1. Left-right asymmetry of striatal dopamine D2 receptors
- Author
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Meyer W, Rolf Larisch, Hans-Wilhelm Müller-Gärtner, Kehren F, Henning Vosberg, and Ansgar Klimke
- Subjects
Adult ,Male ,Striatal dopamine ,Aging ,medicine.medical_specialty ,Pyrrolidines ,media_common.quotation_subject ,Binding ratio ,Asymmetry ,Lateralization of brain function ,Iodine Radioisotopes ,Cerebellum ,Internal medicine ,Dopamine receptor D2 ,medicine ,Single Photon Emission Tomography ,Humans ,Radiology, Nuclear Medicine and imaging ,Receptor ,Aged ,media_common ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,Receptors, Dopamine D2 ,Chemistry ,business.industry ,General Medicine ,Middle Aged ,Corpus Striatum ,Endocrinology ,Benzamides ,Laterality ,Female ,Nuclear medicine ,business - Abstract
Brain functions may be lateralized to the right or the left hemisphere. However, the biochemical characteristics accompanying these functions are largely unknown. To test possible lateralization of striatal dopamine D 2 receptors, we examined 18 volunteers using 123 I-iodobenzamide and single photon emission tomography. The striatum-to-cerebellum D 2 binding ratio was 1.93 ± 0.22 (mean ± s.D.) on the right side and 1.85 ± 0.19 on the left side. In 14 subjects, D 2 binding was higher in the right compared to the left striatum (P < 0.05). These results are supported by a meta-analysis performed on 15 studies reported in the literature. We conclude that side differences of striatal dopamine D 2 receptors exist. We propose that motor activity could be responsible for our findings.
- Published
- 1998