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Your search keyword '"Francisco Llamas-Gutierrez"' showing total 3 results
Start Over Author "Francisco Llamas-Gutierrez" Publisher ovid technologies (wolters kluwer health)
3 results on '"Francisco Llamas-Gutierrez"'

1. Giant Cell Tumors With HMGA2::NCOR2 Fusion

Author

Raul Perret, Zaki Malaka, Valérie Velasco, Francisco Llamas-Gutierrez, Mickael Ropars, Pierre-Antoine Linck, Isabelle Hostein, Rihab Azmani, Isabelle Valo, Louise Galmiche, Anne Moreau, Gonzague de Pinieux, Audrey Michot, Dorian Bochaton, Jean-Michel Coindre, and François Le Loarer

Subjects
Surgery, Anatomy, Pathology and Forensic Medicine
Published
2023

2. Discordant Response of Systemic Mastocytosis Associated With Myelodysplastic Syndrome After Midostaurin and Allogeneic Hematopoietic Stem-cell Transplantation

Author

Cedric Pastoret, Francisco Llamas-Gutierrez, Thierry Fest, Thierry Lamy, Mikael Roussel, Roch Houot, Marie-Laure Boulland, and Marion Haas

Subjects
Oncology, medicine.medical_specialty, lcsh:RC633-647.5, business.industry, medicine.medical_treatment, Case Report, lcsh:Diseases of the blood and blood-forming organs, Hematology, Hematopoietic stem cell transplantation, medicine.disease, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Midostaurin, Systemic mastocytosis, business
Published
2020

3. Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma

Author

Laurent Sulpice, Michel Rayar, Mireille Desille, Cédric Coulouarn, Francisco Llamas-Gutierrez, Alain Fautrel, Karim Boudjema, Bruno Turlin, Bernard Meunier, Bruno Clément, Eveline Boucher, Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], CHU Pontchaillou [Rennes], Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Biologie, CRLCC Eugène Marquis (CRLCC), Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], Hépatotoxicité et xénobiotiques, Détoxication et réparation Tissulaire, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Foie, métabolismes et cancer, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Foie, métabolismes et cancer, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Pathology, medicine.medical_specialty, Stromal cell, [SDV]Life Sciences [q-bio], Laser Capture Microdissection, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Stroma, Transforming Growth Factor beta, Laminin, medicine, Humans, Osteopontin, Aged, Laser capture microdissection, Hepatology, biology, Gene Expression Profiling, Liver Neoplasms, Transforming growth factor beta, Middle Aged, Cell cycle, Prognosis, Up-Regulation, 3. Good health, Gene expression profiling, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Liver, 030220 oncology & carcinogenesis, biology.protein, Female, 030211 gastroenterology & hepatology, Stromal Cells
Abstract

International audience; Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The presence of an abundant stroma is a histological hallmark of ICC. Given the well-established role of the stromal compartment in the progression of cancer diseases, we hypothesized that relevant biomarkers could be identified by analyzing the stroma of ICC. By combining laser capture microdissection and gene expression profiling, we demonstrate that ICC stromal cells exhibit dramatic genomic changes. We identified a signature of 1,073 nonredundant genes that significantly discriminate the tumor stroma from nontumor fibrous tissue. Functional analysis of differentially expressed genes demonstrated that up-regulated genes in the stroma of ICC were related to cell cycle, extracellular matrix, and transforming growth factor beta (TGFβ) pathways. Tissue microarray analysis using an independent cohort of 40 ICC patients validated at a protein level the increased expression of collagen 4A1/COL4A1, laminin gamma 2/LAMC2, osteopontin/SPP1, KIAA0101, and TGFβ2 genes in the stroma of ICC. Statistical analysis of clinical and pathological features demonstrated that the expression of osteopontin, TGFβ2, and laminin in the stroma of ICC was significantly correlated with overall patient survival. More important, multivariate analysis demonstrated that the stromal expression of osteopontin was an independent prognostic marker for overall and disease-free survival. CONCLUSION: The study identifies clinically relevant genomic alterations in the stroma of ICC, including candidate biomarkers for prognosis, supporting the idea that tumor stroma is an important factor for ICC onset and progression.

Published
2013

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