54 results on '"Michelakis, Evangelos D."'
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2. Abstract 15760: A Critical Contribution of Cardiac Myofibroblasts and a Predictive Role of UCP2 SNPs in the RV Decompensation in Pulmonary Hypertension
3. SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes
4. Abstract 9054: Cell-Specific Regulation of the GATA-4/6 Transcription Factors by the Metabolic Enzyme PKM2 Provides Insight into a Biologic Function Essential for Cardiac Health and Survival
5. Abstract 13575: Lack of Both Mitochondrial Proteins Sirt3 and Ucp2 in Mice Recapitulates Many Critical Features of Human Pulmonary Arterial Hypertension (PAH), Including Inflammatory Plexogenic Lesions, Supporting the Metabolic Theory of PAH
6. p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology
7. Immunity Comes to Play in the “Sex Paradox” of Pulmonary Arterial Hypertension
8. PVDOMICS Drive the Pulmonary Hypertension Field Into the Precision Medicine Era
9. Oxygen Sensing in the Pulmonary Circulation
10. A Paradigm Shift Is Needed in the Field of Pulmonary Arterial Hypertension for Its Entrance Into the Precision Medicine Era
11. Abstract 19353: Prohibitin: A Potential Circulating Mitokine That May be Involved in Pulmonary Arterial Hypertension
12. Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy?
13. Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension
14. Addressing Complexity in Pulmonary Hypertension
15. A miR-208–Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension
16. The Metabolic Theory of Pulmonary Arterial Hypertension
17. Pulmonary Arterial Hypertension
18. Response to Lazarus
19. Role for DNA Damage Signaling in Pulmonary Arterial Hypertension
20. Abstract 18991: A Mir-208-mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension
21. Abstract 18830: Mitochondrial Suppression Due to Loss of Sirt3 Deacetylase Activity Causes Pulmonary Arterial Hypertension
22. Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension
23. Endothelin Axis Is Upregulated in Human and Rat Right Ventricular Hypertrophy
24. Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension
25. Abstract 18906: Congenital Right Ventricular Hypertrophy Compensation is Characterized by Sustained Angiogenesis
26. Abstract 19228: Lack of Uncoupling Protein 2 (UCP2) Reduces Mitochondrial Calcium Uptake from the Endoplasmic Reticulum (ER), Triggering Mitochondrial Suppression and Pulmonary Hypertension (PHT)
27. Abstract 19343: Chemical Chaperone Mediated Inhibition of Activating Transcription Factor 6 (ATF6) is a Novel Therapy in Pulmonary Arterial Hypertension (PAH)
28. The Estrogen Puzzle in Pulmonary Arterial Hypertension
29. Abstract 16836: Pioglitazone Reduces Angiogenesis by Altering Mitochondrial Function and Reducing Hypoxia Inducible Factor-1 Activation
30. New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy
31. Dehydroepiandrosterone Reverses Systemic Vascular Remodeling Through the Inhibition of the Akt/GSK3-β/NFAT Axis
32. Comprehensive Invasive and Noninvasive Approach to the Right Ventricle–Pulmonary Circulation Unit
33. Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension
34. Pulmonary Vascular Diseases
35. Mitochondrial Medicine
36. CD36 Expression Contributes to Age-Induced Cardiomyopathy in Mice
37. Abstract 976: Hyperpolarized Mitochondria in Right Ventricular Hypertrophy: a Target for Ventricular-Specific Therapies
38. Abstract 658: Suppressed Hypoxic Pulmonary Vasoconstriction in Malonyl-CoA-Decarboxylase Knock-Out Mice
39. Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
40. Oxygen Activates the Rho/Rho-Kinase Pathway and Induces RhoB and ROCK-1 Expression in Human and Rabbit Ductus Arteriosus by Increasing Mitochondria-Derived Reactive Oxygen Species
41. Absence of Malonyl Coenzyme A Decarboxylase in Mice Increases Cardiac Glucose Oxidation and Protects the Heart From Ischemic Injury
42. An evidence-based approach to the management of pulmonary arterial hypertension
43. An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats
44. Spatio-Temporal Diversity of Apoptosis Within the Vascular Wall in Pulmonary Arterial Hypertension
45. Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury
46. Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis
47. Oxygen-Sensitive Kv Channel Gene Transfer Confers Oxygen Responsiveness to Preterm Rabbit and Remodeled Human Ductus Arteriosus
48. Preferential Expression and Function of Voltage-Gated, O 2 -Sensitive K + Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction
49. Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension
50. In Vivo Gene Transfer of the O 2 -Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats
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