1. Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury
- Author
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Manning J. Sabatier and Arthur W. English
- Subjects
medicine.medical_specialty ,Physical Therapy, Sports Therapy and Rehabilitation ,Biology ,Article ,SOXC Transcription Factors ,Peripheral Nerve Injuries ,Neurotrophic factors ,Internal medicine ,medicine ,Animals ,Humans ,Orthopedics and Sports Medicine ,Axon ,Cyclic AMP Response Element-Binding Protein ,Receptor ,Transcription factor ,Brain-derived neurotrophic factor ,Brain-Derived Neurotrophic Factor ,Axons ,Nerve Regeneration ,Androgen receptor ,Endocrinology ,medicine.anatomical_structure ,nervous system ,Receptors, Androgen ,Peripheral nerve injury ,Signal transduction ,Signal Transduction - Abstract
This article outlines the novel hypothesis that exercise promotes axon regeneration after peripheral nerve injury through neuronal brain-derived neurotrophic factor (BDNF), and there are three required means of promoting BDNF expression: 1) increased signaling through androgen receptors, 2) increased cAMP-responsive element-binding protein expression, and 3) increased expression of the transcription factor SRY-box containing gene 11.
- Published
- 2015
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