1. Primary cutaneous anaplastic large cell lymphoma arising from a long-standing erythema nodosum
- Author
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Shi-Xin Han, Liang-Liang Ma, and Mei-Yun Fang
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,primary cutaneous anaplastic large cell lymphoma ,Primary cutaneous anaplastic large cell lymphoma ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Erythema Nodosum ,Lymphoma, Primary Cutaneous Anaplastic Large Cell ,0302 clinical medicine ,immune system diseases ,hemic and lymphatic diseases ,Humans ,Medicine ,Clinical Case Report ,skin and connective tissue diseases ,Erythema nodosum ,integumentary system ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Lymphoma ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Abdomen ,Female ,20-year history ,business ,Research Article - Abstract
Rationale: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN). Patient concerns: A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks. Diagnoses: The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. The second skin biopsy was performed in 2014 and she was diagnosed as pcALCL with stage IA. Interventions: She was treated with oral prednisone, cyclosporine, and thalidomide. Outcomes: One month later, the ulcerative lesion was decreased in size and became smooth and the patient achieved partial remission. She is still under treatment and has been monitored closely for 4 years. Lessons: The case suggested that stimulation of inflammation in the skin lesions for a long period might be related to clonal transformation into pcALCL and hence should be closely monitored. Immunosuppressive treatment may be effective and safe for patients with pcALCL at early stages.
- Published
- 2018