed a CSC-ASPECTS16 as the best cut-off point that predicted CSC-ASPECTS16 independently predicted a CSC-ASPECTS16, and to 38.1% in patients with NIHSS>16 and PSC-ASPECS≤7. Conclusion: ASPECTS16 or PSC-ASPECTS≤7), confirming ASPECTS upon CSC arrival may not be necessary among AIS transferred from PSC.
Published: 2019
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12. Endovascular treatment improves cognition after stroke

Author: Erik Cobo, Elena López-Cancio, Tudor G. Jovin, Cynthia Cáceres, Marta Jiménez, María Hernández-Pérez, Arturo Renú, Blanca Lara, Pere Cardona, Marian Muchada, Meritxell Gomis, Neus Cerdà, Sandra Boned, Laura Llull, Antoni Dávalos, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
Subjects: Brain Infarction, Male, medicine.medical_specialty, Solitaire Cryptographic Algorithm, Biomatemàtica, Randomization, education, Trail Making Test, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Combinatòria, Neuropsychological Tests, 030204 cardiovascular system & hematology, Article, law.invention, Executive Function, 03 medical and health sciences, Cognition, 60 Probability theory and stochastic processes::60C05 Combinatorial probability [Classificació AMS], 0302 clinical medicine, Physical medicine and rehabilitation, Randomized controlled trial, law, Modified Rankin Scale, Matemàtiques i estadística::Probabilitat [Àrees temàtiques de la UPC], Humans, Medicine, Trombosi, Stroke, 92 Biology and other natural sciences::92C Physiological, cellular and medical topics [Classificació AMS], Thrombectomy, Biomathematics, business.industry, Endovascular Procedures, Thrombosis, Odds ratio, medicine.disease, Confidence interval, Surgery, Spain, Cognició, Combinatorial probabilities, Female, Neurology (clinical), Cognition Disorders, business, human activities, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: Objective:To investigate the effect of endovascular treatment on cognitive function as a prespecified secondary analysis of the REVASCAT (Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours) trial.Methods:REVASCAT randomized 206 patients with anterior circulation proximal arterial occlusion stroke to Solitaire thrombectomy or best medical treatment alone. Patients with established dementia were excluded from enrollment. Cognitive function was assessed in person with Trail Making Test (TMT) Parts A and B at 3 months and 1 year after randomization by an investigator masked to treatment allocation. Test completion within 5 minutes, time of completion (seconds), and number of errors were recorded.Results:From November 2012 to December 2014, 206 patients were enrolled in REVASCAT. TMT was assessed in 82 of 84 patients undergoing thrombectomy and 86 of 87 control patients alive at 3 months and in 71 of 79 patients undergoing thrombectomy and 72 of 78 control patients alive at 1 year. Rates of timely TMT-A completion were similar in both treatment arms, although patients undergoing thrombectomy required less time for TMT-A completion and had higher rates of error-free TMT-A performance. Thrombectomy was also associated with a higher probability of timely TMT-B completion (adjusted odds ratio 3.17, 95% confidence interval 1.51–6.66 at 3 months; and adjusted ratio 3.66, 95% confidence interval 1.60–8.35 at 1 year) and shorter time for TMT-B completion. Differences in TMT completion times between treatment arms were significant in patients with good functional outcome but not in those who were functionally dependent (modified Rankin Scale score >2). Poorer cognitive outcomes were significantly associated with larger infarct volume, higher modified Rankin Scale scores, and worse quality of life.Conclusions:Thrombectomy improves TMT performance after stroke, especially among patients who reach good functional recovery.ClinicalTrials.gov identifier:NCT01692379.Classification of evidence:This study provides Class I evidence that for patients with stroke from acute anterior circulation proximal arterial occlusion, thrombectomy improves performance on the TMT at 3 months.
Published: 2016
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13. Access to Endovascular Treatment in Remote Areas

Author: Sergi Amaro, Xabier Urra, Alejandro Tomasello, Joaquín Serena, Joan Martí-Fàbregas, A. Chamorro, MA de Miquel, Joan Perendreu, Joan Josep Baiges, Yolanda Silva, Anna Pellisé, Antoni Dávalos, Xavier Ustrell, Jordi Jiménez-Conde, Pilar Otermin, Jordi Sanahuja, Pilar Coscojuela, Sònia Abilleira, Carlos Castaño, Rafael Marés, R Delgado Mederos, Josep Maria Aragonés, Elisa Cuadrado-Godia, A Martínez Domeño, Marc Ribó, Francisco Purroy, Marta Rubiera, C van Eendenburg, N Cayuela, Juan Macho, Jurek Krupinski, L San Roman Manzanera, Ana Rodríguez-Campello, J Estela, Angel Ois, Meritxell Gomis, MC Nicolás, Mar Castellanos, Carlos A. Molina, JM Soler Insa, Eva Giralt, S Huertas, M Del Carmen Garcia, Moisés Garcés, Helena Quesada, Natalia Pérez de la Ossa, Manuel Gómez-Choco, J. Pagola, Sebastian Remollo, David Rodriguez-Luna, Paloma Mora, R Marín Bueno, Jordi Blasco, Sonia García, Victor Obach, L Cocho Calderón, Antonio M. López, Laura Dorado, David Cánovas, Jaume Roquer, Lucia Aja, Mónica Millán, Júlia Saura, R Martínez, Blanca Lara, E. López-Cancio, Miquel Gallofré, Leopoldo Guimaraens, Antonio Martínez-Yélamos, E. Palomeras, Pere Cardona, and Marian Muchada
Subjects: Male, medicine.medical_specialty, Population, 030204 cardiovascular system & hematology, Stroke care, Hospitals, Special, Stroke onset, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Thrombolytic Therapy, Registries, Symptom onset, Endovascular treatment, education, Stroke, Aged, Aged, 80 and over, Advanced and Specialized Nursing, education.field_of_study, Groin, business.industry, Endovascular Procedures, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Spain, Baseline characteristics, Reperfusion, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Delivery of Health Care, 030217 neurology & neurosurgery
Abstract: Background and Purpose— Since demonstration of the benefit of endovascular treatment (EVT) in acute ischemic stroke patients with proximal arterial occlusion, stroke care systems need to be reorganized to deliver EVT in a timely and equitable way. We analyzed differences in the access to EVT by geographical areas in Catalonia, a territory with a highly decentralized stroke model. Methods— We studied 965 patients treated with EVT from a prospective multicenter population-based registry of stroke patients treated with reperfusion therapies in Catalonia, Spain (SONIIA). Three different areas were defined: (A) health areas primarily covered by Comprehensive Stroke Centers, (B) areas primarily covered by local stroke centers located less than hour away from a Comprehensive Stroke Center, and (C) areas primarily covered by local stroke centers located more than hour away from a Comprehensive Stroke Center. We compared the number of EVT×100 000 inhabitants/year and time from stroke onset to groin puncture between groups. Results— Baseline characteristics were similar between groups. Throughout the study period, there were significant differences in the population rates of EVT across geographical areas. EVT rates by 100 000 in 2015 were 10.5 in A area, 3.7 in B, and 2.7 in C. Time from symptom onset to groin puncture was 82 minutes longer in group B (312 minutes [245–435]) and 120 minutes longer in group C (350 minutes [284–408]) compared with group A (230 minutes [160–407]; P Conclusions— Accessibility to EVT from remote areas is hampered by lower rate and longer time to treatment compared with areas covered directly by Comprehensive Stroke Centers.
Published: 2016
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14. Abstract TP32: Predictors of Endovascular Treatment Among Stroke Codes Activated Within 6 Hours From Symptom Onset

Author: Xabier Urra Nuin, Sandra Boned, Carlos A. Molina, Sonia Abilleira Castells, Rubiera Marta, Natalia Pérez de la Ossa, Manuel Requena, Marc Ribó, and Pere Cardona Portella
Subjects: Advanced and Specialized Nursing, Nihss score, medicine.medical_specialty, business.industry, Mean age, medicine.disease, Triage, Internal medicine, Ischemic stroke, medicine, Neurology (clinical), Symptom onset, Endovascular treatment, Cardiology and Cardiovascular Medicine, business, Stroke, Large vessel occlusion
Abstract: Introduction: Prehospital stroke code activations help reducing wokflow times during in-hospital triage. We aim to identify predictors of endovascular treatment among activated stroke codes (ASC) within 6 hours from symptom onset. Methods: CICAT is a prospective official mandatory registry of all ASC in Catalunya. We studied all CICAT entries from 5 comprehensive stroke centers during 18 months. We recorded demographic, historic, clinical and imaging variables on admission. We explored the relationship between these variables and endovascular treatment (EVT) Results: From 3944 ASC, 2818 (71.5%) were admitted < 6 hours from symptom onset. Mean age was 72±15.3 years, median RACE scale 4 (IQR 2-6), median onset-to-door time (OTDT) was 87 minutes (IQR 54-158), median NIHSS score 9 (IQR 4-18), median ASPECTS 10 (IQR 8-10. Final diagnosis was ischemic stroke in 1767 patients (62.7%), hemorrhagic stroke in 364 (12.9%), TIA in 167 (5.9%), stroke-mimic in 500 (17.7%). After admision a large vessel occlusion (LVO) was confirmed in 916 (23.2%) patients. While the rate of ASPECTS ≥ 9 among ischemic strokes progressively decreased over time (0-3h: 73.2% vs 3-6h: 57.1%: p2 (p4 (p=0.003) and NIHSSon admission >8 (p4 had 26.0% probability to receive EVT Conclusion: Among ACS within 6 hours from symptom onset, time from onset to arrival is not associated with the probability of receiving EVT. Only 5% of these patients show an ASPECTS
Published: 2018
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15. Abstract 18: External Validation of the RACE Scale After Its Implementation in the Stroke Code Protocol in Catalonia

Author: Antoni Dávalos, Joan Martí-Fàbregas, Moisés Garcés, Natalia Pérez de la Ossa, Pere Cardona, Sònia Abilleira, Ana Rodríguez-Campello, David Cánovas, David Carrera, Xabier Urra, Francisco Purroy, Joaquín Serena, Xavier Ustrell, Jurek Krupinski, Júlia Saura, Millan Monica, Marc Ribó, Montse Gorchs, and Xavier Jiménez
Subjects: Advanced and Specialized Nursing, CODE protocol, Scale (ratio), business.industry, External validation, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Medicine, Neurology (clinical), Medical emergency, Endovascular treatment, Cardiology and Cardiovascular Medicine, business, Stroke, 030217 neurology & neurosurgery, Large vessel occlusion
Abstract: Introduction: We aimed to revalidate the RACE scale as a pre-hospital tool to identify patients with large vessel occlusion (LVO) and patients receiving endovascular treatment (EVT) after its implementation in the Stroke Code protocol of Catalonia (7.5 M inhabitants). Methods: We used data from the CICAT registry (Feb to Jun 2016), a government-mandated, prospective, hospital-based dataset that includes all Stroke Code activations. CICAT is linked to the EMS database to capture information about the pre-hospital care. RACE score, pre-hospital and in-hospital delays, final diagnostic, presence of LVO (TICA, MCA M1 or M2, tandem or basilar occlusion) and revascularization treatment were registered. Sensitivity, specificity and area under the curve (AUC) to identify LVO and patients receiving EVT were calculated for the pre-established cut off RACE≥5. Results: From the 1600 stroke code activations we included in the study the 962 patients in which the RACE scale was available (60%). The RACE scale showed a strong correlation with the NIHSS evaluated at hospital arrival (r=0.74, p Conclusion: This large validation study performed after implementation of the RACE scale in the real clinical practice in the region of Catalonia confirms RACE accuracy to identify candidates to EVT. A RACE score ≥5 detected 77% of patients that finally underwent EVT confirming the scale as a valuable tool at the prehospital level.
Published: 2017
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16. Abstract WP251: Telestroke 2.0 in Catalonia: More Patients Treated and Secondary Transfers Reduced

Author: Dolors Carrión, Natalia Pérez de la Ossa, E. Palomeras, Dolores Cocho, Elsa Puiggros, Josep Maria Aragonés, Sònia Abilleira, Marc Ribó, Eduard Sanjurjo, Moisés Garcés, David Villagrasa, Ester Catena, Nuria López Claverol, Meritxell Gomis, Antoni Dávalos, Elena López-Cancio, Pere Cardona, Mercè López, Iñigo Soteras, Francisco Purroy, and Joaquín Serena
Subjects: Advanced and Specialized Nursing, business.industry, medicine.medical_treatment, Medicine, Cover (algebra), Neurology (clinical), Thrombolysis, Medical emergency, Cardiology and Cardiovascular Medicine, business, medicine.disease, Stroke
Abstract: Objetive: To describe the main results from the implementation of Telestroke 2.0 in Catalonia. Methods: The network consists of 12 community hospitals and an expert stroke neurologist 24h/7d, covering a population of 1.3 million inhabitants. It includes a two-way videoconferencing system and visualization of neuroimaging on a web platform. The neurologist evaluates the patient and decides the therapeutic approach and/or transfer the patient to another facility, entering these data in a mandatory registry (TICAT). Simultaneously, all patients treated locally with reperfusion therapies in all centers of Catalonia are also prospectively recorded in a mandatory registry (SONIIA). Results: From March-2013 to December-2015, 1206 patients were evaluated through Telestroke network. Final diagnosis was: 951 ischemic, 51 TIA, 85 intracranial hemorrhages and 119 with a diagnosis different from stroke. Transfer to another center was avoided in 46.8% of ischemic, 76.5% of TIAs and 23.5% of hemorrhages. A total of 322 patients received rtPA (33.8% of ischemic). Compared with those who received rtPA locally (2897 patients in the same period in Catalonia), the door-to-needle time(minutes) was longer in treated through Telestroke (55[45-70] versus 44[32-59]), and this time was progressively reduced from 2013 to 2015 (59[53- 82] to 40[50-60], p Conclusions: Telestroke favors fibrinolysis therapy safely and effectively, avoiding a large number of secondary transfers to other centers
Published: 2017
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17. Abstract 67: Blood Biomarkers for Prediction of Cardiac Complications in the Stroke Unit

Author: Marta Rubiera, Mikel Terceño, Antoni Dávalos, David Cánovas, Moisés Garcés, Dolors Giralt, Pere Cardona, Teresa García-Berrocoso, Joan Montaner, Joaquín Serena, Elena López-Cancio, Alejandro Bustamante, and Eva Baldrich
Subjects: Advanced and Specialized Nursing, Acute coronary syndrome, medicine.medical_specialty, business.industry, Early detection, medicine.disease, Acute congestive heart failure, Coronary artery disease, Blood biomarkers, Heart failure, Internal medicine, medicine, Cardiology, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Stroke
Abstract: Introduction: Cardiac complications such as acute coronary syndrome (ACS) or acute congestive heart failure (ACHF) account for 2-6%of mortality after stroke. Early detection of the patients at the highest risk to suffer from cardiac complications could be of interest to indicate a closer monitoring or therapeutic measures. We aimed to test whether a panel of blood biomarkers could predict the development of cardiac complications during stroke unit admission. Methods: The StrokeChip was a prospective, observational study, conducted at six Hospitals in Catalonia. Patients with suspected stroke were enrolled at Emergency Departments. Blood samples were obtained within the first six hours after symptom onset to measure a 21-biomarker panel. In-hospital development of cardiac complications (ACS and ACHF) was recorded. The association between the measured biomarkers and the development of complications was assessed by logistic regression analysis. Results: From August-2012 to December-2013, 941 out of 1308 patients enrolled were ischemic strokes. Cardiac complications were developed by 25 patients, including 19 ACHF and six cases of ACS. Due to the small number of ACS, just ACHF were further analyzed. Patients with ACHF had higher baseline levels of D-dimer, endostatin, VAP-1, NT-proBNP, FasL and vWF, and lower levels of IGFBP-3. After logistic regression analysis, NT-proBNP [OR=3.56(1.17-10.84)], FasL [OR=4.94(1.60-15.26)], VAP-1 [OR=6.56(2.21-19.46)] and IGFBP-3 [OR=0.21(0.07-0.67)] were independently associated with ACHF after adjustment by clinical predictors such as stroke severity, previous disability or history of coronary disease. Addition of the biomarker panel over clinical predictors resulted in improved accuracy (AUC from 0.808 to 0.925, p=0.05). Conclusions: Baseline measurement of blood biomarkers in acute stroke could be useful to predict the development of cardiac complications during stroke unit admission.
Published: 2017
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18. Abstract W P14: Endovascular Treatment for M2 Occlusions. A Descriptive Multicenter Experience on Behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR)

Author: Pablo Garcia Bermejo, Jaume Roquer, Alejandro Tomasello, David Cánovas, Marc Ribó, Sònia Abilleira, Xabi Urra, Alan Flores, Victor Obach, Meritxell Gomis, Marti-Fabregas Joan, M Anges De Miquel, and Pere Cardona
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, Groin, business.industry, Infarction, medicine.disease, Surgery, Diagnostic angiogram, medicine.anatomical_structure, Baseline characteristics, Occlusion, Infarct volume, medicine, cardiovascular diseases, Neurology (clinical), Endovascular treatment, Cardiology and Cardiovascular Medicine, business, Stroke
Abstract: Background: Patients with M2-MCA occlusion are not always considered for endovascular treatment. We aimed to study patients with an M2 occlusion treated with endovascular procedures. Methods: We studied patients prospectively included in the SONIIA register (January 2011-December 2012), a mandatory and externally audited register that monitors quality of reperfusion therapies in Catalonia under routine practice conditions. Baseline characteristics including NIHSS and occlusion location were collected. Complete recanalization was defined as a post-procedure TICI>2a, dramatic recovery: NIHSS drop>10 points or NIHSS Results: Of the 571 registered patients that received endovascular treatment, 65 (11.4%) presented an M2 occlusion on initial angiogram: mean age 66±15, female 47.7% median pre-procedure NIHSS 16(IQR:6). Mean time from symptom onset to groin puncture was 289±195 minutes, 35 patients (54%) received iv tPA before the procedure. Patients were treated with mechanic thrombectomy (n=49, 75.4%), ia tPA (n=3, 4.6%), both (n=7, 10.8%) or only diagnostic angiogram (n=6, 9.2%) according to interventionalist preferences. Patients who achieved complete recanalization (78.5%) had more often dramatic improvement (48% Vs 14.8%, p=0.023) smaller infarct volumes (8 vs. 82cc, p=0.013) and better outcome (66.3% Vs 30%; p=0.032) than those who did not recanalize. Rate of SICH was 9%. Independent predictors of dramatic improvement was complete recanalization (OR: 0,169 p=0.03 CI95%: 0.034-0.838) adjusted for age and baseline NIHSS Independent predictors of good outcome at 3 months were age (OR 1.067 p=0.033 CI95%: 1.005-1132) and baseline NIHSS (OR: 1.162 p=0.007 CI95%: 1.041-1.297) Conclusion: Endovascular treatment of M2 MCA occlusion seems safe. Induced recanalization may double the chances to achieve a favourable outcome
Published: 2014
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19. Abstract 2967: Recurrent TIA and Early Risk of Stroke

Author: Francisco Purroy, Pedro E Jiménez-Caballero, Arantxa Gorospe, MarÍa José Torres, José Álvarez-SabÍn, Estevo Santamarina, Patricia Sánchez-MartÍnez, David Cánovas, Mar Freijo, José A Egido, Juan M Giron, José M RamÍrez-Moreno, Arantza Alonso, Ana RodrÍguez-Campello, Ignacio Casado, Raquel Delgado-Medeiros, Joan MartÍ-Fábregas, Exuperio DÍez-Tejedor, Yolanda Silva, Helena Quesada, Pere Cardona, Ana Morales, Natalia P de la Ossa, Antonio GarcÍa-Pastor, Juan F Arenillas, Tomás Segura, Carmen Jiménez, Josep Montserrat, and Jaime Masjuán
Subjects: Advanced and Specialized Nursing, cardiovascular diseases, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Background: Many guidelines recommend urgent intervention for TIA patients with 2 or episodes within 7-days to reduce the early risk of stroke. However, whether all patients with multiple TIAs are at high early risk of stroke is unknown. Methods: Between April 2008 and December 2009, we included 1255 consecutive TIA patients from 30 Spanish stroke centers (PROMAPA study). We prospectively recorded clinical characteristics. We also determined the early short-term risk of stroke (at seven and ninety days). Aetiology of TIA was categorised using the SSS-TOAST classification Results: Enough information was assessed in 1137 patients (90.6%). 7-day and 90-day stroke risk were 2.6% and 3.8% respectively. Atherosclerotic etiology (AE) was confirmed in 190 (16.7%) patients. Recurrent TIA was observed in 274 (24,1%) patients. Duration Conclusion: According to our results, recurrent TIA within 7-days is associated with a greater subsequent stroke risk than after a single TIA. Nevertheless, we were not able to find any independent predictor of stroke recurrence among these patients.
Published: 2012
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19 results on '"Pere, Cardona"'

1. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas

2. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

3. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

4. Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice

5. Effects of Bihemispheric Transcranial Direct Current Stimulation Combined With Repetitive Peripheral Nerve Stimulation in Acute Stroke Patients

6. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke

7. Abstract 36: Endovascular Thrombectomy Beyond 24 Hours From Last Known Well: A Pooled Multicenter International Cohort

8. Abstract P75: Cerebrovascular Events and Outcomes in Hospitalized Patients With Covid-19: The Society of Vascular and Interventional Neurology Multinational Registry

9. Abstract WP101: Remote Ischemic Perconditioning Among Acute Ischemic Stroke Patients in Catalonia: Remote-Cat Project

10. Abstract WMP70: Etiology of Stroke Based on Early Analysis of Clot Cytometry Obtained Through First Pass Technique for Mechanical Thrombectomy

11. Abstract TP307: Clinical and Neuroimaging Criteria to Improve Transfers to Comprehensive Stroke Centers for Endovascular Reperfusion Treatment Evaluation

12. Endovascular treatment improves cognition after stroke

13. Access to Endovascular Treatment in Remote Areas

14. Abstract TP32: Predictors of Endovascular Treatment Among Stroke Codes Activated Within 6 Hours From Symptom Onset

15. Abstract 18: External Validation of the RACE Scale After Its Implementation in the Stroke Code Protocol in Catalonia

16. Abstract WP251: Telestroke 2.0 in Catalonia: More Patients Treated and Secondary Transfers Reduced

17. Abstract 67: Blood Biomarkers for Prediction of Cardiac Complications in the Stroke Unit

18. Abstract W P14: Endovascular Treatment for M2 Occlusions. A Descriptive Multicenter Experience on Behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR)

19. Abstract 2967: Recurrent TIA and Early Risk of Stroke

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