Search

Your search keyword '"Naggara ON"' showing total 85 results
Start Over Author "Naggara ON" Publisher ovid technologies (wolters kluwer health)
85 results on '"Naggara ON"'

1. Early Recanalization Among Patients Undergoing Bridging Therapy With Tenecteplase or Alteplase

Author

Checkouri, Thomas, primary, Gerschenfeld, Gaspard, additional, Seners, Pierre, additional, Yger, Marion, additional, Ben Hassen, Wagih, additional, Chausson, Nicolas, additional, Olindo, Stéphane, additional, Caroff, Jildaz, additional, Marnat, Gaultier, additional, Clarençon, Frédéric, additional, Baron, Jean-Claude, additional, Turc, Guillaume, additional, Alamowitch, Sonia, additional, Arquizan, Caroline, additional, Berthezene, Yves, additional, Boulouis, Grégoire, additional, Bracard, Serge, additional, Bricout, Nicolas, additional, Cho, Tae-Hee, additional, Consoli, Arturo, additional, Costalat, Vincent, additional, Cottier, Jean-Philippe, additional, Debiais, Séverine, additional, Gory, Benjamin, additional, Henon, Hilde, additional, Lapergue, Bertrand, additional, Obadia, Michael, additional, Oppenheim, Catherine, additional, Pico, Fernando, additional, Piotin, Michel, additional, Richard, Sébastien, additional, Zuber, Mathieu, additional, Blanc, Clémence, additional, Calvet, David, additional, Denier, Christian, additional, Ghazanfari, Sam, additional, Kalsoum, Erwah, additional, L’Hermitte, Yann, additional, Legrand, Laurence, additional, Liegey, Jean-Sebastien, additional, Milnerowicz, Malgorzata, additional, Naggara, Olivier, additional, Poli, Mathilde, additional, Premat, Kévin, additional, Sibon, Igor, additional, Sabben, Candice, additional, Shotar, Eimad, additional, Smadja, Didier, additional, and Spelle, Laurent, additional

Published
2023
Full Text
View/download PDF

2. Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy

Author

Scopelliti, Giuseppe, primary, Benzakoun, Joseph, additional, Ben Hassen, Wagih, additional, Bretzner, Martin, additional, Bricout, Nicolas, additional, Puy, Laurent, additional, Turc, Guillaume, additional, Boulouis, Grégoire, additional, Oppenheim, Catherine, additional, Naggara, Olivier, additional, Cordonnier, Charlotte, additional, Henon, Hilde, additional, and Pasi, Marco, additional

Published
2023
Full Text
View/download PDF

3. TAGE Score for Symptomatic Intracranial Hemorrhage Prediction After Successful Endovascular Treatment in Acute Ischemic Stroke

Author

Paul Janvier, Basile Kerleroux, Guillaume Turc, Marco Pasi, Wassim Farhat, Nicolas Bricout, Joseph Benzakoun, Laurence Legrand, Frédéric Clarençon, Serge Bracard, Catherine Oppenheim, Grégoire Boulouis, Hilde Henon, Olivier Naggara, and Wagih Ben Hassen

Subjects
Blood Glucose, Advanced and Specialized Nursing, Treatment Outcome, Endovascular Procedures, Humans, Prospective Studies, Neurology (clinical), Cardiology and Cardiovascular Medicine, Intracranial Hemorrhages, Ischemic Stroke
Abstract

Background: Determine if early venous filling (EVF) after complete successful recanalization with mechanical thrombectomy in acute ischemic stroke is an independent predictor of symptomatic intracranial hemorrhage (sICH) and integrate EVF into a risk score for sICH prediction. Methods: Consecutive patients with anterior acute ischemic stroke treated by mechanical thrombectomy issued from patients enrolled in the THRACE trial (Thrombectomie des Artères Cérébrales) and from 2 prospective registries were included and divided into a derivation (Center I; n=402) and validation cohorts (THRACE and center 2; n=507). EVF was evaluated by 2 blinded readers. sICH was defined according to the modified European cooperative acute stroke study II. Clinical and radiological data were analyzed in the derivation cohort (C1) to identify independent predictors of sICH and construct a predictive score test on the validation cohort (THRACE + C2). Results: Symptomatic ICH rate was similar between the two cohorts (9.9% and 8.9% respectively, P =0.9). Time from onset-to-successful recanalization >270 minutes (odds ratio [OR], 7.8 [95% CI, 2.5–24]), Alberta Stroke Program Early CT Score (≤5 [OR, 2.49 (95% CI, 1.8–8.1) or 6–7 [OR, 1.15 (95% CI, 1.03–4.46)]), glucose blood level >7 mmol/L (OR, 2.92 [95% CI, 1.26–6.7]), and EVF presence (OR, 11.9 [95% CI, 3.8–37.5]) were independent predictors of sICH and constituted the Time–Alberta Stroke Program Early CT–Glycemia–EVF score. Time–Alberta Stroke Program Early CT–Glycemia–EVF score was associated with an increased risk of sICH in the derivation cohort (OR increase per unit, 1.99 [95% CI, 1.53–2.59]; P Conclusions: Time–Alberta Stroke Program Early CT–Glycemia–EVF score is a simple tool with readily available clinical variables with good performances for sICH prediction after mechanical thrombectomy. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01062698.

Published
2022

4. Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy

Author

Giuseppe Scopelliti, Joseph Benzakoun, Wagih Ben Hassen, Martin Bretzner, Nicolas Bricout, Laurent Puy, Guillaume Turc, Grégoire Boulouis, Catherine Oppenheim, Olivier Naggara, Charlotte Cordonnier, Hilde Henon, and Marco Pasi

Subjects
Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Background: Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We aimed to compare, in patients Methods: We retrospectively analyzed data of patients treated for an anterior circulation acute ischemic stroke with large vessel occlusion in 2 French hospitals, who underwent baseline and 24-hour follow-up magnetic resonance imaging, with baseline DWI lesion volume ≥10 cc. The percentage of DWIR (DWIR%), was calculated as follows: DWIR%=(DWIR volume/baseline DWI volume)×100. Data on demographics, medical history, and baseline clinical and radiological characteristics were collected. Results: Among 433 included patients (median age, 68 years), median DWIR% after mechanical thrombectomy was 22% (6–35) in patients ≥80, and 19% (interquartile range, 10–34) in patients P =0.948). In multivariable analyses, successful recanalization after mechanical thrombectomy was associated with higher median DWIR% in both ≥80 ( P =0.004) and P =0.002) patients. In subgroup analyses performed on a minority of subjects, collateral vessels status score (n=87) and white matter hyperintensity volume (n=131) were not associated with DWIR% ( P >0.2). In multivariable analyses, DWIR% was associated with increased rates of favorable 3-month outcomes in both ≥80 ( P =0.003) and P =0.013) patients; the effect of DWIR% on outcome was not influenced by the age group ( P interaction=0.185) Conclusions: DWIR might be an important and nonage-dependent effect of arterial recanalization, as it seems to beneficially impact 3-month outcomes of both younger and older subjects treated with mechanical thrombectomy for acute ischemic stroke and large vessel occlusion.

Published
2023

6. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author

Bakker, Mark K., primary, Kanning, Jos P., additional, Abraham, Gad, additional, Martinsen, Amy E., additional, Winsvold, Bendik S., additional, Zwart, John-Anker, additional, Bourcier, Romain, additional, Sawada, Tomonobu, additional, Koido, Masaru, additional, Kamatani, Yoichiro, additional, Morel, Sandrine, additional, Amouyel, Philippe, additional, Debette, Stéphanie, additional, Bijlenga, Philippe, additional, Berrandou, Takiy, additional, Ganesh, Santhi K., additional, Bouatia-Naji, Nabila, additional, Jones, Gregory, additional, Bown, Matthew, additional, Rinkel, Gabriel J.E., additional, Veldink, Jan H., additional, Ruigrok, Ynte M., additional, Hege Aamodt, Anne, additional, Heidi Skogholt, Anne, additional, Brumpton, Ben M, additional, Willer, Cristen J, additional, Sandset, Else C, additional, Kristoffersen, Espen S, additional, Ellekjær, Hanne, additional, Heuch, Ingrid, additional, Nielsen, Jonas B, additional, Hagen, Knut, additional, Hveem, Kristian, additional, Fritsche, Lars G, additional, Thomas, Laurent F, additional, Pedersen, Linda M, additional, Gabrielsen, Maiken E, additional, Holmen, Oddgeir L, additional, Børte, Sigrid, additional, Zhou, Wei, additional, Abboud, Shérine, additional, Pandolfo, Massimo, additional, Thijs, Vincent, additional, Leys, Didier, additional, Bodenant, Marie, additional, Louillet, Fabien, additional, Touzé, Emmanuel, additional, Mas, Jean-Louis, additional, Samson, Yves, additional, Leder, Sara, additional, Léger, Anne, additional, Deltour, Sandrine, additional, Crozier, Sophie, additional, Méresse, Isabelle, additional, Canaple, Sandrine, additional, Godefroy, Olivier, additional, Giroud, Maurice, additional, Béjot, Yannick, additional, Decavel, Pierre, additional, Medeiros, Elizabeth, additional, Montiel, Paola, additional, Moulin, Thierry, additional, Vuillier, Fabrice, additional, Dallongeville, Jean, additional, Metso, Antti J, additional, Metso, Tiina, additional, Tatlisumak, Turgut, additional, Grond-Ginsbach, Caspar, additional, Lichy, Christoph, additional, Kloss, Manja, additional, Werner, Inge, additional, Arnold, Marie-Luise, additional, Dos Santos, Michael, additional, Grau, Armin, additional, Dichgans, Martin, additional, Thomas-Feles, Constanze, additional, Weber, Ralf, additional, Brandt, Tobias, additional, Pezzini, Alessandro, additional, De Giuli, Valeria, additional, Caria, Filomena, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Bersano, Anna, additional, Lanfranconi, Silvia, additional, Beretta, Simone, additional, Ferrarese, Carlo, additional, Giacolone, Giacomo, additional, Paolucci, Stefano, additional, Lyrer, Philippe, additional, Engelter, Stefan, additional, Fluri, Felix, additional, Hatz, Florian, additional, Gisler, Dominique, additional, Bonati, Leo, additional, Gensicke, Henrik, additional, Amort, Margareth, additional, Markus, Hugh, additional, Majersik, Jennifer, additional, Worrall, Bradford, additional, Southerland, Andrew, additional, Cole, John, additional, Kittner, Steven, additional, Evangelou, Evangelos, additional, Warren, Helen R, additional, Gao, He, additional, Ntritsos, Georgios, additional, Dimou, Niki, additional, Esko, Tonu, additional, Mägi, Reedik, additional, Milani, Lili, additional, Almgren, Peter, additional, Boutin, Thibaud, additional, Ding, Jun, additional, Giulianini, Franco, additional, Holliday, Elizabeth G, additional, Jackson, Anne U, additional, Li-Gao, Ruifang, additional, Lin, Wei-Yu, additional, Luan, Jian’an, additional, Mangino, Massimo, additional, Oldmeadow, Christopher, additional, Peter Prins, Bram, additional, Qian, Yong, additional, Sargurupremraj, Muralidharan, additional, Shah, Nabi, additional, Surendran, Praveen, additional, Thériault, Sébastien, additional, Verweij, Niek, additional, Willems, Sara M, additional, Zhao, Jing-Hua, additional, Connell, John, additional, de Mutsert, Renée, additional, Doney, Alex SF, additional, Farrall, Martin, additional, Menni, Cristina, additional, Morris, Andrew D, additional, Noordam, Raymond, additional, Paré, Guillaume, additional, Poulter, Neil R, additional, Shields, Denis C, additional, Stanton, Alice, additional, Thom, Simon, additional, Abecasis, Gonçalo, additional, Amin, Najaf, additional, Arking, Dan E, additional, Ayers, Kristin L, additional, Barbieri, Caterina M, additional, Batini, Chiara, additional, Bis, Joshua C, additional, Blake, Tineka, additional, Bochud, Murielle, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Bottinger, Erwin P, additional, Braund, Peter S, additional, Brumat, Marco, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chakravarti, Aravinda, additional, Chambers, John C, additional, Chauhan, Ganesh, additional, Ciullo, Marina, additional, Cocca, Massimiliano, additional, Collins, Francis, additional, Cordell, Heather J, additional, Davies, Gail, additional, de Borst, Martin H, additional, de Geus, Eco J, additional, Deary, Ian J, additional, Deelen, Joris, additional, Del Greco M, Fabiola, additional, Yusuf Demirkale, Cumhur, additional, Dörr, Marcus, additional, Ehret, Georg B, additional, Elosua, Roberto, additional, Enroth, Stefan, additional, Mesut Erzurumluoglu, A, additional, Ferreira, Teresa, additional, Frånberg, Mattias, additional, Franco, Oscar H, additional, Gandin, Ilaria, additional, Gasparini, Paolo, additional, Giedraitis, Vilmantas, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gow, Alan J, additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Harris, Sarah E, additional, Hartman, Catharina A, additional, Havulinna, Aki S, additional, Hicks, Andrew A, additional, Hofer, Edith, additional, Hofman, Albert, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Hwang, Shih-Jen, additional, Ingelsson, Erik, additional, James, Alan, additional, Jansen, Rick, additional, Jarvelin, Marjo-Riitta, additional, Joehanes, Roby, additional, Johansson, Åsa, additional, Johnson, Andrew D, additional, Joshi, Peter K, additional, Jousilahti, Pekka, additional, Wouter Jukema, J, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Keavney, Bernard D, additional, Khaw, Kay-Tee, additional, Knekt, Paul, additional, Knight, Joanne, additional, Kolcic, Ivana, additional, Kooner, Jaspal S, additional, Koskinen, Seppo, additional, Kristiansson, Kati, additional, Kutalik, Zoltan, additional, Laan, Maris, additional, Larson, Marty, additional, Launer, Lenore J, additional, Lehne, Benjamin, additional, Lehtimäki, Terho, additional, Liewald, David CM, additional, Lin, Li, additional, Lind, Lars, additional, Lindgren, Cecilia M, additional, Liu, YongMei, additional, Loos, Ruth JF, additional, Lopez, Lorna M, additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Mamasoula, Chrysovalanto, additional, Marrugat, Jaume, additional, Marten, Jonathan, additional, Milaneschi, Yuri, additional, Morgan, Anna, additional, Morris, Andrew P, additional, Morrison, Alanna C, additional, Munson, Peter J, additional, Nalls, Mike A, additional, Nandakumar, Priyanka, additional, Nelson, Christopher P, additional, Niiranen, Teemu, additional, Nolte, Ilja M, additional, Nutile, Teresa, additional, Oldehinkel, Albertine J, additional, Oostra, Ben A, additional, O’Reilly, Paul F, additional, Org, Elin, additional, Padmanabhan, Sandosh, additional, Palmas, Walter, additional, Palotie, Aarno, additional, Pattie, Alison, additional, WJH Penninx, Brenda, additional, Perola, Markus, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pramstaller, Peter P, additional, Tri Nguyen, Quang, additional, Raitakari, Olli T, additional, Rettig, Rainer, additional, Rice, Kenneth, additional, Ridker, Paul M, additional, Ried, Janina S, additional, Riese, Harriëtte, additional, Ripatti, Samuli, additional, Robino, Antonietta, additional, Rose, Lynda M, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia F, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Sarin, Antti-Pekka, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Shrine, Nick, additional, Siscovick, David, additional, Smith, Albert V, additional, Snieder, Harold, additional, Sõber, Siim, additional, Sorice, Rossella, additional, Starr, John M, additional, Stott, David J, additional, Strachan, David P, additional, Strawbridge, Rona J, additional, Sundström, Johan, additional, Swertz, Morris A, additional, Taylor, Kent D, additional, Teumer, Alexander, additional, Tobin, Martin D, additional, Tomaszewski, Maciej, additional, Toniolo, Daniela, additional, Traglia, Michela, additional, Trompet, Stella, additional, Tuomilehto, Jaakko, additional, Tzourio, Christophe, additional, Uitterlinden, André G, additional, Vaez, Ahmad, additional, van der Most, Peter J, additional, van Duijn, Cornelia M, additional, Verwoert, Germaine C, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Vuckovic, Dragana, additional, Watkins, Hugh, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wright, Alan F, additional, Yao, Jie, additional, Zemunik, Tatijana, additional, Zhang, Weihua, additional, Attia, John R, additional, Butterworth, Adam S, additional, Chasman, Daniel I, additional, Conen, David, additional, Cucca, Francesco, additional, Danesh, John, additional, Hayward, Caroline, additional, Howson, Joanna MM, additional, Laakso, Markku, additional, Lakatta, Edward G, additional, Langenberg, Claudia, additional, Melander, Olle, additional, Mook-Kanamori, Dennis O, additional, Palmer, Colin NA, additional, Risch, Lorenz, additional, Scott, Robert A, additional, Scott, Rodney J, additional, Sever, Peter, additional, Spector, Tim D, additional, van der Harst, Pim, additional, Wareham, Nicholas J, additional, Zeggini, Eleftheria, additional, Levy, Daniel, additional, Munroe, Patricia B, additional, Newton-Cheh, Christopher, additional, Brown, Morris J, additional, Metspalu, Andres, additional, Psaty, Bruce M., additional, Wain, Louise V, additional, Elliott, Paul, additional, Caulfield, Mark J, additional, Gormley, Padhraig, additional, Anttila, Verneri, additional, Palta, Priit, additional, Pers, Tune H, additional, Farh, Kai-How, additional, Cuenca-Leon, Ester, additional, Muona, Mikko, additional, Furlotte, Nicholas A, additional, Kurth, Tobias, additional, Ingason, Andres, additional, McMahon, George, additional, Ligthart, Lannie, additional, Terwindt, Gisela M, additional, Kallela, Mikko, additional, Freilinger, Tobias M, additional, Ran, Caroline, additional, Gordon, Scott G, additional, Stam, Anine H, additional, Steinberg, Stacy, additional, Borck, Guntram, additional, Koiranen, Markku, additional, Quaye, Lydia, additional, Adams, Hieab H H, additional, Wedenoja, Juho, additional, Hinds, David A, additional, Buring, Julie E, additional, Schürks, Markus, additional, Gudlaug Hrafnsdottir, Maria, additional, Stefansson, Hreinn, additional, Ring, Susan M, additional, Penninx, Brenda W J H, additional, Färkkilä, Markus, additional, Artto, Ville, additional, Kaunisto, Mari, additional, Vepsäläinen, Salli, additional, Malik, Rainer, additional, Heath, Andrew C, additional, Madden, Pamela A F, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, Kurki, Mitja I, additional, Kals, Mart, additional, Pärn, Kalle, additional, Hämäläinen, Eija, additional, Huang, Hailiang, additional, Byrnes, Andrea E, additional, Franke, Lude, additional, Huang, Jie, additional, Stergiakouli, Evie, additional, Lee, Phil H, additional, Sandor, Cynthia, additional, Webber, Caleb, additional, Cader, Zameel, additional, Muller-Myhsok, Bertram, additional, Schreiber, Stefan, additional, Meitinger, Thomas, additional, Eriksson, Johan G, additional, Heikkilä, Kauko, additional, Loehrer, Elizabeth, additional, Uitterlinden, Andre G, additional, Cherkas, Lynn, additional, Stubhaug, Audun, additional, Nielsen, Christopher S, additional, Männikkö, Minna, additional, Mihailov, Evelin, additional, Göbel, Hartmut, additional, Esserlind, Ann-Louise, additional, Francke Christensen, Anne, additional, Folkmann Hansen, Thomas, additional, Werge, Thomas, additional, Kaprio, Jaakko, additional, Aromaa, Arpo J, additional, Raitakari, Olli, additional, Arfan Ikram, M, additional, Spector, Tim, additional, Järvelin, Marjo-Riitta, additional, Kubisch, Christian, additional, Ferrari, Michel D, additional, Belin, Andrea C, additional, Wessman, Maija, additional, van den Maagdenberg, Arn M J M, additional, Davey Smith, George, additional, Stefansson, Kari, additional, Eriksson, Nicholas, additional, Daly, Mark J, additional, Neale, Benjamin M, additional, Olesen, Jes, additional, Nyholt, Dale R, additional, Akiyama, Masato, additional, Alg, Varinder S., additional, Broderick, Joseph P., additional, Brumpton, Ben M., additional, Dauvillier, Jérôme, additional, Desal, Hubert, additional, Dina, Christian, additional, Friedrich, Christoph M., additional, Gaál-Paavola, Emília I., additional, Gentric, Jean-Christophe, additional, Hirsch, Sven, additional, Hostettler, Isabel C., additional, Houlden, Henry, additional, Jääskeläinen, Juha E., additional, Johnsen, Marianne Bakke, additional, Li, Liming, additional, Lin, Kuang, additional, Lindgren, Antti, additional, Martin, Olivier, additional, Matsuda, Koichi, additional, Millwood, Iona Y., additional, Naggara, Olivier, additional, Niemelä, Mika, additional, Pera, Joanna, additional, Redon, Richard, additional, Rouleau, Guy A., additional, Sandvei, Marie Søfteland, additional, Schilling, Sabine, additional, Shotar, Eimad, additional, Slowik, Agnieszka, additional, Terao, Chikashi, additional, Verschuren, W. M. Monique, additional, Walters, Robin G., additional, Werring, David J., additional, Willer, Cristen J., additional, Woo, Daniel, additional, Worrall, Bradford B., additional, and Zhou, Sirui, additional

Published
2023
Full Text
View/download PDF

7. Arterial Spin Labeling for the Etiological Workup of Intracerebral Hemorrhage in Children

Author

Francis Brunelle, Gregoire Boulouis, Vincent Vidal, Nadine Girard, Olivier Naggara, Philippe Meyer, Thomas Blauwblomme, Basile Kerleroux, Florent Gariel, Manoelle Kossorotoff, Sarah Stricker, Nathalie Boddaert, Lorenzo Garzelli, Jean François Hak, Volodia Dangouloff Ros, and Sandro Benichi

Subjects
Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, Adolescent, Fistula, Computed tomography, Lesion, medicine, Humans, Prospective Studies, Registries, Child, Stroke, Cerebral Hemorrhage, Retrospective Studies, Advanced and Specialized Nursing, Intracerebral hemorrhage, medicine.diagnostic_test, business.industry, Angiography, Digital Subtraction, Magnetic resonance imaging, medicine.disease, Cerebrovascular Circulation, Child, Preschool, Arteriovenous Fistula, Arterial spin labeling, Etiology, Female, Spin Labels, Neurology (clinical), Radiology, medicine.symptom, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business
Abstract

Background and Purpose: Pediatric nontraumatic intracerebral hemorrhage accounts for half of stroke in children. Early diagnostic of the causative underlying lesion is the first step toward prevention of hemorrhagic recurrence. We aimed to investigate the performance of arterial spin labeling sequence (ASL) in the acute phase etiological workup for the detection of an arteriovenous shunt (AVS: including malformation and fistula), the most frequent cause of pediatric nontraumatic intracerebral hemorrhage. Methods: Children with a pediatric nontraumatic intracerebral hemorrhage between 2011 and 2019 enrolled in a prospective registry were retrospectively included if they had undergone ASL-magnetic resonance imaging before any etiological treatment. ASL sequences were reviewed using cerebral blood flow maps by 2 raters for the presence of an AVS. The diagnostic performance of ASL was compared with admission computed tomography angiography, other magnetic resonance imaging sequences including contrast-enhanced sequences and subsequent digital subtraction angiography. Results: A total of 121 patients with pediatric nontraumatic intracerebral hemorrhage were included (median age, 9.9 [interquartile range, 5.8–13]; male sex 48.8%) of whom 76 (63%) had a final diagnosis of AVS. Using digital subtraction angiography as an intermediate reference, visual ASL inspection had a sensitivity and a specificity of, respectively, 95.9% (95% CI, 88.5%–99.1%) and 79.0% (95% CI, 54.4%–94.0%). ASL had a sensitivity, specificity, and accuracy of 90.2%, 97.2%, and 92.5%, respectively for the detection of the presence of an AVS, with near perfect interrater agreement (κ=0.963 [95% CI, 0.912–1.0]). The performance of ASL alone was higher than that of other magnetic resonance imaging sequences, individually or combined, and higher than that of computed tomography angiography. Conclusions: ASL has strong diagnostic performance for the detection of AVS in the initial workup of intracerebral hemorrhage in children. If our findings are confirmed in other settings, ASL may be a helpful diagnostic imaging modality for patients with pediatric nontraumatic intracerebral hemorrhage. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifiers: 3618210420, 2217698.

Published
2022

8. TAGE Score for Symptomatic Intracranial Hemorrhage Prediction After Successful Endovascular Treatment in Acute Ischemic Stroke

Author

Janvier, Paul, primary, Kerleroux, Basile, additional, Turc, Guillaume, additional, Pasi, Marco, additional, Farhat, Wassim, additional, Bricout, Nicolas, additional, Benzakoun, Joseph, additional, Legrand, Laurence, additional, Clarençon, Frédéric, additional, Bracard, Serge, additional, Oppenheim, Catherine, additional, Boulouis, Grégoire, additional, Henon, Hilde, additional, Naggara, Olivier, additional, and Ben Hassen, Wagih, additional

Published
2022
Full Text
View/download PDF

9. Impact of Repeated Clot Retrieval Attempts on Infarct Growth and Outcome After Ischemic Stroke

Author

Olivier Naggara, Martin Bretzner, Nicolas Bricout, Guillaume Turc, C Rodriguez, Laurence Legrand, Pierre Seners, Alice Le Berre, Joseph Benzakoun, Charlotte Cordonnier, Caroline Touloupas, Hilde Hénon, Wagih Ben Hassen, Gregoire Boulouis, and Catherine Oppenheim

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Arterial Occlusive Diseases, 030204 cardiovascular system & hematology, Neurosurgical Procedures, 03 medical and health sciences, 0302 clinical medicine, Meta-Analysis as Topic, Risk Factors, Modified Rankin Scale, Internal medicine, medicine, Humans, Thrombolytic Therapy, Binary logistic regression analysis, Prospective Studies, Aged, Ischemic Stroke, Thrombectomy, Aged, 80 and over, Cerebral infarction, business.industry, Cerebral Infarction, Thrombolysis, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Mechanical thrombectomy, Diffusion Magnetic Resonance Imaging, Treatment Outcome, Ischemic stroke, Cardiology, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

ObjectiveTo determine whether the association between increasing number of clot retrieval attempts (CRA) and unfavorable outcome is due to an increase in emboli to new territory (ENT) and greater infarct growth (IG) in successfully recanalized patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO).MethodsData were extracted from 2 pooled multicentric prospective registries of consecutive patients with anterior AIS-LVO treated with mechanical thrombectomy (MT) between January 2016 and 2019. Patients with pretreatment and 24-hour posttreatment diffusion-weighted imaging (DWI) achieving successful recanalization, defined as expanded Thrombolysis in Cerebral Infarction Scale score of 2B, 2C, or 3, were included. ENT were assessed and IG was measured by voxel-based segmentation after DWI coregistration. Associations between number of CRA, ENT, IG, and 3-month outcome were analyzed.ResultsFour hundred nineteen patients achieving successful recanalization were included. ENT occurrence was strongly correlated with increasing CRA (ρ = 0.73, p = 10−4). In multivariable linear analysis, IG was independently associated with CRA (β = 1.6 per retrieval attempt, 95% confidence interval [CI] 0.97–9.74, p = 0.03) and ENT (β = 2.7 [95% CI 1.21–4.1], p = 0.03). Unfavorable functional outcome (3-month modified Rankin Scale score >2) increased with each additional CRA. IG was an independent predictor of unfavorable outcome (odds ratio 1.05 [95% CI 1.02–1.07] per 1-mL IG increase, p = 10−4) in binary logistic regression analysis.ConclusionsIncreasing number of CRA in acute stroke is correlated with an increased ENT rate and increased IG volume, affecting functional outcome even when successful recanalization is achieved.Classification of EvidenceThis study provides Class II evidence that, for patients with acute stroke undergoing successful recanalization, an increasing number of CRA is associated with poorer functional outcome.

Published
2021

11. Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage

Author

Andrea Morotti, Sarah Stricker, Gregoire Boulouis, Basile Kerleroux, Florent Gariel, Lorenzo Garzelli, Thomas Blauwblomme, Jean-François Hak, Marie Bourgeois, Quentin Alias, Philippe Meyer, Nathalie Boddaert, Manoelle Kossorotoff, Sandro Benichi, Olivier Naggara, and Nicolas Garcelon

Subjects
Male, medicine.medical_specialty, Adolescent, Computed tomography, Cohort Studies, Risk Factors, Odds Ratio, Prevalence, Craniocerebral Trauma, Humans, Medicine, Glasgow Coma Scale, Child, Coagulation Disorder, Cerebral Hemorrhage, Retrospective Studies, Advanced and Specialized Nursing, Intracerebral hemorrhage, medicine.diagnostic_test, business.industry, Odds ratio, Blood Coagulation Disorders, medicine.disease, Treatment Outcome, Child, Preschool, Female, Neurology (clinical), Radiology, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Background and Purpose: Significant hemorrhage expansion (sHE) is a known predictor of poor outcome after an intracerebral hemorrhage (ICH) in adults but remains poorly reported in children. In a large inception cohort, we aimed to explore the prevalence of sHE, its associations with clinical outcomes, and its clinical-imaging predictors in children. Methods: Children admitted between January 2000 and March 2020 at a quaternary care pediatric hospital were screened for inclusion. Sample was restricted to children with 2 computed tomography scans within 72 hours of ICH onset, and a minimal clinical follow-up of months. sHE was defined as an increase from baseline ICH volume by 6 cc or 33% on follow-up computed tomography. Clinical outcome was assessed at 12 months with the King’s Outcome Scale for Childhood Head Injury score and defined as favorable for scores ≥5. Results: Fifty-two children met inclusion criteria, among which 8 (15%) demonstrated sHE, and 18 (34.6%) any degree of expansion. Children with sHE had more frequent coagulation disorders (25.0% versus 2.3%; P =0.022). After multivariable adjustment, only the presence of coagulation disorders at baseline remained independently associated with sHE (adjusted odds ratio, 14.4 [95% CI, 1.04–217]; P =0.048). sHE was independently associated with poor outcome (King’s Outcome Scale for Childhood Head Injury P =0.043). Conclusions: sHE is a frequent phenomenon after admission for a pediatric ICH and more so in children with coagulation defects. As sHE was strongly associated with poorer clinical outcomes, these data mandate a baseline coagulation work up and questions the need for protocolized repeat head computed tomography in children admitted for pediatric ICH.

Published
2021

12. Hyperacute Recanalization Strategies and Childhood Stroke in the Evidence Age

Author

Augustin Ozanne, Manoelle Kossorotoff, Stéphane Chabrier, Gregoire Boulouis, B. Husson, and Olivier Naggara

Subjects
medicine.medical_specialty, medicine.medical_treatment, Disease, Pediatrics, medicine, Humans, Pediatric stroke, Thrombolytic Therapy, Child, Intensive care medicine, Stroke, Advanced and Specialized Nursing, Evidence-Based Medicine, business.industry, Infant, Newborn, Infant, Thrombolysis, Childhood stroke, medicine.disease, Safety profile, Clot lysis, Child, Preschool, Observational study, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Abstract

No controlled pharmacological studies are available in the field of pediatric stroke, except for sickle cell disease. Therefore, while pharmacological and mechanical recanalization treatments have repeatedly shown clinical benefit in adults with arterial ischemic stroke, pediatric strokologists still cannot base their therapeutic management (including hyperacute strategies) on high-level evidence. Once again, pediatricians face the same dichotomic choice: adapting adult procedures now versus waiting—for a long time—for the corresponding pediatric trials. One way out is building a compromise based on observational studies with large, longitudinal, comprehensive, real-life, and multisource dataset. Two recent high-quality observational studies have delivered promising conclusions on recanalization treatments in pediatric arterial ischemic stroke. TIPSTER (Thrombolysis in Pediatric Stroke Extended Results) showed that the risk of severe intracranial hemorrhage after intravenous thrombolysis is low; the Save Childs Study reported encouraging data about pediatric thrombectomy. Beyond the conclusion of a satisfactory global safety profile, a thorough analysis of the methods, populations, results, and therapeutic complications of these studies helps us to refine indications/contraindications and highlights the safeguards we need to rely on when discussing thrombolysis and thrombectomy in children. In conclusion, pediatric strokologists should not refrain from using clot lysis/retrieval tools in selected children with arterial ischemic stroke. But the implementation of hyperacute care is only feasible if the right candidate is identified through the sharing of common adult/pediatric protocols and ward collaboration, formalized well before the child’s arrival. These anticipated protocols should never undervalue contraindications from adult guidelines and must involve the necessary pediatric expertise when facing specific causes of stroke, such as focal cerebral arteriopathy of childhood.

Published
2021

13. Nontraumatic Pediatric Intracerebral Hemorrhage

Author

Mark T Mackay, Adam Kirton, Thomas Blauwblomme, Charlotte Cordonnier, Gregoire Boulouis, Sandro Benichi, Mathilde Chevignard, Elisabeth Tournier-Lasserve, Philippe Meyer, Olivier Naggara, Stéphane Chabrier, Jean François Hak, and Manoelle Kossorotoff

Subjects
Intracranial Arteriovenous Malformations, Hemangioma, Cavernous, Central Nervous System, Adolescent, Computed Tomography Angiography, Vomiting, Arteriovenous fistula, Anemia, Sickle Cell, Neurosurgical Procedures, Magnetic resonance angiography, Cognition, Activities of Daily Living, medicine, Humans, Cognitive Dysfunction, Social Integration, Moyamoya disease, Child, Cerebral Hemorrhage, Central Nervous System Vascular Malformations, Advanced and Specialized Nursing, Intracerebral hemorrhage, Academic Success, medicine.diagnostic_test, Brain Neoplasms, business.industry, Headache, Anticoagulants, Infant, Blood Coagulation Disorders, Physical Functional Performance, Childhood stroke, Decompression, Surgical, Prognosis, medicine.disease, Clinical neurology, Child, Preschool, Education, Special, Anesthesia, Arteriovenous Fistula, Ischemic stroke, Drainage, Neurology (clinical), Moyamoya Disease, Cardiology and Cardiovascular Medicine, business, Magnetic Resonance Angiography
Published
2019

14. Arterial Spin Labeling for the Etiological Workup of Intracerebral Hemorrhage in Children

Author

Hak, Jean François, primary, Boulouis, Grégoire, additional, Kerleroux, Basile, additional, Benichi, Sandro, additional, Stricker, Sarah, additional, Gariel, Florent, additional, Garzelli, Lorenzo, additional, Meyer, Philippe, additional, Kossorotoff, Manoelle, additional, Boddaert, Nathalie, additional, Vidal, Vincent, additional, Girard, Nadine, additional, Dangouloff Ros, Volodia, additional, Brunelle, Francis, additional, Blauwblomme, Thomas, additional, and Naggara, Olivier, additional

Published
2022
Full Text
View/download PDF

16. Impact of Prior Antiplatelet Therapy on Outcomes After Endovascular Therapy for Acute Stroke: Endovascular Treatment in Ischemic Stroke Registry Results

Author

Couture, Marie, primary, Finitsis, Stephanos, additional, Marnat, Gaultier, additional, Richard, Sébastien, additional, Bourcier, Romain, additional, Constant-dits-Beaufils, Pacôme, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Mazighi, Mikaël, additional, Blanc, Raphaël, additional, Eugène, François, additional, Vannier, Stéphane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Touzé, Emmanuel, additional, Barbier, Charlotte, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Rosso, Charlotte, additional, Clarençon, Frédéric, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrysanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Lebras, Anthony, additional, Evain, Sarah, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Gory, Benjamin, additional, Sibon, Igor, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Solène, Hebert, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsjy, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Liao, Liang, additional, Tonnelet, Romain, additional, Liao, François, additional, Zhu, Emmanuelle, additional, Schmitt, Sophie, additional, Planel, Sébastien, additional, Richard, Lisa, additional, Humbertjean, Gioia, additional, Mione, Jean-Christophe, additional, Lacour, Nolwenn, additional, Riou-Comte, Gérard, additional, Audibert, Marcela, additional, Voicu, Lionel, additional, Alb, Marie, additional, Reitter, Madalina, additional, Brezeanu, Agnès, additional, Masson, Adriana, additional, Tabarna, Iona, additional, Podar, Sarah, additional, Guy, Fatiha, additional, Bechiri, Fatiha, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Gimenez, Laetitia, additional, Cosnard, Alexandre, additional, Costalat, Vincent, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Maurice, Sophie Langnier-Lemercier, Axelle, additional, Cochennec, Sabrina, additional, Pinault, Mélanie, additional, Shotar, Eimad, additional, Sourour, Nader, additional, Lenck, Stéphanie, additional, Premat, Kévin, additional, Anne Léger, Yves Samson, additional, Crozier, Sophie, additional, Baronnet, Flore, additional, Alamowitch, Sonia, additional, Bottin, Laure, additional, Yger, Mathon, additional, Degos, Vincent, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Sarov, Mariana, additional, Legris, Nicolas, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Bellanger, Guillaume, additional, Tall, Philippe, additional, Schneckenburger, Romain, additional, Boulanger, Marion, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Gauberti, Maxime, additional, Ognard, Julien, additional, Mathias Merrien., Francois, additional, Wermester, Ozlem Ozku, additional, Massardier, Evelyne, additional, Triquenot, Aude, additional, Lefebvre, Margeaux, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Higue, David, additional, Quenardelle, Veronique, additional, Lauer, Valerie, additional, Gheoca, Roxana, additional, Pierre-Paul, Irene, additional, Beaujeux, Remy, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Pottecher, Julien, additional, Meyer, Alain, additional, Chamaraux-Tran, Thiên-Nga, additional, Le Bras, Anthony, additional, Le Guen, Arnaud, additional, Nighoghossian, Norbert, additional, Riva, Roberto, additional, Eker, Omer, additional, turjman, Francis, additional, Derex, Laurent, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Claire Lukaszewicz, Anne, additional, Philippeau, Frédéric, additional, Cakmak, Serkan, additional, Blanc-Lasserre, Karine, additional, and Vallet, Anne-Evelyne, additional

Published
2021
Full Text
View/download PDF

17. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry

Author

Happi Ngankou, Emmanuel, primary, Gory, Benjamin, additional, Marnat, Gaultier, additional, Richard, Sébastien, additional, Bourcier, Romain, additional, Sibon, Igor, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Maïer, Benjamin, additional, Blanc, Raphaël, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Vannier, Stéphane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Boulanger, Marion, additional, Gauberti, Maxime, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Clarençon, Frédéric, additional, Rosso, Charlotte, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrysanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Lebras, Anthony, additional, Evain, Sarah, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Eugène, François, additional, Finitsis, Stephanos, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Solène, Hebert, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Maacha, Malek Ben, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsjy, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Riou-Comte, Nolwenn, additional, Audibert, Gérard, additional, Voicu, Marcela, additional, Alb, Lionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Guy, Sarah, additional, Bechiri, Fatiha, additional, Bourst, Pauline, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Gimenez, Laetitia, additional, Cosnard, Alexandre, additional, Costalat, Vincent, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Langnier-Lemercier, Sophie, additional, Maurice, Axelle, additional, Cochennec, Sabrina, additional, Pinault, Mélanie, additional, Shotar, Eimad, additional, Sourour, Nader, additional, Lenck, Stéphanie, additional, Premat, Kévin, additional, Léger, Yves Samson Anne, additional, Crozier, Sophie, additional, Baronnet, Flore, additional, Alamowitch, Sonia, additional, Bottin, Laure, additional, Yger, Mathon, additional, Degos, Vincent, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Sarov, Mariana, additional, Legris, Nicolas, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Fontaine, Louis, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Bellanger, Guillaume, additional, Tall, Philippe, additional, Touze, Emmanuel, additional, Barbier, Charlotte, additional, Schneckenburger, Romain, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Ognard, Julien, additional, Merrien, Francois Mathias, additional, Wermester, Ozlem Ozku, additional, Massardier, Evelyne, additional, Triquenot, Aude, additional, Lefebvre, Margeaux, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Higue, David, additional, Quenardelle, Veronique, additional, Lauer, Valerie, additional, Gheoca, Roxana, additional, Pierre-Paul, Irene, additional, Beaujeux, Remy, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Pottecher, Julien, additional, Meyer, Alain, additional, Chamaraux-Tran, Thiên-Nga, additional, Le Bras, Anthony, additional, and Le Guen, Arnaud, additional

Published
2021
Full Text
View/download PDF

18. Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy

Author

Kerleroux, Basile, primary, Benzakoun, Joseph, additional, Janot, Kévin, additional, Dargazanli, Cyril, additional, Eraya, Dimitri Daly, additional, Ben Hassen, Wagih, additional, Zhu, François, additional, Gory, Benjamin, additional, Hak, Jean-Francois, additional, Perot, Charline, additional, Detraz, Lili, additional, Bourcier, Romain, additional, Aymeric, Rouchaud, additional, Forestier, Géraud, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Mordasini, Pasquale, additional, Seners, Pierre, additional, Turc, Guillaume, additional, Kaesmacher, Johannes, additional, Oppenheim, Catherine, additional, Naggara, Olivier, additional, and Boulouis, Gregoire, additional

Published
2021
Full Text
View/download PDF

19. Effect of Operator’s Experience on Proficiency in Mechanical Thrombectomy: A Multicenter Study

Author

Zhu, François, primary, Ben Hassen, Wagih, additional, Bricout, Nicolas, additional, Kerleroux, Basile, additional, Janot, Kevin, additional, Gory, Benjamin, additional, Anxionnat, René, additional, Richard, Sébastien, additional, Marchal, Adrien, additional, Blanc, Raphael, additional, Piotin, Michel, additional, Consoli, Arturo, additional, Trystram, Denis, additional, Rodriguez Regent, Christine, additional, Desilles, Jean-Philippe, additional, Weisenburger-Lile, David, additional, Escalard, Simon, additional, Herbreteau, Denis, additional, Ifergan, Heloise, additional, Lima Maldonado, Igor, additional, Labreuche, Julien, additional, Henon, Hilde, additional, Naggara, Olivier, additional, Lapergue, Bertrand, additional, Boulouis, Grégoire, additional, Hocine, Redjem, additional, Gabriele, Ciccio, additional, Stanislas, Smajda, additional, Benjamin, Maier, additional, Mikael, Mazighi, additional, Mikael, Obadia, additional, Candice, Sabben, additional, Roxanne, Peres, additional, Ovide, Corabianu, additional, Thomas, De Broucker, additional, Didier, Smadja, additional, Sonia, Alamowitch, additional, Olivier, Ille, additional, Eric, Manchon, additional, Pierre-Yves, Garcia, additional, Guillaume, Taylor, additional, Malek, Ben Maacha, additional, Adrien, Wang, additional, Serge, Evrard, additional, Maya, Tchikviladze, additional, Nadia, Ajili, additional, Lucas, Gorza, additional, Géraldine, Buard, additional, Oguzhan, Coskun, additional, Maria Federico, Di, additional, Georges, Rodesh, additional, Sergio, Zimatore, additional, Morgan, Leguen, additional, Julie, Gratieux, additional, Fernando, Pico, additional, Haja, Rakotoharinandrasana, additional, Philippe, Tassan, additional, Roxanna, Poll, additional, Sylvie, Marinier, additional, Norbert, Nighoghossian, additional, Roberto, Riva, additional, Omer, Eker, additional, Francis, Turjman, additional, Laurent, Derex, additional, Tae-Hee, Cho, additional, Laura, Mechtouff, additional, Lukaszewicz Anne, Claire, additional, Frédéric, Philippeau, additional, Serkan, Cakmak, additional, Karine, Blanc-Lasserre, additional, Anne-Evelyne, Vallet, additional, Gaultier, Marnat, additional, Florent, Gariel, additional, Xavier, Barreau, additional, Jérôme, Berge, additional, Patrice, Menegon, additional, Igor, Sibon, additional, Sebastien, Liegey, additional, Stéphane, Olindo, additional, Pauline, Renou, additional, Sharmila, Sagnier, additional, Mathilde, Poli, additional, Sabrina, Debruxelles, additional, Nicolas, Pangon, additional, Romain, Bourcier, additional, Lili, Detraz, additional, Benjamin, Daumas-Duport, additional, Pierre-Louis, Alexandre, additional, Monica, Roy, additional, Cédric, Lenoble, additional, Vincent, L’allinec, additional, Jean-Baptiste, Girot, additional, Hubert, Desal, additional, Serge, Bracard, additional, Marc, Braun, additional, Anne-Laure, Derelle, additional, Romain, Tonnelet, additional, Liang, Liao, additional, Patricio, Muszynski, additional, Emmanuelle, Schmitt, additional, Sophie, Planel, additional, Lisa, Humbertjean, additional, Gioia, Mione, additional, Jean-Christophe, Lacour, additional, Nolwenn, Riou-Comte, additional, Gérard, Audibert, additional, Marcela, Voicu, additional, Ionel, Alb, additional, Marie, Reitter, additional, Madalina, Brezeanu, additional, Agnès, Masson, additional, Ioana, Tabarna Adriana, Podar, additional, Francisco, Macian-Montoro, additional, Suzanna, Saleme, additional, Charbel, Mounayer, additional, Aymeric, Rouchaud, additional, Vincent, Costalat, additional, Caroline, Arquizan, additional, Cyril, Dargazanli, additional, Grégory, Gascou, additional, Pierre-Henri, Lefèvre, additional, Imad, Derraz, additional, Carlos, Riquelme, additional, Nicolas, Gaillard, additional, Isabelle, Mourand, additional, Lucas, Corti, additional, Eugene, Francois, additional, Stéphane, Vannier, additional, Jean-Christophe, Ferre, additional, Helene, Raoult, additional, Thomas, Ronziere, additional, Maria, Lassale, additional, Christophe, Paya, additional, Jean-Yves, Gauvrit, additional, Clément, Tracol, additional, Sophie, Langnier-Lemercier, additional, Yves, Samson, additional, Charlotte, Rosso, additional, Anne, Leger, additional, Sandrine, Deltour, additional, Frederic, Clarencon, additional, Eimad, Shotar, additional, Laurent, Spelle, additional, Christian, Denier, additional, Olivier, Chassin, additional, Vanessa, Chalumeau, additional, Jildaz, Caroff, additional, Laura, Venditti, additional, Guillaume, Turc, additional, Pierre, Seners, additional, Valérie, Domigo, additional, Catherine, Lamy, additional, Julia, Birchenall, additional, Clothilde, Isabel, additional, Alain, Viguier, additional, Christophe, Cognard, additional, Anne, Christine Januel, additional, Jean-Marc, Olivot, additional, Nicolas, Raposo, additional, Fabrice, Bonneville, additional, Albucher Jean, François, additional, Lionel, Calviere, additional, Emmanuel, Touze, additional, Charlotte, Barbier, additional, Romain, Schneckenburger, additional, Marion, Boulanger, additional, Julien, Cogez, additional, Sophie, Guettier, additional, Serge, Timsit, additional, Jean-Christophe, Gentric, additional, Julien, Ognard, additional, Francois, Mathias Merrien, additional, Ozlem, Ozkul Wermester, additional, Evelyne, Massardier, additional, Chrysanthi, Papagiannaki, additional, Frédéric, Bourdain, additional, Bernady, Patricia, additional, Laurent, Lagoarde-Segot, additional, Hélène, Cailliez, additional, Louis, Veunac, additional, David, Higue, additional, Valérie, Wolff, additional, Raoul, Pop, additional, Rémi, Beaujeux, additional, Dan-Sorin, Mihoc, additional, Monica, Manisor, additional, Anthony, Le Bras, additional, Sarah, Evain, additional, Arnaud, Le Guen, additional, Sebastian, Richter, additional, Regis, Hubrecht, additional, Stéphanie, Demasles, additional, Bruno, Barroso, additional, Mathieu, Zuber, additional, Wassim, Farhat, additional, Quentin, Alias, additional, François, Lun, additional, Delphine, Stenvenoot, additional, Olivier, Heinzlef, additional, Sylvie, Godon Hardy, additional, Valentin, Bohotin, additional, and Jérôme, Grimaud, additional

Published
2021
Full Text
View/download PDF

20. Impact of Repeated Clot Retrieval Attempts on Infarct Growth and Outcome After Ischemic Stroke

Author

Ben Hassen, Wagih, primary, Touloupas, Caroline, additional, Benzakoun, Joseph, additional, Boulouis, Gregoire, additional, Bretzner, Martin, additional, Bricout, Nicolas, additional, Legrand, Laurence, additional, Rodriguez, Christine, additional, Le Berre, Alice, additional, Seners, Pierre, additional, Turc, Guillaume, additional, Cordonnier, Charlotte, additional, Oppenheim, Catherine, additional, Henon, Hilde, additional, and Naggara, Olivier, additional

Published
2021
Full Text
View/download PDF

21. Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage

Author

Boulouis, Gregoire, primary, Hak, Jean-François, additional, Kerleroux, Basile, additional, Benichi, Sandro, additional, Stricker, Sarah, additional, Gariel, Florent, additional, Alias, Quentin, additional, Bourgeois, Marie, additional, Meyer, Philippe, additional, Kossorotoff, Manoelle, additional, Garzelli, Lorenzo, additional, Garcelon, Nicolas, additional, Boddaert, Nathalie, additional, Morotti, Andrea, additional, Blauwblomme, Thomas, additional, and Naggara, Olivier, additional

Published
2021
Full Text
View/download PDF

22. Primary angiitis of the CNS and reversible cerebral vasoconstriction syndrome

Author

Christian Pagnoux, Hubert de Boysson, Mathieu Zuber, G Boulouis, Emmanuel Touzé, Olivier Naggara, Marie-Germaine Bousser, Anne Ducros, Jean-Jacques Parienti, Cécilia Burcin, Jérôme Mawet, Achille Aouba, and Caroline Arquizan

Subjects
Adult, Male, medicine.medical_specialty, Headache Disorders, Primary, Subarachnoid hemorrhage, Adolescent, Migraine Disorders, Context (language use), Gastroenterology, Diagnosis, Differential, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Vasculitis, Central Nervous System, Aged, Retrospective Studies, Thunderclap headaches, Aged, 80 and over, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Reversible cerebral vasoconstriction syndrome, Hyperintensity, 3. Good health, Stroke, Cerebrovascular Disorders, Dissection, Treatment Outcome, Vasoconstriction, Female, Neurology (clinical), Tomography, X-Ray Computed, business, Vasculitis, 030217 neurology & neurosurgery
Abstract

ObjectivesTo further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS).MethodsWe compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled).ResultsPatients with RCVS were predominantly female (p < 0.0001), with migraines (p < 0.0001), and were more often exposed to vasoactive substances (p < 0.0001) or postpartum (p = 0.002) than patients with PACNS. Headache, especially thunderclap headache, was more frequent in RCVS (both p < 0.0001). Thunderclap headache was absent in only 6% of patients with RCVS and was mainly recurrent (87%) and provoked (77%) mostly by sexual intercourse, exertion, or emotion. All other neurologic symptoms (motor deficit, seizure, cognitive disorder, or vigilance impairment, all p < 0.0001) were more frequent in PACNS. At admission, brain CT or MRI was abnormal in all patients with PACNS and in 31% of patients with RCVS (p < 0.0001). Acute ischemic stroke was more frequent in PACNS than in RCVS (p < 0.0001). Although intracerebral hemorrhage was more frequent in PACNS (p = 0.006), subarachnoid hemorrhage and vasogenic edema predominated in RCVS (p = 0.04 and p = 0.01, respectively). Multiple small deep infarcts, extensive deep white matter lesions, tumor-like lesions, or multiple gadolinium-enhanced lesions were observed only in PACNS, whereas cervical artery dissection was found only in RCVS.ConclusionsOur study confirms that careful analysis of clinical context, headache features, and patterns of brain lesions can distinguish PACNS and RCVS within the first few days of admission in most cases. However, diagnosis remains challenging in a few cases.

Published
2018

23. Treatment and Long-Term Outcomes of Primary Central Nervous System Vasculitis

Author

M. Zuber, Olivier Naggara, Emmanuel Touzé, Christian Pagnoux, Achille Aouba, Loïc Guillevin, Gregoire Boulouis, Hubert de Boysson, and Caroline Arquizan

Subjects
030203 arthritis & rheumatology, Advanced and Specialized Nursing, medicine.medical_specialty, Multivariate analysis, business.industry, Central nervous system, Odds ratio, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Maintenance therapy, Modified Rankin Scale, Internal medicine, Cohort, Long term outcomes, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Vasculitis, 030217 neurology & neurosurgery
Abstract

Background and Purpose— We aimed to analyze the long-term outcomes of patients with primary central nervous system vasculitis according to the different therapeutic strategies used to induce remission. Methods— We assessed the rate of prolonged remission (defined by the absence of relapse at ≥12 months after diagnosis) and the functional status at last follow-up in patients with primary central nervous system vasculitis included in the French cohort, who achieved a first remission according to the 3 main groups of treatments administered: glucocorticoids only (group 1); induction treatment with glucocorticoids and an immunosuppressant, but no maintenance (group 2); and combined treatment with glucocorticoids and an immunosuppressant for induction followed by maintenance therapy (group 3). Good functional status was defined as a modified Rankin Scale score ≤2 at the last follow-up. Results— Remission was achieved with the initial induction treatment in 106 (95%) of the 112. Prolonged remission without relapse was observed in 70 (66%) patients after 57 (12–198) months of follow-up. A good functional status at last follow-up (ie, modified Rankin Scale score ≤2) was observed in 63 (56%) patients. Overall mortality was 8%. The initial severity and the radiological presentations were comparable in the 3 treatment groups. More prolonged remissions ( P =0.003) and a better functional status at the last follow-up ( P =0.0004) were observed in group 3. In multivariate analysis, the use of maintenance therapy was associated with prolonged remission (odds ratio, 4.32 [1.67–12.19]; P =0.002) and better functional status (odds ratio, 8.09 [3.24–22.38]; P Conclusions— This study suggests that maintenance therapy with an immunosuppressant combined with glucocorticoids lead to the best long-term clinical and functional outcomes in patients with primary central nervous system vasculitis after having achieved remission with either glucocorticoids alone or in combination with another immunosuppressant.

Published
2018

24. Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity

Author

Raphaël, Le Bouc, Frédéric, Clarençon, Elena, Meseguer, Bertrand, Lapergue, Arturo, Consoli, Guillaume, Turc, Olivier, Naggara, Duc Long, Duong, Jerome, Servan, Peggy, Reiner, Marc Antoine, Labeyrie, Mathieu, Fisselier, Raphaël, Blanc, Wassim, Farhat, Christine, Pires, Mathieu, Zuber, Michael, Obadia, Mikael, Mazighi, Fernando, Pico, Jean-Louis, Mas, Pierre, Amarenco, Yves, Samson, and Sophie, Gerber

Subjects
Male, medicine.medical_specialty, Stroke severity, Ischemia, Severity of Illness Index, Endovascular therapy, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Internal medicine, Humans, Medicine, Clinical severity, Prospective Studies, Registries, 030212 general & internal medicine, Endovascular treatment, Stroke, Acute ischemic stroke, Aged, Aged, 80 and over, Advanced and Specialized Nursing, business.industry, Endovascular Procedures, Age Factors, Middle Aged, medicine.disease, Combined Modality Therapy, Treatment Outcome, Case-Control Studies, Tissue Plasminogen Activator, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Large vessel occlusion
Abstract

Background and Purpose— Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients’ age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, or poor prognostic score. Methods— A total of 4079 patients with an acute ischemic stroke were identified from the Paris Stroke Consortium registry. We developed the stroke checkerboard (SC) score (SC score=1 point per decade ≥50 years of age and 2 points per 5 points on the National Institutes of Health Stroke Scale) to predict spontaneous outcome. The primary outcome was the adjusted common odds ratio for an improvement in the modified Rankin Scale at 90 days after EVT, in patients with low, intermediate, or high SC scores. To rule out potential selection biases, a nested case-control analysis, with individual matching for all major prognostic factors, was also performed, to compare patients with large vessel occlusion in the anterior circulation treated or not with EVT. Results— In patients untreated with EVT, SC scores 12 were predictive of poor outcomes (modified Rankin Scale score, 4–6; area under the curve, 0.88). In the overall population, there was an interaction between EVT and prognosis group ( P 12 (common odds ratio, 1.70; 95% confidence interval, 1.13–2.56) and SC scores 8 to 12 (odds ratio, 1.37; 95% confidence interval, 1.11–1.69) but not in patients with SC scores Conclusions— In patients stratified with the SC score, EVT was associated with improved functional outcome in older and more severe patients but not in younger and less severe patients.

Published
2018

27. Predictors of Unexplained Early Neurological Deterioration After Endovascular Treatment for Acute Ischemic Stroke

Author

Girot, Jean-Baptiste, primary, Richard, Sébastien, additional, Gariel, Florent, additional, Sibon, Igor, additional, Labreuche, Julien, additional, Kyheng, Maéva, additional, Gory, Benjamin, additional, Dargazanli, Cyril, additional, Maier, Benjamin, additional, Consoli, Arturo, additional, Daumas-Duport, Benjamin, additional, Lapergue, Bertrand, additional, Bourcier, Romain, additional, Piotin, Michel, additional, Blanc, Raphael, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Desilles, Jean-Philippe, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Peres, Roxanne, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Smadja, Didier, additional, Alamowitch, Sonia, additional, Ille, Olivier, additional, Manchon, Eric, additional, Garcia, Pierre-Yves, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, Weisenburger, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Nighoghossian, Norbert, additional, Riva, Roberto, additional, Eker, Omer, additional, Turjman, Francis, additional, Derex, Laurent, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Claire Lukaszewicz, Anne, additional, Philippeau, Frédéric, additional, Cakmak, Serkan, additional, Blanc-Lasserre, Karine, additional, Vallet, Anne-Evelyne, additional, Marnat, Gaultier, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Veunac, Louis, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Tourdias et Jean-Sebastien Liegey, Thomas, additional, Detraz, Lili, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, L’allinec, Vincent, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Bonnerot, Mathieu, additional, Riou-Comte, Nolwenn, additional, Macian-Montoro, Francisco, additional, Saleme, Suzanna, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Francois, Eugene, additional, Vannier, Stéphane, additional, Ferre, Jean-Christophe, additional, Raoult, Helene, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Langnier-Lemercier, Sophie, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Leger, Anne, additional, Deltour, Sandrine, additional, Clarencon, Frederic, additional, Shotar, Eimad, additional, Spelle, Laurent, additional, Denier, Christian, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Turc, Guillaume, additional, Naggara, Glivier, additional, Boulouis, Gregoire, additional, Ben Hassen, Waghih, additional, Seners, Pierre, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Christine Januel, Anne, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Touze, Emmanuel, additional, Barbier, Charlotte, additional, Schneckenburger, Romain, additional, Boulanger, Marion, additional, Cogez, Julien, additional, and Guettier, Sophie, additional

Published
2020
Full Text
View/download PDF

28. Acute Stroke Management During the COVID-19 Pandemic

Author

Hajdu, Steven D., primary, Pittet, Valerie, additional, Puccinelli, Francesco, additional, Ben Hassen, Wagih, additional, Ben Maacha, Malek, additional, Blanc, Raphaël, additional, Bracco, Sandra, additional, Broocks, Gabriel, additional, Bartolini, Bruno, additional, Casseri, Tommaso, additional, Clarençon, Frederic, additional, Naggara, Olivier, additional, Eugène, François, additional, Ferré, Jean-Christophe, additional, Guédon, Alexis, additional, Houdart, Emmanuel, additional, Krings, Timo, additional, Lehmann, Pierre, additional, Limbucci, Nicola, additional, Machi, Paolo, additional, Macho, Juan, additional, Mandruzzato, Nicolo, additional, Nappini, Sergio, additional, Nawka, Marie Teresa, additional, Nicholson, Patrick, additional, Marto, João Pedro, additional, Pereira, Vitor, additional, Correia, Manuel A., additional, Pinho-e-Melo, Teresa, additional, Nuno Ramos, João, additional, Raz, Eytan, additional, Ferreira, Patrícia, additional, Reis, João, additional, Shapiro, Maksim, additional, Shotar, Eimad, additional, van Horn, Noel, additional, Piotin, Michel, additional, and Saliou, Guillaume, additional

Published
2020
Full Text
View/download PDF

29. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak

Author

Kerleroux, Basile, primary, Fabacher, Thibaut, additional, Bricout, Nicolas, additional, Moïse, Martin, additional, Testud, Benoit, additional, Vingadassalom, Sivadji, additional, Ifergan, Héloïse, additional, Janot, Kévin, additional, Consoli, Arturo, additional, Ben Hassen, Wagih, additional, Shotar, Eimad, additional, Ognard, Julien, additional, Charbonnier, Guillaume, additional, L’Allinec, Vincent, additional, Guédon, Alexis, additional, Bolognini, Federico, additional, Marnat, Gaultier, additional, Forestier, Géraud, additional, Rouchaud, Aymeric, additional, Pop, Raoul, additional, Raynaud, Nicolas, additional, Zhu, François, additional, Cortese, Jonathan, additional, Chalumeau, Vanessa, additional, Berge, Jérome, additional, Escalard, Simon, additional, Boulouis, Grégoire, additional, Chivot, Cyril, additional, Hanafi, Riyad, additional, Pasco, Anne, additional, Girot, Jean-Baptiste, additional, Biondi, Alessandra, additional, Di Caterino, Fortunato, additional, Primikiris, Panagiotis, additional, Vitale, Giovanni, additional, Bonnet, Louise, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Debruxelles, Sabrina, additional, Lucas, Ludovic, additional, Menegon, Patrice, additional, Olindo, Stéphane, additional, Poli, Mathilde, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Sibon, Igor, additional, Veunac, Louis, additional, Gentric, Jean-Christophe, additional, Barbier, Charlotte, additional, Boulanger, Marion, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Schneckenburger, Romain, additional, Touze, Emmanuel, additional, Delaitre, Mariette, additional, Lebendinsky, Pablo, additional, Musacchio, Mariano, additional, Ricolfi, Frédéric, additional, Thouant, Pierre, additional, Caparros, François, additional, Casolla, Barbara, additional, Della Schiava, Lucie, additional, Dequatre, Nelly, additional, Henon, Hilde, additional, Pasi, Marco, additional, Kazemi, Apolline, additional, Bala, Fouzi, additional, Estrade, Laurent, additional, Mounayer, Charbel, additional, Saleme, Susanna, additional, Macian-Montoro, Francisco, additional, Eker, Omer, additional, Cotton, François, additional, Blanc-Lasserre, Karine, additional, Cakmak, Serkan, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Lukaszewicz, Anne-Claire, additional, Mechtouff, Laura, additional, Nighoghossian, Norbert, additional, Philippeau, Frédéric, additional, Riva, Roberto, additional, Turjman, Francis, additional, Vallet, Anne-Evelyne, additional, Carle, Xavier, additional, Dory-Lautrec, Philippe, additional, Reyre, Anthony, additional, Hak, Jean-François, additional, Brunel, Hervé, additional, Benali, Amel, additional, Collemiche, François-Louis, additional, Dargazanli, Cyril, additional, Cagnazzo, Frederico, additional, Derraz, Imad, additional, Arquizan, Caroline, additional, Corti, Lucas, additional, Costalat, Vincent, additional, Gaillard, Nicolas, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Derelle, Anne Laure, additional, Gory, Benjamin, additional, Liao, Liang, additional, Tonnelet, Romain, additional, Anxionnat, René, additional, Bonnerot, Mathieu, additional, Bracard, Serge, additional, Braun, Marc, additional, Humbertjean, Lisa, additional, Lacour, Jean-Christophe, additional, Mione, Gioia, additional, Planel, Sophie, additional, Richard, Sébastien, additional, Riou-Comte, Nolwenn, additional, Schmitt, Emmanuelle, additional, Bourcier, Romain, additional, Detraz, Lili, additional, Desal, Hubert, additional, Alexandre, Pierre-Louis, additional, Daumas-Duport, Benjamin, additional, Lenoble, Cédric, additional, Roy, Monica, additional, Coskun, Oghuzan, additional, Di Maria, Frederico, additional, Lapergue, Bertrand, additional, Rodesch, Georges, additional, Wang, Adrien, additional, Weisenburger-Lile, David, additional, Zimatore, Sergio, additional, Ajili, Nadia, additional, Buard, Géraldine, additional, Evrard, Serge, additional, Gorza, Lucas, additional, Gratieux, Julie, additional, Leguen, Morgan, additional, Marinier, Sylvie, additional, Pico, Fernando, additional, Poll, Roxanna, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Tchikviladze, Maya, additional, Delvoye, François, additional, Hebert, Solène, additional, Blanc, Raphaël, additional, Ciccio, Gabriele, additional, Desilles, Jean-Philippe, additional, Maier, Benjamin, additional, Mazighi, Mikael, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Smajda, Stanislas, additional, Ben Maacha, Malek, additional, Corabianu, Ovide, additional, De Broucker, Thomas, additional, Ille, Olivier, additional, Manchon, Eric, additional, Obadia, Michael, additional, Obadia, Mickael, additional, Raynouard, Igor, additional, Peres, Roxanne, additional, Sabben, Candice, additional, Smadja, Didier, additional, Taylor, Guillaume, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Spelle, Laurent, additional, Denier, Christian, additional, Caroff, Jildaz, additional, Chassin, Olivier, additional, Spelle, laurent, additional, Venditti, Laura, additional, Aymard, Armand, additional, Betty, Jean, additional, Civelli, Vittorio, additional, Eliezer, Michael, additional, Fantoni, Matteo, additional, Houdart, Emmanuel, additional, Labeyrie, Marc-Antoine, additional, Saint Maurice, Jean-Pierre, additional, Kalsoum, Erwah, additional, Pacini, Aurelien, additional, Ramadane, Chawkat, additional, Tuilier, Titien, additional, Villain, Adrien, additional, Clarencon, Frédéric, additional, Degos, Vincent, additional, Elhfnawy, Ahmed, additional, Elhorany, Mahmoud, additional, Lenck, Stéphanie, additional, Premat, Kevin, additional, Sourour, Nader-Antoine, additional, Alamowitch, Sonia, additional, Baronnet, Flore, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Leger, Anne, additional, Rosso, Charlotte, additional, Pyatigorskaya, Nadya, additional, Rodriguez Regent, Christine, additional, Trystram, Denis, additional, Naggara, Olivier, additional, Seners, Pierre, additional, Turc, Guillaume, additional, Edjlali, Myriam, additional, Agbonon, Rémi, additional, Alotaibi, Mohammed, additional, Sonchet, Antoine, additional, Oppenheim, Catherine, additional, Meder, Jean François, additional, Benzakoun, Joseph, additional, Legrand, Laurence, additional, Fauché, Cédric, additional, Velasco, Stéphane, additional, Manceau, Pierre François, additional, Moulin, Sebastien Solène Soize, additional, Eugene, François, additional, Ferre, Jean-Christophe, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Langnier-Lemercier, Sophie, additional, Lassale, Maria, additional, Raoult, helene, additional, Ronziere, thomas, additional, Tracol, Clément, additional, Vannier, Stéphane, additional, Burel, Julien, additional, Le Moal, Julien, additional, Papagiannaki, Chrysanthi, additional, Aggour, Mohamed, additional, Sachet, Marina, additional, Boutet, Claire, additional, Beaujeux, Remy, additional, Hasiu, Anca, additional, Manisor, Monica, additional, Mihoc, Dan, additional, Kremer, Stéphane, additional, Arteaga, Charles, additional, Gazzola, Sébastien, additional, Darcourt, Jean, additional, Cognard, Christophe, additional, Bonneville, Fabrice, additional, Christine Januel, Anne, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Viguier, Alain, additional, Bibi, Richard, additional, Boustia, Fakhreddine, additional, Herbreteau, Denis, additional, Maldonado, Igor, additional, and Narata, Ana-Paula, additional

Published
2020
Full Text
View/download PDF

32. Prediction of Unruptured Intracranial Aneurysm Evolution: The UCAN Project

Author

L’Allinec, Vincent, primary, Chatel, Stéphanie, additional, Karakachoff, Matilde, additional, Bourcereau, Emmanuelle, additional, Lamoureux, Zeineb, additional, Gaignard, Alban, additional, Autrusseau, Florent, additional, Jouan, Solène, additional, Vion, Anne-Clemence, additional, Loirand, Gervaise, additional, Desal, Hubert, additional, Naggara, Olivier, additional, Redon, Richard, additional, Edjlali, Myriam, additional, and Bourcier, Romain, additional

Published
2020
Full Text
View/download PDF

33. Nontraumatic Pediatric Intracerebral Hemorrhage

Author

Boulouis, Gregoire, primary, Blauwblomme, Thomas, additional, Hak, Jean François, additional, Benichi, Sandro, additional, Kirton, Adam, additional, Meyer, Philippe, additional, Chevignard, Mathilde, additional, Tournier-Lasserve, Elisabeth, additional, Mackay, Mark T., additional, Chabrier, Stéphane, additional, Cordonnier, Charlotte, additional, Kossorotoff, Manoëlle, additional, and Naggara, Olivier, additional

Published
2019
Full Text
View/download PDF

34. Regional Pediatric Acute Stroke Protocol

Author

Manoelle Kossorotoff, David Grevent, Augustin Ozanne, Christian Denier, Céline Bellesme, Laurence Tabone, Olivier Naggara, Nicolas Mediamolle, Fabrice Lesage, Catherine Lamy, Beatrice Husson, and Isabelle Desguerre

Subjects
Male, medicine.medical_specialty, Time Factors, Adolescent, Treatment outcome, 030204 cardiovascular system & hematology, Tissue plasminogen activator, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Thrombolytic Therapy, Prospective Studies, Child, Prospective cohort study, Intensive care medicine, Stroke, Retrospective Studies, Acute stroke, Advanced and Specialized Nursing, Protocol (science), business.industry, Endovascular Procedures, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Arterial Ischemic Stroke, Treatment Outcome, Child, Preschool, Tissue Plasminogen Activator, Reperfusion, Administration, Intravenous, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background and Purpose— To evaluate hyperacute management of pediatric arterial ischemic stroke, setting up dedicated management pathways is the first recommended step to prove the feasibility and safety of such treatments. A regional pediatric stroke alert protocol including 2 centers in the Paris-Ile-de-France area, France, was established. Methods— Consecutive pediatric patients (28 days–18 years) with confirmed arterial ischemic stroke who had acute recanalization treatment (intravenous r-tPA [recombinant tissue-type plasminogen activator], endovascular procedure, or both) according to the regional pediatric stroke alert were retrospectively reviewed during a 40-month period. Results— Thirteen children, aged 3.7 to 16.6 years, had recanalization treatment. Median time from onset to magnetic resonance imaging was 165 minutes (150–300); 9 out of 13 had large-vessel occlusion. Intravenous r-tPA was used in 11 out of 13 patients, with median time from onset to treatment of 240 minutes (178–270). Endovascular procedure was performed in patients time-out for intravenous r-tPA (n=2) or after intravenous r-tPA inefficiency (n=2). No intracranial or peripheral bleeding was reported. One patient died of malignant stroke; outcome was favorable in 11 out of 12 survivors (modified Rankin Scale score 0–2). Conclusions— Hyperacute recanalization treatment in pediatric stroke, relying on common protocols and adult/pediatric ward collaboration, is feasible. Larger systematic case collection is encouraged.

Published
2017

35. Primary Angiitis of the Central Nervous System

Author

Loïc Guillevin, Eric Meary, Mathieu Zuber, Hubert de Boysson, Christian Pagnoux, Grégoire Boulouis, O Naggara, and Vincent Costalat

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Central nervous system, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Parenchyma, Humans, Medicine, Brain magnetic resonance imaging, Vasculitis, Central Nervous System, Stroke, Cerebral Hemorrhage, Retrospective Studies, Advanced and Specialized Nursing, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Cerebral Infarction, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Female, France, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Vasculitis, Magnetic Resonance Angiography, 030217 neurology & neurosurgery
Abstract

Background and Purpose— Primary angiitis of the central nervous system remains challenging. To report an overview and pictorial review of brain magnetic resonance imaging findings in adult primary angiitis of the central nervous system and to determine the distribution of parenchymal, meningeal, and vascular lesions in a large multicentric cohort. Methods— Adult patients from the French COVAC cohort (Cohort of Patients With Primary Vasculitis of the Central Nervous System), with biopsy or angiographically proven primary angiitis of the central nervous system and brain magnetic resonance imaging available at the time of diagnosis were included. A systematic imaging review was performed blinded to clinical data. Results— Sixty patients met inclusion criteria. Mean age was 45 years (±12.9). Patients initially presented focal deficit(s) (83%), headaches (53%), cognitive disorder (40%), and seizures (38.3%). The most common magnetic resonance imaging finding observed in 42% of patients was multiterritorial, bilateral, distal acute stroke lesions after small to medium artery distribution, with a predominant carotid circulation distribution. Hemorrhagic infarctions and parenchymal hemorrhages were also frequently found in the cohort (55%). Acute convexity subarachnoid hemorrhage was found in 26% of patients and 42% demonstrated pre-eminent leptomeningeal enhancement, which is found to be significantly more prevalent in biopsy-proven patients (60% versus 28%; P =0.04). Seven patients had tumor-like presentations. Seventy-seven percent of magnetic resonance angiographic studies were abnormal, revealing proximal/distal stenoses in 57% and 61% of patients, respectively. Conclusions— Adult primary angiitis of the central nervous system is a heterogenous disease, with multiterritorial, distal, and bilateral acute stroke being the most common pattern of parenchymal lesions found on magnetic resonance imaging. Our findings suggest a higher than previously thought prevalence of hemorrhagic transformation and other hemorrhagic manifestations.

Published
2017

36. Long-term Outcome After Multiple Burr Hole Surgery in Children With Moyamoya Angiopathy: A Single-Center Experience in 108 Hemispheres

Author

Marianne de Montalembert, Bertrand Mathon, M. Zerah, S. Puget, Olivier Naggara, Christian Sainte-Rose, Valentine Brousse, Philippe Meyer, Manoelle Kossorotoff, Marie Bourgeois, Thomas Blauwblomme, and Francis Brunelle

Subjects
Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Cerebral Revascularization, Revascularization, Angiopathy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pediatric stroke, 030212 general & internal medicine, Moyamoya disease, Child, Stroke, Retrospective Studies, medicine.diagnostic_test, business.industry, Skull, Digital subtraction angiography, Perioperative, medicine.disease, Surgery, Treatment Outcome, Child, Preschool, Female, Neurology (clinical), Radiology, Moyamoya Disease, business, 030217 neurology & neurosurgery
Abstract

Background Multiple burr hole (MBH) surgery is a simple, safe, and effective indirect technique of revascularization in moyamoya angiopathy (MM). However, it is not yet recognized as a first-line treatment. Objective To assess the long-term outcome and perioperative complications in a large single-center cohort of children with MM who underwent burr hole surgery. Methods This study is a retrospective analysis of children who underwent surgery for MM in a national reference center for pediatric stroke between 1999 and 2015. Sixty-four children (108 hemispheres, median age 7 years) were consecutively treated. The indication for revascularization was previous stroke or transient ischemic attack (TIA) or rapidly progressive disease on brain magnetic resonance imaging (MRI) and digital subtraction angiography. Children were followed with clinical examinations, telephone interviews, and MRI with any clinical recurrence of stroke or TIA used as the primary endpoint. Surgical mortality and morbidity were documented. Results Sixty-four patients were operated (bilateral MBH n = 39, unilateral procedure n = 25). At a mean follow-up of 4.2 years and 270.6 patient years, 89.1% of patients had not suffered any recurrent stroke or TIA. A second surgery was required in 5 cases after unilateral revascularization, and in 3 cases after bilateral MBH. Mortality associated with the procedure was 0. Postoperative Matsushima angiographic grading was the only predictive factor of ischemic recurrence ( P = .036). Conclusion In pediatric MM, MBH compares favorably to other indirect or direct revascularization techniques in children in the prevention of stroke or TIA.

Published
2017

37. ASPECTS (Alberta Stroke Program Early CT Score) Assessment of the Perfusion–Diffusion Mismatch

Author

Louis Lassalle, Guillaume Turc, Jean-Claude Baron, Jean-François Meder, Olivier Naggara, Pauline Roca, Jean-Louis Mas, Laurence Legrand, Marie Tisserand, Stéphanie Lion, Sylvain Charron, Catherine Oppenheim, and Myriam Edjlali

Subjects
Male, medicine.medical_specialty, Perfusion Imaging, Perfusion scanning, 030204 cardiovascular system & hematology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, medicine.artery, medicine, Humans, cardiovascular diseases, Perfusion diffusion mismatch, Stroke, Aged, Retrospective Studies, Thrombectomy, Advanced and Specialized Nursing, medicine.diagnostic_test, business.industry, Brain, Infarction, Middle Cerebral Artery, Magnetic resonance imaging, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging, Treatment Outcome, Tissue Plasminogen Activator, Middle cerebral artery, Female, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Background and Purpose— Rapid and reliable assessment of the perfusion-weighted imaging (PWI)/diffusion-weighted imaging (DWI) mismatch is required to promote its wider application in both acute stroke clinical routine and trials. We tested whether an evaluation based on the Alberta Stroke Program Early CT Score (ASPECTS) reliably identifies the PWI/DWI mismatch. Methods— A total of 232 consecutive patients with acute middle cerebral artery stroke who underwent pretreatment magnetic resonance imaging (PWI and DWI) were retrospectively evaluated. PWI-ASPECTS and DWI-ASPECTS were determined blind from manually segmented PWI and DWI volumes. Mismatch-ASPECTS was defined as the difference between PWI-ASPECTS and DWI-ASPECTS (a high score indicates a large mismatch). We determined the mismatch-ASPECTS cutoff that best identified the volumetric mismatch, defined as Volume T max>6s /Volume DWI ≥1.8, a volume difference≥15 mL, and a Volume DWI Results— Inter-reader agreement was almost perfect for PWI-ASPECTS (κ=0.95 [95% confidence interval, 0.90–1]), and DWI-ASPECTS (κ=0.96 [95% confidence interval, 0.91–1]). There were strong negative correlations between volumetric and ASPECTS-based assessments of DWI lesions (ρ=−0.84, P P Conclusions— The mismatch-ASPECTS method can detect a true mismatch in patients with acute middle cerebral artery stroke. It could be used for rapid screening of patients with eligible mismatch, in centers not equipped with ultrafast postprocessing software.

Published
2016

38. Fluid-Attenuated Inversion Recovery Vascular Hyperintensities–Diffusion-Weighted Imaging Mismatch Identifies Acute Stroke Patients Most Likely to Benefit From Recanalization

Author

Marie Tisserand, Denis Trystram, Laurence Legrand, Myriam Edjlali, Olivier Naggara, Jean-Louis Mas, Pauline Roca, Guillaume Turc, David Calvet, Jean-Claude Baron, Jean-François Meder, and Catherine Oppenheim

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Fluid-attenuated inversion recovery, Magnetic resonance angiography, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Modified Rankin Scale, medicine, Humans, Registries, cardiovascular diseases, Stroke, Aged, Retrospective Studies, Aged, 80 and over, Advanced and Specialized Nursing, medicine.diagnostic_test, business.industry, Patient Selection, Infarction, Middle Cerebral Artery, Odds ratio, Thrombolysis, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Confidence interval, Diffusion Magnetic Resonance Imaging, Treatment Outcome, Tissue Plasminogen Activator, Female, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Magnetic Resonance Angiography, 030217 neurology & neurosurgery, Fibrinolytic agent
Abstract

Background and Purpose— Fluid-attenuated inversion recovery vascular hyperintensities (FVH) beyond the boundaries of diffusion-weighted imaging (DWI) lesion (FVH-DWI mismatch) have been proposed as an alternative to perfusion-weighted imaging (PWI)-DWI mismatch. We aimed to establish whether FVH-DWI mismatch can identify patients most likely to benefit from recanalization. Methods— FVH-DWI mismatch was assessed in 164 patients with proximal middle cerebral artery occlusion before intravenous thrombolysis. PWI-DWI mismatch (PWI Tmax>6sec /DWI>1.8) was assessed in the 104 patients with available PWI data. We tested the associations between 24-hours complete recanalization on magnetic resonance angiography and 3-month favorable outcome (modified Rankin Scale score ≤2), stratified on FVH-DWI (or PWI-DWI) status. Results— FVH-DWI mismatch was present in 121/164 (74%) patients and recanalization in 50/164 (30%) patients. The odds ratio for favorable outcome with recanalization was 16.2 (95% confidence interval, 5.7–46.5; P P =0.22) in those without FVH-DWI mismatch ( P =0.048 for interaction). Recanalization was associated with favorable outcome in patients with PWI-DWI mismatch (odds ratios, 9.9; 95% confidence interval, 3.1–31.3; P =0.0001) and in patients without PWI-DWI mismatch (odds ratios, 7.0; 95% confidence interval, 1.1–44.1; P =0.047), P =0.76 for interaction. Conclusion— The FVH-DWI mismatch may rapidly identify patients with proximal occlusion most likely to benefit from recanalization.

Published
2016

39. White matter hyperintensity burden in patients with ischemic stroke treated with thrombectomy

Author

Boulouis, Grégoire, primary, Bricout, Nicolas, additional, Benhassen, Wagih, additional, Ferrigno, Marc, additional, Turc, Guillaume, additional, Bretzner, Martin, additional, Benzakoun, Joseph, additional, Seners, Pierre, additional, Personnic, Thomas, additional, Legrand, Laurence, additional, Trystram, Denis, additional, Rodriguez-Regent, Christine, additional, Charidimou, Andreas, additional, Rost, Natalia S., additional, Bracard, Serge, additional, Cordonnier, Charlotte, additional, Oppenheim, Catherine, additional, Naggara, Olivier, additional, and Henon, Hilde, additional

Published
2019
Full Text
View/download PDF

40. Imaging Findings After Mechanical Thrombectomy in Acute Ischemic Stroke

Author

Puntonet, Julien, primary, Richard, Marie-Edith, additional, Edjlali, Myriam, additional, Ben Hassen, Wagih, additional, Legrand, Laurence, additional, Benzakoun, Joseph, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Naggara, Olivier, additional, Méder, Jean-Francois, additional, Boulouis, Grégoire, additional, and Oppenheim, Catherine, additional

Published
2019
Full Text
View/download PDF

41. Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy

Author

Seners, Pierre, primary, Roca, Pauline, additional, Legrand, Laurence, additional, Turc, Guillaume, additional, Cottier, Jean-Philippe, additional, Cho, Tae-Hee, additional, Arquizan, Caroline, additional, Bracard, Serge, additional, Ozsancak, Canan, additional, Ben Hassen, Wagih, additional, Naggara, Olivier, additional, Lion, Stéphanie, additional, Debiais, Séverine, additional, Berthezene, Yves, additional, Costalat, Vincent, additional, Richard, Sébastien, additional, Magni, Christophe, additional, Mas, Jean-Louis, additional, Baron, Jean-Claude, additional, and Oppenheim, Catherine, additional

Published
2019
Full Text
View/download PDF

42. Magnetic Resonance Imaging or Computed Tomography Before Treatment in Acute Ischemic Stroke

Author

Provost, Corentin, primary, Soudant, Marc, additional, Legrand, Laurence, additional, Ben Hassen, Wagih, additional, Xie, Yu, additional, Soize, Sébastien, additional, Bourcier, Romain, additional, Benzakoun, Joseph, additional, Edjlali, Myriam, additional, Boulouis, Grégoire, additional, Raoult, Hélène, additional, Guillemin, Francis, additional, Naggara, Olivier, additional, Bracard, Serge, additional, and Oppenheim, Catherine, additional

Published
2019
Full Text
View/download PDF

43. Response by Boulouis et al to Letter Regarding Article, 'Primary Angiitis of the Central Nervous System: Magnetic Resonance Imaging Spectrum of Parenchymal, Meningeal, and Vascular Lesions at Baseline'

Author

Hubert de Boysson, Olivier Naggara, and Gregoire Boulouis

Subjects
Advanced and Specialized Nursing, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Central nervous system, Magnetic resonance imaging, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Ischemic insult, Parenchyma, medicine, Effective diffusion coefficient, Neurology (clinical), Cardiology and Cardiovascular Medicine, Vasculitis, business, Pathological, 030217 neurology & neurosurgery, Cerebral vasculitis
Abstract

We thank Dr Stanley et al for pointing out a potentially important aspect of the ischemic insult in primary and secondary cerebral vasculitis as assessed by signal changes in diffusion-weighted imaging. The authors report that, in their experience, both diffusion-weighted imaging positivity and decreased diffusion coefficient on apparent diffusion coefficient maps can be sustained long after 3 weeks in those pathological conditions. This is of importance, given the fact that acute ischemic lesions, detected by magnetic resonance imaging diffusion-weighted imaging sequences, are known as the most prevalent feature of primary angiitis of the central nervous system at …

Published
2017

44. Long-Term Outcome of 106 Consecutive Pediatric Ruptured Brain Arteriovenous Malformations After Combined Treatment

Author

Stéphanie Puget, Francis Brunelle, Philippe Meyer, Michel Zerah, Marie Bourgeois, Federico Di Rocco, Nathalie Boddaert, Thomas Blauwblomme, Christian Sainte Rose, and Olivier Naggara

Subjects
Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Treatment outcome, Radiosurgery, Combined treatment, Humans, Medicine, Multimodal treatment, Embolization, Child, Cerebral Hemorrhage, Retrospective Studies, Advanced and Specialized Nursing, Intracerebral hemorrhage, Rupture, Spontaneous, business.industry, Microsurgery, medicine.disease, Cerebral Angiography, Surgery, Female, Neurology (clinical), Neurosurgery, Radiology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Background and Purpose— Childhood intracerebral hemorrhage is mainly attributable to underlying brain arteriovenous malformations (bAVMs). Multimodal treatment options for bAVMs include microsurgery and embolization, allowing an immediate cure, and radiosurgery, entailing longer obliteration times. Follow-up data on pediatric ruptured bAVMs are scarce, making it difficult to assess the risk of subsequent intracerebral hemorrhage. Our aim was to assess the clinical and angiographic outcome and to analyze risk factors for rebleeding during and after combined treatment of pediatric bAVMs. Methods— A prospectively maintained database of children referred to our institution between January 1997 and October 2012 for bAVMs was retrospectively queried to identify all consecutive ruptured bAVMs treated by surgery, embolization, and radiosurgery. The impact of baseline clinical and bAVM characteristics on clinical outcome, rebleeding rate, annual bleeding rate, and bAVM obliteration was studied using univariate and multivariate Cox regression analysis. Results— One hundred six children with ruptured bAVMs were followed up for a total of 480.5 patient-years (mean, 4.5 years). Thirteen rebleeding events occurred, corresponding to an annual bleeding rate of 2.71±1.32%, significantly higher in the first year (3.88±1.39%) than thereafter (2.22±1.38%; P P =0.004) or any deep venous drainage (relative risk, 2.97; P =0.002), in univariate and multivariate analysis. Partial embolization was associated with a higher annual bleeding rate, whereas initial surgery for intracerebral hemorrhage evacuation was associated with a lower risk of rebleeding. Conclusions— Associated aneurysms and any deep venous drainage are independent risk factors for rebleeding in pediatric ruptured bAVMs. Immediate surgery or total embolization might be advantageous for children harboring such characteristics, whereas radiosurgery might be targeted at patients without such characteristics.

Published
2014

45. Intracranial aneurysm wall enhancement decreases under anti-inflammatory treatment

Author

Imad Derraz, Christine Rodriguez-Régent, Gregoire Boulouis, Olivier Naggara, Wagih Ben Hassen, Myriam Edjlali, Catherine Oppenheim, Denis Trystram, and Jean-François Meder

Subjects
medicine.medical_specialty, Anti inflammatory treatment, Anti-Inflammatory Agents, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, Image Interpretation, Computer-Assisted, medicine, Humans, cardiovascular diseases, Aged, Palsy, Right optic nerve, business.industry, Intracranial Aneurysm, medicine.disease, Visual field, Intensity (physics), Optic Nerve Injuries, cardiovascular system, Optic nerve, Female, Steroids, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery
Abstract

A 68-year-old woman presented with visual field defect, caused by right optic nerve compression by a giant carotid-ophthalmic aneurysm. Steroids were initiated at 1 mg/kg/d with a 3-month dose decrease and resolution of symptoms. Any other intervention was refused. Vessel wall MRIs (figure) showed a decrease in intensity and thickness of initial circumferential aneurysm wall enhancement (CAWE) at 6 weeks, sustained at 1 year. CAWE is hypothesized to be related to inflammation,1 a marker of aneurysm instability.2 This observation suggested an anti-inflammatory effect of steroids on aneurysm wall enhancement that may have contributed to the resolution of the optic nerve palsy.

Published
2018

47. Primary angiitis of the CNS and reversible cerebral vasoconstriction syndrome

Author

de Boysson, Hubert, primary, Parienti, Jean-Jacques, additional, Mawet, Jérôme, additional, Arquizan, Caroline, additional, Boulouis, Grégoire, additional, Burcin, Cécilia, additional, Naggara, Olivier, additional, Zuber, Mathieu, additional, Touzé, Emmanuel, additional, Aouba, Achille, additional, Bousser, Marie-Germaine, additional, Pagnoux, Christian, additional, and Ducros, Anne, additional

Published
2018
Full Text
View/download PDF

50. Does Aneurysmal Wall Enhancement on Vessel Wall MRI Help to Distinguish Stable From Unstable Intracranial Aneurysms?

Author

Denis Trystram, Patrick A. Turski, Oliver Wieben, Jean Raymond, Stéphanie Lion, Catherine Oppenheim, Olivier Naggara, Jean-Christophe Gentric, Wajih Ben Hassen, François Nataf, Christine Régent-Rodriguez, Jean-François Meder, and Myriam Edjlali

Subjects
Inflammation, Male, Advanced and Specialized Nursing, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Arterial disease, Intracranial Aneurysm, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Confidence interval, Surgery, Aneurysm, Image Interpretation, Computer-Assisted, Humans, Medicine, Female, In patient, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business
Abstract

Background and Purpose— Arterial wall enhancement on vessel wall MRI was described in intracranial inflammatory arterial disease. We hypothesized that circumferential aneurysmal wall enhancement (CAWE) could be an indirect marker of aneurysmal wall inflammation and, therefore, would be more frequent in unstable (ruptured, symptomatic, or undergoing morphological modification) than in stable (incidental and nonevolving) intracranial aneurysms. Methods— We prospectively performed vessel wall MRI in patients with stable or unstable intracranial aneurysms. Two readers independently had to determine whether a CAWE was present. Results— We included 87 patients harboring 108 aneurysms. Interreader and intrareader agreement for CAWE was excellent (κ=0.85; 95% confidence interval, 0.75–0.95 and κ=0.90; 95% confidence interval, 0.83–0.98, respectively). A CAWE was significantly more frequently seen in unstable than in stable aneurysms (27/31, 87% versus 22/77, 28.5%, respectively; P P =0.0002). Conclusions— CAWE was more frequently observed in unstable intracranial aneurysms and may be used as a surrogate of inflammatory activity in the aneurysmal wall.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results