1. Routine echocardiography in patients with myotonic dystrophy type 1
- Author
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Teodora Paunic, Marina Peric, Stojan Peric, Edita Cvitan, Srdjan Raspopovic, Vidosava Rakocevic Stojanovic, and Gorana Mandic Stojmenovic
- Subjects
musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Left ventricle dysfunction ,Diastole ,Disease ,030204 cardiovascular system & hematology ,Myotonic dystrophy ,03 medical and health sciences ,0302 clinical medicine ,Mitral valve ,Internal medicine ,Medicine ,Mitral valve prolapse ,lcsh:R5-920 ,Myotonic dystrophy type 1 ,business.industry ,Retrospective cohort study ,General Medicine ,medicine.disease ,3. Good health ,medicine.anatomical_structure ,Echocardiography ,Heart failure ,Cardiology ,Abnormality ,lcsh:Medicine (General) ,business ,030217 neurology & neurosurgery - Abstract
Background: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant disease. One third of DM1 patients die suddenly, most of them due to the heart conduction abnormalities and arrhythmias. The aim of this study was to analyze echocardiographic findings in a large cohort of DM1 patients. Methods: This retrospective study comprised 111 patients and 71 healthy controls (HCs) matched for gender and age. Results: Mitral valve (MV) prolapse was observed in 23% of our DM1 patients vs. 8.5% of HCs (p 0.05). Systolic dysfunction was more common in patients with severe electrocardiographic (ECG) abnormality (18.8% vs. 2.7%, p
- Published
- 2017