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Kaposi sarcoma (KS) is a tumor caused by human herpesvirus 8, also known as KS-associated herpesvirus. Epidemiological varieties are represented by an epidemic form, strongly associated with AIDS, classic form, endemic form, and transplant-related form in association with severely immunosuppressive drug regimens, pointing to a role for immunodeficiency in the development of KS. We report the case of a woman who had preexisting immune system damage because of recurrent Hodgkin's lymphoma and presented with KS of the pelvis with high FDG uptake on PET/CT mimicking nodal relapse. Clinicians and nuclear medicine physicians should be aware that KS can present as intense FDG uptake. Moreover, our case emphasizes the importance of obtaining a biopsy.