1. Abstract 332: Long-term Post-discharge Survival and Healthcare Utilization Following Out-of-hospital Cardiac Arrest: Insights From a Novel Province-wide Linkage
- Author
-
Brian Grunau, Christopher B. Fordyce, Jim Christenson, Jennie Helmer, May K. Lee, Meijiao Guan, Nathaniel M. Hawkins, Graham C. Wong, and Karin H. Humphries
- Subjects
Linkage (software) ,Resuscitation ,medicine.medical_specialty ,Healthcare utilization ,business.industry ,Post discharge ,Physiology (medical) ,Emergency medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Out of hospital cardiac arrest ,Term (time) - Abstract
Introduction: Out-of-hospital cardiac arrest (OHCA) is associated with poor short-term outcomes. However, the impact of pre- and in-hospital factors on long-term outcomes is ill-defined, mainly related to challenges combining disparate data sources. Methods: We linked adult non-traumatic EMS-treated OHCAs from the British Columbia Cardiac Arrest Registry (Jan 2009 - Dec 2016) to provincial datasets describing co-morbidities, medications, procedures, mortality, and hospital admission and discharge. Among hospital-discharge survivors, we examined the 3-year composite endpoint of mortality ± all-cause readmission using the Kaplan-Meier (KM) method and multivariable Cox model for predictors. Results: Of 10,876 successfully linked OHCAs, 1325 survived to hospital discharge: mean age 62.8 years, 77.9% male, 72.6% shockable rhythms, 60.1% non-public locations, 69.1% bystander CPR, and 30.3% STEMI. During admission, 78.6% required mechanical ventilation, 69.1% received coronary angiography (37.5% PCI, 10.3% CABG), and 24.8% received an ICD. At 3 years post-discharge, the estimated KM event rates were 15.9% (95% CI 13.9%, 19.3%) for mortality and 68.2% (95% CI 65.3%, 71.0%) for mortality and readmission, which differed by age, initial rhythm, and arrest location ( Figure ). Following multivariable analysis, patients with a history of HF [HR 1.62 (95% CI 1.34 - 1.96)], age >75 [1.62 (1.35, 1.96)], anticoagulation use [2.55 (1.36, 4.79)], non-shockable rhythm [1.29 (1.07, 1.55)] and non-public arrest location [1.21(1.04, 1.40)] were more likely to experience the composite endpoint; those receiving coronary angiography were less likely [0.79 (0.64, 0.98)]. Conclusions: The long-term death or readmission risk persists even among OHCA hospital-discharge survivors, and is associated with both pre- and in-hospital factors. An enriched, linked dataset detailing the entire OHCA “journey” may be a promising tool to identify care and treatment gaps.
- Published
- 2020