1. Palmitic Acid Kinetics in Fasting, Traumatized Patients
- Author
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Ronald H. Birkhahn, Keith A. Crist, Robert J. Cardwell, Neil R. Thomford, Gertrude C. Birkhahn, and Assad Taha
- Subjects
Adult ,Male ,medicine.medical_specialty ,Continuous infusion ,Kinetics ,Palmitic Acid ,Palmitic Acids ,Fatty Acids, Nonesterified ,Critical Care and Intensive Care Medicine ,Palmitic acid ,chemistry.chemical_compound ,Injury Severity Score ,Internal medicine ,medicine ,Humans ,Resting energy expenditure ,Postoperative Period ,Beta oxidation ,Aged ,chemistry.chemical_classification ,Total plasma ,Multiple Trauma ,business.industry ,Fatty acid ,Calorimetry, Indirect ,Fasting ,Middle Aged ,Surgery ,Endocrinology ,chemistry ,Female ,Energy Metabolism ,business ,Plasma free fatty acid - Abstract
The contribution of free fatty acid oxidation to the elevation in energy expenditure after trauma has not been well characterized. Six control subjects and six traumatized patients were fasted for 48 hours and given a primed continuous infusion of (1-14C)palmitate to measure plasma palmitate and total free fatty acid kinetics. Traumatized patients had greater urinary nitrogen losses (20.8 vs. 9.3 g N per day) and a significantly greater ratio of measured to predicted resting energy expenditure (+36% vs. -6%) compared with controls. Individual and total plasma free fatty acid concentrations were similar for the two groups. The turnover and oxidation of plasma palmitate and total free fatty acids were not changed by multiple trauma. These results demonstrated that plasma free fatty acids and palmitate do not contribute to increased energy expenditure following trauma.
- Published
- 1992
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