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Your search keyword '"Kim, Dong-Woon"' showing total 15 results
Start Over "Kim, Dong-Woon" Publisher ovid technologies (wolters kluwer health)
15 results on '"Kim, Dong-Woon"'

2. Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke

Author

Kim Dong Woon, Dongyeong Yoon, Sang Ryong Kim, and Min-Tae Jeon

Subjects
0301 basic medicine, Genetic Vectors, mTORC1, Cell Enlargement, Neuroprotection, Mice, 03 medical and health sciences, Transduction (genetics), 0302 clinical medicine, Downregulation and upregulation, Transduction, Genetic, Neurotrophic factors, Animals, Fluorescent Dyes, Ischemic Stroke, Neurons, Rose Bengal, biology, Brain-Derived Neurotrophic Factor, General Neuroscience, Gene Transfer Techniques, Motor Cortex, Dependovirus, Cell biology, Disease Models, Animal, 030104 developmental biology, nervous system, Mutation, biology.protein, Ras Homolog Enriched in Brain Protein, Thrombotic Stroke, Signal transduction, Gait Analysis, 030217 neurology & neurosurgery, Neurotrophin, RHEB
Abstract

We recently reported that upregulation of the constitutively active ras homolog enriched in brain [Rheb(S16H)], which induces the activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, can protect adult neurons, mediated by the induction of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in animal models of neurodegenerative diseases. Here we show that neuronal transduction of Rheb(S16H) using adeno-associated virus serotype 1 provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Rheb(S16H)-expressing neurons exhibited neurotrophic effects, such as mTORC1 activation, increases in neuronal size, and BDNF production, in mouse cerebral cortex. Moreover, the upregulation of neuronal Rheb(S16H) significantly attenuated ischemic damage and behavioral impairments as compared to untreated mice, suggesting that Rheb(S16H) upregulation in cortical neurons may be a useful strategy to treat ischemic stroke.

Published
2020
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4. Relationship between arterial stiffness and circadian pattern of blood pressure

Author

Park, Jin-Sun, primary, Shin, Joon-Han, additional, Park, Jeong-Bae, additional, Choi, Dong-Ju, additional, Youn, Ho-Joong, additional, Park, Chang-Gyu, additional, Kwan, Jun, additional, Ahn, Youngkeun, additional, Kim, Dong-Woon, additional, Rim, Se-Joong, additional, Park, Seung-Woo, additional, Sung, Jidong, additional, and Bae, Jang-Ho, additional

Published
2019
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6. PS 11-16 POSTPRANDIAL HYPOTENSION, IS IT REAL?

Author

Lee, Ju-Hee, primary, Lee, Dae-In, additional, Kim, Sang-Min, additional, Lee, Sang-Yeub, additional, Bae, Jang-Whan, additional, Hwang, Kyung-Kuk, additional, Kim, Dong-Woon, additional, and Cho, Myeong-Chan, additional

Published
2016
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15. Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis

Author

Heldman, Alan W., primary, Cheng, Linda, additional, Jenkins, G. Mark, additional, Heller, Phillip F., additional, Kim, Dong-Woon, additional, Ware, Melvin, additional, Nater, Cynthia, additional, Hruban, Ralph H., additional, Rezai, Banafsheh, additional, Abella, Benjamin S., additional, Bunge, Katherine E., additional, Kinsella, James L., additional, Sollott, Steven J., additional, Lakatta, Edward G., additional, Brinker, Jeffrey A., additional, Hunter, William L., additional, and Froehlich, Jeffrey P., additional

Published
2001
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